Calpains are a family of calcium‐dependent thiol‐proteases which are proposed to be involved in many physiological processes as well as pathological conditions. Calpains are likely to be involved in processing of numerous enzymes and cytoskeletal components, thereby linking their activity to a variety of intracellular events. Although widely studied, the precise mechanism(s) involved in calpain activation and activity in vivo remain poorly understood. Initial studies suggested that calpain exists primarily as an inactive proenzyme that required autolytic cleavage for activation. It (...) was also hypothesized that calpain associated with membrane phospholipids, serving to increase calcium sensitivity, facilitating autolytic conversion and thus activating the enzyme. These hypotheses, however, have not been universally accepted and there is increasing evidence that intact, non‐autolyzed calpain is the physiologically active calpain form. (shrink)

The ethical principle of respect for autonomy has come into its own In American medicine since World War II as equal in importance to the traditional medicomoral principles of nonmaleficence and beneficence. Respect for autonomy provides the ethical underpinning for the patient's right to exercise an informed choice – whether to consent to or to refuse recommended medical treatment. However, an informed choice demands a certain level of competence. Typical criteria for patient competence to accept or to refuse medical treatments (...) Include ability to make a choice and ability to comprehend the nature of the treatment, as well as the risks and benefits of accepting or refusing the treatment. (shrink)

Good reasoning can lead to success; bad reasoning can lead to catastrophe. Yet, it's not obvious how we reason, and why we make mistakes. This new book by one of the pioneers of the field, Philip Johnson-Laird, looks at the mental processes that underlie our reasoning. It provides the most accessible account yet of the science of reasoning.

Responsible Robotics is about developing robots in ways that take their social implications into account, which includes conceptually framing robots and their role in the world accurately. We are now in the process of incorporating robots into our world and we are trying to figure out what to make of them and where to put them in our conceptual, physical, economic, legal, emotional and moral world. How humans think about robots, especially humanoid social robots, which elicit complex and sometimes disconcerting (...) reactions, is not predetermined. The animal–robot analogy is one of the most commonly used in attempting to frame interactions between humans and robots and it also tends to push in the direction of blurring the distinction between humans and machines. We argue that, despite some shared characteristics, when it comes to thinking about the moral status of humanoid robots, legal liability, and the impact of treatment of humanoid robots on how humans treat one another, analogies with animals are misleading. (shrink)

Monte Johnson examines one of the most controversial aspects of Aristiotle's natural philosophy: his teleology. Is teleology about causation or explanation? Does it exclude or obviate mechanism, determinism, or materialism? Is it focused on the good of individual organisms, or is god or man the ultimate end of all processes and entities? Is teleology restricted to living things, or does it apply to the cosmos as a whole? Does it identify objectively existent causes in the world, or is it (...) merely a heuristic for our understanding of other causal processes? Johnson argues that Aristotle's aporetic approach drives a middle course between these traditional oppositions, and avoids the dilemma, frequently urged against teleology, between backwards causation and anthropomorphism. Although these issues have been debated with extraordinary depth by Aristotle scholars, and touched upon by many in the wider philosophical and scientific community as well, there has been no comprehensive historical treatment of the issue. Aristotle is commonly considered the inventor of teleology, although the precise term originated in the eighteenth century. But if teleology means the use of ends and goals in natural science, then Aristotle was rather a critical innovator of teleological explanation. Teleological notions were widespread among his predecessors, but Aristotle rejected their conception of extrinsic causes such as mind or god as the primary causes for natural things. Aristotle's radical alternative was to assert nature itself as an internal principle of change and an end, and his teleological explanations focus on the intrinsic ends of natural substances - those ends that benefit the natural thing itself. Aristotle's use of ends was subsequently conflated with incompatible 'teleological' notions, including proofs for the existence of a providential or designer god, vitalism and animism, opposition to mechanism and non-teleological causation, and anthropocentrism. Johnson addresses these misconceptions through an elaboration of Aristotle's methodological statements, as well as an examination of the explanations actually offered in the scientific works. Reviewed in: Notre Dame Philosophical Review 2006.06.15; Bryn Mawr Classical Review 2006.08.37; Il-Sole – 24 Ore 6 Aug. 2006; Philosophy in Review 26 (2006): 360-2; Rhizai 3 (2006): 171-8; Journal of the History of Philosophy 45 (2007): 323-4; Ancient Philosophy 27 (2007): 191-200; Phronesis 52 (2007): 248-9; Isis 98 (2007): 375; Aestimatio 4 (2007) 146-152; The British Journal for the History of Science 41 (2008): 129-130. The European Legacy 14 (2009); La Cultura 47 (2009): 174-175; Sean M. Row, Teleology in Political Contexts: an assessment of Monte Ransome Johnson’s “Aristotle on Teleology”. (A thesis presented to the faculty of the college of arts and sciences of Ohio University, 2009.). (shrink)

This comprehensive compendium provides a rigorous framework to tackle the daunting challenges of designing correct and efficient algorithms. It gives a uniform approach to the design, analysis, optimization, and verification of algorithms. The volume also provides essential tools to understand algorithms and their associated data structures. This useful reference text describes a way of thinking that eases the task of proving algorithm correctness. Working through a proof of correctness reveals an algorithm's subtleties in a way that a typical description does (...) not. Algorithm analysis is presented using careful definitions that make the analyses mathematically rigorous. (shrink)

The late eleventh and twelfth centuries were Europe's first age of pamphlet warfare, of invective and satire. The perceived failure, or at least hypocrisy, of its new institutions-the new monastic orders and the reformed papacy-gave rise to the phenomenon, and it was shaped by the study of grammar and rhetoric in the new Schools. The central figures in the texts in the present book are Bernard of Clairvaux, the powerful ostensible founder of the Cistercian order, and the popular and influential (...) teacher Peter Abelard, leader of the radical faction in the Schools of Paris. The event which sparked this controversy was the Church council at Sens in 1141 which had led to the condemnation of Abelard's doctrines. Abelard proposed to use reason to explain the mysteries of faith, and this had led him into all kinds of difficulties with established church doctrine. The leading light in the atttack on his ideas was Bernard, the famous abbot of Clairvaux, a group of whose letters, written to gather support for it before and after the Council, are presented here. A little while later Abelard was defended by the vituperative but otherwise unknown Berengar, who wrote an outrageous Apology attacking Bernard; we also edit his remaining polemical works: his Letter to the Carthusians, and his Letter to the Bishop of Mende. None of Berengar's works has been translated before. An extensive introductory essay describes the course of the debate and the personnel, and analyses the invective employed by both Bernard and Berengar. There is full annotation identifying the writers' sources and clarifying the issues."-- Back cover. (shrink)

Police killings of unarmed Black people have ignited a national and international response unlike any in decades. But differing from their civil rights-oriented predecessors, today’s activists do not think that the institutions and values of liberal democracy can eradicate structural racism. They draw instead on a Black radical tradition that, Terrence L. Johnson argues, derives its force from its unacknowledged ethical and religious dimensions. We Testify with Our Lives traces Black religion’s sustained influence from SNCC to the present, reconstructing (...) a radical lived ethics of freedom and justice. Johnson demonstrates that Black Power fundamentally contests liberalism’s abstract understanding of democracy, calling instead for new embodied frameworks to achieve human flourishing and dignity. Black bodies represent the primary form of resistance against violent and oppressive regimes of white supremacy and exploitation, and the individual and collective struggles of Black life bear witness to the dogged determination to cultivate beauty, rage, and joy. Considering the writings of Audre Lorde, Toni Cade Bambara, Stokely Carmichael, Martin Luther King Jr., Malcolm X, and James Baldwin, We Testify with Our Lives makes its case through a new narrative of the evolution of Black radicalism from the civil rights movement through the Movement for Black Lives. It forges new insights into Black Power’s vital contributions to debates on ethics, transnational politics, democracy, political solidarity, and freedom—and its potent resources for the ongoing struggle to build democratic possibilities for all. (shrink)

Artificial intelligence research has foundered on the issue of representation. When intelligence is approached in an incremental manner, with strict reliance on interfacing to the real world through perception and action, reliance on representation disappears. In this paper we outline our approach to incrementally building complete intelligent Creatures. The fundamental decomposition of the intelligent system is not into independent information processing units which must interface with each other via representations. Instead, the intelligent system is decomposed into independent and parallel activity (...) producers which all interface directly to the world through perception and action, rather than interface to each other particularly much. The notions of central and peripheral systems evaporateeverything is both central and peripheral. Based on these principles we have built a very successful series of mobile robots which operate without supervision as Creatures in standard office environments. (shrink)

The uncanniness of Freud's uncanny -- Alligators, crocodiles and the monstrous uncanny -- The uncanny urban underside -- The uncanniness of Schelling's uncanny -- The uncanny and the work of Walter Benjamin -- The uncanny cyborg -- The uncanny and the fictional -- The uncanny and the modern adult literary fairy tale -- The uncanny and the gothic vampire romance -- The uncanny and the detective story -- The uncanny and the weird horror story -- The uncanny and the dystopian (...) science fiction novel -- The uncanny and the historiographic metafictional novel -- The uncanny commonwealth of Christianity -- The living Polytheism of the Fung Loy Kok institute of Taoism/Taoist Tai Chi. (shrink)

Democracy faces threats from an emerging right-wing movement in democratic governments around the world. This may be even more prevalent in the United States because there is an evil that uses rhetorical tropes to undermine the anchor institutions of democracy: press, courts, universities, and Congress. This evil has a personification--former President Donald Trump. All the rhetorical critiques of Trump, that he is a demagogue, an authoritarian, a serial liar, a populist on steroids, fail to take into account the evil that (...) is fomented by his angry and vengeful rhetoric. Pictures of evil in Scripture, philosophy, and rhetoric bear a striking resemblance to Trump. It is not enough to say that he is dangerous to democracy. Kennedy claims that he is the evil seed in democracy that is even now sprouting new versions of the Trump rhetoric as each acolyte attempts to outrage the next. Good and Evil in the Garden of Democracy screams at the evil, fights against the evil, and then attempts to sing the songs of goodness and democracy from poets, prophets, and rhapsodes. For the health of democracy these words have been written. (shrink)

Ungodly theories and scurrilous metaphors -- The elements of faith -- Monotheism and morality -- Religious experiences, miracles, and revelations -- The rise and fall of religious movements -- Church and sect: religious group dynamics -- Ecclesiastical influences -- Religious hostility and civility -- Individual causes and consequences of religiousness -- Meaning and metaphysics -- Propositions, definitions, and deductions.

The emergence of private authority has become a feature of the post-Cold War world. The contributors to this volume examine the implications of this erosion of the power of the state for global governance. They analyse actors as diverse as financial institutions, multinational corporations, religious terrorists and organised criminals. The themes of the book relate directly to debates concerning globalization and the role of international law, and will be of interest to scholars and students of international relations, politics, sociology and (...) law. (shrink)

This edited volume represents a unique addition to the available literature on animal ethics, animal studies, and neuroethics. Its goal is to expand discussions on animal ethics and neuroethics by weaving together different threads: philosophy of mind and animal minds, neuroscientific study of animal minds, and animal ethics. Neuroethical questions concerning animals’ moral status, animal minds and consciousness, animal pain, and the adequacy of animal models for neuropsychiatric disease have long been topics of debate in philosophy and ethics, and more (...) recently also in neuroscientific research. The book presents a transdisciplinary blend of voices, underscoring different perspectives on the broad questions of how neuroscience can contribute to our understanding of nonhuman minds, and on debates over the moral status of nonhuman animals. All chapters were written by outstanding scholars in philosophy, neuroscience, animal behavior, biology, neuroethics, and bioethics, and cover a range of issues and species/taxa. Given its scope, the book will appeal to scientists and students interested in the debate on animal ethics, while also offering an important resource for future researchers. Chapter 13 of this book is available open access under a CC BY 4.0 license at link.springer.com. (shrink)

"Written in a racy, persuasive style, the book impresses the reader as a work of significant scholarship...I encourage students of comparative religions- and especially those of Islamic economics- to read it with great care."&$151; Islamic Studies The worlds of economics and theology rarely intersect. The former appears occupied exclusively with the concrete equations of supply and demand, while the latter revolves largely around the less tangible concerns of the soul and spirit. Intended as an interfaith clarification of the relationship between (...) the material and the spiritual worlds, this volume first inspects secular beliefs about the relationship between economics and ethics. Exploring the differences and similarities between the treatment of economic issues in each of the great monotheistic religions, Rodney Wilson reveals how each tradition considers such subjects as individual wealth, lending, economic regulation, usury, insurance capitalism, socialism, and banking. He concludes with an intriguing epilogue on the rapidly expanding field of business ethics. (shrink)

In this paper I shall outline the approach to consciousness adopted by ethnomethodology and its `associate'conversation analysis. I shall attempt to do this by taking a minimalist stance, namely a basic formulation of the elements of these approaches, trying to strip away the ornate superstructures which have been erected upon that basis. I shall proceed in two ways. First, I shall seek to define ethnomethodology and conversation analysis by contrasting them to varying degrees with a variety of other approaches: symbolic (...) interactionism and, derivatively, the work of Goffman, the -social psychology of Rom Harre and his associates and with Norbert Wiley. Secondly, I shall give some examples of the use of the notion of `self'held by ethnomethodologists and conversation analysts that take a definitive turn towards a non-ironic, non-mentalist, non-essentialist and non-cognitivist approach to knowledge, consciousness and self. (shrink)

The challenge that confronts corporate decision-makers in connection with global labor conditions is often in identifying the standardsby which they should govern themselves. In an effort to provide greater direction in the face of possible global cultural conflicts, ethicistsThomas Donaldson and Thomas Dunfee draw on social contract theory to develop a method for identifying basic human rights: Integrated Social Contract Theory (ISCT). In this paper, we apply ISCT to the challenge of global labor standards, attempting to identify labor rights that (...) could serve as guides for corporations producing or outsourcing outside of their home country. In addition to identifying areas of universal agreement, we also examine whether ISCT is, in fact, a sufficient basis for determining worker rights; we seek to define the parameters of the “sweatshop” problem; we include the application and results of our ISCT analysis as applied to labor standards: the global labor rights hypernorms; and conclude that ISCT is sufficient only for rights that are universal. We also discuss whether market-driven decisions can identify the boundaries of labor rights, or at least assure that market outcomes are compatible with maintaining labor rights, in order to respond to the shortcomings of ISCT. We conclude with some comments on directions of analysis for labor rights determination. (shrink)

The possibilities of unconscious perception and unconscious bias prompt parallel debates about unconscious mental content. This chapter argues that claims within these debates alleging the existence of unconscious content are made fraught by ambiguity and confusion with respect to the two central concepts they involve: consciousness and content. Borrowing conceptual resources from the debate about unconscious perception, the chapter distills the two conceptual puzzles concerning each of these notions and establishes philosophical strategies for their resolution. It then argues that empirical (...) evidence for unconscious bias falls victim to these same puzzles, but that progress can be made by adopting similar philosophical strategies. Throughout, the chapter highlights paths forward in both debates, illustrates how they serve as fruitful domains in which to study the relationship between philosophy and empirical science, and uses their combined study to further understanding of a general theory of unconscious content. (shrink)

_Skepticism and Cognitivism_ addresses the fundamental question of epistemology: Is knowledge possible? It approaches this query with an evaluation of the skeptical tradition in Western philosophy, analyzing thinkers who have claimed that we can know nothing. After an introductory chapter lays out the central issues, chapter 2 focuses on the classical skeptics of the Academic and Pyrrhonistic schools and then on the skepticism of David Hume. Chapters 3 through 5 are devoted to contemporary defenders of skepticism—Keith Lehrer, Arne Næss, and (...) Peter Unger. In chapter 6, author Oliver A. Johnson dons the mantle of skeptic himself and develops and adds theories to the skeptical arsenal. He closes with an examination of the relationship between skepticism and cognitivism, reaching and defending conclusions on the nature and extent of possible human knowledge. (shrink)

Transform your yoga practice into a force for creating social change with this concise, eloquent guide to social justice tools and skills. Skill in Action asks you to explore the deeply transformational practice of yoga as a way to become an agent of social change and work toward a just world. Through yoga practices and philosophy, this book explores liberation for ourselves and others, while asking us to engage in our own agency-whether that manifests as activism, volunteer work, or changing (...) our relationships with others and ourselves. To provide a strong foundation to begin this work, Michelle Cassandra Johnson clearly defines power and privilege, oppression, liberation, and suffering, and invites you to make changes in your life that promote equality and freedom for all. Each chapter ends with a breathwork, asana, meditation, or interpersonal relational practice to help you incorporate this wisdom into your daily life. Each of the practices extend beyond the individual to offer resources and tools to shift institutional policies and procedures in a culture that has left all of us negatively impacted by white supremacy and social inequity. We must awaken to the injustice and suffering of marginalized communities, and we must use our voices and actions toward the liberation of all people. (shrink)

The need for ethical naturalism -- Moral problem-solving as an empirical inquiry -- Where are our values bred? : sources of moral norms -- Intuitive processes of moral cognition -- Moral deliberation as cognition, imagination, and feeling -- The nature of "reasonable" moral deliberation -- There is no moral faculty -- Moral fundamentalism is immoral -- The making of a moral self.

In C. S. Lewis’s Christian Apologetics: Pro and Con, I took the con in a debate with Victor Reppert about the soundness of Lewis’s famous “argument from reason.” Reppert then extended his argument in an article for Philosophia Christi; this article is my reply. I show that Reppert’s argument fails for three reasons. (1) It “loads the die” by falsely assuming that naturalism, by definition, can't include mental causation "on the basic level." (I provide multiple examples of naturalist theories of (...) mind that do exactly that). (2) Physical processes can reliably produce true beliefs. And (3) reasoning isn’t necessarily mental. (shrink)

"In the first study of its kind, David W. Johnson's "Watsuji on Nature" reconstructs the astonishing philosophy of nature of Watsuji Tetsurō (1889-1960), situating it in relation both to his reception of the thought of Heidegger and to his renewal of core ontological positions in classical Confucian and Buddhist philosophy. Johnson shows that for Watsuji we have our being in the lived experience of nature, one in which nature and culture compose a tightly interwoven texture called "fūdo". By (...) fully unfolding Watsuji's novel and radical claim that this is a setting that is neither fully external to human subjectivity nor merely a product of it, this book also sets out what still remains unthought in this concept, as well as in the relational structure that underwrites it. Johnson argues that what remains unarticulated is nothing less than the recovery of a reenchanted conception of nature and an elucidation of the wide-ranging implications of a relational conception of the self for questions about the disclosive character of experience, the distinction between fact and value, and the possibility of a place-based ecological ethics. In an engagingly lucid and deft analysis, "Watsuji on Nature" radically expands our appreciation of twentieth-century Japanese philosophy and shows what it has to offer to a global philosophical conversation"--Provided by publisher. (shrink)

In 1984, Harvard University asked Italo Calvino to deliver the next Charles Eliot Norton Lectures. After working obsessively for a year, Calvino died the day before he was to travel to Boston. Fortunately, Calvino had already written out all but one of the six planned lectures, which were framed as meditations on Lucretius. These are the titles of the five completed lectures: (1) “Lightness,” (2) “Quickness,” (3) “Exactitude,” (4) “Visibility,” (5) “Multiplicity.” The last lecture - worked out but unwritten - (...) was entitled: (6) “Consistency.” These are the names of concepts that fill Deleuze’s oeuvre. Our essay follows the structure of Calvino’s lectures - each section corresponding to each of Calvino’s titles - in order to offer one take on minor ethics. As the title of Calvino’s lectures is Six Memos for the Next Millennium, we now begin A Memorandum for Past Millennia. (shrink)

A grand, unified "natural philosophy of mind" that draws equally from the embodied cognition and cognitive neuroscience literature.

Improving the Odds: Raising the Class is a book aimed at legislators, school administrators, home school advocates, and college and university professors which examines the education system and provides a paradigm for improvement. The aim of this book is to find simple ways to approach improving the school system in America based on a belief that we need to build a system that has improvement built into the process of training and educating both teacher and students.

We hope to show that the overall protreptic plan of Aristotle's ethical writings is based on the plan he used in his published work Protrepticus (Exhortation to Philosophy), by highlighting those passages that primarily offer hortatory or protreptic motivation rather than dialectical argumentation and analysis, and by illustrating several ways that Aristotle adapts certain arguments and examples from his Protrepticus. In this essay we confine our attention to the books definitely attributable to the Nicomachean Ethics (thus excluding the common books).

Most animals have significant behavioral expertise built in without having to explicitly learn it all from scratch. This expertise is a product of evolution of the organism; it can be viewed as a very long term form of learning which provides a structured system within which individuals might learn more specialized skills or abilities. This paper suggests one possible mechanism for analagous robot evolution by describing a carefully designed series of networks, each one being a strict augmentation of the previous (...) one, which control a six legged walking machine capable of walking over rough terrain and following a person passively sensed in the infrared spectrum. As the completely decentralized networks are augmented. the robot’s performance and behavior repetoire demonstrably improve. The rationale for such demonstrations is that they may provide a hint as to the requirements for automatically building massive networks to carry out complex sensory-motor tasks. The experiments with an actual robot ensure that an essence of reality is maintained and that no critical disabling problems have been ignored. (shrink)

Now that mankind has created the capability of destroying itself through nuclear technology, is it still possible to think in terms of a "just war"? Johnson argues that it is, and in the context of specific case studies he offers moral guidelines for addressing such major contemporary problems as terrorist activity in a foreign country, an individual’s conscientious objection to military service, and an American defense policy that requires development of weapons that may be morally employed in case of (...) need. "Remarkable.... A thoughtful and even profound book, which can be warmly recommended."—Adam Roberts, _New Society_ __ "[A] wise, prudential, and moral thesis.... A most important book, one that all Americans who can should read."—George Armstrong Kelly, _Political Science Quarterly_ __ "At its heart, _Can Modern War be Just? _Is a challenge to the common assumption that any modern war must be total—an unrestrained, spasmodic release of one’s entire destructive capacity against the whole of the enemy’s population."—Richard Allen, _Journal of Religious Ethics_ __ "Johnson... seriously attempt[s] to balance principles and respect facts. For this he is to be praised."—Gary Jason, _Chronicles of Culture_ __ "Johnson’s application of just war doctrine to the hardest problems of contemporary warfare is both morally sensitive and intellectually bold. Readers will sometimes disagree with his arguments, but they will be forced to think hard, and they will learn what it is to work within a moral tradition."—Michael Walzer. (shrink)

This is an exciting time for brain science. Recent progress has been such that it now seems realistic to look toward an explanation of mind in terms of the brain's anatomy and physiology. Models based on artificially symmetrical arrays of idealized neurons are now being superseded by ones which properly take into account the brain's actual circuitry. This book presents a comprehensive overview of the current state of brain modeling, containing contributions from many leading researchers in this field. It will (...) be of interest not only to researchers in the fields of brain science and neurobiology, but also to psychologists and those involved in the study of artificial intelligence. (shrink)

In order to build autonomous robots that can carry out useful work in unstructured environments new approaches have been developed to building intelligent systems. The relationship to traditional academic robotics and traditional artificial intelligence is examined. In the new approaches a tight coupling of sensing to action produces architectures for intelligence that are networks of simple computational elements which are quite broad, but not very deep. Recent work within this approach has demonstrated the use of representations, expectations, plans, goals, and (...) learning, but without resorting to the traditional uses, of central, abstractly manipulable or symbolic representations. Perception within these systems is often an active process, and the dynamics of the interactions with the world are extremely important. The question of how to evaluate and compare the new to traditional work still provokes vigorous discussion. (shrink)