Empirical approaches on topics such as consciousness, self-awareness, or introspective perspective, need a conceptual framework so that the emerging, still unconnected findings can be integrated and put into perspective. We introduce a model of self-consciousness derived from phenomenology, philosophy, the cognitive, and neurosciences. We will then give an overview of research data on one particular aspect of our model, self-agency, trying to link findings from cognitive psychology and neuroscience. Finally, we will expand on pathological aspects of self-agency, and in particular (...) on psychosis in schizophrenia. We show, that a deficient self-monitoring system underlies, in part, hallucinations and formal thought (language) disorder in schizophrenia. We argue, that self-consciousness is a valid construct and can be studied with the instruments of cognitive and neuroscience. (shrink)
These are set against introductory essays describing the philosophical, historical and psychological approaches, making this a uniquely inclusive overview.
We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)
Four predictors were posited to affect business student attitudes about the social responsibilities of business, also known as corporate social responsibility (CSR). Applying Forsyth’s ( 1980 , Journal of Personality and Social Psychology 39 , 175–184, 1992 , Journal of Business Ethics 11 , 461–470) personal moral philosophy model, we found that ethical idealism had a positive relationship with CSR attitudes, and ethical relativism a negative relationship. We also found materialism to be negatively related to CSR attitudes. Spirituality among business (...) students did not significantly predict CSR attitudes. Understanding the relationship between CSR attitudes and the significant predictors has important implications for researchers and teachers in particular. (shrink)
The self seems to be a unitary entity remaining stable across time. Nevertheless, current theorizing conceptualizes the self as a number of interacting sub-systems involving perception, intention and action (self-model). One important function of such a self-model is to distinguish between events occurring as a result of one's own actions and events occurring as the result of somebody else's actions. We conducted an fMRI experiment that compared brain activation after an abrupt mismatch between one's own movement and its visual consequences (...) with an abrupt mismatch between one's own movement and somebody else's visually perceived hand movement. A right fronto-parietal network was selectively active during a sudden mismatch between one's own observed and performed hand action. (shrink)
Though he’s perhaps best known for his work on vagueness, Timothy Williamson also produced a series of outstanding papers in epistemology in the late 1980's and the 1990's. Knowledge and its Limits brings this work together. The result is, in my opinion, the best book in epistemology to come out since 1975.
Timothy Michael Fowler has argued that, as a consequence of their commitment to neutrality in regard to comprehensive doctrines, political liberals face a dilemma. In essence, the dilemma for political liberals is that either they have to give up their commitment to neutrality (which is an indispensible part of their view), or they have to allow harm to children. Fowler’s case for this dilemma depends on ascribing to political liberals a view which grants parents a great degree of freedom (...) in deciding on the education of their children. I show that ascribing this view to political liberals rests upon a misinterpretation of political liberalism. Since political liberals have access to reasons based upon the interests of children, they need not yield to parent’s wishes about the education of their children. A correct understanding of political liberalism thus shows that political liberals do not face the dilemma envisaged by Fowler. (shrink)
Timothy Williamson (2002) has offered an argument for the claim that, necessarily, he exists, that is, that he is a necessary existent.1 Though this argument has attracted a great deal of attention (e.g., Rumfitt 2003 and Wiggins 2003), I present a new argument for the same conclusion which reveals a new way of denying the soundness of Williamson’s argument, one which denies not only that it is necessary that he exists but also that there are any true necessities about (...) Williamson at all. In conclusion, given that it is contingent that Williamson exists, I nevertheless distinguish a sense in which he is, after all, a necessary existent: Williamson necessarily exists, though it is not necessary that he exists. (shrink)
Timothy Mahoney discovers and champions an ecologically benign account of Plato in opposition to my own critical analysis of the reason-centeredness, reason-nature dualism, and nature and body devaluation in the Platonic dialogues, in which multiple linked dualisms of reason and nature associated with systems of oppression provide major organizing principles for Platonic philosophy. I show first that Mahoney's criticisms of my interpretation involve some careless and mistaken readings of my own text. Second, I argue that Mahoney* s account of (...) nature is significantly different from Plato's. Mahoney's interpretation of Plato is an overly generous and idealized one which plays on the multiplicity and elasticity of the concept of nature and the notorious vagueness of the concept of participation to conflate, among other things, Plato's attitude to celestial nature with his attitude to biological nature. Mahoney's interpretation involves setting aside Plato's gender politics, playing down some of Plato's most offensive and revealing passages of earth disparagement, and ignoring the network of social meanings from which Plato's philosophy emerges. Finally, I give some reasons why Mahoney's accounts of participation and nature, even considered as a reworking of Plato, would be highly problematic as the foundation for an ecological philosophy. (shrink)
In his essay ‘“Conceptual Truth”’, Timothy Williamson (2006) argues that there are no truths or entailments that are constitutive of understanding the sentences involved. In this reply I provide several examples of entailment patterns that are intuitively constitutive of understanding in just the way that Williamson rejects, and I argue that Williamson’s argument does nothing to show otherwise. Williamson bolsters his conclusion by appeal to a certain theory about the nature of understanding. I argue that his theory fails to (...) consider the role that the structure of a sentence plays in determining its meaning. The cases I present suggest that this role imposes greater cognitive requirements on understanding than Williamson can acknowledge. (shrink)
What is our epistemic access to metaphysical modality? Timothy Williamson suggests that the epistemology of counterfactuals will provide the answer. This paper challenges Williamson's account and argues that certain elements of the epistemology of counterfactuals that he discusses, namely so called background knowledge and constitutive facts, are already saturated with modal content which his account fails to explain. Williamson's account will first be outlined and the role of background knowledge and constitutive facts analysed. Their key role is to restrict (...) our imagination to rule out irrelevant counterfactual suppositions. However, background knowledge turns out to be problematic in cases where we are dealing with metaphysically possible counterfactual suppositions that violate the actual laws of physics. As we will see, unless Williamson assumes that background knowledge corresponds with the actual, true laws of physics and that these laws are metaphysically necessary, it will be difficult to address this problem. Furthermore, Williamson's account fails to accommodate the distinction between conceivable yet metaphysically impossible scenarios, and conceivable and metaphysically possible scenarios. This is because background knowledge and constitutive facts are based strictly on our knowledge of the actual world. Williamson does attempt to address this concern with regard to metaphysical necessities – as they hold across all possible worlds – but we will see that even in this case the explanation is questionable. These problems, it will be suggested, cannot be addressed in a counterfactual account of the epistemology of modality. The paper finishes with an analysis of Williamson's possible rejoinders and some discussion about the prospects of an alternative account of modal epistemology. (shrink)
O’Connor refines the “transfer” or “consequence” argument for Incompatibilism, and responds to objections (chap. 1). He argues against attempts to save freedom of action by appeal to the “simple” indeterminism of Carl Ginet and the “causal” indeterminism of Robert Kane and others (chap. 2). The main positive project of Persons and Causes is to explain the selfdetermination of action by appeal to agent causation (chaps 3-5). O’Connor’s strategy is to defend a nonHumean view about event causation, and then argue that (...) agent causation is no more mysterious or objectionable than event causation is on this nonHumean view. I will argue that O’Connor does not succeed in making agent causation palatable. But his general strategy should recommend itself to all defenders of agent causation, and his development of agency theory is an important contribution to the project. In.. (shrink)
