Online research in philosophy

Should innovative therapy occur only within a research paradigm and under institutional review board oversight? The health risks from current human embryonic stem cell clinical applications have raised again a fundamental question addressed first in papers submitted to inform the writing of the Belmont Report. Revisiting the thinking underlying the Belmont Report, together with examining changed circumstances since then, leads to a new model for overseeing innovative therapy based on its unique risks and context, important changes since the Belmont Report, (...) and new opportunities for addressing risks through safety and quality systems in health care. (shrink)

Much research on cognitive development focuses either on early-emerging domain-specific knowledge or domain-general learning mechanisms. However, little research examines how these sources of knowledge interact. Previous research suggests that young infants can make inferences from samples to populations (Xu & Garcia, 2008) and 11- to 12.5-month-old infants can integrate psychological and physical knowledge in probabilistic reasoning (Teglas, Girotto, Gonzalez, & Bonatti, 2007; Xu & Denison, 2009). Here, we ask whether infants can integrate a physical constraint of immobility into (...) a statistical inference mechanism. Results from three experiments suggest that, first, infants were able to use domain-specific knowledge to override statistical information, reasoning that sometimes a physical constraint is more informative than probabilistic information. Second, we provide the first evidence that infants are capable of applying domain-specific knowledge in probabilistic reasoning by using a physical constraint to exclude one set of objects while computing probabilities over the remaining sets. (shrink)

Internationally, calls for feedback of findings to be made an ‘ethical imperative’ or mandatory have been met with both strong support and opposition. Challenges include differences in issues by type of study and context, disentangling between aggregate and individual study results, and inadequate empirical evidence on which to draw. In this paper we present data from observations and interviews with key stakeholders involved in feeding back aggregate study findings for two Phase II malaria vaccine trials among children under the age (...) of 5 years old on the Kenyan Coast. In our setting, feeding back of aggregate findings was an appreciated set of activities. The inclusion of individual results was important from the point of view of both participants and researchers, to reassure participants of trial safety, and to ensure that positive results were not over-interpreted and that individual level issues around blinding and control were clarified. Feedback sessions also offered an opportunity to re-evaluate and re-negotiate trial relationships and benefits, with potentially important implications for perceptions of and involvement in follow-up work for the trials and in future research. We found that feedback of findings is a complex but key step in a continuing set of social interactions between community members and research staff (particularly field staff who work at the interface with communities), and among community members themselves; a step which needs careful planning from the outset. We agree with others that individual and aggregate results need to be considered separately, and that for individual results, both the nature and value of the information, and the context, including social relationships, need to be taken into account. (shrink)

the importance of this story in relation to the evidence for the ostensibly supernormal physical phenomena of Spiritualism. From 1869 onwards Sidgwick began to be associated with Myers in a common interest in psychical research. In the very ...

Scientific misconduct includes the fabrication, falsification, and plagiarism (FFP) of concepts, data or ideas; some institutions in the United States have expanded this concept to include “other serious deviations (OSD) from accepted research practice.” It is the absence of this OSD clause that distinguishes scientific misconduct policies of the past from the “research misconduct” policies that should be the basis of future federal policy in this area. This paper introduces a standard for judging whether an action should be considered research (...) misconduct as distinguished from scientific misconduct: by this standard, research misconduct must involve activities unique to the practice of science and must have the potential to negatively affect the scientific record. Although the number of cases of scientific misconduct is uncertain (only the NIH and the NSF keep formal records), the costs are high in terms of the integrity of the scientific record, diversions from research to investigate allegations, ruined careers of those eventually exonerated, and erosion of public confidence in science. Existing scientific misconduct policies vary from institution to institution and from government agency to government agency; some have highly developed guidelines that include OSD, others have no guidelines at all. One result has been that the federal False Claims Act has been used to pursue allegations of scientific misconduct. As a consequence, such allegations have been adjudicated in federal courts, rather than judged by scientific peers. The federal government is now establishing a first-ever research misconduct policy that would apply to all research funded by the federal government regardless of which agency funded the research or whether the research was carried out in a government, industrial or university laboratory. Physical scientists, who up to now have only infrequently been the subject of scientific misconduct allegations, must nonetheless become active in the debate over research misconduct policies and how they are implemented since they will now be explicitly covered by this new federal wide policy. (shrink)

We want to consider anew the question, which is recurrent along the history of philosophy, of the relationship between rationality and mathematics, by inquiring to which extent the structuration of rationality, which ensures the unity of its function under a variety of forms (and even according to an evolution of these forms), could be considered as homeomorphic with that of mathematical thought, taken in its movement and made concrete in its theories. This idea, which is as old as philosophy itself, (...) although it has not been dominant, has still been present to some degree in the thought of modern science, in Descartes as well as in Kant, Poincaré or Einstein (and a few other scientists and philosophers). It has been often harshly questioned, notably in the contemporaneous period, due to the failure of the logistic programme, as well as to the variety of “empirical” knowledges, and, in a general way, to the character of knowledges that show them as transitory, evolutive and mind-built. However, the analysis of scientific thought through its inventive and creative processes leads to characterize this thought as a type of rational form whose configurations can be detailed rather precisely. In this work we shall propose, first, a quick sketch of some philosophical requirements for such a research programme, among which the need for an harmonization, and even a conciliation, between the notions of rational (or rationality), of intuitive grasp and of creative thought. Then we shall examine some processes of creative scientific thought bearing on the knowledge and the understanding of the world, distinct from mathematics although keeping tight relations with them. Contemporary physical theories are privileged witnesses in this respect, for in them the rational thought of phenomena makes an intrinsic use of mathematical thought, which contributes to the structuration of the formers and to the expression of their concepts (which entails the physical contents of the latter). The General Theory of Relativity and the Quantum Theory are exemplar to this, as they directly reveal what can be called the “drag of physical thought par the mathematical form”, which makes possible to overcome the limitations of the physical knowledge previously adquired. This process is tightly related to the modalities and to the stucture of the rational thought underlying it. This is what we would like to show. DOI:10.5007/1808-1711.2011v15n2p303. (shrink)

This engaging and informative text will hold the attention of students and scholars as they take a journey through time to understand the role that history and philosophy have played in shaping the course of sport and physical education in Western and selected non-Western civilizations. Using appropriate theoretical and interpretive frameworks, students will investigate topics such as the historical relationship between mind and body; what philosophers and intellectuals have said about the body as a source of knowledge; educational philosophy (...) and the value of physical education and/or sport; philosophical positions that have impacted the historical development of sport and physical education; the history of women in sport and physical education; the role and scope of sport and physical education in Ancient Greece and Rome; the Ancient Olympic Games; the relationship between sport and religion in ancient and modern times; the theoretical and professional development of physical education; the rise of sport in modern America; the history and politics of the modern Olympic Games; and the contributions of men, women, and social movements to the development of sport and physical education from ancient times to the modern era. (shrink)

In this paper we argue that the consensus around normative standards for the ethics of research in clinical trials, strongly influenced by the Declaration of Helsinki, is perceived from various quarters as too conservative and potentially restrictive of research that is seen as urgent and necessary. We examine this problem from the perspective of various challengers who argue for alternative approaches to what ought or ought not to be permitted. Key themes within this analysis will examine these claims and argue (...) they have implications for the interests of the research subject, research governance and regulation. Using our work with TREAT-NMD, the neuromuscular clinical trials network, we posit that there is a place for advancing the discourse of moral rights and moral duties in the context of research, especially from the perspective of patients and their families, and for including the politics of patient activism and empowerment. At the same time we remain vigilant to the danger that the therapeutic misconception and other serious vulnerabilities for the patient population in clinical trials, are at risk of being overlooked. (shrink)

In this paper, we describe the potential role laypersons on ethics committees can play in ensuring community concerns are addressed in the design and implementation of genomic research. We draw inferences from the outcome of an empirical study of the impact of training of laypersons to address community engagement issues in ethics review of research protocol. While this paper does not advocate a particular solution, it describes the importance of community engagement in genomic research, the current limitations there are in (...) engaging communities in the design of these research projects and how communities can be indirectly engaged in the design and implementation of genomic research through the engagement of laypersons on ethics committees. However, to ensure that these laypersons can play this role, their capacity needs to be built to play this role appropriately. There is evidence to show that where resources are invested in building the capacity of laypersons to play their role as community ‘watchdogs’ in research, they play this role aptly. Community engagement is important in genomic research as genomic researchers will increasingly require community perspectives in critical ethics decision making. (shrink)

This book presents a detailed analysis of three ancient models of spatial magnitude, time, and local motion. The Aristotelian model is presented as an application of the ancient, geometrically orthodox conception of extension to the physical world. The other two models, which represent departures from mathematical orthodoxy, are a "quantum" model of spatial magnitude, and a Stoic model, according to which limit entities such as points, edges, and surfaces do not exist in (physical) reality. The book is unique (...) in its discussion of these ancient models within the context of later philosophical, scientific, and mathematical developments. (shrink)

In this paper I try to shed some light on how one discerns a physical effect or phenomenon from experimental background ‘noise’. To this end I revisit the discovery of Weak Neutral Currents (WNC), which has been right at the centre of discussion of some of the most influential available literature on this issue. Bogen and Woodward (1988) have claimed that the phenomenon of WNC was inferred from the data without higher level physical theory explaining this phenomenon (here: (...) the Weinberg-Salam model of electroweak interactions) being involved in this process. Mayo (1994, 1996), in a similar vein, holds that the discovery of WNC was made on the basis of some piecemeal statistical techniques—again without the Salam-Weinberg model (predicting and explaining WNC) being involved in the process. Both Bogen & Woodward and Mayo have tried to back up their claims by referring to the historical work about the discovery of WNC by Galison (1983, 1987). Galison’s presentation of the historical facts, which can be described as realist, has however been challenged by Pickering (1984, 1988, 1989), who has drawn sociological-relativist conclusions from this historical case. Pickering’s conclusions, in turn, have recently come under attack by Miller and Bullock (1994), who delivered a defence of Galison’s realist account. In this paper I consider all of these historical studies in order to evaluate the philosophical claims that have been made on the basis of them. I conclude that—contrary to Bogen & Woodward (1988) and Mayo (1994)—statistical methods and other experimental inference procedures from the “bottom-up” (i.e. from the data to the phenomena) were insufficient for discerning WNC from their background noise. I also challenge Galison’s notion of the “end of experiments” and shall take the wind out of the sail of Miller and Bullock’s attack on some of Pickering’s claims, whilst rejecting Pickering’s sociological-relativist conclusions. Instead, I claim that an epistemic warrant from the ‘top down’ in the form of a theoretical postulate of the Weinberg-Salam model was necessary for “ending the experiments”, i.e. for the acceptance of WNC as a genuine phenomenon in the scientific community. (shrink)

The issue of benefits in international clinical research is highly controversial. Against the background of wide recognition of the need to share benefits of research, the nature of benefits remains strongly contested. Little is known about the perspectives of research populations on this issue and the extent to which research ethics discourses and guidelines are salient to the expectations and aspirations existing on the ground. This exploratory study contributes to filling this void by examining perspectives of people in low-income South (...) African communities on benefits in international clinical research. Twenty-four individuals with and without experience of being involved in clinical research participated in in-depth interviews. Respondents felt that ancillary care should be provided to clinical research participants, while a clinical study conducted in particular community should bring better health to its members through post-trial benefits. Respondents' perspectives were grounded in the perception that the ultimate goal of international clinical research is to improve local health. We argue that perspectives and understandings of the respondents are shaped by local moral traditions rather than clinical research specificities and require attention as valid moral claims. It is necessary to acknowledge such claims and cultural worlds from which they emerge, thus building the foundation for equal and embracing dialogue to bridge different perspectives and handle contradicting expectations. (shrink)

Shepard's internalization concept is defended against Hecht's criticisms. By ignoring both Shepard's evolutionary perspective and the fact that internalization does not preclude modularization, Hecht advances inconclusive evidence. Developmental research supports Shepard's conclusion that kinematic geometry may be more deeply internalized than physical dynamics. This research also suggests that the internalization concept should be broadened to include representations acquired during ontogeny. [Hecht; Shepard].

For decades, the dominant research paradigm has included trials conducted in clinical settings with little involvement from communities. The move toward community engaged research (CEnR) necessitates the inclusion of diverse perspectives to address complex problems. Using a relationship paradigm, CEnR reframes the context, considerations, practical steps, and outcomes of research.

The authors co-organized (Snyder and Crooks) and gave a keynote presentation at (Turner) a conference on ethical issues in medical tourism. Medical tourism involves travel across international borders with the intention of receiving medical care. This care is typically paid for out-of-pocket and is motivated by an interest in cost savings and/or avoiding wait times for care in the patient’s home country. This practice raises numerous ethical concerns, including potentially exacerbating health inequities in destination and source countries and disrupting continuity (...) of care for patients. In this report, we synthesize conference presentations and present three lessons from the conference: 1) Medical tourism research has the potential for cross- or inter-disciplinarity but must bridge the gap between researchers trained in ethical theory and scholars unfamiliar with normative frameworks; 2) Medical tourism research must engage with empirical research from a variety of disciplines; and 3) Ethical analyses of medical tourism must incorporate both individual and population-level perspectives. While these lessons are presented in the context of research on medical tourism, we argue that they are applicable in other areas of research where global practices, such as human subject research and health worker migration, are occurring in the face of limited regulatory oversight. (shrink)

It is widely believed that empathy is a good thing, from a moral point of view. It is something we should cultivate because it makes us better people. Perhaps that’s true. But it is also sometimes suggested that empathy is somehow necessary for morality. That is the hypothesis I want to interrogate and challenge. Not only is there little evidence for the claim that empathy is necessary, there is also reason to think empathy can interfere with the ends of morality. (...) A capacity for empathy might make us better people, but placing empathy at the center of our moral lives may be ill‐advised. That is not to say that morality shouldn’t centrally involve emotions. I think emotions are essential for moral judgment and moral motivation (Prinz, 2007). It’s just that empathetic emotions are not ideally suited for these jobs. Before embarking on this campaign against empathy, I want to say a little more about the target of the attack. What is empathy? And what would it mean to say empathy is necessary for morality? With respect to the first question, much has been written. Theories of empathy abound. Batson et al. (1995: 1042) define empathy as, “as an other‐oriented emotional response congruent with the perceived welfare of another person.” This is not the definition I will be using. Batson’s construct might be better characterized as “concern,” because of its focus on another person’s welfare. Indeed, in much of his research he talks about “empathetic concern.” Notice that this construct seems to be a combination of two separable things. Being concerned for someone is worrying about their welfare, which is something one can do even if one doesn’t feel what it would be like to be in their place. One can have concern for a plant, for example, and an insect, or even an artifact, like a beautiful building that has into disrepair. Empathy, seems to connote a kind of feeling that has to be at last possible for the object of empathy. If so, “empathetic concern” combines two different things—a find of feeling‐for an object and a feeling‐on‐behalf‐of an object. Much of the empirical literature, including the superb research that Batson has done, fails to isolate these components, and, as a result, some of the existing studies are confounded. They purport to show the value of empathy, but may really show the value of concern. My focus below will be on empathy, and I leave it as an open possibility that concern is highly important, if not necessary, for morality. Indeed, concern often seems to involve an element kind of moral anger, which I will argue is very important to morality. It is also important to distinguish empathy from sympathy. Suppose I feel outraged for someone who has been brainwashed into thinking she should follow a cult leader who is urging mass suicide. That would not necessarily qualify as empathy. As Darwall (1998: 261) points out, sympathy is a third‐person emotional response, whereas empathy involves putting oneself in another person’s shoes. But 1 Darwall’s definition is also somewhat problematic. He says, “Empathy consists in feeling what one imagines he feels, or perhaps should feel (fear, say), or in some imagined copy of these feelings, whether one comes thereby to be concerned … or not.” This definition has two features, which I would like to avoid. First, the appeal to imagination seems overly intellectual. Imagination sounds like a kind of mental act that requires effort on the part of the imaginer. As Darwell recognizes, empathy in its simplest form empathy is just emotional contagion: catching the emotion that another person feels (Hatfield et al., 1994; Hoffman, 2000). It seems inflated to call contagion an imaginative act. Also, I want to resist Darwall’s application of “empathy” to cases where one has a feeling that someone should feel, but does not feel. The problem is that this tends to blur the distinction between empathy and sympathy. Suppose I encounter a member of a cult who is delighted by the cult leader’s nefarious plans. The cult member should by afraid, but is not. If I feel fear on the cult member’s behalf, that is not putting myself in the cult member’s shoes. As I will use the term, empathy requires a kind of emotional mimicry. I do not wish to imply that empathy is always an automatic process, in the way that emotional contagion is. Sometimes imagination is requires, and sometimes we experience emotions that we think someone would be experiencing, even if we have not seen direct evidence that the emotion is, in fact, being experienced. For example, one might feel empathetic hope for a marathon runner who is a few steps behind the runner is first place, or anxiety for the first place runner, and the second place runner catches up. We can experience these feelings even if the runners’ facial expressions reveal little more than muscular contortions associated with concentration and physical exertion. A situation can reveal a feeling. The core idea, as I will use the term, is that empathy is a kind of vicarious emotion: it’s feeling what one takes another person to be feeling. And the “taking” here can be a matter of automatic contagion or the result of a complicated exercise of the imagination. I don’t think there is anything anachronistic about this notion of empathy. I think it has a long tradition in moral philosophy, even though the term “empathy” is only 100 years old. The British moralists, including David Hume and Adam Smith, used “sympathy” in way that is similar to the way I want to use “empathy.” Here is Smith (1759: II.i): “Whatever is the passion which arises from any object in the person principally concerned, an analogous emotion springs up, at the thought of his situation, in the breast of every attentive spectator.” My question, in the pages that follow, is whether empathy so‐defined is necessary for morality. I should note again, in advance, that the empirical literature does not always distinguish between the constructs I have been discussing, but I do think that all the studies I discuss below can, by inference at least, shed some light on empathy as defined here. The suggestion that empathy is necessary for morality can be interpreted in at least three different ways. One might hold the view that empathy is necessary for making moral judgment. One might think empathy is necessary for moral development. And one might think empathy is necessary for motivating moral conduct. I think each of these conjectures is false. Empathy is not necessary for any of these things. We can have moral systems without empathy. Of course, it doesn’t follow directly that empathy should be eliminated from morality. One might think the modal question—Can there be morality without empathy?—and the related.... (shrink)

It seems that if abortion is permissible, then stem cell research must be as well: it involves the death of a less significant thing (an embryo rather than a fetus) for a greater good (lives saved rather than nine months of physical imposition avoided). However, I argue in this essay that this natural thought is mistaken. In particular, on the assumption that embryos and fetuses have the full moral status of persons, abortion is permissible but one form of stem (...) cell research is notFthe practice of creating embryos and then destroying them to extract cell.. (shrink)

: The underdetermination argument establishes that scientists may use political values to guide inquiry, without providing criteria for distinguishing legitimate from illegitimate guidance. This paper supplies such criteria. Analysis of the confused arguments against value-laden science reveals the fundamental criterion of illegitimate guidance: when value judgments operate to drive inquiry to a predetermined conclusion. A case study of feminist research on divorce reveals numerous legitimate ways that values can guide science without violating this standard.

Our world is a world of change. Children are born and grow into adults. Material possessions rust and decay with age and ultimately perish. Yet scepticism about change is as old as philosophy itself. Heraclitus, for example, argued that nothing could survive the replacement of parts, so that it is impossible to step into the same river twice. Zeno argued that motion is paradoxical, so that nothing can alter its location. Parmenides and his followers went even further, arguing that the (...) very concept of qualitative change is inconsistent. Change in any respect is impossible, they argued, as change requires difference and nothing differs from itself. Few today would accept the Eleatic conclusion that change is impossible. But the topic of change continues to be a source of much debate, as it brings together various issues that are central to metaphysics, language, and logic – including identity, persistence, time, tense, and temporal logic. Author Recommends Wasserman, Ryan. 'The Problem of Change.' Philosophy Compass 1 (2006): 1–10. This article presents the problem of change and provides a brief survey of potential solutions. Haslanger, Sally. 'Persistence Through Time.' The Oxford Handbook of Metaphysics . Eds. M. Loux and D. Zimmerman. Oxford: Oxford University Press, 2003. This article presents the problem of change and provides a detailed survey of potential solutions. Heller, Mark. 'Things Change.' Philosophy and Phenomenological Research 52 (1992): 695–704. This article presents, explains, and defends the temporal parts solution to the problem of change. Hinchliff, Mark. 'The Puzzle of Change.' Philosophical Perspectives 10 (1996): 119–36. This article presents, explains, and defends the presentist solution to the problem of change. Wasserman, Ryan. 'The Argument from Temporary Intrinsics.' Australasian Journal of Philosophy 81 (2003): 413–19. This article presents, explains, and defends the relationist solution to the problem of change. Sider, Theodore. Four-Dimensionalism . Oxford: Oxford University Press, 2001. This book provides an introduction to various issues related to the problem of change, including the nature of time, tense, and persistence. Chapter 5 presents, explains, and defends the stage-view solution to the problem of change. Online Materials Change. URL: http://plato.stanford.edu/entries/change/ The Stanford Encyclopedia of Philosophy entry on change, by Chris Mortensen. Time. URL: http://plato.stanford.edu/entries/time/ The Stanford Encyclopedia of Philosophy entry on time, by Ned Markosian. Temporal Parts. URL: http://plato.stanford.edu/entries/temporal-parts/ The Stanford Encyclopedia of Philosophy entry on temporal parts, by Katherine Hawley. Material Constitution. URL: http://plato.stanford.edu/entries/material-constitution/ The Stanford Encyclopedia of Philosophy entry on material constitution, by Ryan Wasserman. Persistence Bibliography. URL: http://tedsider.org/teaching/pp_bibliography.pdf A bibliography on change and related issues, by Theodore Sider. Sample Syllabus Books on Syllabus Rea, Michael. Material Constitution: A Reader . Lanham: Rowman & Littlefield, 1997. Sider, Theodore. Four-Dimensionalism . Oxford: Oxford University Press, 2001. van Inwagen, P. and Zimmerman, D. 2008. Metaphysics: The Big Questions . 2nd ed. Oxford: Blackwell, 2008. Week 1: Time and Tense Four-Dimensionalism , chapters 1 and 2. Markosian, Ned. 'A Defence of Presentism.' Oxford Studies in Metaphysics, Volume 1. Ed. D. Zimmerman. Oxford: Oxford University Press, 2004: 47–82. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 116-123. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 124-129. Week 2: Time and Persistence Four-Dimensionalism , chapter 3. McGrath, Matthew. 'Temporal Parts.' Philosophy Compass 2 (2007): 730–48. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 265-267. Hawthorne, J, Scala, M., and Wasserman, R. 'Recombination, Humean Supervenience, and Causal Constraints: An Argument for Temporal Parts?' Oxford Studies in Metaphysics , Volume 1. Ed. D. Zimmerman, Oxford: Oxford University Press, 2004: 301-318. Week 3: Change and Presentism In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 141-149. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 267-269. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 269-281. Week 4: Change and Temporal Parts Four-Dimensionalism , pp. 92–8. Heller, Mark. 'Things Change.' Philosophy and Phenomenological Research 52 (1992): 695–704. Lombard, Lawrence. 'The Doctrine of Temporal Parts and the "No Change" Objection.' Philosophy and Phenomenological Research 54 (1994): 365–72. Week 5: Change, Relationism, and Adverbialism Hawley, Katherine. 'Why Temporary Properties are not Relations between Physical Objects and Times.' Proceedings of the Aristotelian Society 98 (1998): 211–16. Wasserman, Ryan. 'The Argument from Temporary Intrinsics.' Australasian Journal of Philosophy 81 (2003): 413–19. Lewis, David. 'Tensing the Copula.' Mind 111 (2002): 1–13. Caplan, Ben. 'Why so Tense about the Copula?' Mind 114 (2007): 703–8. Week 6: Change and Tropes Ehring, Douglas. 'Lewis, Temporary Intrinsics and Momentary Tropes.' Analysis 57 (1997): 254–8. MacBride, Fraser. 'Four New Ways to Change Your Shape.' Australasian Journal of Philosophy 79 (2001): 81–9. Simons, Peter. 'On Being Spread Out in Time: Temporal Parts and the Problem of Change.' Existence and Explanation . Eds. W. Spohn, B.C. van Fraassen, and B. Skyrms. Dordrecht: Kluwer, 1991: 131-147. Weeks 7 and 8: Special Topic – Material Change Four-Dimensionalism , chapter 5. Selections from Material Constitution: A Reader. Week 9: Special Topic – Change of Position In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 186-195. In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 195-215. Week 10: Special topic – Changing the Past In van Inwagen, P. and Zimmerman, D. Metaphysics: The Big Questions. 2nd ed. Oxford: Blackwell, 2008: 224-235. van Iwagen, Peter. 'Changing the Past.' Oxford Studies in Metaphysics , Volume 5 . Ed. D. Zimmerman. Oxford: Oxford University Press, 2009: 1-22. Hudson, H. and Wasserman, R. 'Van Inwagen on Time Travel and Changing the Past.' Oxford Studies in Metaphysics , Volume 5. Ed. D. Zimmerman. Oxford: Oxford University Press, 2009: 41-49. (shrink)

A spate of recent anti-localizationist publications have re-ignited the old debate about the localization of function. Many of the recent attacks on localization, however, are directed at what I will argue to be a narrow and outmoded view of localization, and thus have little conceptual or empirical impact. What I hope to present here is an analysis of functional localization that more adequately reflects the sophistication and complexity of its use in neuroscientific research, both historically and recently. Proceeding first by (...) way of contrast, I examine theanti-localizationist positions of holism andequipotentiationism. Then, I present a four-fold analysis of localization according to physical scope, physical kind, functional scope, and functional kind. Next, I turn to a discussion of the heuristic value oflocalization in deciphering structure-functionrelationships. Finally, I hope to show that the overall view of functional localization that emerges from these considerations constitutes a much more elusive target than its critics assume. It serves to mitigate, and insome instances even defeat, some forms ofanti-localizationist criticisms. (shrink)

Using mainly historical material fromAustralia, the paper seeks to understand earlyforms of school physical training, sport andmedical inspection as specialised means ofschooling bodies. The study adopts a socialepistemological perspective in seeking tounderstand the meaning-in-use of notions suchas physical training. It explores the socialconsequences of the practices carried out inthe name of physical training, particularly inrelation to shifts in the social regulation ofbodies over time from a mass, externalised, andcentralised form to a relatively moreindividualised, internalised and diffuse form.This (...) focus on the body is of key importance fora social epistemological study of physicaleducation because it forces us to look closelyat the practices constituting physicaleducation. (shrink)

The ethical concept of Informed Consent provides individuals with the right and the opportunity to approve of events that will occur regarding his or her own person. In medicine, informed consent is obtained for treatment and for research participation. However, under some circumstances, prospective informed consent cannot be obtained because of the devastating clinical condition of the patient. In emergency circumstances, treatment is never withheld if obtaining informed consent from a critically ill person is not possible or if a delay (...) while seeking surrogates would further endanger life. In emergency research circumstances, waiving informed consent for study participation is fraught with additional ethical considerations. This article will review a presentation given at the June 2, 2006 conference entitled “The Ethics of Research in Emergency Medicine”. (shrink)

The role demographic, personality, and situational factors play in the ethical decision making process has received a significant amount of attention (Ford and Richardson, 1994). However, the empirical research on students' decisions to engage in collegiate cheating has not been included in this literature. This paper reviews the last 25 years of empirical research on collegiate cheating. The individual/situational factor typology from Ford and Richardson's review (1994) is used to compare the two literatures. In addition, issues pertaining to the quantification (...) of academic dishonesty, the perception that cheating is increasing, and methodological considerations are addressed in this review. (shrink)

In research ethics there is a canon regarding what ethical rules ought to be followed by investigators vis-à-vis their treatment of subjects and a canon regarding what fundamental ethical principles apply to the endeavor. What I aim to demonstrate here is that several of the rules find no support in the principles. This leaves anyone who would insist that we not abandon those rules in the difficult position of needing to establish that we are nevertheless justified in believing in the (...) validity of the rules. I conclude by arguing that this is not likely to be accomplished.The rules I call into question are the rules requiring:– that studies be designed in a scientifically valid way– that risks to subjects be minimized– that subjects be afforded post-trial access to experimental interventions– that inducements paid to subjects not be counted as a benefit to them– that inducements paid to subjects not be ‘undue’– that subjects must remain free to withdraw from the study at any time for any reason without penaltyBoth canons, the canon on principles and the canon on rules, are found in the overlap among ethical pronouncements that are themselves canonical: the Nuremberg Code, the Declaration of Helsinki, the Belmont Report, CIOMS's International Ethical Guidelines for Biomedical Research Involving Human Subjects, and NBAC's 2001 report, Ethical Issues in International Research: Clinical Trials in Developing Countries. (shrink)

Several feminist philosophers of science have argued that social and political values are compatible with, and may even enhance, scientific objectivity. A variety of normative recommendations have emerged regarding how to identify, manage, and critically evaluate social values in science. In particular, several feminist theorists have argued that scientific communities ought to: 1) include researchers with diverse experiences, interests, and values, with equal opportunity and authority to scrutinize research; 2) investigate or “study up” scientific phenomena from the perspectives, interests, and (...) conditions of marginalized stakeholders potentially affected by the research; and 3) make gender, ethnicity, class, and geographical location “visible,” or use them as categories of analysis when appropriate. Yet, more work is needed to determine what exactly these recommendations would require, and the benefits they would yield, in specific research contexts.Using the recent development of the human papillomavirus (HPV) vaccines, we examine how these three feminist recommendations would have applied. We argue that these principles would have yielded several epistemic and social benefits in the HPV case, as well as in biomedical research more generally. That is, biomedical research guided by these principles would not only be epistemically superior, but also more socially responsible. (shrink)

It is universally accepted that participants in biomedical research have the right to withdraw from participation at any time, except, perhaps, when withdrawal would constitute a threat to their health or the health of others. The right to withdraw is encoded in nearly every document on the requirements for ethical conduct of research on humans, including the U.S. Code of Federal Regulations governing all federally-funded research, the Common Rule (45 CFR 46); the Declaration of Helsinki (WMA 2008); the 2002 research (...) guidelines of the Council for International Organizations of Medical Sciences (CIOMS 2002); and the Belmont Report (National Commission 1979). Presumably, if codification of the right in these .. (shrink)

This original and enticing book provides a fresh, unifying perspective on many old and new logico-philosophical conundrums. Its basic thesis is that many concepts central in ordinary and philosophical discourse are inherently circular and thus cannot be fully understood as long as one remains within the confines of a standard theory of definitions. As an alternative, the authors develop a revision theory of definitions, which allows definitions to be circular without this giving rise to contradiction (but, at worst, to “vacuous” (...) uses of definienda). The theory is applied with varying levels of detail to a circular analysis of concepts as diverse as truth, predication, necessity, physical object, etc. The focus is on truth, and hope is expressed that a deeper understanding of the Liar and related paradoxes has been provided: “We have tried to show that once the circularity of truth is recognized, a great deal of its behavior begins to make sense. In particular, from this viewpoint, the existence of the paradoxes seems as natural as the existence of the eclipses” (p. 142). We think that this hope is fully justified, although some problems remain that future research in this field should take into account. The following assumptions constitute the typical background in which the truth paradoxes arise: (i) classical first-order logic, (ii) a language allowing for self-reference, and (iii) the “semantic” Tarskian schema: (TS) T ‘A’ ↔ A (where ‘T’ is the truth predicate, and the single quotes are a nominalization device applicable to sentences; for simplicity, we only consider homophonic versions of TS). This background can be seen as somehow part of our ordinary linguistic and conceptual background and yet, to avoid inconsistency, one or more of these assumptions must be suitably weakened. The classical, Tarskian strategy is to forbid self-reference, whereas the fixed-point approaches stemming from the work of Saul Kripke (1975) and Robert Martin and Peter Woodruff (1975) weaken the logic.. (shrink)

This original and enticing book provides a fresh, unifying perspective on many old and new logico-philosophical conundrums. Its basic thesis is that many concepts central in ordinary and philosophical discourse are inherently circular and thus cannot be fully understood as long as one remains within the confines of a standard theory of definitions. As an alternative, the authors develop a revision theory of definitions, which allows definitions to be circular without this giving rise to contradiction (but, at worst, to “vacuous” (...) uses of definienda). The theory is applied with varying levels of detail to a circular analysis of concepts as diverse as truth, predication, necessity, physical object, etc. The focus is on truth, and hope is expressed that a deeper understanding of the Liar and related paradoxes has been provided: “We have tried to show that once the circularity of truth is recognized, a great deal of its behavior begins to make sense. In particular, from this viewpoint, the existence of the paradoxes seems as natural as the existence of the eclipses” (p. 142). We think that this hope is fully justified, although some problems remain that future research in this field should take into account. (shrink)

Tversky and Kahneman (1974) originally discussed three main heuristics: availability, representativeness, and anchoring-and-adjustment. Research on judgemental forecasting suggests that the type of information on which forecasts are based is the primary factor determining the type of heuristic that people use to make their predictions. Specifically, availability is used when forecasts are based on information held in memory; representativeness is important when the value of one variable is forecast from explicit information about the value of another variable; and anchoring-and-adjustment is employed (...) when the value of a variable is forecast from explicit information about previous values of that same variable. Although there has been increased emphasis on the adaptiveness of heuristics and increased interest in specifying their use in terms of computational models, this way of structuring our knowledge about judgemental forecasting continues to be a useful one. I use it to frame discussion of some recent debates in the area. (shrink)

Audit standards require auditors to conduct audits being independent in mental attitude from their clients. Regulators and financial statement users are concerned that auditors compromise their independence by allowing clients that contract for consulting services, i.e., non-audit services, more financial statement discretion relative to clients that demand relatively little non-audit services from their auditor. This paper begins by discussing the role of auditing in the capital markets and the various stakeholders that rely on audited financial information in making their capital (...) allocation decisions. The paper continues by explaining the ethical dilemma inherent in audit contracts in general, and more specifically, how the provision of non-audit services threatens auditor independence. The paper concludes by summarizing research studies that report conflicting evidence that there is a violation of auditor independence due to the provision of non-audit services to audit clients. (shrink)

There has been relatively little empirical research into the causes of research misconduct. To begin to address this void, the authors collected data from closed case files of the Office of Research Integrity (ORI). These data were in the form of statements extracted from ORI file documents including transcripts, investigative reports, witness statements, and correspondence. Researchers assigned these statements to 44 different concepts. These concepts were then analyzed using multidimensional scaling and cluster analysis. The authors chose a solution consisting of (...) seven clusters: (1) personal and professional stressors, (2) organizational climate, (3) job insecurities, (4) rationalizations A, (5) personal inhibitions, (6) rationalizations B and, (7) personality factors. The authors discuss the implications of their findings for policy and for future research. (shrink)

Reports of research fraud have raised concerns about research integrity similar to concerns raised about financial accounting fraud. We propose a departure from self-regulation in that researchers adopt the financial accounting approach in establishing trust through an external validation process, in addition to the reporting entities and the regulatory agencies. The general conceptual framework for reviewing financial reports, utilizes external auditors who are certified and objective in using established standards to provide an opinion on the financial reports. These standards have (...) become both broader in scope and increasingly specific as to what information is reported and the methodologies to be employed. We believe that the financial reporting overhaul encompassed in the US Sarbanes–Oxley Act of 2002, which aims at preventing accounting fraud, can be applied to scientific research in 4 ways. First, Sarbanes–Oxley requires corporations to have a complete set of internal accounting controls. Research organizations should use appropriate sampling techniques and audit research projects for conformity with the initial research protocols. Second, corporations are required to have the chief financial officer certify the accuracy of their financial statements. In a similar way, each research organization should have their vice-president of research (or equivalent) certify the research integrity of their research activities. In contrast, the primary responsibility of the existing Research Integrity Officers is to handle allegations of research misconduct, an after-the-fact activity. Third, generally accepted auditing standards specify the appropriate procedures for external review of a corporation’s financial statements. For similar reasons, the research review process would also require corresponding external auditing standards. Finally, these new requirements would be implemented in stages, with the largest 14 research organizations that receive 25% of the total National Institutes of Health funding, adopting these research oversight enhancements first. (shrink)

This paper shares my reflections on the research ethics review process, from the point of view of both a qualitative researcher and a member of an institutional research ethics review board. By considering research ethics review, first as practice, then as policy, as a relationship and, finally, as a performance, I attempt to outline a new vision of research ethics, one that engages seriously with the relationship between receiving ethics approval, and conducting ethical research.

In this paper I argue, against the current consensus, that the right to withdraw from research is sometimes alienable. In other words, research subjects are sometimes morally permitted to waive their right to withdraw. The argument proceeds in three major steps. In the first step, I argue that rights typically should be presumed alienable, both because that is not illegitimately coercive and because the general paternalistic motivation for keeping them inalienable is untenable. In the second step of the argument, I (...) consider three special characteristics of the right to withdraw, first that its waiver might be exploitative, second that research involves intimate bodily access, and third that it is irreversible. I argue that none of these characteristics justify an inalienable right to withdraw. In the third step, I examine four considerations often taken to justify various other allegedly inalienable rights: concerns about treating yourself merely as a means as might be the case in suicide, concerns about revoking all your future freedoms in slavery contracts, the resolution of coordination problems, and public interest. I argue that the motivations involved in these four types of situations do not apply to the right to withdraw from research. (shrink)

No matter one’s wealth or social position, all are subject to the threats of natural hazards. Be it fire, flood, hurricane, earthquake, tornado, or drought, the reality of hazard risk is universal. In response, governments, non-profits, and the private sector all support research to study hazards. Each has a common end in mind: to increase the resilience of vulnerable communities. While this end goal is shared across hazards, the conception of how to get there can diverge considerably. The earthquake and (...) hurricane research endeavors in the US provide an illustrative contrast. The earthquake community sets out to increase resilience through a research process that simultaneously promotes both high quality and usable – preparedness-focused - science. In order to do so, the logic suggests that research must be collaborative, responsive, and transparent. Hurricane research, by contrast, largely promotes high quality science – predictions - alone, and presumes that usability should flow from there. This process is not collaborative, responsive, or transparent. Experience suggests, however, that the latter model – hurricane research - does not prepare communities or decision makers to use the high quality science it has produced when a storm does hit. The predictions are good, but they are not used effectively. Earthquake research, on the other hand, is developed through a collaborative process that equips decision makers to know and use hazards research knowledge as soon as an earthquake hits. The contrast between the two fields suggests that earthquake research is more likely to meet the end goal of resilience than is hurricane research, and thus that communities might be more resilient to hurricanes were the model by which research is funded and conducted to change. The earthquake research experience can provide lessons for this shift. This paper employs the Public Value Mapping (PVM) framework to explore these two divergent public value logics, their end results, and opportunities for improvement. (shrink)

Contrary to Perruchet & Vinter's self-organizing consciousness (SOC) model, subliminal mere exposure (SME) research indicates that stimuli perceived without awareness produce robust effects. Moreover, SME effects are significantly stronger than mere exposure effects produced by clearly recognized stimuli. The SOC model must be revised to accommodate findings from studies that use affect-based outcome measures.

Nanotechnology has from its very beginning been surrounded with an aura of novelty. For instance, on the 28 introductory pages of the report that prepared the US National Nanotechnology Initiative (NNI), Nanotechnology Research Directions (NSTC/IWGN 1999), we read 73 times the term “new”, 15 times “novel”, 7 times “innovation”, and 21 times “revolution”. The authors concede that one should distinguish between different nanotechnologies, because “Many existing technologies do already depend on nanoscale processes. Photography and catalysis are two examples of ‘old’ (...) nanotechnologies” (ibid, p. xxvi). One might conclude here that, if all the existing nanotechnologies are “old” nanotechnologies, “new” nanotechnologies do not yet exists but are only promises of the future. However, without further explanation and distinction between presence and future, they suggest that most nanotechnologies are or will be new. Furthermore, they claim that nanotechnology (in singular) is a generator of further new technologies, since “Nanotechnology will give birth to new fields that at present are only visions of leading researchers” (ibid., p. xviii). Whenever science managers speak of nanotechnology (in singular), sophisticated distinctions seem to give way to plain claims about the present and future novelty of nanotechnology. As the NNI director Mihail Roco wrote in a 2001 report, “A revolution is occurring in science and technology […] Nanotechnology will fundamentally transform science, technology, and society. In 10 to 20 years, a significant proportion of industrial production, healthcare practice, and environmental management will be changed by the new technology.” (Roco & Bainbridge, pp. 1, 19) When they put on their hats as science managers, scientists rarely reject but mostly support such novelty claim, as did for instance the chemists George Whitesides and Paul Alivisatos in the earlier report: “Nanostructures are the entry into a new realm in physical and biological science.” (NSTC/IWGN 1999, p.. (shrink)

The National Institutes of Health and other federal health agencies are considering establishing a national biobank to study the roles of genes and environment in human health. A preliminary public engagement study was conducted to assess public attitudes and concerns about the proposed biobank, including the expectations for return of individual research results. A total of 141 adults of different ages, incomes, genders, ethnicities, and races participated in 16 focus groups in six locations across the country. Focus group participants voiced (...) a strong desire to be able to access individual research results. Recognizing the wide range of possible research results from a large cohort study, they repeatedly and spontaneously suggested that cohort study participants be given ongoing choices as to which results they received. (shrink)

Summary Why was nuclear fission discovered under the repressive conditions of the Third Reich and not in one of the other leading countries in science? The attempts to answer this question leads to the formulation of the hypothesis that under the very special constellation of the working relations between Hahn and Meitner, the forced emigration of Meitner was advantageous insofar as it emancipated Hahn from the physical guardianship of Meitner, and liberated his chemical competence. This was a prerequisite to (...) recognizing the presence of Barium in the debris of Uranium decay. At the same time it liberated Meitner so that she could break with the old physicalconcepts of knowledge when accepting Hahn's chemical results, and find the correct interpretation of the experiment. Moreover, Hahn's and Strassmann's inner emigration which kept them away from participating in political activities and engagements, as well as their abstinence from competing in fashionable research (which was stimulated by the increasing political isolation of Germany) helped them to concentrate on their more restricted investigations following unfashionable lines of thinking and were among the favourable conditions for making their great discovery. (shrink)

: Research in emergency settings (RES) has become a major public issue with urgent policy implications. Significant attention has focused recently on RES in response to the trial of PolyHeme, a synthetic blood substitute, in trauma victims in hemorrhagic shock. Unfortunately, the discussion of the PolyHeme trial in the popular and scholarly press leaves important questions unanswered. This paper articulates three important lessons from the PolyHeme trial that have significant policy implications. First, the RES regulations should be re-visited, particularly the (...) requirement that existing treatments be unproven or unsatisfactory in order for research to be acceptable without consent. Second, further conceptual and empirical scholarship is needed to accomplish the goal of effectively involving communities. Third, a more subtle analysis is needed regarding how to balance the needs of maintaining public trust and protecting confidential trade information in the context of RES. (shrink)

"Clear and coherent ... One of the most exciting aspects of the book is the author's account of how the consequences and implications of the breakthroughs in quantum mechanics challenged the mechanistic, deterministic philosophy fostered by classical science."-- The Science Teacher . Written by a respected Harvard physicist, this introductory account of the evolution of quantum physics also explores the subject's philosophical implications. The opening chapters trace the development of physics from antiquity onward, chronicling the origins of (...) class='Hi'>quantum mechanics and the ways in which quantum theory was used to address previously unsolved problems and to interpret observable atomic phenomena. Succeeding chapters are devoted to matters at the forefront of research pertaining to elementary particles, and the text concludes with a look at the old and new concepts of physical science and their relationship to issues of philosophy and religion--including considerations of causality, determinism, and free will. 1968 ed. 36 black-and-white figures. 12 halftones. (shrink)

OBJECTIVE: To apply component analysis, a structured approach to the ethical analysis of risks and potential benefits in research, to published emergency research using a waiver of/exception from informed consent. The hypothesis was that component analysis could be used with a high degree of interrater reliability, and that the vast majority of emergency research would comply with a minimal-risk threshold. METHODS: A Medline search and manual search were done to identify studies using a waiver of/exception from informed consent published between (...) July 1996 and December 2000. A review panel of physicians and bioethicists independently classified nontherapeutic procedures in each study as minimal risk, probably minimal risk, or probably more than minimal risk. RESULTS: Seventy studies using a waiver of/exception from informed consent were identified. A majority of reviewers classified nontherapeutic procedures in 62 studies (88.6%) as minimal risk. Reviewers classified nontherapeutic procedures in six studies (8.6%) as minimal risk or probably minimal risk. In two studies (2.9%), nontherapeutic procedures were classified as probably more than minimal risk. The intraclass correlation coefficient was 0.89 (95% CI = 0.85 to 0.93), indicating very high interrater reliability. CONCLUSIONS: Component analysis can be used with high reliability to review emergency research and may improve the consistency of institutional review board review of emergency research. The vast majority of published emergency research performed using a waiver of/exception from consent complies with a properly-applied minimal-risk threshold. A minimal-risk threshold for nontherapeutic procedures protects subjects better than current U.S. regulations while permitting important emergency research to continue. (shrink)

The National Science Foundation (NSF) evaluates grant proposals based on two criteria: intellectual merit and broader impacts. NSF gives applicants wide latitude to choose among a number of broader impacts, which include both benefits for the scientific community and benefits for society. This paper considers whether including potential societal benefits in the Broader Impacts Criterion leads to enhanced benefits for society. One prerequisite for realizing societal benefit is to transfer research results to potential users in a meaningful format. To determine (...) whether researchers who discuss broader impacts for society are more likely to engage in broad dissemination activities beyond the scientific publication, I analysed proposed broader impacts statements from recent award abstracts. Although 43% of researchers discussed potential benefits for society, those researchers were no more likely to propose dissemination of results to potential users than researchers who only discussed broader impacts for science. These findings suggest that considering potential societal benefit as a broader impact may not lead to more actual societal benefits and that many potentially useful results may not be disseminated beyond the scientific community. I conclude with policy recommendations that could increase the likelihood of realizing potential societal benefits from academic research. (shrink)

It is generally assumed in research ethics that research participants have an unconditional right to withdraw from research without any detriment or reprisal. This paper analyses this right in the context of biobank research and argues that the traditional shape of the right in clinical research can be modified in biobank research without incurring significant ethical cost. The paper falls in three parts. The first part is a brief explication of the philosophical justification of the right to withdraw. The second (...) part presents a number of extant criticisms of the right. And the third and final part argues that although a right to withdraw is crucial in relation to biobank research, such a right has to be specified in a different way to the similar right in relation to clinical research. (shrink)

Schizophrenia affects more than 1% of the world's population, causing great personal suffering and socioeconomic burden. These costs associated with schizophrenia necessitate inquiry into the causes and treatment of the illness but generate ethical challenges related to the specific nature and deficits of the illness itself. In this article, we present a systematic analysis of narrative data from 63 people living with the illness of schizophrenia collected through semistructured interviews about their attitudes, beliefs, and experiences related to psychiatric research. In (...) the comments of these individuals, half of whom had had prior personal experience in research protocols, we identified factors influencing openness toward research involvement as well as deterrents that appear to lessen interest in participation. Clear response pattern differences emerged between those with prior research experience and those without such experience. In the discussion, we explore these key findings and outline the implications for safeguards in mental illness research. (shrink)

Most codes of research ethics and the practice of Institutional Review Boards (IRBs) allow human subjects to withdraw from research at any time. Consent forms invariably make a statement to this effect. So understood, a subject's right to withdraw from research is inalienable; she cannot, through her consent, surrender this right. Recently critics have argued that in selected circumstances the right to withdraw from research is alienable; subjects have the moral authority, through their consent, to obligate themselves not to withdraw. (...) Two kinds of cases have been cited to support this. In one case, there will be great benefits lost if subjects are permitted to withdraw before the completion of the protocol. In the other case, there will be harm to third parties if subjects withdraw from the experiment. In this paper, I defend the inalienability of the right to withdraw from research. I argue, first, that securing the desired benefits and avoiding the feared harms can be achieved without allowing waiver. Second, I show that permitting waiver in these cases does not guarantee that the ends sought will be achieved. And third, I articulate positive reasons for conceiving subjects' right to withdraw from research as inalienable. (shrink)

Research during war has many levels of complexities but presents researchers with valuable lessons into design, conduct and conclusions of research. The Arab region has endemic conflicts and recurring wars but there are limited reports of experiences of research conducted in the context of such conflicts and wars. This article summarizes the lessons learnt from an epidemiologic survey, concerned with assessing mental health of internally displaced persons (IDPs), conducted during the summer 2006 Israeli-Hezbollah war in Lebanon. Researchers reflect on issues (...) encountered and/or considered within three main directions: Practical, epidemiological and ethical considerations specific to wartime. Many identified issues bear similarities to challenges of research conducted in other emergency and war situations. This case study explores the challenges to internal and external validity of the results within a context of particular socio-political organization and reflects on additional ethical considerations regarding the particular living conditions imposed on IDPs. In addition, this article discusses ways that researchers used to overcome some of the constraints encountered. (shrink)

Previous research with adults suggests that a catalog of minimally counterintuitive concepts, which underlies supernatural or religious concepts, may constitute a cognitive optimum and is therefore cognitively encoded and culturally transmitted more successfully than either entirely intuitive concepts or maximally counterintuitive concepts. This study examines whether children's concept recall similarly is sensitive to the degree of conceptual counterintuitiveness (operationalized as a concept's number of ontological domain violations) for items presented in the context of a fictional narrative. Seven- to nine-year-old (...) children who listened to a story including both intuitive and counterintuitive concepts recalled the counterintuitive concepts containing one (Experiment 1) or two (Experiment 2), but not three (Experiment 3), violations of intuitive ontological expectations significantly more and in greater detail than the intuitive concepts, both immediately after hearing the story and 1 week later. We conclude that one or two violations of expectation may be a cognitive optimum for children: They are more inferentially rich and therefore more memorable, whereas three or more violations diminish memorability for target concepts. These results suggest that the cognitive bias for minimally counterintuitive ideas is present and active early in human development, near the start of formal religious instruction. This finding supports a growing literature suggesting that diverse, early-emerging, evolved psychological biases predispose humans to hold and perform religious beliefs and practices whose primary form and content is not derived from arbitrary custom or the social environment alone. (shrink)

Influential or frequently cited business ethics research does not appear in a vacuum; our study reveals its predominant sources and contributors by discipline. By examining citations from articles published in three top business ethics journals (Journal of Business Ethics, Business Ethics Quarterly and Business Ethics: A European Review) over the period 2004–2008, we document that the preponderance of influential business ethics research comes primarily from the management faculty. In addition, management journals and management books are the predominant sources for influential (...) business ethics research. Further, among the management fields, organizational behavior and organizational structure predominate leadership and strategy as the major subject areas for influential business ethics research, suggesting that this influential body of research is focused on a micro rather than on a macro context. These empirical results lend credence to the perception that there is a silo effect in influential business ethics research and suggest that business ethics research in a micro context might have permeated to the teaching of business ethics. (shrink)

Background: Clinical trials involving children previously considered unethical are now considered a necessity because of the inherent physiological differences between children and adults. An integral part of research ethics is the informed consent, which for children is obtained by proxy from a consenting parent or guardian. The informed consent process is governed by international ethical codes that are interpreted in accordance with local laws and procedures raising the importance of contextualizing their implementation.DiscussionThe Zimbabwean parental informed consent document for children participating (...) in clinical research is modeled along western laws of ethics and requires that the parent or legally authorized representative provide consent on behalf of a minor. This article highlights the experiences and lessons learnt by Zimbabwean researchers in interpreting and obtaining informed consent for orphaned children participating in a collaborative HIV clinical trial involving the Medical Research Council, United Kingdom and four centers, three of which are in Uganda. Researchers were faced with a situation where caregivers of orphaned children were not permitted to provide informed consent for trial participation if the Zimbabwean courts had not legally appointed them. The situation contrasted with general clinical practice where legal papers where not required for providing consent for surgical procedures for example.SummaryExperiences gained from this clinical trial revealed that while there may be internationally established guidelines governing the process of obtaining informed consent for children participating in research, there may be need to be cognizant of the culture within which the research is taking place. This may call for the development of an ethico-legal framework that governs research-involving children in Zimbabwe that would facilitate their participation in clinical research, while ensuring that they are protected from exploitation. The Medical Research Council of Zimbabwe has since started developing that framework in a process that is expected to involve critical stakeholders namely the community including children, ethicists, the legal fraternity and researchers. (shrink)

Background: There is general consensus internationally that unfair distribution of the benefits of research is exploitative and should be avoided or reduced. However, what constitutes fair benefits, and the exact nature of the benefits and their mode of provision can be strongly contested. Empirical studies have the potential to contribute viewpoints and experiences to debates and guidelines, but few have been conducted. We conducted a study to support the development of guidelines on benefits and payments for studies conducted by the (...) KEMRI-Wellcome Trust programme in Kilifi, Kenya. Methods: Following an initial broad based survey of cash, health services and other items being offered during research by all programme studies (n = 38 studies), interviews were held with research managers (n = 9), and with research staff involved in 8 purposively selected case studies (n = 30 interviewees). Interviews explored how these ‘benefits’ were selected and communicated, experiences with their administration, and recommendations for future guidelines. Data fed into a consultative workshop attended by 48 research staff and health managers, which was facilitated by an external ethicist.FindingsThe most commonly provided benefits were medical care (for example free care, and strengthened quality of care), and lunch or snacks. Most cash given to participants was reimbursement of transport costs (for example to meet appointments or facilitate use of services when unexpectedly sick), but these payments were often described by research participants as benefits. Challenges included: tensions within households and communities resulting from lack of clarity and agreement on who is eligible for benefits; suspicion regarding motivation for their provision; and confusion caused by differences between studies in types and levels of benefits. Conclusions: Research staff differed in their views on how benefits should be approached. Echoing elements of international benefit sharing and ancillary care debates, some research staff saw research as based on goodwill and partnership, and aimed to avoid costs to participants and a commercial relationship; while others sought to maximise participant benefits given the relative wealth of the institution and the multiple community needs. An emerging middle position was to strengthen collateral or indirect medical benefits to communities through collaborations with the Ministry of Health to support sustainability. (shrink)

The study examines, in the context of Crawford's (1970) study items, the influence of non-anonymity deriving from feedback of research results on marketing professionals' research ethics judgements, particularly that of response patterns (social desirability of responses) and item omissions. The results indicate that such non-anonymity does not significantly influence the social desirability of responses or item omissions — thus suggesting the appropriateness of its use to stimulate research ethics responses.

Sussman and colleagues provide no evidence supporting their claim that the human vocal production system is specialized to produce locus equations with high correlations and linearity. We propose the alternative null hypothesis that these features result from physical and physiological factors common to all mammalian vocal tracts and we recommend caution in assuming that human speech production mechanisms are unique.

This paper discusses the hazards of regulating controversial biomedical research in light of the emergence of powerful, multi-national biotechnology corporations. Prohibitions on the use of government funds can simply force controversial research into the private sphere, and unilateral or multilateral research bans can simply encourage multi-national companies to conduct research in countries that lack restrictive laws. Thus, a net effect of government regulation is that research migrates from the public to the private sphere. Because private research receives less oversight and (...) external scrutiny than public research, it can threaten the welfare and rights of human subjects, scientific progress and openness, and the quality of the approval process for new biomedical technologies. In order to avoid the harmful effects of government regulation of biotechnology, society should promote meaningful discussion and dialogue among scientists, industry leaders, and the public before resorting to regulatory solutions. Legislative or executive initiatives should be applied with great discretion and care, and should be crafted in such a way that they protect public health and safety, promote scientific progress, and avoid the hazards of privatized research and polarized debates. (shrink)

The clinical trial is the major investigational tool of clinical medicine. Two recent reports highlight the fact that the most often quoted mechanisms for the protection of research subjects, viz., research ethics board review and eligibility criteria, are insufficient to achieve this end. In this paper, we argue that the prime mechanism for the protection of persons in clinical trials should be the clinical judgement of the physician-investigator. The clinical investigator has a duty to protect subjects from both harm and (...) undue risk. It is argued that the clinical investigator has a duty to screen for, and exclude, potential research subjects who may be unduly vulnerable to the risks of a particular clinical trial. In order to fulfill this obligation, the investigator should personally screen each potential research subject at the time of accrual. In larger trials in which this is not feasible, this task could be delegated to another appropriately qualified health care professional, with the principal investigator retaining personal responsibility. To reinforce and make explicit this legal and moral duty, we propose that the investigator sign a statement, appended to each subject's consent form, to attest that this duty has been responsibly discharged. (shrink)

The argument is made that psychometric forms of assessment are essential to the large-scale adoption of developmental approaches to moral education. In this respect, the Defining Issues Test has been an invaluable tool for research and practice in moral education. However, because such instruments are based upon previous developmental research, they are by definition derivative and unsuited for basic research on moral development. In addition standardised measures, while essential to educational research on the correlates of moral growth, run the risk (...) of reifying extant views and assumptions about morality and moral development. Thus, such measures may stand in the way of generating new knowledge and/or impeding the assimilation of alternative conceptions of morality and social development within educational research and practice. To avoid these problems, while at the same time benefiting from the utility of measures such as the DIT, requires a constant reciprocal interaction between the generation of standardised measures and basic developmental research. (shrink)

How international research might contribute to justice in global health has not been substantively addressed by bioethics. This article describes how the provision of ancillary care can link international clinical research to the reduction of global health disparities. It identifies the ancillary care obligations supported by a theory of global justice, showing that Jennifer Ruger’s health capability paradigm requires the delivery of ancillary care to trial participants for a limited subset of conditions that cause severe morbidity and mortality. Empirical research (...) on the Shoklo Malaria Research Unit’s (SMRU) vivax malaria treatment trial was then undertaken to demonstrate whether and how these obligations might be upheld in a resource-poor setting. Our findings show that fulfilment of the ancillary care obligations is feasible where there is commitment from chief investigators and funders and is strongly facilitated by SMRU’s dual role as a research unit and medical non-governmental organization. (shrink)

Recently adopted international texts have given a new focus on conflicts of interests and access to information resulting from biomedical research. They confirmed ethical review committees as a central point to guarantee individual rights and the effective application of ethical principles. Therefore specific attention should be paid in giving such committees all the facilities necessary to keep them independent and qualified.

Research on the ethical, legal, and social implications (ELSI) of human genomics has devoted significant attention to the research ethics issues that arise from genomic science as it moves through the translational process. Given the prominence of these issues in today's debates over the state of research ethics overall, these studies are well positioned to contribute important data, contextual considerations, and policy arguments to the wider research ethics community's deliberations, and ultimately to develop a research ethics that can help guide (...) biomedicine's future. In this essay, we illustrate this thesis through an analytic summary of the research presented at the 2011 ELSI Congress, an international meeting of genomics and society researchers. We identify three pivotal factors currently shaping genomic research, its clinical translation, and its societal implications: (1) the increasingly blurred boundary between research and treatment; (2) uncertainty — that is, the indefinite, indeterminate, and incomplete nature of much genomic information and the challenges that arise from making meaning and use of it; and (3) the role of negotiations between multiple scientific and non-scientific stakeholders in setting the priorities for and direction of biomedical research, as it is increasingly conducted “in the public square.”. (shrink)

This article, which stems from separate research projects pursued by each author in Oaxaca, Mexico, explores conducting fieldwork through the lenses of community autonomy , and hospitality . Engaging with these concepts made us question how the process of research can contradict cultural ethics that operate within fieldwork locations, as well as consider how such concepts may inform a more ethical set of inquiry practices. Such a set of alternative ethics can provide, furthermore, means for negotiating situations marked by interculturality, (...) particularly as it emerges through contemporary processes of globalization. (shrink)

This article argues for the need to put into practice a profound and comprehensive intellectual revolution, affecting to a greater or lesser extent all branches of scientific and technological research, scholarship and education. This intellectual revolution differs, however, from the now familiar kind of scientific revolution described by Kuhn. It does not primarily involve a radical change in what we take to be knowledge about some aspect of the world, a change of paradigm. Rather it involves a radical change in (...) the fundamental, overall intellectual aims and methods of inquiry. At present inquiry is devoted to the enhancement of knowledge. This needs to be transformed into a kind of rational inquiry having as its basic aim to enhance personal and social wisdom. This new kind of inquiry gives intellectual priority to the personal and social problems we encounter in our lives as we strive to realize what is desirable and of value – problems of knowledge and technology being intellectually subordinate and secondary. For this new kind of inquiry, it is what we do and what we are that ultimately matters: our knowledge is but an aspect of our life and being. (shrink)

In this paper I address the conflict of interest (CoI) issue from a legal point of view at a European level. We will see that the regulatory framework that exists in Europe does state the need for the independence of ethics committee involved in authorisation of research and clinical trials. We will see that CoI is an element that has to be closely monitored at National and International level. Therefore, Member States and Newly Associated States do have to address CoI (...) in the authorisation process of research and clinical protocols of biomedicine. (shrink)

: During the "institutional revolution" between 1870 and 1910 almost two dozen physics institutes were newly erected in Germany. The design of these buildings was largely determined by sets of precautions against various sorts of disturbances. These undertakings were by no means unique. Recent historical studies have identified similar attempts in physics institutes outside Germany. But as yet, hardly a word has been wasted on the necessity of these precautionary measures. It seems to be self-explanatory that disturbances should be precluded (...) from scientific investigations. My paper criticizes this approach. The evidential nature of this assertion rests on the questionable assumption that disturbances are "external factors," which hinder physical research. I examine the 'architecture of disturbance' and show that it is the set of precautions itself which sometimes produces 'disturbing' effects. I then focus on particular sources of disturbance that were taken into account in the design of the buildings, and analyze the aporias that characterize the 'external' definition of disturbances. In conclusion, an alternative understanding of disturbances is offered. Following Michel Serres's concept of the parasite, I suggest that disturbances indicate the "being of relation" in physics research around 1900. From this point of view I finally sketch two novel features that governed the design of physics institutes after the turn of the century. (shrink)

Does a kindly, charitable interest in others have health benefits for the agent, particularly when coupled with helping behaviours? Although the answer remains unclear, researchers have established that there is an association between generous emotions, helping behaviour, and longevity. Increasingly, emotional states and their related behaviours are being studied by mainstream scientists in relation to health promotion and disease prevention. If helping affect or behaviour can be linked with health and longevity, there are significant implications for how we think about (...) human nature and prosperity. Although studies show that those who are physically or psychologically overwhelmed by the needs of others do experience a stressful burden that can have significant negative health consequences, little attention has been given to whether there are health benefits from helping behaviour that is fulfilling, not overwhelming. In this book, Stephen Post brings together distinguished researchers from basic science to address this question in objective terms. The book provides heuristic models, from evolution and neuroscience, to explain the association between altruism and health, and examines potential public health and practical implications of the existing data. (shrink)

Presenting the history of space-time physics, from Newton to Einstein, as a philosophical development DiSalle reflects our increasing understanding of the connections between ideas of space and time and our physical knowledge. He suggests that philosophy's greatest impact on physics has come about, less by the influence of philosophical hypotheses, than by the philosophical analysis of concepts of space, time, and motion and the roles they play in our assumptions about physical objects and physical measurements. This way (...) of thinking leads to new interpretations of the work of Newton and Einstein and the connections between them. It also offers new ways of looking at old questions about a priori knowledge, the physical interpretation of mathematics, and the nature of conceptual change. Understanding Space-Time will interest readers in philosophy, history and philosophy of science, and physics, as well as readers interested in the relations between physics and philosophy. (shrink)

Although in the US there have been dozens of subpoenas seeking information gathered by academic researchers under a pledge of confidentiality, few cases have garnered as much attention as the two sets of subpoenas issued to Boston College seeking interviews conducted with IRA operatives who participated in The Belfast Project, an oral history of The Troubles in Northern Ireland. For the researchers and participants, confidentiality was understood to be unlimited, while Boston College has asserted that it pledged confidentiality only “to (...) the extent American law allows.” This a priori limitation to confidentiality is invoked by many researchers and universities in the United States, Canada and Great Britain, but there has been little discussion of what the phrase means and what ethical obligations accompany it. An examination of the researchers’ and Boston College’s behaviour in relation to the subpoenas provides the basis for that discussion. We conclude that Boston College has provided an example that will be cited for years to come of how not to protect research participants to the extent American law allows. (shrink)

Machine generated contents note: Preface; 1. Introduction; 2. The savior of capitalism: the power of economic discourse; 3. The mentors of the Holocaust and the power of race science; 4. Protectors of nature: the power of climate change research; 5. Conclusion; Bibliography.

In their 2010 article ‘Research Integrity in China: Problems and Prospects’, Zeng and Resnik challenge others to engage in empirical research on research integrity in China. Here we respond to that call in three ways: first, we provide updates to their analysis of regulations and allegations of scientific misconduct; second, we report on two surveys conducted in Hong Kong that provide empirical backing to describe ways in which problems and prospects that Zeng and Resnik identify are being explored; and third, (...) we continue the discussion started by Zeng and Resnik, pointing to ways in which China's high-profile participation in international academic research presents concerns about research integrity. According to our research, based upon searches of both English and Chinese language literature and policies, and two surveys conducted in Hong Kong, academic faculty and research post-graduate students in Hong Kong are aware of and have a positive attitude towards responsible conduct of research. Although Hong Kong is but one small part of China, we present this research as a response to concerns Zeng and Resnik introduce and as a call for a continued conversation. (shrink)

Guidelines for health research focus on protecting individual research subjects. It is also vital to protect the communities involved in health research. In particular, a number of studies have been criticized on the grounds that they exploited host communities. The present paper attempts to address these concerns by providing an analysis of community exploitation and, based on this analysis, determining what safeguards are needed to protect communities in health research against exploitation. (edited).

This paper is an assessment of the key debates on Heidegger’s existential conception of science. It relates the topics to contemporary problems in the philosophy of the natural sciences, providing the reader with a framework to evaluate various versions of hermeneutic phenomenology of scientific research as alternatives to both, naturalistic and normativeepistemological conceptions of scientific research. The paper delineates a context of constitution that is irreducible to the context-distinction between discovery and justification. In this context, the tenets of the doctrine (...) of cognitive existentialism are formulated. (shrink)

Not much. I demonstrate this by constructing a model of a memory system governed by deterministic, time reversible laws only, thereby showing that the mere fact of our having memories solely of the past does not necessitate an indeterministic, time asymmetric or stochastic physics, essentially thermodynamic processes or a primitive notion of time asymmetric causation.

This paper addresses the extent to which both Julian Barbour‘s Machian formulation of general relativity and his interpretation of canonical quantum gravity can be called timeless. We differentiate two types of timelessness in Barbour‘s (1994a, 1994b and 1999c). We argue that Barbour‘s metaphysical contention that ours is a timeless world is crucially lacking an account of the essential features of time—an account of what features our world would need to have if it were to count as being one in which (...) there is time. We attempt to provide such an account through considerations of both the representation of time in physical theory and in orthodox metaphysical analyses. We subsequently argue that Barbour‘s claim of timelessness is dubious with respect to his Machian formulation of general relativity but warranted with respect to his interpretation of canonical quantum gravity. We conclude by discussing the extent to which we should be concerned by the implications of Barbour‘s view. (shrink)