Search results for 'pathogenesis' (try it on Scholar)

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  1.  1
    Olli S. Miettinen & Kenneth M. Flegel (2003). Elementary Concepts of Medicine: VI. Genesis of Illness: Pathogenesis, Aetiogenesis. Journal of Evaluation in Clinical Practice 9 (3):325-327.
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  2. Anne Joutel (2011). Pathogenesis of CADASIL. Bioessays 33 (1):73-80.
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  3.  5
    Mads Gram Henriksen, Andrea Raballo & Josef Parnas (2016). The Pathogenesis of Auditory Verbal Hallucinations in Schizophrenia: A Clinical–Phenomenological Account. Philosophy, Psychiatry, and Psychology 22 (3):165-181.
    Auditory verbal hallucinations form an essential criterial feature in the schizophrenia definition in the Diagnostic and Statistical Manual of Mental Disorders -IV and International Classification of Diseases -10. In both classificatory systems, the presence of a hallucinatory voice that continuously comments the patient’s behavior or thoughts, or the presence of several voices that discuss the patient with each other, is a sufficient criterion to diagnose schizophrenia. The DSM-IV defines a hallucination as “a sensory perception that has the..
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  4.  46
    Reinhart Koselleck (1988). Critique and Crisis: Enlightenment and the Pathogenesis of Modern Society. MIT Press.
    In this way progressive bourgeois philosophy, which seemed to offer the promise of a unified and peaceful world, in fact produced just the opposite.The book ...
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  5.  6
    Dominik Wodarz & Martin A. Nowak (2002). Mathematical Models of HIV Pathogenesis and Treatment. Bioessays 24 (12):1178-1187.
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  6.  5
    June E. Osborn (1986). Co‐Factors and HIV: What Determines the Pathogenesis of AIDS? Bioessays 5 (6):287-289.
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  7.  4
    Susann Schweiger & Rainer Schneider (2003). The MID1/PP2A Complex: A Key to the Pathogenesis of Opitz BBB/G Syndrome. Bioessays 25 (4):356-366.
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  8.  15
    Vadim S. Rotenberg (2004). The Ontogeny and Asymmetry of the Highest Brain Skills and the Pathogenesis of Schizophrenia. Behavioral and Brain Sciences 27 (6):864-865.
    The most developed and the latest-to-mature mental skills represented in the creation of mono- versus polysemantic contexts are related respectively to the left and right frontal lobe. A polysemantic way of thinking is responsible for the subject's successful integration in the polydimensional world. The functional insufficiency of this right-hemispheric way of thinking displays a predisposition toward the development of mental disorders, including schizophrenia.
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  9.  3
    H. T. Wright (2000). Alzheimer's Disease and Related Disorders. Etiology, Pathogenesis, and Therapeutics. Bioessays 22 (7):682-683.
  10.  3
    V. Fóti (1982). Thought, Affect, Drive and Pathogenesis in Spinoza and Freud. History of European Ideas 3 (2):221-236.
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  11.  1
    Michael P. Kelly, Rachel S. Kelly & Federica Russo (2014). The Integration of Social, Behavioral, and Biological Mechanisms in Models of Pathogenesis. Perspectives in Biology and Medicine 57 (3):308-328.
    One of the guiding principles of modern medical and health sciences is the discovery and description of the modes of origin and the actions of pathogenic precursors of disease. This principle facilitates the design of interventions to reduce the burden of mortality and morbidity in individuals and populations. This enterprise is challenging because of the complexity of the pathogenic mechanisms involved. Although highly intricate descriptions of these mechanisms have been developed, they have mainly been at the biological level. In this (...)
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  12.  6
    Louis Arnorsson Sass (2001). Pathogenesis, Common Sense, and the Cultural Framework: A Commentary on Stanghellini. Philosophy, Psychiatry, and Psychology 8 (2):219-224.
  13.  6
    Francesco Pansera (1987). Pathogenesis of Osteoarthritis From an Evolutionary Perspective. Acta Biotheoretica 36 (4):281-282.
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  14.  2
    Anthony A. Nash (1985). The Viral Enigma. Viral Pathogenesis and Immunology. By CEDRIC A. MIMS and DAVID O. WHITE, Blackwell Scentific Publications, 1984. Pp. 398. £14.80. [REVIEW] Bioessays 3 (5):237-237.
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  15.  1
    Sabra L. Klein (2011). Implications of X‐Linked Gene Regulation for Sex Differences in Disease Pathogenesis (Comment on DOI 10.1002/Bies. 201100047). [REVIEW] Bioessays 33 (11):789-790.
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  16.  1
    Andrea Cossarizza, Cristina Mussini & Alessandra Viganò (2001). Mitochondria in the Pathogenesis of Lipodystrophy Induced by Anti‐HIV Antiretroviral Drugs: Actors or Bystanders? Bioessays 23 (11):1070-1080.
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  17.  1
    Peter Burke (1988). Critique and Crisis: Enlightenment and the Pathogenesis of Modern Society. History of European Ideas 9 (6):762-762.
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  18.  1
    P. Burke (1988). Critique and Crisis: Enlightenment and the Pathogenesis of Modern Society Reinhart Koselleck , X + 204pp., £25. [REVIEW] History of European Ideas 9 (6):762.
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  19.  1
    J. Wayne Streilein & Wade P. Parks (1986). Challenges: On the Pathogenesis of Immune Incompetence in the Acquired Immune Deficiency Syndrome. Bioessays 4 (6):286-291.
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  20. J. S. Abramson (1987). The Pathogenesis of Bacterial Infections in Infants and Children: The Role of Viruses. Perspectives in Biology and Medicine 32 (1):63-72.
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  21. Hobson & Bishop (2004). The Pathogenesis of Autism: Insights From Congenital Blindness. In Uta Frith & Elisabeth Hill (eds.), Autism: Mind and Brain. OUP Oxford
     
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  22. Alvin F. Coburn (1963). The Pathogenesis of Rheumatic Fever—a Concept. Perspectives in Biology and Medicine 6 (4):493-511.
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  23. Graham S. Jackson (2001). Spontaneous Conformational Change Within the Prion Protein—Implications for Disease Pathogenesis? Bioessays 23 (9):772-774.
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  24. Carl J. Marienfeld (1976). Pulmonary Emphysema: Redefinition and Pathogenesis, a View From the Epidemiological Armchair. Perspectives in Biology and Medicine 19 (2):171-186.
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  25. R. A. McCance & E. M. Widdowson (1976). Obesity: Pathogenesis and Management. Edited by Trevor Silverstone. Pp 240. (Medical and Technical Publishing Co, Lancaster, 1975.) Price £8.50. [REVIEW] Journal of Biosocial Science 8 (2):175-176.
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  26. R. D. Terry (1992). The Pathogenesis of Alzheimer's Disease. What Causes Dementia? In Y. Christen & P. S. Churchland (eds.), Neurophilosophy and Alzheimer's Disease. Springer-Verlag 123--130.
  27. Per Westermark & Kenneth H. Johnson (1988). The Pathogenesis of Maturity‐Onset Diabetes Mellitus: Is There a Link to Islet Amyloid Polypeptide? Bioessays 9 (1):30-33.
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  28.  8
    Víctor de Lorenzo (2014). From Theselfish Genetoselfish Metabolism: Revisiting the Central Dogma. Bioessays 36 (3):226-235.
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  29.  1
    George R. Young, Jonathan P. Stoye & George Kassiotis (2013). Are Human Endogenous Retroviruses Pathogenic? An Approach to Testing the Hypothesis. Bioessays 35 (9):794-803.
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  30.  4
    Stephen V. Gordon, Daria Bottai, Roxane Simeone, Timothy P. Stinear & Roland Brosch (2009). Pathogenicity in the Tubercle Bacillus: Molecular and Evolutionary Determinants. Bioessays 31 (4):378-388.
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  31. Edmond A. Murphy (1997). The Logic of Medicine. Johns Hopkins University Press.
    When first published twenty years ago, The Logic of Medicine presented a new way of thinking about clinical medicine as a scholarly discipline as well as a profession. Since then, advances in research and technology have revolutionized both the practice and theory of medicine. In this new, extensively rewritten edition, Dr. Murphy includes changes to show how these different areas of scholarship may affect details of "the logic of medicine" without compromising its fundamental coherence. New to this edition are discussions (...)
     
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  32.  80
    Jakob Hohwy & Raben Rosenberg (2005). Unusual Experiences, Reality Testing and Delusions of Alien Control. Mind and Language 20 (2):141-162.
    Some monothematic types of delusions may arise because subjects have unusual experiences. The role of this experiential component in the pathogenesis of delusion is still not understood. Focussing on delusions of alien control, we outline a model for reality testing competence on unusual experiences. We propose that nascent delusions arise when there are local failures of reality testing performance, and that monothematic delusions arise as normal responses to these. In the course of this we address questions concerning the tenacity (...)
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  33.  90
    J. A. Shapiro (2007). Bacteria Are Small but Not Stupid: Cognition, Natural Genetic Engineering and Socio-Bacteriology. Studies in History and Philosophy of Science Part C 38 (4):807-819.
    Forty years’ experience as a bacterial geneticist has taught me that bacteria possess many cognitive, computational and evolutionary capabilities unimaginable in the first six decades of the twentieth century. Analysis of cellular processes such as metabolism, regulation of protein synthesis, and DNA repair established that bacteria continually monitor their external and internal environments and compute functional outputs based on information provided by their sensory apparatus. Studies of genetic recombination, lysogeny, antibiotic resistance and my own work on transposable elements revealed multiple (...)
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  34.  32
    Raphael Scholl (2013). Causal Inference, Mechanisms, and the Semmelweis Case. Studies in History and Philosophy of Science Part A 44 (1):66-76.
    Semmelweis’s discovery of the cause of puerperal fever around the middle of the 19th century counts among the paradigm cases of scientific discovery. For several decades, philosophers of science have used the episode to illustrate, appraise and compare views of proper scientific methodology.Here I argue that the episode can be profitably reexamined in light of two cognate notions: causal reasoning and mechanisms. Semmelweis used several causal reasoning strategies both to support his own and to reject competing hypotheses. However, these strategies (...)
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  35.  4
    Christoph Gradmann (2001). Isolation, Contamination, and Pure Culture: Monomorphism and Polymorphism of Pathogenic Micro-Organisms as Research Problem 1860-1880. Perspectives on Science 9 (2):147-172.
    : This article analyzes German debates on the microbiology of infectious diseases from 1865 to 1875 and asks how and when organic pollution in tissues became noteworthy for aetiology and pathogenesis. It was with Ernst Hallier's pleomorphistic microbiology that the organic character of alien material in tissues came to be regarded as important for pathology. The process that followed saw both vigorous biological critique and a number of medical applications of Hallier's work. Around 1874 contemporaries reached the conclusion that (...)
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  36.  12
    P. Thagard (1998). Ulcers and Bacteria I: Discovery and Acceptance. Studies in History and Philosophy of Science Part C 29 (1):107-136.
    In 1983, Dr. J. Robin Warren and Dr. Barry Marshall reported finding a new kind of bacteria in the stomachs of people with gastritis. Warren and Marshall were soon led to the hypothesis that peptic ulcers are generally caused, not by excess acidity or stress, but by a bacterial infection. Initially, this hypothesis was viewed as preposterous, and it is still somewhat controversial. In 1994, however, a U. S. National Institutes of Health Consensus Development Panel concluded that infection appears to (...)
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  37.  2
    Mads Gram Henriksen & Josef Parnas (2016). Phenomenology, Meaning, and Metaphor. Philosophy, Psychiatry, and Psychology 22 (3):193-196.
    The first commentary that we discuss is the quite critical one by Thomas and Long-den. The pertinent question is if the authors’ criticism hits the mark or if it is simply off the mark? We will let the reader decide. In the following, we address some of the most important problems in their commentary. First, Thomas and Longden seem to conflate the concept of pathogenesis with that of etiology. We have presented a phenomenological account of the pathogenesis of (...)
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  38.  5
    Wim Dekkers & Marcel Olde Rikkert (2006). What is a Genetic Cause? The Example of Alzheimer's Disease. Medicine, Health Care and Philosophy 9 (3):273-284.
    This paper focuses on the causation of diseases, particularly on the idea of a “genetic cause” taking Alzheimer’s Disease (AD) as an example. We (1) provide some historical information and a synopsis of the current knowledge on the etiology and pathogenesis of AD, (2) analyse some conceptual problems related to the notion of “genetic disease” (3) elaborate on the alleged (genetic) cause of AD, and (4) place the discussion on the cause of AD in a broader philosophical context, paying (...)
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  39.  5
    Christoph Gradmann (2004). A Harmony of Illusions: Clinical and Experimental Testing of Robert Koch's Tuberculin 1890–1900. Studies in History and Philosophy of Science Part C 35 (3):465-481.
    One of Ludwik Fleck’s ideas about the development of scientific knowledge is that—once a system of interpretation is in place—the process that follows can be characterised as one of inertia: any new evidence comes under a strong pressure to be incorporated into the established frame. This can result in what Fleck called a harmony of illusions when contradictory evidence becomes almost invisible or is incorporated into the established frame only by huge efforts.The paper analyses early explanations of the tuberculin reaction (...)
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  40.  26
    H. Nederbragt (2000). The Biomedical Disciplines and the Structure of Biomedical and Clinical Knowledge. Theoretical Medicine and Bioethics 21 (6):553-566.
    The relation between biomedical knowledge and clinicalknowledge is discussed by comparing their respectivestructures. The knowledge of a disease as a biologicalphenomenon is constructed by the interaction of factsand theories from the main biomedical disciplines:epidemiology, diagnostics, clinical trial, therapydevelopment and pathogenesis. Although these facts andtheories are based on probabilities andextrapolations, the interaction provides a reliableand coherent structure, comparable to a Kuhnianparadigma. In the structure of clinical knowledge,i.e. knowledge of the patient with the disease, notonly biomedical knowledge contributes to the structurebut (...)
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  41.  19
    Paul M. Jenkinson, Nicola M. J. Edelstyn, Justine L. Drakeford & Simon J. Ellis (2009). Reality Monitoring in Anosognosia for Hemiplegia. Consciousness and Cognition 18 (2):458-470.
    Anosognosia for hemiplegia is a lack of awareness about paralysis following stroke. Recent explanations use a ‘forward model’ of movement to suggest that AHP patients fail to register discrepancies between internally- and externally-generated sensory information. We predicted that this failure would impair the ability to recall from memory whether information is internally- or externally-generated . Two experiments examined this prediction. Experiment 1 demonstrated that AHP patients exhibit a reality monitoring deficit for non-motor information , whilst hemiplegic controls without anosognosia perform (...)
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  42.  3
    S. Camporesi & G. Boniolo (2008). Fearing a Non-Existing Minotaur? The Ethical Challenges of Research on Cytoplasmic Hybrid Embryos. Journal of Medical Ethics 34 (11):821-825.
    In this paper we address the ethical challenges of research on cytoplasmic hybrid embryos, or “cybrids”. The controversial pronouncement of the UK’s Human Embryology and Fertilisation Authority of September 2007 on the permissibility of this area of research is the starting point of our discussion, and we argue in its favour. By a rigorous definition of the entities at issue, we show how the terms “chimera” and “hybrid” are improper in the case of cybrids, and how their use can bias (...)
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  43.  5
    Forogh Tavakoli, Nastaran Khodadad, Behzad Dehghani & Afagh Moattari (2015). In Silico Functional and Structural Characterization of H1N1 Influenza A Viruses Hemagglutinin, 2010–2013, Shiraz, Iran. Acta Biotheoretica 63 (2):183-202.
    Hemagglutinin is a major virulence factor of influenza viruses and plays an important role in viral pathogenesis. Analysis of amino acid changes, epitopes’ regions, glycosylation and phosphorylation sites have greatly contributed to the development of new generations of vaccine. The hemagglutinins of 10 selected isolates, 8 of 2010 and 2 of 2013 samples were sequenced and analyzed by several bioinformatic softwares and the results were compared with those of 3 vaccine isolates. The study detected several amino acid changes related (...)
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  44.  3
    Richard Ganis (2015). Insecure Attachment and Narcissistic Vulnerability: Implications for Honneth's Recognition-Theoretic Reconstruction of Psychoanalysis. Critical Horizons 16 (4):329-351.
    This paper endeavours to move Axel Honneth's recognition-theoretic reconstruction of psychoanalysis beyond its existing focus on the perspective of Winnicott. To this end, it places Honneth into conversation with several non-Winnicottian approaches to the phenomena of insecure attachment and narcissistic vulnerability: the attachment theory of John Bowlby and Mary Ainsworth, the self psychological perspective of Heinz Kohut, and a more recent intersubjectivist psychoanalytic paradigm set forth by Robert Stolorow, George Atwood, Bernard Brandchaft, and Donna Orange. Similar to Honneth, these authors (...)
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  45.  21
    Sean M. Quinlan (2009). Monstrous Births and Medical Networks: Debates Over Forensic Evidence, Generation Theory, and Obstetrical Authority in France, Ca. 1780-1815. Early Science and Medicine 14 (5):599-629.
    In France between 1780 and 1815, doctors opened a broad correspondence with medical faculties and public officials about foetal anomalies . Institutional and legal reforms forced doctors to encounter monstrous births with greater frequency, and they responded by developing new ideas about heredity and embryology to explain malformations to public officials. Though doctors achieved consensus on pathogenesis, they struggled to apply these ideas in forensic cases, especially with doubtful sex. Medical networks simultaneously allowed doctors to explore obstetrical techniques, as (...)
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  46.  13
    Jason Edwards (2006). Critique and Crisis Today: Koselleck, Enlightenment and the Concept of Politics. Contemporary Political Theory 5 (4):428.
    Over the last 20 years, Reinhart Koselleck has become familiar to an Anglophone audience as the foremost practitioner of Begriffsgeschichte . Yet, an early work of his, Critique and Crisis: the Pathogenesis of Modern Society, is today largely overlooked by political theorists. In this paper, I argue that the book is an important resource for contemporary political theory. Not only does it outline a highly cogent approach to the relationship between political theory and practice, but its substantive argument concerning (...)
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  47.  3
    Camilo A. L. S. Colaco & Bruce J. Roser (1994). Atherosclerosis and Glycation. Bioessays 16 (2):145-147.
    Atherosclerosis is the major cause of death in the industrialised world. Though much work on the pathogenesis of atherosclerosis points to 'oxidised' low density lipoprotein (LDL) as a key aetiological feature in the generation of the atherosclerotic plaque, the nature of this 'oxidised' LDL in vivo remains an enigma. We argue here that glycated LDL shows many of the characteristics attributed to 'oxidised LDL' and may be the source of the latter in vivo. These include the increased uptake and (...)
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  48.  3
    Y. Du, X. Chen, X. Wei, K. R. Bales, D. T. Berg, S. M. Paul, M. R. Farlow, B. Maloney, Y. W. Ge & D. K. Lahiri (2005). NF-B Mediates Amyloid Beta Peptide-Stimulated Activity of the Human Apolipoprotein E Gene Promoter in Human Astroglial Cells. Brain Res Mol Brain Res 136:177-88.
    The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment containing (...)
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  49.  7
    Sabine Brauckmann (2000). Steps Towards an Ecology of Cognition. Sign Systems Studies 28:397-419.
    The essay infonns on Gregory Bateson's holistic approach towards an epistemic view of nature. The ecology of mind relies upon a biological holism serving as a methodic tool to explain living "phenomena", like, e.g., communication, learning, and cognition. Starting from the idea, the smallest unit of information, Bateson developed a type hierarchy of learning that is based on a cybernetic view of mind. The communication model focuses on paradoxa caused by false signification. It leads to a pathogenesis of sckizophrenia (...)
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  50.  1
    Ben Bambery, Michael Selgelid, Charles Weijer, Julian Savulescu & Andrew J. Pollard (2016). Ethical Criteria for Human Challenge Studies in Infectious Diseases. Public Health Ethics 9 (1):92-103.
    Purposeful infection of healthy volunteers with a microbial pathogen seems at odds with acceptable ethical standards, but is an important contemporary research avenue used to study infectious diseases and their treatments. Generally termed ‘controlled human infection studies’, this research is particularly useful for fast tracking the development of candidate vaccines and may provide unique insight into disease pathogenesis otherwise unavailable. However, scarce bioethical literature is currently available to assist researchers and research ethics committees in negotiating the distinct issues raised (...)
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