Search results for 'RNA viruses' (try it on Scholar)

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  1. Susie Fisher (2010). Are Rna Viruses Vestiges of an Rna World? Journal for General Philosophy of Science 41 (1):121-141.score: 90.0
    This paper follows the circuitous path of theories concerning the origins of viruses from the early years of the twentieth century until the present, considering RNA viruses in particular. I focus on three periods during which new understandings of the nature of viruses guided the construction and reconstruction of origin hypotheses. During the first part of the twentieth century, viruses were mostly viewed from within the framework of bacteriology and the discussion of origin centered on the (...)
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  2. Jeremy Bruenn (2012). Genes From Double-Stranded RNA Viruses in the Nuclear Genomes of Fungi. In. In Witzany (ed.), Biocommunication of Fungi. Springer. 71--83.score: 45.0
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  3. Mart Krupovic (2012). Recombination Between RNA Viruses and Plasmids Might Have Played a Central Role in the Origin and Evolution of Small DNA Viruses. Bioessays 34 (10):867-870.score: 45.0
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  4. Michael G. Rossmann (1987). The Evolution of RNA Viruses. Bioessays 7 (3):99-103.score: 45.0
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  5. Peter Schuster (forthcoming). How Do RNA Molecules and Viruses Explore Their Worlds? Complexity.score: 36.0
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  6. Jérôme Pierrel (2012). An RNA Phage Lab: MS2 in Walter Fiers' Laboratory of Molecular Biology in Ghent, From Genetic Code to Gene and Genome, 1963-1976. [REVIEW] Journal of the History of Biology 45 (1):109 - 138.score: 27.0
    The importance of viruses as model organisms is well-established in molecular biology and Max Delbrück's phage group set standards in the DNA phage field. In this paper, I argue that RNA phages, discovered in the 1960s, were also instrumental in the making of molecular biology. As part of experimental systems, RNA phages stood for messenger RNA (mRNA), genes and genome. RNA was thought to mediate information transfers between DNA and proteins. Furthermore, RNA was more manageable at the bench than (...)
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  7. Donald L. Nuss (1986). What the Papers Say: Engineering a Plant RNA Virus for Expression of Foreign Genetic Sequences. Bioessays 4 (3):133-134.score: 21.0
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  8. Guy Barry & John S. Mattick (2012). The Role of Regulatory RNA in Cognitive Evolution. Trends in Cognitive Sciences 16 (10):497-503.score: 18.0
    The evolution of the human brain has resulted in the emergence of higher-order cognitive abilities, such as reasoning, planning and social awareness. Although there has been a concomitant increase in brain size and complexity, and component diversification, we argue that RNA regulation of epigenetic processes, RNA editing, and the controlled mobilization of transposable elements have provided the major substrates for cognitive advance. We also suggest that these expanded capacities and flexibilities have led to the collateral emergence of psychiatric fragilities and (...)
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  9. H. Fraenkel-Conrat (1990). Virus Reconstitution and the Proof of the Existence of Genomic RNA. Bioessays 12 (7):351-352.score: 18.0
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  10. John S. Mattick, Paulo P. Amaral, Marcel E. Dinger, Tim R. Mercer & Mark F. Mehler (2009). RNA Regulation of Epigenetic Processes. Bioessays 31 (1):51-59.score: 18.0
    There is increasing evidence that dynamic changes to chromatin, chromosomes and nuclear architecture are regulated by RNA signalling. Although the precise molecular mechanisms are not well understood, they appear to involve the differential recruitment of a hierarchy of generic chromatin modifying complexes and DNA methyltransferases to specific loci by RNAs during differentiation and development. A significant fraction of the genome-wide transcription of non-protein coding RNAs may be involved in this process, comprising a previously hidden layer of intermediary genetic information that (...)
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  11. Wenwen Fang & Laura F. Landweber (2013). RNA‐Mediated Genome Rearrangement: Hypotheses and Evidence. Bioessays 35 (2):84-87.score: 15.0
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  12. Anne Gabory, Hélène Jammes & Luisa Dandolo (2010). The H19 Locus: Role of an Imprinted Non‐Coding RNA in Growth and Development. Bioessays 32 (6):473-480.score: 15.0
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  13. Willemijn M. Gommans, Sean P. Mullen & Stefan Maas (2009). RNA Editing: A Driving Force for Adaptive Evolution? Bioessays 31 (10):1137-1145.score: 15.0
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  14. John S. Mattick (2010). RNA as the Substrate for Epigenome‐Environment Interactions. Bioessays 32 (7):548-552.score: 15.0
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  15. Alka Saxena & Piero Carninci (2011). Long Non‐Coding RNA Modifies Chromatin. Bioessays 33 (11):830-839.score: 15.0
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  16. Erik Schultes, Peter T. Hraber & Thomas H. LaBean (1999). A Parameterization of RNA Sequence Space. Complexity 4 (4):61-71.score: 15.0
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  17. Susie Fisher (2010). Not Beyond Reasonable Doubt: Howard Temin's Provirus Hypothesis Revisited. [REVIEW] Journal of the History of Biology 43 (4):661 - 696.score: 13.0
    During the 1960s, Howard M. Temin (1934-1994), dared to advocate a "heretical" hypothesis that appeared to be at variance with the central dogma of molecular biology, understood by many to imply that information transfer in nature occurred only from DNA to RNA. Temin's provirus hypothesis offered a simple explanation of both virus replication and viral-induced cancer and stated that Rous sarcoma virus, an RNA virus, is replicated via a DNA intermediate. Popular accounts of this scientific episode, written after the discovery (...)
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  18. I. V. Carvalho (2009). Our Common Enemy: Combatting the World's Deadliest Viruses to Ensure Equity Health Care in Developing Nations. Zygon 44 (1):51-63.score: 12.0
    In a previous issue of Zygon (Carvalho 2007), I explored the role of scientists—especially those engaging the science-religion dialogue—within the arena of global equity health, world poverty, and human rights. I contended that experimental biologists, who might have reduced agency because of their professional workload or lack of individual resources, can still unite into collective forces with other scientists as well as human rights organizations, medical doctors, and political and civic leaders to foster progressive change in our world. In this (...)
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  19. Jacques Demongeot, Nicolas Glade & Andrés Moreira (forthcoming). Evolution and RNa Relics. A Systems Biology View. Acta Biotheoretica.score: 12.0
    The genetic code has evolved from its initial non-degenerate wobble version until reaching its present state of degeneracy. By using the stereochemical hypothesis, we revisit the problem of codon assignations to the synonymy classes of amino-acids. We obtain these classes with a simple classifier based on physico-chemical properties of nucleic bases, like hydrophobicity and molecular weight. Then we propose simple RNA (or more generally XNA, with X for D, P or R) ring structures that present, overlap included, one and only (...)
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  20. Alvaro Moreno Bergareche & Julio Fernandez Ostolaza (1992). From Records to Self-Description: The Role Played by RNA in Early Evolutive Systems. Acta Biotheoretica 40 (1).score: 12.0
    We study the appearance of genetic information starting from a system where self-reproductive and enzymatic functions are supported by the same sort of molecules. In a first phase, the information must have arisen in the form of rate independent sequences as records of enzymatic functions. Although this stage must have played an important role in evolution, it will be shown how its evolutive capacities were blocked by the impossibility of appearance of geno/phenotype duality. Finally, a logical scheme is proposed for (...)
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  21. Günther Witzany (2006). Natural Genome-Editing Competences of Viruses. Acta Biotheoretica 54 (4).score: 12.0
    It is becoming increasingly evident that the driving forces of evolutionary novelty are not randomly derived chance mutations of the genetic text, but a precise genome editing by omnipresent viral agents. These competences integrate the whole toolbox of natural genetic engineering, replication, transcription, translation, genomic imprinting, genomic creativity, enzymatic inventions and all types of genetic repair patterns. Even the non-coding, repetitive DNA sequences which were interpreted as being ancient remnants of former evolutionary stages are now recognized as being of viral (...)
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  22. Gregory J. Morgan (2006). Why There Was a Useful Plausible Analogy Between Geodesic Domes and Spherical Viruses. History and Philosophy of the Life Sciences 28 (2):215 - 235.score: 12.0
    In 1962, Donald Caspar and Aaron Klug published their classic theory of virus structure. They developed their theory with an explicit analogy between spherical viruses and Buckminster Fuller's geodesic domes. In this paper, I use the spherical virus-geodesic dome case to develop an account of analogy and deductive analogical inference based on the notion of an isomorphism. I also consider under what conditions there is a good reason to claim an experimentally untested analogy is plausible.
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  23. Stephen T. Abedon (2012). Salutary Contributions of Viruses to Medicine and Public Health. In Witzany (ed.), Viruses: Essential Agents of Life. Springer. 389--405.score: 12.0
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  24. Harald Brüssow (2012). On Viruses, Bats and Men: A Natural History of Food-Borne Viral Infections. In Witzany (ed.), Viruses: Essential Agents of Life. Springer. 245--267.score: 12.0
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  25. Michael Doyle, Lukas Badertscher, Lukasz Jaskiewicz, Stephan Güttinger, Sabine Jurado, Tabea Hugenschmidt, Ulrike Kutay & Witold Filipowicz, The Double-Stranded RNA Binding Domain of Human Dicer Functions as a Nuclear Localization Signal.score: 12.0
    Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and doublestranded RNA into ~21-nt-long products ultimately triggering sequence-dependent gene silencing. Although processing of substrates in vertebrate cells occurs in the cytoplasm, there is growing evidence suggesting Dicer is also present and functional in the nucleus. To address this possibility, we searched for a nuclear localization signal (NLS) in human Dicer and identified its C-terminal double-stranded RNA binding domain (dsRBD) as harboring NLS activity. We (...)
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  26. Jonathan Filée & Michael Chandler (2012). Unpacking the Baggage: Origin and Evolution of Giant Viruses. In Witzany (ed.), Viruses: Essential Agents of Life. Springer. 203--216.score: 12.0
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  27. Jean-Paul Gaudillière (1996). Molecular Biologists, Biochemists, and Messenger RNA: The Birth of a Scientific Network. [REVIEW] Journal of the History of Biology 29 (3):417 - 445.score: 12.0
    This paper investigated the part played by collaborative practices in chaneling the work of prominent biochemists into the development of molecular biology. The RNA collaborative network that emerged in the 1960s in France encompassed a continuum of activities that linked laboratories to policy-making centers. New institutional frameworks such as the DGRST committees were instrumental in establishing new patterns of funding, and in offering arenas for multidisciplinary debates and boundary assessment. It should be stressed however, that although this collaborative network was (...)
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  28. Dario Giacomoni (1993). The Origin of DNA:RNA Hybridization. [REVIEW] Journal of the History of Biology 26 (1):89 - 107.score: 12.0
    Besides its use in basic research, the DNA:RNA hybridization technique has helped the development of genetic engineering: it is instrumental in the isolation of specific genes that can be inserted into foreign cells, thus modifying their genetic information. Plants, animals, and microorganisms can now be altered to yield improved crops, pest-resistant plants, and a cheaper source of important proteins or drugs. The social relevance of genetic engineering received official sanction in 1980 when the U.S. Supreme Court ruled that genetically modified (...)
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  29. John S. Mattick (2003). Challenging the Dogma: The Hidden Layer of Non-Protein-Coding RNAs in Complex Organisms. Bioessays 25 (10):930-939.score: 12.0
    The central dogma of biology holds that genetic information normally flows from DNA to RNA to protein. As a consequence it has been generally assumed that genes generally code for proteins, and that proteins fulfil not only most structural and catalytic but also most regulatory functions, in all cells, from microbes to mammals. However, the latter may not be the case in complex organisms. A number of startling observations about the extent of non-protein-coding RNA (ncRNA) transcription in the higher eukaryotes (...)
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  30. Stephen S. Morse (1992). Evolving Views of Viral Evolution: Towards an Evolutionary Biology of Viruses. History and Philosophy of the Life Sciences 14 (2):215 - 248.score: 12.0
    Despite considerable interest in viral evolution, at least among virologists, viruses are rarely considered from the same evolutionary vantage point as other organisms. Early work of necessity emphasized phenotype and phenotypic variation (and therefore arguably was more oriented towards the broader biological and ecological perspectives). More recent work (essentially since the development of molecular evolution in the 1960's but beginning earlier) has concentrated on genotypic variation, with less clarity about the significance of such variations. Other aspects of evolutionary theory, (...)
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  31. Philippe Pérot, Pierre-Adrien Bolze & François Mallet (2012). From Viruses to Genes: Syncytins. In Witzany (ed.), Viruses: Essential Agents of Life. Springer. 325--361.score: 12.0
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  32. Marilyn J. Roossinck (2012). Persistent Plant Viruses: Molecular Hitchhikers or Epigenetic Elements? In Witzany (ed.), Viruses: Essential Agents of Life. Springer. 177--186.score: 12.0
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  33. Erin E. Gill & Fiona Sl Brinkman (2011). The Proportional Lack of Archaeal Pathogens: Do Viruses/Phages Hold the Key? Bioessays 33 (4):248-254.score: 11.0
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  34. Aare Abroi & Julian Gough (2011). Are Viruses a Source of New Protein Folds for Organisms?–Virosphere Structure Space and Evolution. Bioessays 33 (8):626-635.score: 11.0
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  35. Hans D. Klenk, Wolfgang Garten & Mikhail Matrosovich (2011). Molecular Mechanisms of Interspecies Transmission and Pathogenicity of Influenza Viruses: Lessons From the 2009 Pandemic. Bioessays 33 (3):180-188.score: 11.0
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  36. Sabra L. Klein (2012). Sex Influences Immune Responses to Viruses, and Efficacy of Prophylaxis and Treatments for Viral Diseases. Bioessays 34 (12):1050-1059.score: 11.0
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  37. Anja Pm Verhagen & Ger Jm Pruijn (2011). Are the Ro RNP‐Associated Y RNAs Concealing microRNAs? Y RNA‐Derived miRNAs May Be Involved in Autoimmunity. Bioessays 33 (9):674-682.score: 11.0
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  38. Doogab Yi (2008). Cancer, Viruses, and Mass Migration: Paul Berg's Venture Into Eukaryotic Biology and the Advent of Recombinant DNA Research and Technology, 1967-1980. [REVIEW] Journal of the History of Biology 41 (4):589 - 636.score: 10.0
    The existing literature on the development of recombinant DNA technology and genetic engineering tends to focus on Stanley Cohen and Herbert Boyer's recombinant DNA cloning technology and its commercialization starting in the mid-1970s. Historians of science, however, have pointedly noted that experimental procedures for making recombinant DNA molecules were initially developed by Stanford biochemist Paul Berg and his colleagues, Peter Lobban and A. Dale Kaiser in the early 1970s. This paper, recognizing the uneasy disjuncture between scientific authorship and legal invention (...)
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  39. David Penny (2005). An Interpretive Review of the Origin of Life Research. Biology and Philosophy 20 (4):633-671.score: 9.0
    Life appears to be a natural property of matter, but the problem of its origin only arose after early scientists refuted continuous spontaneous generation. There is no chance of life arising ‘all at once’, we need the standard scientific incremental explanation with large numbers of small steps, an approach used in both physical and evolutionary sciences. The necessity for considering both theoretical and experimental approaches is emphasized. After describing basic principles that are available (including the Darwin-Eigen cycle), the search for (...)
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  40. Hans-Jörg Rheinberger (1992). Experiment, Difference, and Writing: II. The Laboratory Production of Transfer RNA. Studies in History and Philosophy of Science Part A 23 (3):389-422.score: 9.0
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  41. Gunther Witzany (2008). The Viral Origins of Telomeres and Telomerases and Their Important Role in Eukaryogenesis and Genome Maintenance. Biosemiotics 1 (2):191-206.score: 9.0
    Whereas telomeres protect terminal ends of linear chromosomes, telomerases identify natural chromosome ends, which differ from broken DNA and replicate telomeres. Although telomeres play a crucial role in the linear chromosome organization of eukaryotic cells, their molecular syntax most probably descended from an ancient retroviral competence. This indicates an early retroviral colonization of large double-stranded DNA viruses, which are putative ancestors of the eukaryotic nucleus. This contribution demonstrates an advantage of the biosemiotic approach towards our evolutionary understanding of telomeres, (...)
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  42. Richard Taylor (2000). Philosophical Viruses. Philosophy Now 27:32-33.score: 9.0
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  43. Jean-Paul Gaudillière (2000). Rockefeller Strategies for Scientific Medicine: Molecular Machines, Viruses and Vaccines. Studies in History and Philosophy of Science Part C 31 (3):491-509.score: 9.0
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  44. Gaudilliere J.-P. (2000). Rockefeller Strategies for Scientific Medicine: Molecular Machines, Viruses and Vaccines. Studies in History and Philosophy of Science Part C 31 (3):491-509.score: 9.0
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  45. Neeraja Sankaran (2012). How the Discovery of Ribozymes Cast RNA in the Roles of Both Chicken and Egg in Origin-of-Life Theories. Studies in History and Philosophy of Science Part C 43 (4):741-750.score: 9.0
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  46. Julian Chela-Flores (1996). Ideas in Theoretical Biology Preservation of Relics From the RNA World Through Natural Selection, Symbiosis and Horizontal Gene Transfer. Acta Biotheoretica 44 (2).score: 9.0
  47. Richard Dawkins (1993). Viruses of the Mind. In Bo Dahlbom (ed.), Dennett and His Critics: Demystifying Mind. Blackwell. 13--27.score: 9.0
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  48. Purificación López-García (2012). The Place of Viruses in Biology in Light of the Metabolism-Versus-Replication-First Debate. History and Philosophy of the Life Sciences 34 (3):391-406.score: 9.0
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  49. M. Stone (2014). In Defense of Viruses. Bioscience 64 (3):260-260.score: 9.0
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  50. Marcia Stone (2013). RNA's First Four Billion Years on Earth: A Biography. Bioscience 63 (4):247-252.score: 9.0
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