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  1. Sylvia Culp (1997). Establishing Genotype/Phenotype Relationships: Gene Targeting as an Experimental Approach. Philosophy of Science 64 (4):278.
    In this paper, I examine an experimental technique, gene targeting, used for establishing genotype/phenotype relationships. Through analyzing a case study, I identify many pitfalls that may lead to false conclusions about these relationships. I argue that some of these pitfalls may seriously affect gene targeting's usefulness for associating phenotypes with genes cataloged by the Human Genome Project. This case also shows the use of gene targeted mice as model systems for studying genotype/phenotype relationships in humans. Moreover, I argue that it (...)
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  2. Robert Hafner & Sylvia Culp (1996). Elaborating the Structures of a Science Discipline to Improve Problem-Solving Instruction: An Account of Classical Genetics' Theory Structure, Function, and Development. Science and Education 5 (4):331-355.
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  3. Sylvia Culp (1995). Objectivity in Experimental Inquiry: Breaking Data-Technique Circles. Philosophy of Science 62 (3):438-458.
    I respond to H. M. Collins's claim (1985, 1990, 1993) that experimental inquiry cannot be objective because the only criterium experimentalists have for determining whether a technique is "working" is the production of "correct" (i.e., the expected) data. Collins claims that the "experimenters' regress," the name he gives to this data-technique circle, cannot be broken using the resources of experiment alone. I argue that the data-technique circle, can be broken even though any interpretation of the raw data produced by techniques (...)
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  4. Sylvia Culp (1994). Defending Robustness: The Bacterial Mesosome as a Test Case. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1994:46 - 57.
    Rasmussen (1993) argues that, because electron microscopists did not use robustness and would not have been warranted in using it as a criterion for the reality or the artifactuality of mesosomes, the bacterial mesosome serves as a test case for robustness that it fails. I respond by arguing that a more complete reading of the research literature on the mesosome shows that ultimately the more robust body of data did not support the mesosome and that electron microscopists used and were (...)
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  5. Sylvia Culp & Philip Kitcher (1989). Theory Structure and Theory Change in Contemporary Molecular Biology. British Journal for the Philosophy of Science 40 (4):459-483.
    Traditional approaches to theory structure and theory change in science do not fare well when confronted with the practice of certain fields of science. We offer an account of contemporary practice in molecular biology designed to address two questions: Is theory change in this area of science gradual or saltatory? What is the relation between molecular biology and the fields of traditional biology? Our main focus is a recent episode in molecular biology, the discovery of enzymatic RNA. We argue that (...)
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