This paper focuses on the question of whether DNA patents help or hinder scientific discovery and innovation. While DNA patents create a wide variety of possible benefits and harms for science and technology, the evidence we have at this point in time supports the conclusion that they will probably promote rather than hamper scientific discovery and innovation. However, since DNA patenting is a relatively recent phenomena and the biotechnology industry is in its infancy, we (...) should continue to gather evidence about the effects of DNA patenting on scientific innovation and discovery as well the economic, social, and legal conditions relating to intellectual property in biotechnology. We should give the free market, the courts, researchers, and patent offices a chance to settle issues related to innovation and discovery, before we seek legislative remedies, since new laws proposed at this point would lack adequate foresight and could do more harm than good. However, we should be open to new laws or regulations on DNA patents if they are required to in order to deal with some of the biases and limitations of the free market. (shrink)

This book defines 'nanowares' as the ideas and products arising out of nanotechnology. Koepsell argues that these rapidly developing new technologies demand a new approach to scientific discovery and innovation in our society. He takes established ideas from social philosophy and applies them to the nanoparticle world. In doing so he breaks down the subject into its elemental form and from there we are better able to understand how these elements fit into the construction of a more (...) complex system of products, rules and regulations about these products. (shrink)

This study examined scientific tolerance as a human way to life in the context of Sunnah, a much debatable topic among critics and scholars. The study also highlighted prophetic visions in the application of scientific tolerance. Using a normative descriptive approach in this qualitative research, the data was collected from library archives and Islamic data sources. This approach enabled to raise questions about the nature of scientific tolerance in the light of Sunnah, prophetic mechanisms used to establish (...) the scientific tolerance, and its advantages. The findings revealed that scientific tolerance was integrated to the prophetic visions and the Sunnah, aiming at peace, tranquility, and stability for the entire mankind. The study found out how the Sunnah of the Prophet laid the foundation of scientific tolerance, and how it was carried forward by the Companions and mujtahids through their discussions, dialogues, and debates. It was also observed that the scientific tolerance reached its peak in the era of Arab and Islamic civilization, through the translation movement that began in the Umayyad era and reached its culmination, and gained heights through scientific discoveries, innovations, and civilizational achievements. In the Abbasid era, the subsequent transfer and translation of these languages into Latin and other European languages, further enhanced the depth of scientific tolerance in the contemporary renaissance and modern civilization. (shrink)

Scientific communities as social groupings and the role that such communities play in scientific change and the production of scientific knowledge is currently under debate. I examine theory change as a complex social interaction among individual scientists and the scientific community, and argue that individuals will be motivated to adopt a more radical or innovative attitude when confronted with striking similarities between model systems and a more robust understanding of specialised vocabulary. Two case studies from the (...) biological sciences, Barbara McClintock and Stanley Prusiner, help motivate the idea that sharing of models and specialised vocabulary fill the gap between discovery and scientific change by promoting the dispersal of important information throughout the scientific community. (shrink)

Philosophers and historians of philosophy have come to recognize that at the core of logical positivism was an attachment to prediction as the necessary condition for scientific knowledge.1 The inheritors of their tradition, especially the Bayesians among us, continue to seek a theory of confirmation that reflects this epistemic commitment. The importance of prediction in the growth of scientific knowledge is a commitment I share with the positivists, so I do not blanch at that designation, much less employ (...) it as a term of abuse. Precisely expressing and conclusively establishing the claims of prediction as a necessary condition for certifying claims as increments of knowledge is a goal that has so far eluded us post-positivists. Philosophers know the problems well: defining a positive instance, distinguishing projectible from nonprojectible predicates, deciding whether retrodiction is as epistemically probative as prediction. 2 But I can't help thinking that these problems are technicalities - important and arresting, but not impediments to embracing the positivist demand that increments in scientific knowledge withstand tests of predictive success. (shrink)

This book explores and explains how deep semantics works, how new deep semantics research can be conducted, and how the new scientific method of deep semantics can be used to create new scientific theories and discoveries.

In this book, Augustine Brannigan provides a critical examination of the major theories which have been devised to account for discoveries and innovations in ...

In philosophy of science, the literature on abduction and the literature on styles of thinking have existed almost totally in parallel. Here, for the first time, we bring them together and explore their mutual relevance. What is the consequence of the existence of several styles of scientific thinking for abduction? Can abduction, as a general creative mode of inference, have distinct characteristic forms within each style? To investigate this, firstly, we present the concept of abduction; secondly we analyze what (...) is understood by styles of thinking; thirdly, we give some comments on abduction and styles of thinking by analyzing examples of scientific discovery or innovation within each style. We develop a case-based comparative investigation of creative aspects of abductive reasoning with examples drawn from different styles of scientific thinking and doing as understood by the Crombie/hacking tradition. We argue that abduction, as a general mode of reasoning, can have a variety of specific expressions enabled and constrained by the styles of scientific thinking. Finally, we draw some conclusions on the relationship between abduction and styles of thinking suggesting that scientific discovery is a dynamical goal-directed activity within the scientific community that benefits from distinct styles of thinking and doing research. (shrink)

Thomas Nickles challenges my thesis that innovative discoveries can be based on deliberately chosen problems and research strategies. He suggests that all significant innovation can be seen as such only in retrospect and that its generation must be serendipitous. Here I argue in response that significant innovations can and do often arise from self conscious critical appraisal of orthodox practice combined with regulated though speculative abductive argumentation to alternative explanatory schemata. Orthodox practice is not based upon monolithic systems of (...) belief about the subject of inquiry. Rather major domains of scientific practice often are approached from different conceptualizations that provide grounds for critical dialectic and consilient empirical information. Abductive arguments that meet appropriate conditions of likelihood, probability and analogy are an important means of justifying allocating resources to innovative practices that have yet to produce products that can rival those of established orthodoxy. (shrink)

The discovery of RNA interference in 1998 has made a lasting impact on biological research. Identifying the regulatory role of small RNAs changed the modes of molecular biological inquiry as well as biologists' understanding of genetic regulation. This article examines the early years of small RNA biology's success story. I query which factors had to come together so that small RNA research came into life in the blink of an eye. I primarily look at scientific repertoires as facilitators (...) of rapid scientific change. I show that for a short period of time, between the years 1998 and 2002, different model organism communities, investigative strategies, technological innovations, and research interests could be successfully aligned to take small RNA research off the ground. I discuss how the keystone discoveries were situated in specific experimental traditions and what strategies were employed to establish these discoveries as more general phenomena. Providing thus a practice-based approach of rapid scientific change, I ask how to relate the change in propositional bits of scientific knowledge with changes in scientific practice. (shrink)

This paper examines the points of disagreement between Petrus Camper and J. W. von Goethe regarding the existence of the inter-maxillary bone in humans as the link between man and the rest of nature. This historical case illustrates the fundamental role of aesthetic judgements in scientific discovery. Thus, I shall show how the eighteenth century discovery of the inter-maxillary bone in humans was largely determined by aesthetic factors—specifically, those sets of assumptions and criteria implied in the aesthetic (...) schemata of Camper and Goethe. I argue that the relevance of scientifically ascertainable morphological properties that count as evidence for the existence of bona fide anatomical structures depend on the aesthetic schema adopted by the communities assessing the classification. At the same time, I propose and explain mechanisms by which aesthetic considerations might determine the acceptability of empirical claims about the world. Based on the reconstruction of the arguments of Camper and Goethe, I conclude that aesthetic considerations play a substantive role in both the generation and preliminary evaluation of scientific hypotheses. This paper suggests a complementary relation between the mediation of aesthetic criteria in theory choice and in scientific discovery in that while aesthetic considerations in theory choice lead to conservatism; in the context of discovery they often lead to innovation. (shrink)

In our current climate of rapid technological progress, it seems counterintuitive to think that modern science can learn anything of ethical value from the dark recesses of the nineteenth century or earlier. However, this happens to be quite true, with plenty of knowledge and wisdom to be gleaned by studying our scientific predecessors. Presently, our journals are flooded with original concepts and potential breakthroughs, a continuous stream of ideas pushing the frontiers of knowledge ever forward. Some ideas flourish while (...) others flounder; but what sets the two apart? The distinguishing feature between success and failure within this context is the ability to discern the appropriate time to accept an innovation with open arms, versus when to take a more cautious approach. And the primary arbiters for whether an idea will catch on or not are the professional audience. I illustrate this concept by comparing the initial reception of two innovative ideas from Medicine’s past: sterile technique, and prefrontal lobotomy. Sterile technique was first introduced by Dr. Ignaz Semmelweis and was initially ridiculed and rejected, with Semmelweis eventually dying in exile. Conversely, lobotomy was accepted and lauded and its inventor, Dr. Egas Moniz, won the Nobel Prize for his “discovery”. This begs the question: why was a technique with the potential to save millions of lives initially rejected, whereas paradoxically, one that compromised and sometimes destroyed lives, accepted? Here I explore and analyze the potential reasons why, suggest how we can learn from these mistakes of the past and apply new insight to some current ethical dilemmas. (shrink)

We have been discussing some of the fundamental features of the classical calculus of probability. The equiprobability of rival events was seen to be a major assumption of the calculus. Moreover, it is an assumption which the pure mathematician need not bother to justify. He need only present his formal system as follows.

When you type the word “serendipity” in a word-processor application such as Microsoft Word, the autocorrection engine suggests you choose other words like “luck” or “fate”. This correcting act turns out to be incorrect. However, it points to the reality that serendipity is not a familiar English word and can be misunderstood easily. Serendipity is a very much scientific concept as it has been found useful in numerous scientific discoveries, pharmaceutical innovations, and numerous humankind’s technical and technological advances. (...) Therefore, there have been many books written around the concept. So why do we need this additional book? This is not just another book about serendipity. It has evolved from the Editor’s question lingering for a decade after finishing his widely cited article (coauthored with Prof. Nancy K. Napier of Boise State University, ID, USA) “Serendipity as a strategic advantage?” in T. Wilkinson’s edited volume Strategic Management in the 21st Century, published by Praeger. The Editor and contributing authors have tried to achieve the following in this title. Demystifying the Serendipity Myth The phenomenon of serendipity has always been thought of as a “miracle”. It is the mystery of human innovation and one of the ultimate secrets of our society. But serendipity is not just a lucky coincidence nor any hidden conspiracy. This book explores the science of the information process behind this seemingly miraculous phenomenon. It connects human society with nature, going back to the root of our existence and looking at the flame of survival to discover the harmony in making creativity. Presenting the nuts and bolts of being an adventurer of science The authors present their conceptual investigations into serendipity’s nature and its mechanism by examining interesting real events and stories. The content is thought-provoking, and readers are led to question and explore their own life stories and problems along the journey of reading this book. Catching an elusive high-value target requires great strategies and efforts. But there are no dark secrets here because this is the “way of nature” – how we humans have always strived for innovation without realizing the blueprints behind such processes. Unlike other books on serendipity, this book will show you that a powerful “secret” is closer than you think. Delivering practical uses for different audiences By understanding the conditionality and survival drivers of serendipity, individuals or organizations can make better decisions on creating the right environment to facilitate the encounter and attainment of this valuable phenomenon. For scientists: With clear explanations of the information processes underlying serendipity, flexible theoretical frameworks of mindsponge and the 3D principle of creativity, researchers are provided with the tools they need to dig deeper into their own fields of study and find practical applications, be it psychology, economics, sociology, or anything that involves innovation (which is, in fact, every scientific discipline). For curious casual readers: Everybody needs innovation to make breakthroughs or spice up one’s life. If you think great ideas come to people randomly from an unknown fairy place, this book will convince you otherwise without taking away that awe and wonder. But above all, you will know how to become more creative, scientifically and straightforwardly, with no snake oil and no weird tricks. For ambitious business people: The flame that brought about great successes throughout human history is within you. But you can only use it if you understand it. While others wait for serendipity to come, you will be able to actively hunt for those precious moments. As it has always been: the best hunters triumph, not the passive wanderers. And in this age of information chaos, finding the golden fruits is not easy. Those from information technology know this problem well, and this book is the treasure map that they have been seeking to navigate that stormy ocean looking for jewels. Like a kingfisher tracking its prey through the water, waiting to gracefully strike, with serendipity, a person seizes the prize of creativity amid the chaos of life. ¤ ¤ ¤ Official introduction: The book explores the nature, underlying causes, and the information processing mechanism of serendipity. It proposes that natural or social survival demands drive serendipity, and serendipity is conditional on the environment and the mindset, on both individual and collective levels. From Darwin's evolution theory to Sun Tzu's war tactics, major innovations throughout human history are unified by this key concept. In the rapidly changing world, information is abundant but rather chaotic. The adaptive power of serendipity allows people to notice treasures within this wild sea, but only for those who understand how it works. To increase the probability of encountering and attaining serendipity, one should employ the mindsponge mechanism and the 3D process of creativity, for without these frameworks, serendipity is truly an elusive target. The book also discusses methods to build environments and cultures rich in navigational and useful information to maximize the chance of finding and capitalizing on serendipity. As a skill, serendipity has a resemblance to how kingfishers observe and hunt their prey. (shrink)

Recent and ongoing developments in science and technology - such as the prevention and treatment of disease through genetics and the development of increasingly sophisticated computer systems with wide-ranging applications - hold out the promise of vastly improving the quality of human life, but they can also raise serious ethical, legal, and public policy questions. The thirteen essays in this volume address these questions and related issues from a variety of perspectives. Written by prominent philosophers, economists, and legal theorists, these (...) essays offer valuable insights into the nature of scientific innovation and its implications for our social policies and practices. (shrink)

Much has been written about the linear model of innovation. While it may have been the dominant model used to explain technological innovation for decades, alternatives did exist. One such alternative—generally discussed as being the exact opposite of the linear model—is the demand-pull model. Beginning in the 1960s, people from different disciplines started looking at technological innovation from a demand rather than a supply perspective. The theory was that technological innovation is stimulated by market demand rather (...) than by scientific discoveries. However, few traces of the demand-pull model remain in the literature today. This article looks at what happened to the demand-pull model from a historical perspective, at three points in time: birth, crystallization, and death. It suggests that the idea of demand as a factor explaining technological innovation emerged in the 1960s, was formalized into models in the 1970-1980s, then got integrated into “multidimensional” models. From then on, the demand-pull model disappeared from the literature, existing only as an object of the past, like the linear model of innovation. (shrink)

The determining role that tool development plays in neuroscientific progress poses special challenges to the Kuhnian-rooted philosophy of scientific change. Some philosophers of neuroscience argue that revolutions in neuroscience do not involve paradigm shifts, but instead depend exclusively on technical or experimental innovation. By studying the historical episode of the discovery of the neuron (1873-1909), I argue that revolutions in neuroscience, like many other laboratory revolutions, are frequently driven by the intertwining of technical innovations and conceptual change.

Amateur scientists were important in the science of the eighteenth century as patrons, investors in talent and new equipment, as the maintainers of gardens and libraries, and, occasionally, as men who could and did make discoveries or significant innovations. The article shows that the 3rd Duke of Argyll was one of these men. He was also much more. Ilay's interests in science, because of his important political position in Scotland, touched not only his immediate friends but helped to reshape Scottish (...) culture itself. This essay looks at his scientific interests, his political career, and his patronage to argue that the results of his long career in politics were to institutionalize a new set of modern values in most Scottish institutions. (shrink)

Martin Sand and Luca Chiapperino find in the concept of serendipity a versatile umbrella term to reassess their previous work on moral luckLuck (also, Epistemic Luck, Moral Luck) and collectiveCollectiveresponsibilityResponsibility. Moral luck supposedly occurs when someone receives praise or blame for things beyond control. Given the ubiquity of luckLuck (also, Epistemic Luck, Moral Luck), this seems to be a seriously disquieting aspect of ordinary morality. The rewards and recognition for serendipitous discoveries fall into exactly this category. That is: more than (...) the intentions, actions, and characters of scientists matters for discoveries to obtain, just as in cases of moral luckLuck (also, Epistemic Luck, Moral Luck) something beyond morality affectsAffect our moral judgments. Even if a theoretical way of resolving the conceptual ambiguities that underlie this debate were found, there remain practical questions of how to perform stratification in science and innovationInnovation in ways that both hinge on, and yet refrain from, considerations of desert and achievement. With the example of Edward Jenner’sJenner, EdwardluckLuck (also, Epistemic Luck, Moral Luck)- and serendipity-infused discoveryDiscovery (also, Scientific Discovery) of vaccination, the authors attempt to better understand the intricate valueValue trade-offs that underlie stratification policies in science, which have to be constantly re-negotiated to maintain their legitimacy. Thereby, Sand and Ciapperino aim to take a bold step towards understanding the ethicsEthics of serendipity. (shrink)

Kepler, the father of modern physical astronomy, believed that the world is ordered by Archetypes . As quaint as this may seem, I argue that Kepler's archetypes provided methodological and epistemological solutions to problems in physical astronomy acknowledged during his time. ;Kepler used the assumption of a harmony between the archetypal and physical world to argue for the legitimacy of certain methodological innovations. The main difficulty facing astronomers at that time was the availability of observationally equivalent competing astronomical hypotheses. Kepler's (...) solution was to argue that the hypotheses could be distinguished between by proper testing and by bringing in considerations from other disciplines, especially physics. Kepler's account of the proper testing of hypotheses, though modern in appearance, was grounded in his archetypal cosmology. The use of physics in astronomy, also a modern innovation, was not considered to be methodologically sound during Kepler's time unless certain conditions were met. Under Kepler's archetypal cosmology these conditions were met, thereby legitimating the use of physics in astronomy. ;Kepler's archetypes play another role in his physical astronomy. The Aristotelian account of physics still dominant was qualitative in character. The use of mathematical physics was acceptable if it was grounded in qualitative theory, which Kepler was unable to fully provide. I argue that Kepler's archetypal cosmology enabled him to overcome this conceptual barrier. While Kepler agreed with Aristotle that mathematics is unable to reveal anything about physical causes, he believed that the archetypes are not limited in this manner. For Kepler, God's only reason for creating physical powers was to instantiate the archetypes; hence a study of archetypes can provide information about physical causes. When Kepler was unable to attach mathematical models to qualitative physical theory, he attached them to archetypal models, thereby legitimating their use in physics. ;Kepler's archetypes are no longer scientifically significant. At the time, however, they functioned to break down some of the conceptual barriers to his new physical astronomy. As a result, understanding Kepler's archetypes is of paramount importance for understanding his role in the scientific revolution of the sixteenth and seventeenth centuries. (shrink)

Modern science, whose methodologies give special privilege to using decontextualizing strategies and downplay the role of context-sensitive strategies, have been extraordinarily successful in producing knowledge whose applications have transformed the shape of the lifeworld. Nevertheless, I argue that how the mainstream of the modern scientific tradition interprets the nature and objectives of science is incoherent; and that today there are two competing interpretations of scientific activities that are coherent and that maintain continuity with the success of the tradition: (...) "commercially-oriented technoscience" and "multi-strategy research" . The greater part of this article is devoted to discussing what is involved in MS, by pointing to its positive research program in three areas , and its critical stance towards the innovations of CT, especially insofar as it makes use of the Precautionary Principle. In this way important dimensions of the agenda of science and technology for social justice, democratic participation and sustainability become clear. (shrink)

I explore the process of changes in the observability of entities and objects in science and how such changes impact two key issues in the scientific realism debate: the claim that predictively successful elements of past science are retained in current scientific theories, and the inductive defense of a specific version of inference to the best explanation with respect to unobservables. I provide a case-study of the discovery of radium by Marie Curie in order to show that (...) the observability of some entities can change and that such changes are relevant for arguments seeking to establish the reliability of success-to-truth inferences with respect to unobservables. (shrink)

Norwood Russell Hanson was one of the most important philosophers of science of the post-war period. Hanson brought Wittgensteinian ordinary language philosophy to bear on the concepts of science, and his treatments of observation, discovery, and the theory-ladenness of scientific facts remain central to the philosophy of science. Additionally, Hanson was one of philosophy's great personalities, and his sense of humor and charm come through fully in the pages of Perception and Discovery. Perception and Discovery, originally (...) published in 1969, is Hanson's posthumous textbook in philosophy of science. The book focuses on the indispensable role philosophy plays in scientific thinking. Perception and Discovery features Hanson's most complete and mature account of theory-laden observation, a discussion of conceptual and logical boundaries, and a detailed treatment of the epistemological features of scientific research and scientific reasoning. This book is of interest to scholars of philosophy of science, particularly those concerned with Hanson's thought and the development of the discipline in the middle of the 20th century. However, even fifty years after Hanson's early death, Perception and Discovery still has a great deal to offer all readers interested in science. (shrink)

Since its introduction in the 1980s, use of the innovation systems conceptual approach has been growing, particularly on the part of national governments including, recently, the Hong Kong Government. In 2004, the Hong Kong Government set forth a ‘‘new strategy’’ for innovation and technology policy making. Because it marked a significant break from the past, it was necessary to convince a wider audience to accept this new strategy, a strategy that included the IS conceptual approach. Adopting a science (...) and technology studies perspective, I show how the IS conceptual approach is being used as a rhetorical resource by the Hong Kong Government in its innovation and technology policy making in an effort to persuade its perceived audience of the efficacy of its new strategy for its policies—policies that are in fact unrelated to the basic precepts of the IS conceptual approach. The case provides a cautionary tale in the ways in which policy makers transform scholarly work and scientific discovery into rhetorical instruments in support of a political agenda. (shrink)

Humans continuously delegate and distribute cognitive functions to the environment to lessen their limits. They build models, representations, and other various mediating structures, that are thought to be good to think. The case of scientific innovation is particularly important: the main aim of this paper is to revise and criticize the concept of scientific innovation, reframing it in what I will call an eco-epistemic perspective, taking advantage of recent results coming from the area of distributed cognition (...) and abductive cognition . Taking advantage of this eco-cognitive perspective the article outlines how innovative scientific modeling activity can be better described taking advantage of the concept of “epistemic warfare”, which sees scientific enterprise as a complicated struggle for rational knowledge in which it is crucial to distinguish epistemic from non epistemic weapons. (shrink)

Norwood Russell Hanson was one of the most important philosophers of science of the post-war period. Hanson brought Wittgensteinian ordinary language philosophy to bear on the concepts of science, and his treatments of observation, discovery, and the theory-ladenness of scientific facts remain central to the philosophy of science. Additionally, Hanson was one of philosophy’s great personalities, and his sense of humor and charm come through fully in the pages of Perception and Discovery. Perception and Discovery, originally (...) published in 1969, is Hanson’s posthumous textbook in philosophy of science. The book focuses on the indispensable role philosophy plays in scientific thinking. Perception and Discovery features Hanson’s most complete and mature account of theory-laden observation, a discussion of conceptual and logical boundaries, and a detailed treatment of the epistemological features of scientific research and scientific reasoning. This book is of interest to scholars of philosophy of science, particularly those concerned with Hanson’s thought and the development of the discipline in the middle of the 20th century. However, even fifty years after Hanson’s early death, Perception and Discovery still has a great deal to offer all readers interested in science. (shrink)

I offer an analysis of the concept of scientific innovation. When research is innovated, highly novel and useful elements of investigation begin to spread through a scientific community, resulting from a process which is neither due to blind chance nor to necessity, but to a minimal use of rationality. This, however, leads to tension between two claims: (1) scientific innovation can be explained rationally; (2) no existing account of rationality explains scientific innovation. There (...) are good reasons to maintain (1) and (2), but it is difficult for both claims to be accepted simultaneously by a rational subject. In particular, I argue that neither standard nor bounded theories of rationality can deliver a satisfactory explanation of scientific innovations. (shrink)

Philosophers, historians, and sociologists of science have grown interested in the daily practices of scientists. Recent studies have drawn linkages between scientific innovations and more ordinary procedures, craft skills, and sources of sponsorship. These studies dispute the idea that science is the application of a unified method or the outgrowth of a progressive history of ideas. This book critically reviews arguments and empirical studies in two areas of sociology that have played a significant role in the 'sociological turn' in (...) science studies: ethnomethodology and the sociology of scientific knowledge. In both fields, efforts to study scientific practices have led to intractable difficulties and debates, due in part to scientistic and foundationalist commitments that remain entrenched with social-scientific research policies and descriptive language. The central purpose of this book is to explore the possibility of an empirical approach to the epistemic contents of science that avoids the pitfalls of scientism and foundationalism. (shrink)

We begin with some questions. What constitutes a scientific discovery? How do we tell when a discovery has been made and whom to credit? Is making a discovery (always) the same as solving a problem? Is it an individual psychological event (an ahal experience), or something more articulated such as a logical argument or a mathematical derivation? May discovery require a long, intricate social process? Could it be an experimental demonstration? How do we tell exactly (...) what has been discovered, given that old discoveries are often recharacterized in very different ways by succeeding generations? What kinds of items can be discovered, and how? Is the discovery of a theory accomplished in much the same way as the discovery of a new comet, or is “discovery” an inhomogeneous domain of items or activities calling for quite diverse accounts? Must a discovery be both new and true? How is discovery related to (other?) forms of innovation, such as invention and social construction? Can there be a logic or method of discovery? Just one? Many? What could such a procedure be? How is it possible that an (a priori?) logic or method available now has so much future knowledge already packed into it? How could a logic of discovery itself be discovered? How general in scope must a method of discovery be? Must it apply to all sciences, independently of the subject matter (as we might expect of a “logic”), or might it apply only to problems of a certain type or depend on substantive scientific claims? How, if at all, is their discovery related to the justification of scientific claims? Is the manner in which scientists make discoveries at all similar to the way in which they test them? Is this justificatory “checkout” procedure really part of the larger discovery process rather than distinct from it? Can discoveries be explained rationally, or do they always contain irrational or nonrational elements, such as inspiration or blind luck? Are historians, sociologists, and psychologists better equipped than philosophers to explain scientific creativity? Can a methodology of discovery help to explain the explosion of scientific and technological progress since 1600? If there is no logic of discovery, and if discovery is irrelevant to justification, then why include the subject of discovery in the domain of philosophy (epistemology or methodology of science) at all? What could philosophers have to say about it? Are there historical patterns of discovery, for example, that tell us something about the rationality, if not the logic (in the strict sense), of the growth of scientific knowledge? (shrink)

How do scientific innovations spread within and across scientific communities? In this paper, we propose a general account of the diffusion of scientific innovations. This account acknowledges that novel ideas must be elaborated on and conceptually translated before they can be adopted and applied to field-specific problems. We motivate our account by examining an exemplary case of knowledge diffusion, namely, the early spread of theories of rational decision-making. These theories were grounded in a set of novel mathematical (...) tools and concepts that originated in John von Neumann and Oskar Morgenstern's Theory of Games and Economic Behavior and subsequently spread widely across the social and behavioral sciences. Introducing a network-based diffusion measure, we trace the spread of those tools and concepts into distinct research areas. We furthermore present an analytically tractable typology for classifying publications according to their roles in the diffusion process. The proposed framework allows for a systematic examination of the conditions under which scientific innovations spread within and across preexisting and newly emerging scientific communities. (shrink)

ABSTRACTWhile the emergence of a new scientific culture in 16th-century Europe is well known, the role of the actors of the Hispanic New World in this time of renewal of knowledge has long been judged marginal for two reasons: first, because the strong presence of the Inquisition in the Hispanic World has been considered by historians to have been an obstacle for research or scientific innovation; and second, because the discontinuity of the territories of the Hispanic Monarchy (...) and the problem of distances between Spain and the New World have long been interpreted in ways that suggest the marginality and peripheral status of the American colonies. However, some works counterbalance this dismissal and shed new light on the scientific activity of the Hispanic New World. This is the case with the treatise Arte de los Metales, by the secular priest Alvaro Alonso Barba, which would achieve remarkable fame and circulation, and would become a seminal work in the fields of metallurgy and mining until the mid-1700s. The article demonstrates that this treatise also presents ideas that can be traced back to a set of Paracelsian ideas combining alchemy, pharmacopoeia, and medicine, and studies specific examples of these ideas – the description of three fundamental substances as components of all matter, references to Epatica sulfuris, an oil capable of turning silver into gold and curing certain diseases; and the use of antimony – that together testify to the spread of the ideas of Basil Valentine and of Paracelsian influences. From this point of view, Arte de los Metales can be viewed as part of a tradition unexpectedly renewed by the author through many observations based on his own work in Peru and the discoveries he made thanks to alternative techniques. This demonstrates the richness and diversity of knowledge rooted in the New World, and links Alonso Barba’s scholarly activity to some of the great schools of thought that spanned the Early Modern European world. (shrink)

Despite the prodigious inventiveness of the Middle Ages, the era is often characterized as deeply suspicious of novelty. But if poets and philosophers urged caution about the new, Patricia Clare Ingham contends, their apprehension was less the result of a blind devotion to tradition than a response to radical expansions of possibility in diverse realms of art and science. Discovery and invention provoked moral questions in the Middle Ages, serving as a means to adjudicate the ethics of invention and (...) opening thorny questions of creativity and desire. The Medieval New concentrates on the preoccupation with newness and novelty in literary, scientific, and religious discourses of the twelfth through sixteenth centuries. Examining a range of evidence, from the writings of Roger Bacon and Geoffrey Chaucer to the letters of Christopher Columbus, and attending to histories of children's toys, the man-made marvels of romance, the utopian aims of alchemists, and the definitional precision of the scholastics, Ingham analyzes the ethical ambivalence with which medieval thinkers approached the category of the new. With its broad reconsideration of what the "newfangled" meant in the Middle Ages, The Medieval New offers an alternative to histories that continue to associate the medieval era with conservation rather than with novelty, its benefits and liabilities. Calling into question present-day assumptions about newness, Ingham's study demonstrates the continued relevance of humanistic inquiry in the so-called traditional disciplines of contemporary scholarship. (shrink)

Following on from Roy Bhaskarâe(tm)s first two books, A Realist Theory of Science and The Possibility of Naturalism, Scientific Realism and Human Emancipation, establishes the conception of social science as explanatoryâe"and thence emancipatoryâe"critique. Scientific Realism and Human Emancipation starts from an assessment of the impasse of contemporary accounts of science as stemming from an incomplete critique of positivism. It then proceeds to a systematic exposition of scientific realism in the form of transcendental realism, highlighting a conception of (...) science as explanatory of a structured, differentiated and changing world. Turning to the social domain, the book argues for a view of the social order as conditioned by, and emergent from, nature. Advocating a critical naturalism, the author shows how the transformational model of social activity together with the conception of social science as explanatory critique which it entails, resolves the divisions and dualisms besetting orthodox social and normative theory: between society and the individual, structure and agency, meaning and behavior, mind and body, reason and cause, fact and value, and theory and practice. The book then goes on to discuss the emancipatory implications of social science and sketches the nature of the depth investigation characteristically entailed. In the highly innovative third part of the book Roy Bhaskar completes his critique of positivism by developing a theory of philosophical discourse and ideology, on the basis of the transcendental realism and critical naturalism already developed, showing how positivism functions as a restrictive ideology of and for science and other social practices. (shrink)

The past three decades have witnessed a sharp reduction in the rate of growth of public research funding, and sometimes an actual decline in its level. In many countries, this decline has been accompanied by substantial changes in the ways that such funding has been allocated and monitored. In addition, the institutions governing how research is directed and conducted underwent significant reforms. In this paper we examine how these changes have affected scientists’ research goals and practices by comparing the development (...) of three scientific innovations in four European countries, namely Germany, the Netherlands, Switzerland, and Sweden. We find that the increased number of actors exercising authority over research goals does not necessarily lead to a greater diversity of interests funding research. A narrowing of goals and frameworks is especially probable when the increasing importance of external project funding is combined with reductions in state financing of universities and public research institutes. Finally, the growing standardisation of project cycle times and resource packages across funding agencies and scientific communities make it more difficult for researchers to pursue projects that deviate from these norms, especially, if they challenge mainstream beliefs and assessment criteria. (shrink)

Philosophers of science diverge on the question what drives the growth of scientific knowledge. Most of the twentieth century was dominated by the notion that theories propel that growth whereas experiments play secondary roles of operating within the theoretical framework or testing theoretical predictions. New experimentalism, a school of thought pioneered by Ian Hacking in the early 1980s, challenged this view by arguing that theory-free exploratory experimentation may in many cases effectively probe nature and potentially spawn higher evidence-based theories. (...) Because theories are often powerless to envisage workings of complex biological systems, theory-independent experimentation is common in the life sciences. Some such experiments are triggered by compelling observation, others are prompted by innovative techniques or instruments, whereas different investigations query big data to identify regularities and underlying organizing principles. A distinct fourth type of experiments is motivated by a major question. Here I describe two question-guided experimental discoveries in biochemistry: the cyclic adenosine monophosphate mediator of hormone action and the ubiquitin-mediated system of protein degradation. Lacking underlying theories, antecedent data bases, or new techniques, the sole guides of the two discoveries were respective substantial questions. Both research projects were similarly instigated by theory-free exploratory experimentation and continued in alternating phases of results-based interim working hypotheses, their examination by experiment, provisional hypotheses again, and so on. These two cases designate theory-free, question-guided, stepwise biochemical investigations as a distinct subtype of the new experimentalism mode of scientific enquiry. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Emergence of Scientific Culture: Science and the Shaping of Modernity, 1210–1685Helen HattabStephen Gaukroger. The Emergence of Scientific Culture: Science and the Shaping of Modernity, 1210–1685. Oxford: Clarendon Press, 2007. Pp. ix + 563. Cloth, $65.00.The sheer variety of both cognitive and non-cognitive contributions to the emergence of a scientific culture in the West and the complex relations to pre-modern developments that scholars have brought (...) to light over the past decades have put into question both the Enlightenment and Kuhnian accounts of the scientific revolution. Gaukroger’s work performs the ambitious but indispensable task of beginning to formulate an alternative way of understanding this momentous transition, one based on recent scholarship. Gaukroger treats science as both “a particular kind of cognitive product, and as a particular kind of cultural product” (3). His overarching goal is to show that examining the interrelations between the two can teach us something about modernity that focusing on one, to the exclusion of the other, cannot. He argues that the enduring success of Western science was not due to its advances (there were previous advances in other cultures), but due to its ability to consolidate. Successful consolidation promotes the cognitive claims of science and builds a scientific culture to legitimate them. Hence, throughout this book, Gaukroger explores how particular advances (e.g., in astronomy and natural philosophy) were legitimated by their ability to reinforce revelation, unify different disciplines, and exemplify the scientific persona. Since these means of consolidation, unlike methods of scientific discovery, rely on both cultural forces and intellectual advances, Gaukroger makes good on his promise to teach us something that intellectual and cultural histories taken separately cannot.Gaukroger characterizes Western modernity in terms of the eventual assimilation of all cognitive values to scientific ones. He targets the Enlightenment view which, as a result of this assimilation, reinterprets the success of scientific practices over others in ahistorical terms. On this view, the longstanding success of science results solely from cognitive advances, such as the commitment to objectivity (science was assumed to have dissociated itself from religion), the employment of adversarial, non-dogmatic arguments, and the development of quantitative and empirical methods. Gaukroger shows instead that: (1) early modern Epicurean and mechanist natural philosophies forged a closer connection to religious doctrine in response to the ultimate failure to maintain the Thomist reconciliation of theology with Aristotelian natural philosophy; (2) the threat posed by the naturalism of Renaissance philosophers like Pomponazzi led to a privileging of systematization over innovation in late Scholasticism, as well as a renewed interest in natural history, which later spawned the enterprise of physico-theology; (3) the adversarial character of ancient means of cultivating wisdom was rejected in favor of gentlemanly cooperation. This went hand-in-hand with a gradual reassignment of the aims of enquiry from the attainment of a transcendent truth to a productive truth, and the corresponding construction, by Bacon and others, of the scientific persona, which embodied the cognitive virtue of objectivity rather than the ethical virtue of ancient and medieval wisdom. Finally, (4) Beeckman and Descartes failed to achieve the quantification of natural philosophy they aimed for, in large part due to their conflicting commitment to corpuscularian matter theory. The successful replacement of Aristotelian causal explanations in natural philosophy by mechanistic explanations lay in mechanism’s ability to unify all causal explanation, rather than its ability to offer quantitative [End Page 640] explanations of various natural phenomena. Similarly, the experimental methods of Gilbert and Boyle were at first hotly contested, the eventual success of non-foundationalist, empirical approaches owing more to the unifying role played by the experiments of Gilbert, Boyle, and Newton. Although Boyle’s experimental philosophy included a mechanistic matter theory, unlike strict mechanists, experimentalists used experiments to focus and unify heterogeneous phenomena rather than grounding explanations in matter theory.Gaukroger presents the relevant cultural developments and theoretical advances with an impressive degree of detail and accuracy. Readers will gain insights about everything from the differences between early medieval Augustinianism and late medieval Aristotelianism, to Spinozism versus its late seventeenth-century alternatives. Scholars with expertise in specific areas will no doubt take issue with individual claims... (shrink)

ObjectiveTo assess the scientific and ethical basis for clinical innovation in psychopharmacology.MethodsWe conducted a literature review, utilizing MEDLINE search and bibliographic cross-referencing, and historical evidence regarding the discovery and development of new medications in psychiatry. Clinical innovation was defined as use of treatments in a clinical setting which have not been well-proven in a research setting.ResultsEmpirical data regarding the impact of clinical innovation in psychopharmacology are lacking. A conceptual and historical assessment of this topic highlights (...) the ethical and scientific importance of clinical innovation. Ethically, it touches a borderline that, in our judgment, is not adequately framed in contemporary mainstream bioethics. Currently, research is viewed as not at all benefiting the patients who participate in it, while clinical care is viewed as being solely for the benefit of patients. Clinical innovation straddles these two worlds, uncomfortably at times. While many argue that clinical innovation should either be avoided or folded into research projects, we argue that clinical innovation is necessary for progress in psychopharmacology research, and that it can prosper best when guided by the following ethical principles: 1.) The treatment should be based on a viable hypothesis. 2.) Whenever possible, one's clinical observations should be reported so they can be evaluated by the scientific community. 3.) One should be willing to report unexpected observations of drug effects. 4.) A high standard of informed consent should be maintained. Again, this proposal goes against the standard view among bioethicists that research and clinical care are categorically opposed activities, as made clear by the either-or dichotomy of the Belmont Report on bioethics. This approach has so polarized our profession into clinicians versus researchers, that many clinicians will not apply new knowledge produced by clinical research until it eventually gets incorporated into formal treatment guidelines, while researchers have little to guide them as to what kind of new knowledge it is most important to provide.SummaryClinical innovation brings out the ambiguities in our current ethical conceptions of research versus clinical care. Yet, historically, clinical innovation has been an important contributor to progress in psychopharmacology. We argue that clinical innovation should not be discouraged, but rather it should occur under certain ethical conditions."Almost everyone can and should do research...because almost everyone has a unique observational opportunity at some time in his life which he has an obligation to record....If one considers the fundamental operations or methods of research, one immediately realizes that most people do research at some time or another, except that they do not call their activity by that name. There are seven operations....In simple language they are counting, sorting, measuring, comparing, nature-study, guess testing, and reappraisal....Guess testing is of course what most people think of when the word research is mentioned; except that it is bad manners to call a guess a guess. It should be called an hypothesis. Let us make one plea. Guessing becomes merely a game unless it is done in the context of a plan for action. It is a waste of time elaborating untestable hypotheses [1]."John Cade. (shrink)