Scott Gordon provides a magisterial review of the historical development of the social sciences from their beginnings in renaissance Italy to the present day.

It seems to me that no substantial support can be provided for the thesis that the Darwinian theory of evolution drew significantly upon ideas in contemporary Political Economy. What Darwin may have derived from Malthus was not an integral part of the theory of population that the classical economists, including Malthus, put forward. He did not know the literature of Political Economy; and if he had been acquainted with it, he would not have been able to derive anything from it (...) that was important for the theory of natural selection. The judgment that “with Darwin's theory there was a real transfer of knowledge from political economy to biology” (Pancaldi 1985:262) cannot be sustained. (shrink)

The main theme of these lectures is man's struggle to understand himself as a social being. A discussion of the major problems confronting man in his attempts to come to grips with the modern social world ends with a plea for liberalism and rationalism as the political and intellectual foundations of freedom and progress.

Challenging recent work that contends that seventeenth-century English discourses privilege the notion of a self-enclosed, self-sufficient individual, The Power of the Passive Self in English Literature recovers a counter-tradition that imagines selves as more passively prompted than actively choosing. This tradition - which Scott Paul Gordon locates in seventeenth-century religious discourse, in early eighteenth-century moral philosophy, in mid eighteenth-century acting theory, and in the emergent novel - resists autonomy and defers agency from the individual to an external 'prompter'. Gordon argues (...) that the trope of passivity aims to guarantee a disinterested self in a culture that was increasingly convinced that every deliberate action involves calculating one's own interest. Gordon traces the origins of such ideas from their roots in the non-conformist religious tradition to their flowering in one of the central texts of eighteenth-century literature, Samuel Richardson's Clarissa. (shrink)

Lower plasma levels of high-density lipoproteins in adolescents with type 2 diabetes have been associated with a higher pulse wave velocity, a marker of arterial stiffness. Evidence suggests that HDL proteins or particle subspecies are altered in T2D and these may drive these relationships. In this work, we set out to reveal any specific proteins and subspecies that are related to arterial stiffness in youth with T2D from proteomics data. Plasma and PWV measurements were previously acquired from lean and T2D (...) adolescents. Each plasma sample was separated into 18 fractions and evaluated by mass spectrometry. Then, we applied a validated network-based computational approach to reveal HDL subspecies associated with PWV. Among 68 detected phospholipid-associated proteins, we found that seven were negatively correlated with PWV, indicating that they may be atheroprotective. Conversely, nine proteins show positive correlation with PWV, suggesting that they may be related to arterial stiffness. Intriguingly, our results demonstrate that apoA-I and histidine-rich glycoprotein may reverse their protective roles and become antagonistic in the setting of T2D. Furthermore, we revealed two arterial stiffness-associated HDL subspecies, each of which contains multiple PWV-related proteins. Correlation and disease association analyses suggest that these HDL subspecies might link T2D to its cardiovascular-related complications. (shrink)