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    D. R. Rokyta, P. Joyce, S. B. Caudle & H. A. Wichman (2005). An Empirical Test of the Mutational Landscape Model of Adaptation Using a Single-Stranded DNA Virus. Nature Genetics 37 (4):441-444.
    The primary impediment to formulating a general theory for adaptive evolution has been the unknown distribution of fitness effects for new beneficial mutations. By applying extreme value theory, Gillespie circumvented this issue in his mutational landscape model for the adaptation of DNA sequences, and Orr recently extended Gillespie's model, generating testable predictions regarding the course of adaptive evolution. Here we provide the first empirical examination of this model, using a single-stranded DNA bacteriophage related to phiX174, and find that our data (...)
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