Search results for 'Roxanne M. Spindle' (try it on Scholar)

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  1. Marc J. Epstein, Ruth Ann McEwen & Roxanne M. Spindle (1994). Shareholder Preferences Concerning Corporate Ethical Performance. Journal of Business Ethics 13 (6):447 - 453.score: 870.0
    This study surveyed investors to determine the extent to which they preferred ethical behavior to profits and their interest in having information about corporate ethical behavior reported in the corporate annual report. First, investors were asked to determine what penalties should be assessed against employees who engage in profitable, but unethical, behavior. Second, investors were asked about their interest in using the annual report to disclose the ethical performance of the corporation and company officials. Finally, investors were asked if they (...)
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  2. A. Eroglu, L. T. & M. Toner (1998). Discussion. Studies in History and Philosophy of Science Part A 29 (4):623-637.score: 30.0
    Objective: To determine cryopreservation-induced alterations in the cytoskeleton of metaphase II mouse oocytes and the implications of these alterations in functionality of the cytoskeleton and polyploidy after fertilization.Design: Comparative study.Setting: Clinical and academic research environment at a medical school teaching hospital.Intervention(s): Oocytes were frozen using a slow-cooling (0.5oC/min) and slow-thawing (8oC/min) protocol in 1.5 M dimethyl sulfoxide and 0.2 M sucrose and were analyzed before and after fertilization.Main Outcome Measure(s): Cytoskeletal alterations, (...) fertilization, and polyploidy rates.Result(s): When analyzed immediately after thawing, the oocytes displayed dramatic cytoskeletal alterations. Only slight recovery was observed upon removal of the cryoprotectants. However, incubation after thawing of 1 hour at 37oC completely reestablished a normal microfilament and microtubule pattern while partially restoring normal spindle morphology and chromosome alignment. Accordingly, insemination immediately after removal of cryoprotectants resulted in a significantly decreased fertilization rate and aberrant dynamics of cytoskeleton-dependent events, whereas oocytes inseminated after the post-thaw incubation displayed fertilization rates and cytoskeletal dynamics comparable to those in controls. Cryopreservation did not increase polyspermy but significantly increased digyny when the oocytes were inseminated after the post-thaw incubation. All digynic eggs displayed an abnormal spindle remnant in comparison with diploid or polyspermic eggs.Conclusion(s): A brief period of incubation after thawing allows recovery and positively affects fertilization and cytoskeletal dynamics. Cryopreservation does not impair the functionality of microfilaments and cytoplasmic microtubules during postfertilization events. Our findings suggest that the increased rate of digyny in cryopreserved oocytes may be related to the spindle disorganization, leading to failure in segregation of the chromosomes, rather than to direct malfunction of the microfilaments in polar body formation. (shrink)
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  3. Margarete M. S. Heck (1999). Dr. Dolittle and the Making of the Mitotic Spindle. Bioessays 21 (12):985-990.score: 24.0
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  4. Paul M. Churchland (2005). Chimerical Colors: Some Phenomenological Predictions From Cognitive Neuroscience. Philosophical Psychology 18 (5):527-560.score: 12.0
    The Hurvich-Jameson (H-J) opponent-process network offers a familiar account of the empirical structure of the phenomenological color space for humans, an account with a number of predictive and explanatory virtues. Its successes form the bulk of the existing reasons for suggesting a strict identity between our various color sensations on the one hand, and our various coding vectors across the color-opponent neurons in our primary visual pathways on the other. But anti-reductionists standardly complain that the systematic parallels discovered by the (...)
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  5. A. M. L. Coenen (1998). Neuronal Phenomena Associated with Vigilance and Consciousness: From Cellular Mechanisms to Electroencephalographic Patterns. Consciousness and Cognition 7 (1):42-53.score: 4.0
    The neuroanatomical substrates controlling and regulating sleeping and waking, and thus consciousness, are located in the brain stem. Most crucial for bringing the brain into a state conducive for consciousness and information processing is the mesencephalic part of the brain stem. This part controls the state of waking, which is generally associated with a high degree of consciousness. Wakefulness is accompanied by a low-amplitude, high-frequency electroencephalogram, due to the fact that thalamocortical neurons fire in a state of tonic depolarization. Information (...)
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