This article looks at the relationship between logistical power and the assemblages of sites that constitute modern states. Rather than treating states as centralizing institutions and singular sites of power, we treat them as multi-sited. They gain power by using logistical methods of problem solving, using infrastructures to enforce and depersonalize relations of domination and limit the autonomy of elites. But states necessarily solve diverse problems by different means in multiple locations. So, educating children is not continuous with governing colonies (...) even though both are necessary to nineteenth-century states. For this reason, states use logistical means of coordination to link sites, and they make the power of the state seem unitary even though the exercise of state power is not. (shrink)

According to Mellor, we know what an experience is like if we can imagine it correctly, and we will do so if we recognise the experience as it is imagined. This paper identifies a constraint on adequate accounts of how we ordinarily imagine experiences correctly: the capacities to imagine and to recognise the experience must be jointly operative at the point of forming an intention to imagine the experience. The paper develops an account of imagining experiences correctly that meets this (...) constraint in terms of the subject's possession of a concept of the experience. The account implies that the imagination is active in conscious perception. (shrink)

According to Mellor, we know what an experience is like if we can imagine it correctly, and we will do so if we recognise the experience as it is imagined. This paper identifies a constraint on adequate accounts of how we ordinarily imagine experiences correctly: the capacities to imagine and to recognise the experience must be jointly operative at the point of forming an intention to imagine the experience. The paper develops an account of imagining experiences correctly that meets this (...) constraint in terms of the subject's possession of a concept of the experience. The account implies that the imagination is active in conscious perception. (shrink)

This paper discusses the current initiatives on error and adverse events within healthcare, with a particular focus on the NHS, within the context of health policy. One of the key features of the paper is the proposal for an emergent taxonomy of the medical error literature, developed from the ideologies and rationales that underpin their approaches. This taxonomy provides details of three categories—empiricists, organisational rationalists and reformers of professional culture—and these act as an organising framework for the exploration of the (...) potential consequences of current policy on errors and adverse events. This discussion highlights the tension between optimising health outcomes for patients and managing the health system as effectively as possible. In particular, the inherent tension between explicit managerial formulations of risk and implicit risk management strategies associated with medical professionalism are considered. (shrink)

The primary impediment to formulating a general theory for adaptive evolution has been the unknown distribution of fitness effects for new beneficial mutations. By applying extreme value theory, Gillespie circumvented this issue in his mutational landscape model for the adaptation of DNA sequences, and Orr recently extended Gillespie's model, generating testable predictions regarding the course of adaptive evolution. Here we provide the first empirical examination of this model, using a single-stranded DNA bacteriophage related to phiX174, and find that our data (...) are consistent with Orr's predictions, provided that the model is adjusted to incorporate mutation bias. Orr's work suggests that there may be generalities in adaptive molecular evolution that transcend the biological details of a system, but we show that for the model to be useful as a predictive or inferential tool, some adjustments for the biology of the system will be necessary. (shrink)