7 found
Sort by:
  1. Minh-Uyen Dao Thi, Candice Trocmé, Marie-Paule Montmasson, Eric Fanchon, Bertrand Toussaint & Philippe Tracqui (forthcoming). Investigating Metalloproteinases MMP-2 and MMP-9 Mechanosensitivity to Feedback Loops Involved in the Regulation of In Vitro Angiogenesis by Endogenous Mechanical Stresses. [REVIEW] Acta Biotheoretica.
    Abstract Angiogenesis is a complex morphogenetic process regulated by growth factors, but also by the force balance between endothelial cells (EC) traction stresses and extracellular matrix (ECM) viscoelastic resistance. Studies conducted with in vitro angiogenesis assays demonstrated that decreasing ECM stiffness triggers an angiogenic switch that promotes organization of EC into tubular cords or pseudo-capillaries. Thus, mechano-sensitivity of EC with regard to proteases secretion, and notably matrix metalloproteinases (MMPs), should likely play a pivotal role in this switching mechanism. While most (...)
    Translate to English
    | Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  2. Eric Fanchon & Philippe Tracqui (forthcoming). Proceedings of the XXXIth Seminar of the French-Speaking Society for Theoretical Biology. Acta Biotheoretica.
  3. Audrey Pustoc'H., Jacques Ohayon, Yves Usson, Alain Kamgoue & Philippe Tracqui (2005). An Integrative Model of the Self-Sustained Oscillating Contractions of Cardiac Myocytes. Acta Biotheoretica 53 (4).
    Computational cell models appear as necessary tools for handling the complexity of intracellular cell dynamics, especially calcium dynamics. However, while oscillating intracellular calcium oscillations are well documented and modelled, a simple enough virtual cell taking into account the mechano-chemical coupling between calcium oscillations and cell mechanical properties is still lacking. Considering the spontaneous periodic contraction of isolated cardiac myocytes, we propose here a virtual cardiac cell model in which the cellular contraction is modelled using an hyperelastic description of the cell (...)
    Direct download  
     
    My bibliography  
     
    Export citation  
  4. Caroline Rosello, Pascal Ballet, Emmanuelle Planus & Philippe Tracqui (2004). Model Driven Quantification of Individual and Collective Cell Migration. Acta Biotheoretica 52 (4).
    While the control of cell migration by biochemical and biophysical factors is largely documented, a precise quantification of cell migration parameters in different experimental contexts is still questionable. Indeed, these phenomenological parameters can be evaluated from data obtained either at the cell population level or at the individual cell level. However, the range within which both characterizations of cell migration are equivalent remains unclear. We analyse here to which extent both sources of data could be integrated within a unified description (...)
    Direct download  
     
    My bibliography  
     
    Export citation  
  5. Philippe Tracqui & Jacques Ohayon (2004). Transmission of Mechanical Stresses Within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model. Acta Biotheoretica 52 (4).
    How environmental mechanical forces affect cellular functions is a central problem in cell biology. Theoretical models of cellular biomechanics provide relevant tools for understanding how the contributions of deformable intracellular components and specific adhesion conditions at the cell interface are integrated for determining the overall balance of mechanical forces within the cell. We investigate here the spatial distributions of intracellular stresses when adherent cells are probed by magnetic twisting cytometry. The influence of the cell nucleus stiffness on the simulated nonlinear (...)
    Direct download  
     
    My bibliography  
     
    Export citation  
  6. Patrick Amar, Pascal Ballet, Georgia Barlovatz-Meimon, Arndt Benecke, Gilles Bernot, Yves Bouligand, Paul Bourguine, Franck Delaplace, Jean-Marc Delosme, Maurice Demarty, Itzhak Fishov, Jean Fourmentin-Guilbert, Joe Fralick, Jean-Louis Giavitto, Bernard Gleyse, Christophe Godin, Roberto Incitti, François Képès, Catherine Lange, Lois Le Sceller, Corinne Loutellier, Olivier Michel, Franck Molina, Chantal Monnier, René Natowicz, Vic Norris, Nicole Orange, Helene Pollard, Derek Raine, Camille Ripoll, Josette Rouviere-Yaniv, Milton Saier, Paul Soler, Pierre Tambourin, Michel Thellier, Philippe Tracqui, Dave Ussery, Jean-Claude Vincent, Jean-Pierre Vannier, Philippa Wiggins & Abdallah Zemirline (2002). Hyperstructures, Genome Analysis and I-Cells. Acta Biotheoretica 50 (4).
    New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...)
    Direct download  
     
    My bibliography  
     
    Export citation  
  7. Philippe Tracqui (1995). From Passive Diffusion to Active Cellular Migration in Mathematical Models of Tumour Invasion. Acta Biotheoretica 43 (4).
    Mathematical models of tumour invasion appear as interesting tools for connecting the information extracted from medical imaging techniques and the large amount of data collected at the cellular and molecular levels. Most of the recent studies have used stochastic models of cell translocation for the comparison of computer simulations with histological solid tumour sections in order to discriminate and characterise expansive growth and active cell movements during host tissue invasion. This paper describes how a deterministic approach based on reaction-diffusion models (...)
    Direct download  
     
    My bibliography  
     
    Export citation