The unified theory of dose and effect, as indicated by the median-effect equation for single and multiple entities and for the first and higher order kinetic/dynamic, has been established by T.C. Chou and it is based on the physical/chemical principle of the massaction law (J. Theor. Biol. 59: 253-276, 1976 (質量作用中效定理) and Pharmacological Rev. 58: 621-681, 2006) (普世中效指數定理). The theory was developed by the principle of mathematical induction and deduction (數學演繹歸納法). Rearrangements of the median-effect equation lead to Michaelis-Menten, Hill, Scatchard, (...) and Henderson-Hasselbalch equations. The “median” serves as the universal reference point and the “common link” for the relationship of all entities and is also the “harmonic mean” of kinetic dissociation constants. Over 300 mechanism-specific equations have been derived and published using the mathematical induction-deduction process. These equations can be deduced into several general equations, including the median-mediated whole/part equation, combination index theorem, isobologram equation, and polygonogram. It is proven that “dose” and “effect” are interchangeable, thus, “substance” and “function” are interchangeable, which leads to “the unity theory” (劑效、心物、知行一元論) in quantitative mathematical philosophy (數學的定量哲學) in functional context. Therefore, a general theory centered on the “median” and based on equilibrium dynamics has evolved. In other words: [「中」的宇宙觀： 以「中」爲基凖的動力學生態平衡]. Based on the median-effect equation of the mass-action law, the fundamental claim is that we can draw “a specific cure” for only two data points, if they are determined accurately. This claim has far reaching consequences since it defies the general held belief that two points can dray only a straight line. Remarkably, the unity theory (一元論) providesscientific/mathematical interpretation in equations and in graphics of Chinese ancient philosophy, including Fu-Si Ba Gua (伏羲八卦), Dao’s Harmony (和諧), the Confucian doctrine of the mean (儒家中庸之道), Chou Dun-Yi’s (周敦頤, 1017-1073) From Wu-ji to Tai-ji and Taiji Tu Sho (無極而太極及太極圖說). The moderntopological analysis for trinity yields an exact correspondence to the Ba-Gua, which was introduced over 4,000 years ago. Furthermore, the median-centered algorithm, promotes modern ecological content (生態學) in the equilibral dynamic state of harmony. It is concluded that Western science and Eastern philosophy are directly linked and complementary to each other. Since the truth in mathematical quantitative philosophy (數學的定量哲學) has no boundaries, East and West philosophies can flourish together for the common goal and ideal in science and in humanity (世界大同). (shrink)
Democracy and tragedy captured a delicate poise in ancient Athens. While many today perceive democracy as a finite, unquestionable and almost procedural form of governance that glorifies equality and liberty for their own sake, the Athenians saw it as so much more. Beyond the burgeoning equality and liberty, which were but fronts for a deeper goal, finitude, unimpeachability and procedural norms were constantly contradicted by boundlessness, subversion and disarray. In such a world, where certainty and immortality were luxuries beyond the (...) reach of humankind, tragedy gave comfort and inspired greatness. Before the disciplinary segregation and the delimiting of the poetic and artistic, tragic art dramatized the paradox of existence in a most political manner. The purpose of this paper is to explicitly highlight the crucial links that existed between democracy and tragedy during their formative years in ancient Athens. What was it about democracy that necessarily incited and depended upon the ascendency of tragedy during the time of the Athenian city-state? And why and how did a peculiar institution such as Athenian tragedy play so central a role in the democratic polis of Athens? (shrink)
The main purpose of this study is to explore and map the intellectual structure of business ethics studies during 1997–2006 by analyzing 85,000 cited references of 3,059 articles from three business ethics related journals in SSCI and SCI databases. In this article, co-citation analysis and social network analysis techniques are used to research intellectual structure of the business ethics literature. We are able to identify the important publications and the influential scholars as well as the correlations among these publications by (...) analyzing citation and co-citation. Three factors emerged in this study are: (1) ethical/unethical decision making, (2) corporate governance and firm performance, and (3) ethical principles and code of conduct. (shrink)
We propose adding a temporal dimension to stakeholder management theory, and assess the implications thereof for firm-level competitive advantage. We argue that a firm’s competitive advantage fundamentally depends on its capacity for stakeholder management related, transformational adaptation over time. Our new temporal stakeholder management approach builds upon insights from both the resource-based view (RBV) in strategic management and institutional theory. Stakeholder agendas and their relative salience to the firm evolve over time, a phenomenon well understood in the literature, and requiring (...) what we call level 1 adaptation. However, the dominant direction of stakeholder pressures can also change, namely, from supporting resource heterogeneity at the firm level to fostering industry homogeneity, and vice versa. When dominant stakeholder pressures shift from supporting heterogeneity towards stimulating homogeneity in industry, the firm must engage in level 2 or transformational adaptation. Stakeholders typically provide valuable resources to the firm in an early stage . Without these resources, which foster heterogeneity (in line with RBV thinking), the firm would not exist. At a later stage , stakeholders also contribute to inter-firm homogeneity via isomorphism pressures (in line with institutional theory thinking). Adding a temporal dimension to stakeholder management theory has far reaching implications for this theory’s practical relevance to senior level management in business. (shrink)
We have shown that FEF lesion-induced extinction could be compensated for by changing the relative temporal onsets of two targets presented on either side of the midline. Monkeys were trained to make saccades to either of two identical visual stimuli presented with various stimulus onset asynchronies (SOA). In intact animals the targets were chosen with equal probability when they appeared simultaneously. After unilateral FEF lesions an SOA of 67–116 msec had to be introduced, with the contralesional target appearing first, to (...) obtain equal probability choice. With a smaller target separation, averaging saccades occurred with highest frequency at similar SOAs. Our findings suggest that neglect may be attributable to more time being required in the damaged hemisphere for converting sensory information into motor responses. (shrink)
We give necessary conditions for a set to be definable by a formula with a universal quantifier and an existential quantifier over algebraic integer rings or algebraic number fields. From these necessary conditions we obtain some undefinability results. For example, N is not definable by such a formula over Z. This extends a previous result of R. M. Robinson.
We say φ is an ∀∃ sentence if and only if φ is logically equivalent to a sentence of the form ∀ x∃ y ψ(x,y), where ψ(x,y) is a quantifier-free formula containing no variables except x and y. In this paper we show that there are algorithms to decide whether or not a given ∀∃ sentence is true in (1) an algebraic number field K, (2) a purely transcendental extension of an algebraic number field K, (3) every field with characteristic (...) 0, (4) every algebraic number field, (5) every cyclic (abelian, radical) extension field over Q, and (6) every field. (shrink)
Several authors have characterized a striking phenomenon of perceptual learning in visual discrimination tasks. This learning process is selective for the stimulus characteristics and location in the visual field. Since the human visual system exploits symmetry for object recognition we were interested in exploring how it learns to use preattentive symmetry cues for discriminating simple, meaningless, forms. In this study, similar to previous studies of perceptual learning, we asked whether the effects of practice acquired in the discrimination of pairs of (...) shape with a specific orientation of the symmetry axis would transfer to the discrimination of shapes with different orientation of symmetry axis, or to shapes presented in different areas of the visual field. We found that there was no learning transfer between forms with very different axes of symmetry (90° apart). Interestingly, however, we found a transfer of learning effect to horizontally oriented symmetry axis from a condition with an axis of symmetry differing by 45°. Also it appears that some subjects took a longer time to learn than the typical fast learning paradigm would predict. Data showed that when observers practice discrimination of meaningless symmetric forms, consistent improvement in the performance occurs. This improvement is lasting over days, and it tends to be specific for the area of the visual field trained. We will discuss results from some of the observers whose learning was not fast, but who actually improved with more practice and with large time intervals (1 day) between training sessions. (shrink)
We study the sets definable in an algebraic number field by first order formulas of various simple types, showing in particular that N and Z do not have very simple definitions.
Apoptosis proteins play an essential role in regulating a balance between cell proliferation and death. The successful prediction of subcellular localization of apoptosis proteins directly from primary sequence is much benefited to understand programmed cell death and drug discovery. In this paper, by use of Chou’s pseudo amino acid composition (PseAAC), a total of 317 apoptosis proteins are predicted by support vector machine (SVM). The jackknife cross-validation is applied to test predictive capability of (...) proposed method. The predictive results show that overall prediction accuracy is 91.1% which is higher than previous methods. Furthermore, another dataset containing 98 apoptosis proteins is examined by proposed method. The overall predicted successful rate is 92.9%. (shrink)
1 The Revolutionary Founder Mao Tse-tung's singular prominence within the Chinese Communist Party was not quickly won. His share of leadership was secured ...
