This paper considers, firstly, to what extent the administration of oxytocin can augment the capacity of empathy in human beings; and secondly, whether or not such practice ought to be allowed. In relation to the latter, the author develops an argument in favour of this intervention by virtue of its consistency with the belief that, if a therapeutic treatment is to be considered acceptable, it is essential that it maximizes the well-being of those affected and that it does not (...) compromise the autonomy of the patient. Having rejected several objections related to the nature of this intervention, the author finally questions its morality on the basis of a concern with its universalizability. (shrink)

At least a third of the women giving birth in the United States receive intravenous oxytocin for the induction and augmentation of labor. The problem of inactive or ineffective labor remains a major challenge for birth attendants, midwives, and physicians who practice obstetrics. Before the discovery of oxytocin, traditional approaches to augmentation ranged from magical and folk interventions to extensive bloodletting. Despite its wide use the effectiveness of oxytocin augmentation has not been well studied, and current research (...) raises new questions about its effect on the brain. (shrink)

Face perception is a highly conserved process that directs our attention from infancy and is supported by specialized neural circuitry. Oxytocin can increase accuracy and detection of emotional faces, but these effects are mediated by valence, individual differences, and context. We investigated the temporal dynamics of oxytocin’s influence on the neural substrates of face perception using event related potentials (ERP). In a double blind, placebo controlled within-subject design, 21 healthy male adults inhaled oxytocin or placebo and underwent (...) ERP imaging during two face processing tasks. Experiment 1 investigated effects of oxytocin on neural correlates of fearful versus neutral facial expressions, and Experiment 2 manipulated point-of-gaze to neutral faces. In Experiment 1, we found that oxytocin reduced N170 latency to fearful faces. In Experiment 2, N170 latency was decreased when participant gaze was directed to the eyes of neutral faces; however, there were no oxytocin-associated effects in response to different facial features. Findings suggest oxytocin modulates early stages of social perception for socially complex information such as emotional faces relative to neutral. These results are consistent with models suggesting oxytocin impacts the salience of socially informative cues during processing, which leads to downstream effects in behavior. Future work should examine how oxytocin affects neural processes underlying basic components of social behavior (such as, face perception) while varying emotional expression of stimuli or comparing different characteristics of participants (e.g., gender, personality traits). (shrink)

Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests that although broad traits are affected by genetic variability, the specific links between (...) alleles and behavioural variables might be breed-specific. In the current study, we found that Siberian huskies with the A allele approached a friendly unfamiliar woman less frequently in a greeting test, which indicates that certain polymorphisms are related to human directed behaviour, but that the relationship patterns between polymorphisms and behavioural phenotypes differ between populations. This finding was further supported by our next investigation. According to primate studies, endogenous opioid peptide (e.g. endorphins) receptor genes have also been implicated in social relationships. Therefore, we examined the rs21912990 of the OPRM1 gene. Firstly, we found that the allele frequencies of Siberian huskies and gray wolves were similar, but differed from that of Border collies and German shepherd dogs, which might reflect their genetic relationship. Secondly, we detected significant associations between the OPRM1 SNP and greeting behaviour among German shepherd dogs and a trend in Border collies, but we could not detect an association in Siberian huskies. Although our results with OXTR and OPRM1 gene variants should be regarded as preliminary due to the relatively low sample size, they suggest that (1) OXTR and OPRM1 gene variants in dogs affect human-directed social behaviour and (2) their effects differ between breeds. (shrink)

ZusammenfassungIn massenmedialen Darstellungen wird das Hormon Oxytocin gegenwärtig als biochemische Basis von Sozialität und wirkmächtiger neuropharmakologischer Lösungsansatz für die (Wieder‑)Herstellung der gesellschaftlichen Kohäsion verhandelt. Mit Blick auf die ursprüngliche Bedeutung des Hormons als „Körperhormon“ zu Beginn des 20. Jahrhunderts soll im vorliegenden Artikel die außergewöhnliche Karriere von Oxytocin vom Regulator des Geburtsvorgangs hin zum Regulator der Gesellschaft nachgezeichnet werden. Woraus bezieht eine solch voraussetzungsvolle Behauptung ihre Intelligibilität und Akzeptabilität? Unsere Analyse des wissenschaftlichen Diskurses um Oxytocin (1906–1990), des (...) massenmedialen Diskurses seit den 1990er Jahren sowie dessen Rückwirkungen auf den wissenschaftlichen Diskurs im gleichen Zeitraum verweist auf eine Serie von Re-Konfigurationen von wissenschaftlichen Theorien und Praktiken, sowie der Konzeption der Substanz an sich. Nachdem es sich in der ersten Hälfte des 20. Jahrhunderts etabliert, wird Oxytocin bereits in den 1950er Jahren zum Neurohormon, findet in den folgenden Jahrzehnten jedoch kaum wissenschaftliche Aufmerksamkeit. Erst im Zuge des massenmedialen Interesses für die postulierten Wirkungen des Hormons in Zusammenhang mit Liebe und Bindung gerät die Substanz zunehmend in den Fokus empirischer Forschung. Die Rezeption von Oxytocin als neurohormonelle Basis der individuellen Soziabilität speist sich zum einen aus dem massenmedialen Diskurs, zum anderen aus bereits in der ersten Hälfte des 20. Jahrhunderts gemachten biopolitischen Verknüpfungen, die auf die Regulierung des Lebendigen abzielen, sowie aus einem technowissenschaftlichen Modus der Oxytocinforschung: an ihrem Schnittpunkt avanciert Oxytocin zum Sozialhormon, so unsere These. (shrink)

Current perspectives on attractiveness-related prosocial biases emphasize the contribution of evolutionarily shaped mating drives. Here, we extend these concepts by highlighting the pivotal role of the hypothalamic peptide oxytocin in augmenting the salience and rewarding value of social stimuli, including the partner's face, thereby fostering social bonding in general and the stability of monogamous pair bonds and offspring care in particular.

Spirituality and religiosity have a significant impact on one's well-being. Although previous studies have indicated that the neuropeptide hormone oxytocin is associated with spirituality/religiosity, existing findings remain inconsistent. Some studies have reported a positive relationship between oxytocin and spirituality/religiosity, while other studies have reported a negative association. Herein, we examined the association between endogenous oxytocin and spirituality/religiosity in 200 non-Abrahamic Japanese individuals by measuring the level of salivary oxytocin and spiritual/religious faith. We found that the level (...) of salivary oxytocin was negatively associated with spiritual/religious faith. Individuals with higher levels of salivary oxytocin tend to have more negative spiritual/religious faith compared with those with low oxytocin levels. Moreover, this tendency was only significant in individuals who were not interested in a specific religion. The uniqueness of spirituality/religiosity in Japan could help interpret the current findings. (shrink)

Despite acknowledging that musicality evolved to serve multiple adaptive functions in human evolution, Savage et al. promote social bonding to an overarching super-function. Yet, no unifying neurobiological framework is offered. We propose that oxytocin constitutes a socio-allostatic agent whose modulation of sensing, learning, prediction, and behavioral responses with reference to the physical and social environment facilitates music's social bonding effects.

The question will be raised whether oxytocin can serve as an effective moral enhancer. Different types of moral enhancement will be addressed, one of them being compulsory moral enhancement. It will be argued that oxytocin cannot serve as an effective moral enhancer if its use is being made compulsory. Hence, compulsory administration of oxytocin does not result in genuine moral enhancement. In order to demonstrate this, a stipulation of the main potentially beneficial outcomes of using oxytocin (...) as a moral enhancer will be offered, as well as a discussion of objections to the notion that oxytocin can be an effective moral enhancer. It will be concluded that mandatory administration of oxytocin is ineffective because of a combination of two reasons: mandatory administration of oxytocin renders moral reflection practically superfluous; without moral reflection the beneficial outcomes of the use of oxytocin do not outweigh its drawbacks to the degree that we could speak of effective moral enhancement. (shrink)

The peptide hormone oxytocin plays a critical role in regulating affiliative behaviors including mating, pair‐bond formation, maternal/parenting behavior, social recognition, separation distress and other aspects of attachment. Jin and colleagues1 recently reported intriguing findings that CD38, a transmembrane receptor with ADP‐ribosyl cyclase activity, plays a critical role in maternal nurturing behavior and social recognition by regulating oxytocin secretion. This research may have implications for understanding disorders marked by deficits in social cognition and social functioning, including autism, social anxiety (...) disorder, borderline personality disorder and schizophrenia. BioEssays 29:837–841, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

ZusammenfassungIn massenmedialen Darstellungen wird das Hormon Oxytocin gegenwärtig als biochemische Basis von Sozialität und wirkmächtiger neuropharmakologischer Lösungsansatz für die (Wieder‑)Herstellung der gesellschaftlichen Kohäsion verhandelt. Mit Blick auf die ursprüngliche Bedeutung des Hormons als „Körperhormon“ zu Beginn des 20. Jahrhunderts soll im vorliegenden Artikel die außergewöhnliche Karriere von Oxytocin vom Regulator des Geburtsvorgangs hin zum Regulator der Gesellschaft nachgezeichnet werden. Woraus bezieht eine solch voraussetzungsvolle Behauptung ihre Intelligibilität und Akzeptabilität? Unsere Analyse des wissenschaftlichen Diskurses um Oxytocin (1906–1990), des (...) massenmedialen Diskurses seit den 1990er Jahren sowie dessen Rückwirkungen auf den wissenschaftlichen Diskurs im gleichen Zeitraum verweist auf eine Serie von Re-Konfigurationen von wissenschaftlichen Theorien und Praktiken, sowie der Konzeption der Substanz an sich. Nachdem es sich in der ersten Hälfte des 20. Jahrhunderts etabliert, wird Oxytocin bereits in den 1950er Jahren zum Neurohormon, findet in den folgenden Jahrzehnten jedoch kaum wissenschaftliche Aufmerksamkeit. Erst im Zuge des massenmedialen Interesses für die postulierten Wirkungen des Hormons in Zusammenhang mit Liebe und Bindung gerät die Substanz zunehmend in den Fokus empirischer Forschung. Die Rezeption von Oxytocin als neurohormonelle Basis der individuellen Soziabilität speist sich zum einen aus dem massenmedialen Diskurs, zum anderen aus bereits in der ersten Hälfte des 20. Jahrhunderts gemachten biopolitischen Verknüpfungen, die auf die Regulierung des Lebendigen abzielen, sowie aus einem technowissenschaftlichen Modus der Oxytocinforschung: an ihrem Schnittpunkt avanciert Oxytocin zum Sozialhormon, so unsere These. (shrink)

Background: We define compassion as an enduring disposition that centers upon empathetic concern for another person's suffering and the motivation to act to alleviate it. The contribution of specific candidate genes to the development of dispositional compassion for others is currently unknown. We examine candidate genes in the oxytocin and dopamine signaling pathways.Methods: In a 32-year follow-up of the Young Finns Study, we examined with multiple indicators latent growth curve modeling the molecular genetic underpinnings of dispositional compassion for others (...) across the life span. We selected five single nucleotide polymorphisms whose functions are known in humans: rs2268498, rs3796863, rs1800497, rs4680, and rs1611115. Compassion was measured with Cloninger's Temperament and Character Inventory on three repeated observations spanning 15 years. Differences between gender were tested.Results: We did not find an effect of the five SNPs in oxytocin and dopamine pathway genes on the initial levels of dispositional compassion for others. Individuals who carry one or two copies of the T-allele of DBH rs1611115, however, tend to increase faster in compassion over time than those homozygotes for the C-allele, b = 0.063. This effect was largely driven by male participants, 0.206, and was not significant in female participants when analyzed separately.Conclusions: Men who are known to have, on average, lower compassion than women seem to reduce this difference over time if they carry the T-allele of DBH rs1611115. The direction of the association indicates that dopamine signaling activity rather than overall dopamine levels might drive the development of compassion. (shrink)

Social acceptance is assumed to have widespread positive effects on the recipient; however, ethnic/racial minorities often react negatively to social acceptance by White individuals. One possibility for such reactions might be their lack of trust in the genuineness of White individuals’ positive evaluations. Here, we examined the role that oxytocin—a neuropeptide putatively linked to social processes—plays in modulating reactions to acceptance or rejection during interracial interactions. Black participants received intranasal oxytocin or placebo and interacted with a White, same-sex (...) stranger who provided positive or negative social feedback. After positive feedback, participants given oxytocin tended to display approach-oriented cardiovascular responses of challenge, exhibited more cooperative behavior, and perceived the partner to have more favorable attitudes toward them after the interaction. Following negative feedback, oxytocin reduced anger suppression. Oxytocin did not modulate testosterone reactivity directly, but our exploratory analysis showed that the less participants suppressed anger during the interaction with their partner, the greater testosterone reactivity they displayed after the interaction. These results survived the correction for multiple testing with a false discovery rate of 20%, but not with a rate of 10 or 5%. Discussion centers on the interplay between oxytocin and social context in shaping interracial interactions. (shrink)

It has been shown that various types of stress initiate different physiological and neuroendocrine disorders. Oxytocin is mainly produced in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Hypothalamic OT has antistress effects and attenuates the hypothalamic–pituitary–adrenal axis. One mechanism behind the antistress effects of OT is mediated through the inhibition from GABAA receptors on corticotropin-releasing factor expression at the PVN. Various manual therapies such as acupuncture, transcutaneous electrical nerve stimulation, and massage initiate the stimulation of somatosensory neurons (...) of the body. It is well-known that TENS simulates OT expression, while it inhibits CRF expression at the PVN following chronic stress loading in rodents. Upregulation of OT expression at the hypothalamus is activated by the somatosensory stimulation, which is mediated via the spinothalamic pathway. Thus, somatosensory stimulation is beneficial in treating stress-associated symptoms. Hypothalamic OT is associated with the social behaviors, including maternal care and affiliation. Childhood neglect and/or child abuse are severely responsible for deleterious long-term effects on the cognitive/social activity and behavioral development. At parturition, a profound amount of OT is released into the systemic circulation in response to vaginal and cervical stimulation caused by the body of fetus, which induces the onset of maternal behavior. Peridural anesthesia effectively impairs the sensitivity to vaginal and cervical stimulation at parturition. OT levels in cerebrospinal fluid is significantly reduced following peridural anesthesia. The vaginal delivery mothers had significantly more OT pulses than the caesarian section mothers. Due to low levels of endogenous OT, maternal behavior could be interrupted by epidural anesthesia and CS at parturition because of the reduction of the usual sensory input from the genitalia. (shrink)

Current psychological perspectives emphasize “attack” and “defense” as the behavioral mechanisms underlying conflict. Here, we extend this view by highlighting the relevance of pathological altruism and the neuroendocrine pathways associated with hostile behaviors. Specifically, we elucidate the modulatory role of the neuropeptide hormone oxytocin in motivating extraordinary levels of in-group commitment that can promote extreme behaviors and endure conflict with out-groups.

Oxytocin (OT) is one of the most intensively researched neuropeptides during the three past decades. In benign social contexts, OT exerts a range of desirable socioemotional, stress-reducing, and immunoregulatory effects in mammals and humans and influences mammalian parenting. Consequentially, research in potential pharmacological applications of OT toward human social deficits/disorders and physical illness has increased substantially. Regrettably, the results from the administration of exogenous OT are still relatively inconclusive. Research in rodent maternal developmental programming has demonstrated the susceptibility of (...) offspring endogenous OT systems to maternal somatosensory stimulation, with consequences for behavioral, epigenetic, cognitive, and neurological outcomes. A translation of this animal research into practically feasible human parenting recommendations has yet to happen, despite the significant prevention potential implied by the maternal developmental programming research. Extended physical contact with full-term healthy infants in the months following birth (infant carrying) might constitute the human equivalent of those specific rodent maternal behaviors, found to positively influence emerging OT systems. Findings from both OT and maternal programming research parallel those found for infants exposed to such extended parental physical contact, whether through skin-to-skin contact or infant carrying. Clinical support of parents to engage in extended physical contact represents a feasible intervention to create optimum conditions for the development of infant OT systems, with potential beneficial long-term health effects. (shrink)

The effect of oxytocin on cognitive bias was investigated in rats in a modified conditioned place preference (CPP) paradigm. Fifteen male rats were trained to discriminate between two different cue combinations, one paired with palatable foods (reward training), and the other paired with unpalatable food (aversive training). Next, their reactions to two ambiguous cue combinations were evaluated and their latency to contact the goal pot recorded. Rats were injected with either oxytocin (OT) or saline with the prediction that (...) rats administered oxytocin would display a shorter average latency to approach on ambiguous trials. There was no significant difference between latencies to approach on ambiguous trials compared to reward trials, but the rats were significantly slower on the aversive compared to the ambiguous conditions. Oxytocin did not affect approach time; however, it was unclear, after follow-up testing, whether the OT doses tested were sufficient to produce the desired effects on cognitive bias. Future research should consider this possibility. (shrink)