Search results for 'Stimulation' (try it on Scholar)

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  1. Françoise Baylis (2013). “I Am Who I Am”: On the Perceived Threats to Personal Identity From Deep Brain Stimulation. [REVIEW] Neuroethics 6 (3):513-526.score: 18.0
    This article explores the notion of the dislocated self following deep brain stimulation (DBS) and concludes that when personal identity is understood in dynamic, narrative, and relational terms, the claim that DBS is a threat to personal identity is deeply problematic. While DBS may result in profound changes in behaviour, mood and cognition (characteristics closely linked to personality), it is not helpful to characterize DBS as threatening to personal identity insofar as this claim is either false, misdirected or trivially (...)
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  2. Felicitas Kraemer (2013). Me, Myself and My Brain Implant: Deep Brain Stimulation Raises Questions of Personal Authenticity and Alienation. Neuroethics 6 (3):483-497.score: 18.0
    In this article, I explore select case studies of Parkinson patients treated with deep brain stimulation (DBS) in light of the notions of alienation and authenticity. While the literature on DBS has so far neglected the issues of authenticity and alienation, I argue that interpreting these cases in terms of these concepts raises new issues for not only the philosophical discussion of neuro-ethics of DBS, but also for the psychological and medical approach to patients under DBS. In particular, I (...)
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  3. Maartje Schermer (2013). Health, Happiness and Human Enhancement—Dealing with Unexpected Effects of Deep Brain Stimulation. Neuroethics 6 (3):435-445.score: 18.0
    Deep Brain Stimulation (DBS) is a treatment involving the implantation of electrodes into the brain. Presently, it is used for neurological disorders like Parkinson’s disease, but indications are expanding to psychiatric disorders such as depression, addiction and Obsessive Compulsive Disorder (OCD). Theoretically, it may be possible to use DBS for the enhancement of various mental functions. This article discusses a case of an OCD patient who felt very happy with the DBS treatment, even though her symptoms were not reduced. (...)
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  4. Karsten Witt, Jens Kuhn, Lars Timmermann, Mateusz Zurowski & Christiane Woopen (2013). Deep Brain Stimulation and the Search for Identity. Neuroethics 6 (3):499-511.score: 18.0
    Ethical evaluation of deep brain stimulation as a treatment for Parkinson’s disease is complicated by results that can be described as involving changes in the patient’s identity. The risk of becoming another person following surgery is alarming for patients, caregivers and clinicians alike. It is one of the most urgent conceptual and ethical problems facing deep brain stimulation in Parkinson’s disease at this time. In our paper we take issue with this problem on two accounts. First, we elucidate (...)
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  5. Nir Lipsman & Walter Glannon (2013). Brain, Mind and Machine: What Are the Implications of Deep Brain Stimulation for Perceptions of Personal Identity, Agency and Free Will? Bioethics 27 (9):465-470.score: 18.0
    Brain implants, such as Deep Brain Stimulation (DBS), which are designed to improve motor, mood and behavioural pathology, present unique challenges to our understanding of identity, agency and free will. This is because these devices can have visible effects on persons' physical and psychological properties yet are essentially undetectable when operating correctly. They can supplement and compensate for one's inherent abilities and faculties when they are compromised by neuropsychiatric disorders. Further, unlike talk therapy or pharmacological treatments, patients need not (...)
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  6. Adrian Carter, Emily Bell, Eric Racine & Wayne Hall (2011). Ethical Issues Raised by Proposals to Treat Addiction Using Deep Brain Stimulation. Neuroethics 4 (2):129-142.score: 18.0
    Deep brain stimulation (DBS) has been proposed as a potential treatment of drug addiction on the basis of its effects on drug self-administration in animals and on addictive behaviours in some humans treated with DBS for other psychiatric or neurological conditions. DBS is seen as a more reversible intervention than ablative neurosurgery but it is nonetheless a treatment that carries significant risks. A review of preclinical and clinical evidence for the use of DBS to treat addiction suggests that more (...)
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  7. Daniel A. Pollen (2006). Brain Stimulation and Conscious Experience: Electrical Stimulation of the Cortical Surface at a Threshold Current Evokes Sustained Neuronal Activity Only After a Prolonged Latency. Consciousness and Cognition 15 (3):560-565.score: 18.0
    Libet demonstrated that a substantial duration (>0.5-1.0 s) of direct electrical stimulation of the surface of a sensory cortex at a threshold or liminal current is required before a subject can experience a percept. Libet and his co-workers originally proposed that the result could be due either to spatial and temporal facilitation of the underlying neurons or additionally to a prolonged central processing time. However, over the next four decades, Libet chose to attribute the prolonged latency for evoking conscious (...)
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  8. Farah Focquaert (2013). Deep Brain Stimulation in Children: Parental Authority Versus Shared Decision-Making. Neuroethics 6 (3):447-455.score: 18.0
    This paper discusses the use of deep brain stimulation for the treatment of neurological and psychiatric disorders in children. At present, deep brain stimulation is used to treat movement disorders in children and a few cases of deep brain stimulation for psychiatric disorders in adolescents have been reported. Ethical guidelines on the use of deep brain stimulation in children are therefore urgently needed. This paper focuses on the decision-making process, and provides an ethical framework for (future) (...)
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  9. Veronica Johansson, Martin Garwicz, Martin Kanje, Helena Röcklinsberg, Jens Schouenborg, Anders Tingström & Ulf Görman (2013). Beyond Blind Optimism and Unfounded Fears: Deep Brain Stimulation for Treatment Resistant Depression. Neuroethics 6 (3):457-471.score: 18.0
    The introduction of new medical treatments based on invasive technologies has often been surrounded by both hopes and fears. Hope, since a new intervention can create new opportunities either in terms of providing a cure for the disease or impairment at hand; or as alleviation of symptoms. Fear, since an invasive treatment involving implanting a medical device can result in unknown complications such as hardware failure and undesirable medical consequences. However, hopes and fears may also arise due to the cultural (...)
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  10. Grant Gillett (2011). The Gold-Plated Leucotomy Standard and Deep Brain Stimulation. Journal of Bioethical Inquiry 8 (1):35-44.score: 18.0
    Walter Freeman, the self styled neurosurgeon, became famous (or infamous) for psychosurgery. The operation of frontal leucotomy swept through the world (with Freeman himself performing something like 18,000 cases) but it has tainted the whole idea of psychosurgery down to the present era. Modes of psychosurgery such as Deep Brain Stimulation and other highly selective neurosurgical procedures for neurological and psychiatric conditions are in ever-increasing use in current practice. The new, more exciting techniques are based in a widely held (...)
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  11. Frederic Gilbert (2012). The Burden of Normality: From 'Chronically Ill' to 'Symptom Free'. New Ethical Challenges for Deep Brain Stimulation Postoperative Treatment. Journal of Medical Ethics 8 (7):408-412.score: 18.0
    Although an invasive medical intervention, Deep Brain Stimulation (DBS) has been regarded as an efficient and safe treatment of Parkinson’s disease for the last 20 years. In terms of clinical ethics, it is worth asking whether the use of DBS may have unanticipated negative effects similar to those associated with other types of psychosurgery. Clinical studies of epileptic patients who have undergone an anterior temporal lobectomy have identified a range of side effects and complications in a number of domains: (...)
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  12. Daniel A. Pollen (2004). Brain Stimulation and Conscious Experience. Consciousness and Cognition 13 (3):626-645.score: 18.0
    Libet discovered that a substantial duration (> 0.5-1.0 s) of direct electrical stimulation of the surface of the somatosensory cortex at threshold currents is required before human subjects can report that a conscious somatosensory experience had occurred. Using a reaction time method we confirm that a similarly long stimulation duration at threshold currents is required for activation of elementary visual experiences (phosphenes) in human subjects following stimulation of the surface of the striate cortex. However, the reaction times (...)
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  13. Frederic Gilbert (2013). Deep Brain Stimulation for Treatment Resistant Depression: Postoperative Feelings of Self-Estrangement, Suicide Attempt and Impulsive–Aggressive Behaviours. Neuroethics 6 (3):473-481.score: 18.0
    The goal of this article is to shed light on Deep Brain Stimulation (DBS) postoperative suicidality risk factors within Treatment Resistant Depression (TRD) patients, in particular by focusing on the ethical concern of enrolling patient with history of self-estrangement, suicide attempts and impulsive–aggressive inclinations. In order to illustrate these ethical issues we report and review a clinical case associated with postoperative feelings of self-estrangement, self-harm behaviours and suicide attempt leading to the removal of DBS devices. Could prospectively identifying and (...)
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  14. Jean Levasseur-Moreau, Jerome Brunelin & Shirley Fecteau (2013). Non-Invasive Brain Stimulation Can Induce Paradoxical Facilitation. Are These Neuroenhancements Transferable and Meaningful to Security Services? Frontiers in Human Neuroscience 7.score: 18.0
    For ages, we have been looking for ways to enhance our physical and cognitive capacities in order to augment our security. One potential way to achieve this goal may be to externally stimulate the brain. Methods of noninvasive brain stimulation (NIBS), such as repetitive transcranial magnetic stimulation and transcranial electrical stimulation, have been recently developed to modulate brain activity. Both techniques are relatively safe and can transiently modify motor and cognitive functions outlasting the stimulation period. The (...)
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  15. Hans-Jochen Heinze, Marcus Heldmann, Jürgen Voges, Hermann Hinrichs, Josep Marco-Pallares, Jens-Max Hopf, Ulf Müller, Imke Galazky, Volker Sturm, Bernhard Bogerts & Thomas F. Münte (2009). Counteracting Incentive Sensitization in Severe Alcohol Dependence Using Deep Brain Stimulation of the Nucleus Accumbens: Clinical and Basic Science Aspects. Frontiers in Human Neuroscience 3:22.score: 18.0
    The ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the nucleus accumbens may significantly reduce craving in alcohol-dependent patients. Here we report on preliminary clinical and neurophysiological evidence in three male patients who were treated with high frequency deep brain stimulation of the nucleus accumbens bilaterally. All (...)
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  16. Luigi De Gennaro Maria Concetta Pellicciari, Susanna Cordone, Cristina Marzano, Stefano Bignotti, Anna Gazzoli, Carlo Miniussi (2013). Dorsolateral Prefrontal Transcranial Magnetic Stimulation in Patients with Major Depression Locally Affects Alpha Power of REM Sleep. Frontiers in Human Neuroscience 7.score: 18.0
    Sleep alterations are among the most important disabling manifestation symptoms of Major Depression Disorder (MDD). A critical role of sleep importance is also underlined by the fact that its adjustment has been proposed as an objective marker of clinical remission in MDD. Repetitive transcranial magnetic stimulation (rTMS) represents a relatively novel therapeutic tool for the treatment of drug-resistant depression. Nevertheless besides clinical evaluation of the mood improvement after rTMS, we have no clear understanding of what are the neurophysiological correlates (...)
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  17. Francesco Di Russo Grazia F. Spitoni, Rocco L. Cimmino, Chiara Bozzacchi, Luigi Pizzamiglio (2013). Modulation of Spontaneous Alpha Brain Rhythms Using Low-Intensity Transcranial Direct-Current Stimulation. Frontiers in Human Neuroscience 7.score: 18.0
    Transcranial direct-current stimulation (tDCS) is a form of neurostimulation in which a constant, low current is delivered directly to the brain area of interest by small electrodes. The overall aim of this study was to examine and monitor the modulation of brain activity by electroencephalogram (EEG) in the frequency domain during tDCS in the resting state. To this end, we considered the modulation of spontaneous EEG to be a marker of the perturbation that was induced through the direct current (...)
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  18. Manon Grube, Kwang-Hyuk Lee, Timothy D. Griffiths, Anthony T. Barker & Peter W. Woodruff (2010). Transcranial Magnetic Theta-Burst Stimulation of the Human Cerebellum Distinguishes Absolute, Duration-Based From Relative, Beat-Based Perception of Subsecond Time Intervals. Frontiers in Psychology 1:171-171.score: 18.0
    Cerebellar functions in two types of perceptual timing were assessed: the absolute (duration-based) timing of single intervals and the relative (beat-based) timing of rhythmic sequences. Continuous transcranial magnetic theta-burst stimulation (cTBS) was applied over the medial cerebellum and performance was measured adaptively before and after stimulation. A large and significant effect was found in the TBS (n=12) compared to the SHAM (n=12) group for single-interval timing but not for the detection of a regular beat or a deviation from (...)
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  19. Fabrice Jotterand, Shawn M. McClintock, Archie A. Alexander & Mustafa M. Husain (2010). Ethics and Informed Consent of Vagus Nerve Stimulation (VNS) for Patients with Treatment-Resistant Depression (TRD). Neuroethics 3 (1):13-22.score: 18.0
    Since the Nuremberg trials (1947–1949), informed consent has become central for ethical practice in patient care and biomedical research. Codes of ethics emanating from the Nuremberg Code (1947) recognize the importance of protecting patients and research subjects from abuses, manipulation and deception. Informed consent empowers individuals to autonomously and voluntarily accept or reject participation in either clinical treatment or research. In some cases, however, the underlying mental or physical condition of the individual may alter his or her cognitive abilities and (...)
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  20. Marco Zorzi Konstantinos Priftis, Marco Pitteri, Francesca Meneghello, Carlo Umiltà (2012). Optokinetic Stimulation Modulates Neglect for the Number Space: Evidence From Mental Number Interval Bisection. Frontiers in Human Neuroscience 6.score: 18.0
    Behavioral, neuropsychological, and neuroimaging data support the idea that numbers are represented along a mental number line (MNL), an analogical, visuo-spatial representation of number magnitude. The MNL is left-to-right oriented, with small numbers on the left and larger numbers on the right. Left neglect patients are impaired in processing the left side of the MNL and show a rightward deviation in the mental bisection of numerical intervals. In the present study we investigated the effects of optokinetic stimulation (OKS) -a (...)
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  21. Gottfried Schlaug Bradley W. Vines, Andrea C. Norton (2011). Non-Invasive Brain Stimulation Enhances the Effects of Melodic Intonation Therapy. Frontiers in Psychology 2.score: 18.0
    Research has suggested that a fronto-temporal network in the right hemisphere may be responsible for mediating Melodic Intonation Therapy’s positive effects on speech recovery. We investigated the potential for a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), to augment the benefits of MIT in patients with non-fluent aphasia by modulating neural activity in the brain during treatment with MIT. The polarity of the current applied to the scalp determines the effects of tDCS on the underlying tissue: (...)
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  22. Daniel Strüber Christoph S. Herrmann, Stefan Rach, Toralf Neuling (2013). Transcranial Alternating Current Stimulation: A Review of the Underlying Mechanisms and Modulation of Cognitive Processes. [REVIEW] Frontiers in Human Neuroscience 7.score: 18.0
    Brain oscillations of different frequencies have been associated with a variety of cognitive functions. Convincing evidence supporting those associations has been provided by studies using intracranial stimulation, pharmacological interventions and lesion studies. The emergence of novel non-invasive brain stimulation techniques like repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS) now allows to modulate brain oscillations directly. Particularly, tACS offers the unique opportunity to causally link brain oscillations of a specific frequency range to cognitive (...)
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  23. Bettina Pollok Claudia Wach, Vanessa Krause, Vera Moliadze, Walter Paulus, Alfons Schnitzler (2013). The Effect of 10 Hz Transcranial Alternating Current Stimulation (tACS) on Corticomuscular Coherence. Frontiers in Human Neuroscience 7:511-511.score: 18.0
    Synchronous oscillatory activity at alpha (8-12 Hz), beta (13-30 Hz), and gamma (30-90 Hz) fre-quencies is assumed to play a key role for motor control. Corticomuscular coherence (CMC) represents an established measure of the pyramidal system’s integrity. Transcranial alternating current stimulation (tACS) offers the possibility to modulate ongoing oscillatory activity. Behaviourally, 20 Hz tACS in healthy subjects has been shown to result in movement slowing. However, the neurophysiological changes underlying these effects are not entirely understood yet. The present study (...)
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  24. Lucas C. Parra Davide Reato, Asif Rahman, Marom Bikson (2013). Effects of Weak Transcranial Alternating Current Stimulation on Brain Activity—a Review of Known Mechanisms From Animal Studies. Frontiers in Human Neuroscience 7.score: 18.0
    Rhythmic neuronal activity is ubiquitous in the human brain. These rhythms originate from a variety of different network mechanisms, which give rise to a wide-ranging spectrum of oscillation frequencies. In the last few years an increasing number of clinical research studies have explored transcranial alternating current stimulation (tACS) with weak current as a tool for affecting brain function. The premise of these interventions is that tACS will interact with ongoing brain oscillations. However, the exact mechanisms by which weak currents (...)
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  25. Tobias U. Hauser, Stephanie Rotzer, Roland H. Grabner, Susan Mérillat & Lutz Jäncke (2013). Enhancing Performance in Numerical Magnitude Processing and Mental Arithmetic Using Transcranial Direct Current Stimulation (tDCS). Frontiers in Human Neuroscience 7.score: 18.0
    The ability to accurately process numerical magnitudes and solve mental arithmetic is of highest importance for schooling and professional career. Although impairments in these domains in disorders such as developmental dyscalculia (DD) are highly detrimental, remediation is still sparse. In recent years, transcranial brain stimulation methods such as transcranial Direct Current Stimulation (tDCS) have been suggested as a treatment for various neurologic and neuropsychiatric disorders. The posterior parietal cortex (PPC) is known to be crucially involved in numerical magnitude (...)
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  26. Peter G. Enticott Jed D. Burgess, Sara L. Arnold, Bernadette M. Fitzgibbon, Paul B. Fitzgerald (2013). A Transcranial Magnetic Stimulation Study of the Effect of Visual Orientation on the Putative Human Mirror Neuron System. Frontiers in Human Neuroscience 7.score: 18.0
    Mirror neurons are a class of motor neuron that are active during both the performance and observation of behavior, and have been implicated in interpersonal understanding There is evidence to suggest that the mirror response is modulated by the perspective from which an action is presented (e.g., egocentric or allocentric). Most human research, however, has only examined this when presenting intransitive actions. Twenty-three healthy adult participants completed a transcranial magnetic stimulation (TMS) experiment that assessed corticospinal excitability whilst viewing transitive (...)
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  27. C. Mathys, P. Loui, X. Zheng & G. Schlaug (2010). Non-Invasive Brain Stimulation Applied to Heschl's Gyrus Modulates Pitch Discrimination. Frontiers in Psychology 1:193-193.score: 18.0
    The neural basis of the human brain's ability to discriminate pitch has been investigated by functional neuroimaging and the study of lesioned brains, indicating the critical importance of right and left Heschl's gyrus (HG) in pitch perception. Nonetheless, there remains some uncertainty with regard to localization and lateralization of pitch discrimination, partly because neuroimaging results do not allow us to draw inferences about the causality. To address the problem of causality in pitch discrimination functions, we used transcranial direct current (...) (tDCS) to downregulate (via cathodal stimulation) and upregulate (via anodal stimulation) excitability in either left or right auditory cortex and measured the effect on performance in a pitch discrimination task in comparison with sham stimulation. Cathodal stimulation of HG on the left and on the right hemispheres adversely affected pitch discrimination in comparison to sham stimulation, with the effect on the right being significantly stronger than on the left. Anodal stimulation on either side had no effect on performance in comparison to sham. Our results indicate that both left and right HG are causally involved in pitch discrimination, although the right auditory cortex might be a stronger contributor. (shrink)
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  28. Vincent P. Clark Michael A. Hunter, Brian A. Coffman, Michael C. Trumbo (2013). Tracking the Neuroplastic Changes Associated with Transcranial Direct Current Stimulation: A Push for Multimodal Imaging. Frontiers in Human Neuroscience 7.score: 18.0
    Tracking the neuroplastic changes associated with transcranial direct current stimulation: a push for multimodal imaging.
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  29. S. A. Wylie Nelleke C. Van Wouwe, K. R. Ridderinkhof, W. P. M. Van den Wildenberg, G. P. H. Band, A. Abisogun, W. J. Elias, R. Frysinger (2011). Deep Brain Stimulation of the Subthalamic Nucleus Improves Reward-Based Decision-Learning in Parkinson's Disease. Frontiers in Human Neuroscience 5.score: 18.0
    Recently, the subthalamic nucleus (STN) has been shown to be critically involved in decision-making, action selection, and motor control. Here we investigate the effect of deep brain stimulation (DBS) of the STN on reward-based decision-learning in patients diagnosed with Parkinson’s disease (PD). We determined computational measures of outcome evaluation and reward prediction from PD patients who performed a probabilistic reward-based decision-learning task. In previous work, these measures covaried with activation in the nucleus caudatus (outcome evaluation during the early phases (...)
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  30. Damiaan Denys Sanneke de Haan, Erik Rietveld, Martin Stokhof (2013). The Phenomenology of Deep Brain Stimulation-Induced Changes in OCD: An Enactive Affordance-Based Model. Frontiers in Human Neuroscience 7.score: 18.0
    People suffering from Obsessive-Compulsive Disorder (OCD) do things they do not want to do, and/or they think things they do not want to think. In about 10 percent of OCD patients, none of the available treatment options is effective. A small group of these patients is currently being treated with deep brain stimulation (DBS). Deep brain stimulation involves the implantation of electrodes in the brain. These electrodes give a continuous electrical pulse to the brain area in which they (...)
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  31. Roi Cohen Kadosh Beatrix Krause, Javier Márquez-Ruiz (2013). The Effect of Transcranial Direct Current Stimulation: A Role for Cortical Excitation/Inhibition Balance? Frontiers in Human Neuroscience 7.score: 18.0
    Transcranial direct current stimulation (tDCS) is a promising tool for cognitive enhancement and neurorehabilitation in clinical disorders in both cognitive and clinical domains (e.g., chronic pain, tinnitus). Here we suggest the potential role of tDCS in modulating cortical excitation/inhibition (E/I) balance and thereby inducing improvements. We suggest that part of the mechanism of action of tDCS can be explained by non-invasive modulations of the E/I balance.
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  32. Patrick Ragert Bernhard Sehm (2013). Why Non-Invasive Brain Stimulation Should Not Be Used in Military and Security Services. Frontiers in Human Neuroscience 7.score: 18.0
    Why non-invasive brain stimulation should not be used in military and security services.
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  33. Alexander T. Sack Bruno Verschuere, Teresa Schuhmann (2012). Does the Inferior Frontal Sulcus Play a Functional Role in Deception? A Neuronavigated Theta-Burst Transcranial Magnetic Stimulation Study. Frontiers in Human Neuroscience 6.score: 18.0
    Background. By definition, lying involves withholding the truth. Response inhibition may therefore be the cognitive function at the heart of deception. Neuroimaging research has shown that the same brain region that is activated during response inhibition tasks, namely the inferior frontal region, is also activated during deception paradigms. This led to the hypothesis that the inferior frontal region is the neural substrate critically involved in withholding the truth. Objective. We critically examine the functional necessity of the inferior frontal region in (...)
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  34. Jerome Brunelin, Jean Levasseur-Moreau & Shirley Fecteau (2013). Is It Ethical and Safe to Use Non-Invasive Brain Stimulation as a Cognitive Enhancer Device for Military Services? A Reply to Sehm and Ragert (2013). Frontiers in Human Neuroscience 7:874.score: 18.0
    Is it ethical and safe to use non-invasive brain stimulation as a cognitive and motor enhancer device for military services? A reply to Sehm and Ragert (2013).
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  35. Richard G. Carson & Niamh Clare Kennedy (2013). Modulation of Human Corticospinal Excitability by Paired Associative Stimulation. Frontiers in Human Neuroscience 7:823.score: 18.0
    Paired Associative Stimulation (PAS) has come to prominence as a potential therapeutic intervention for the treatment of brain injury/disease, and as an experimental method with which to investigate Hebbian principles of neural plasticity in humans. Prototypically, a single electrical stimulus is directed to a peripheral nerve in advance of transcranial magnetic stimulation (TMS) delivered to the contralateral primary motor cortex (M1). Repeated pairing of the stimuli (i.e. association) over an extended period may increase or decrease the excitability of (...)
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  36. Andrea Antal Catarina Saiote, Zsolt Turi, Walter Paulus (2013). Combining Functional Magnetic Resonance Imaging with Transcranial Electrical Stimulation. Frontiers in Human Neuroscience 7.score: 18.0
    Transcranial electrical stimulation (tES) is a neuromodulatory method with promising potential for basic research and as a therapeutic tool. The most explored type of tES is transcranial direct current stimulation (tDCS), but also transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) have been shown to affect cortical excitability, behavioral performance and brain activity. Although providing indirect measure of brain activity, functional magnetic resonance imaging (fMRI) can tell us more about the global effects of (...)
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  37. Helen Bronte-Stewart Diane Whitmer, Camille de Solages, Bruce Hill, Hong Yu, Jaimie M. Henderson (2012). High Frequency Deep Brain Stimulation Attenuates Subthalamic and Cortical Rhythms in Parkinson's Disease. Frontiers in Human Neuroscience 6.score: 18.0
    Parkinson’s disease (PD) is marked by excessive synchronous activity in the beta (8-35 Hz) band throughout the cortico-basal ganglia network. The optimal location of high frequency deep brain stimulation (HF DBS) within the subthalamic nucleus (STN) region and the location of maximal beta hypersynchrony are currently matters of debate. Additionally, the effect of STN HF DBS on neural synchrony in functionally connected regions of motor cortex is unknown and of great interest. Scalp EEG studies demonstrated that stimulation of (...)
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  38. F. Carducci Franca Tecchio, A. Cancelli, C. Cottone, L. Tomasevic, B. Devigus, G. Zito, Matilde Ercolani (2013). Regional Personalized Electrodes to Select Transcranial Current Stimulation Target. Frontiers in Human Neuroscience 7.score: 18.0
    Rationale Personalizing transcranial stimulations promises to enhance beneficial effects for individual patients. Objective To stimulate specific cortical regions by developing a procedure to bend and position custom shaped electrodes; to probe the effects on cortical excitability produced when the properly customized electrode is targeting different cortical areas. Method An ad-hoc neuronavigation procedure was developed to accurately shape and place the personalized electrodes on the basis of individual brain magnetic resonance images (MRI) on bilateral primary motor (M1) and somatosensory (S1) cortices. (...)
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  39. Petra Ritter Frank Freyer, Matthias Reinacher, Guido Nolte, Hubert R. Dinse (2012). Repetitive Tactile Stimulation Changes Resting-State Functional Connectivity—Implications for Treatment of Sensorimotor Decline. Frontiers in Human Neuroscience 6.score: 18.0
    Neurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS) has recently gained increasing attention as an alternative to countervail the sensory decline by improving perceptual abilities without the need of active participation. A particularly effective type of high-frequency RSS, utilizing Hebbian learning principles, improves perceptual acuity as well as sensorimotor functions and has been successfully applied to treat (...)
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  40. Frank Freyer, Matthias Reinacher, Guido Nolte, Hubert R. Dinse & Petra Ritter (2012). Repetitive Tactile Stimulation Changes Resting-State Functional Connectivity—Implications for Treatment of Sensorimotor Decline. Frontiers in Human Neuroscience 6.score: 18.0
    Neurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS) has recently gained increasing attention as an alternative to countervail the sensory decline by improving perceptual abilities without the need of active participation. A particularly effective type of high-frequency RSS, utilizing Hebbian learning principles, improves perceptual acuity as well as sensorimotor functions and has been successfully applied to treat (...)
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  41. Flavio Frohlich & Stephen L. Schmidt (2013). Rational Design of Transcranial Current Stimulation (TCS) Through Mechanistic Insights Into Cortical Network Dynamics. Frontiers in Human Neuroscience 7:804.score: 18.0
    Transcranial current stimulation (TCS) is a promising method of non-invasive brain stimulation to modulate cortical network dynamics. Preliminary studies have demonstrated the ability of TCS to enhance cognition and reduce symptoms in both neurological and psychiatric illnesses. Despite the encouraging results of these studies, the mechanisms by which TCS and endogenous network dynamics interact remain poorly understood. Here, we propose that the development of the next generation of TCS paradigms with increased efficacy requires such mechanistic understanding of how (...)
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  42. Joachim Gross Gregor Thut, Philippe G. Schyns (2011). Entrainment of Perceptually Relevant Brain Oscillations by Non-Invasive Rhythmic Stimulation of the Human Brain. Frontiers in Psychology 2.score: 18.0
    The notion of driving brain oscillations by directly stimulating neuronal elements with rhythmic stimulation protocols has become increasingly popular in research on brain rhythms. Induction of brain oscillations in a controlled and functionally meaningful way would likely prove highly beneficial for the study of brain oscillations, and their therapeutic control. We here review conventional and new non-invasive brain stimulation protocols as to their suitability for controlled intervention into human brain oscillations. We focus on one such type of intervention, (...)
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  43. Hubert R. Dinse Jan-Christoph Kattenstroth, Tobias Kalisch, Sören Peters, Martin Tegenthoff (2012). Long-Term Sensory Stimulation Therapy Improves Hand Function and Restores Cortical Responsiveness in Patients with Chronic Cerebral Lesions. Three Single Case Studies. Frontiers in Human Neuroscience 6.score: 18.0
    Rehabilitation of sensorimotor impairment resulting from cerebral lesion (CL) utilizes task specific training and massed practice to drive reorganization and sensorimotor improvement due to induction of neuroplasticity mechanisms. Loss of sensory abilities often complicates recovery, and thus the individual’s ability to use the affected body part for functional tasks. Therefore, the development of additional and alternative approaches that supplement, enhance, or even replace conventional training procedures would be advantageous. Repetitive sensory stimulation protocols (rSS) have been shown to evoke sensorimotor (...)
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  44. Jan-Christoph Kattenstroth, Tobias Kalisch, Sören Peters, Martin Tegenthoff & Hubert R. Dinse (2012). Long-Term Sensory Stimulation Therapy Improves Hand Function and Restores Cortical Responsiveness in Patients with Chronic Cerebral Lesions. Three Single Case Studies. Frontiers in Human Neuroscience 6.score: 18.0
    Rehabilitation of sensorimotor impairment resulting from cerebral lesion (CL) utilizes task specific training and massed practice to drive reorganization and sensorimotor improvement due to induction of neuroplasticity mechanisms. Loss of sensory abilities often complicates recovery, and thus the individual’s ability to use the affected body part for functional tasks. Therefore, the development of additional and alternative approaches that supplement, enhance, or even replace conventional training procedures would be advantageous. Repetitive sensory stimulation protocols (rSS) have been shown to evoke sensorimotor (...)
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  45. Marcelo C. A. Rodrigues Mayara Mendonça-de-Souza, Ubirakitan M. Monteiro, Amana S. Bezerra, Ana P. Silva-de-Oliveira, Belvânia R. Ventura-da-Silva, Marcelo S. Barbosa, Josiane A. De Souza, Elisângela C. Criado, Maria C. M. Ferrarezi, Giselly de A. Alencar, Otávio G. Lins, Maria das G. W. S. Coriolano, Belmira L. S. A. Costa (2012). Resilience in Migraine Brains: Decrease of Coherence After Photic Stimulation. Frontiers in Human Neuroscience 6.score: 18.0
    Background: During migraine attacks, patients generally have photophobia and phonophobia and seek for environments with less sensorial stimulation. Present work aimed to quantify cortical partial directed coherence (PDC) of electroencephalographic (EEG) recordings from migraine patients and controls in occipital, parietal and frontal areas with or without photic stimulation. Our hypothesis is that migraine patients with visual aura might have neuronal networks with higher coherence than controls even in interictal periods due to a predisposition in sensory cortical processing. Methods: (...)
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  46. Neil G. Muggleton Michael J. Banissy (2013). Transcranial Direct Current Stimulation in Sports Training: Potential Approaches. Frontiers in Human Neuroscience 7.score: 18.0
    Transcranial Direct Current Stimulation in Sports Training: Potential Approaches.
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  47. Ulf Ziemann Ming-Kuei Lu, Chon-Haw Tsai (2012). Cerebellum to Motor Cortex Paired Associative Stimulation Induces Bidirectional STDP-Like Plasticity in Human Motor Cortex. Frontiers in Human Neuroscience 6.score: 18.0
    The cerebellum is crucially important for motor control and motor adaptation. Recent non-invasive brain stimulation studies have indicated the possibility to alter the excitability of the cerebellum and its projections to the contralateral motor cortex, with behavioral consequences on motor control and motor adaptation. Here we sought to induce bidirectional spike-timing dependent plasticity (STDP)-like modifications of motor cortex (M1) excitability by application of paired associative stimulation (PAS) in healthy subjects. Conditioning stimulation over the right lateral cerebellum (CB) (...)
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  48. Stephan A. Brandt Sein Schmidt, Michael Scholz, Klaus Obermayer (2013). Patterned Brain Stimulation, What a Framework with Rhythmic and Noisy Components Might Tell Us About Recovery Maximization. Frontiers in Human Neuroscience 7.score: 18.0
    Brain stimulation is having remarkable impact on clinical neurology. Brain stimulation can modulate neuronal activity in functionally segregated circumscribed regions of the human brain. Polarity-, frequency and noise specific stimulation can induce specific manipulations on neural activity.. In contrast to neocortical stimulation, deep-brain stimulation has become a tool that can dramatically improve the impact clinicians can possibly have on movement disorders. In contrast, neocortical brain stimulation is proving to be remarkably susceptible to intrinsic brain-states. (...)
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  49. Charlotte J. Stagg & Heidi Johansen-Berg (2013). Studying The Effects Of Transcranial Direct Current Stimulation In Stroke Recovery Using Magnetic Resonance Imaging. Frontiers in Human Neuroscience 7:857.score: 18.0
    Transcranial direct current stimulation (tDCS) is showing increasing promise as an adjunct therapy in stroke rehabilitation. However questions still remain concerning its mechanisms of action, which currently limit its potential. Magnetic Resonance (MR) techniques are increasingly being applied to understand the neural effects of tDCS. Here, we review the MR evidence supporting the use of tDCS to aid recovery after stroke and discuss the important open questions that remain.
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  50. Christoph S. Herrmann Toralf Neuling, Stefan Rach (2013). Orchestrating Neuronal Networks: Sustained After-Effects of Transcranial Alternating Current Stimulation Depend Upon Brain States. Frontiers in Human Neuroscience 7.score: 18.0
    The interest in transcranial alternating current stimulation (tACS) has significantly increased in the past decade. It has potential to modulate brain oscillations in a frequency specific manner, offering the possibility to demonstrate a causal nature of oscillation behavior relationships. TACS is a strong candidate as a tool for clinical applications, however, to fulfill this potential, certain parameters have yet to be evaluated. First, little is known about long-lasting after-effects of tACS with respect to the modulations of rhythmic brain activity. (...)
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