Online research in philosophy

Kant maintains that his Critique of Pure Reason follows a “synthetic method” which he distinguishes from the analytic method of the Prolegomena by saying that the Critique “rests on no other science” and “takes nothing as given except reason itself”. The paper presents an account of the synthetic method of the Critique, showing how it is related to Kant’s conception of the Critique as the “science of an a priori judging reason”. Moreover, the author suggests, understanding its (...) class='Hi'>synthetic method sheds light on the structure of the Transcendental Deduction, and its function in the work as a whole. (shrink)

Most of Kant's readers have assumed that he demanded explanations for all synthetic a priori claims. I argue that this is not the case, and that Kant accepted some synthetic a priori claims as basic. I further argue that he took himself to be justified in making such claims on the basis of a certain sort of robust reflection. In essence, Kant's method is more like that of the phenomenologists than that of 20th century analytic philosophers.

In the paper we build up the ontology of Leśniewski’s type for formalizing synthetic propositions. We claim that for these propositions an unconventional square of opposition holds, where a, i are contrary, a, o (resp. e, i) are contradictory, e, o are subcontrary, a, e (resp. i, o) are said to stand in the subalternation. Further, we construct a non-Archimedean extension of Boolean algebra and show that in this algebra just two squares of opposition are formalized: conventional and the (...) square that we invented. As a result, we can claim that there are only two basic squares of opposition. All basic constructions of the paper (the new square of opposition, the formalization of synthetic propositions within ontology of Leśniewski’s type, the non-Archimedean explanation of square of opposition) are introduced for the first time. (shrink)

Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie (...) into two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge-making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. (shrink)

This is the published version of a paper presented at the Hegel conference on the occasion of 200 years of Hegel's essay Glauben und Wissen, held in Jena in 2002. It concerns a critical Kantian account of Hegel's critique of Kant.

In twentieth-century Kant scholarship, few have provided an account of the analytic-synthetic distinction and of the problem of the synthetic a priori that takes into consideration the views of Kant's idealist successors such as Maimon, Fichte, Schelling, and Hegel. I first explain how Kant formulates the analytic-synthetic distinction in terms of the determinate-indeterminate distinction, which, in turn, is based on the distinction between general and transcendental logic. Kant's problem of the synthetic a priori , then, is (...) the problem of showing how the logical forms of judgment can be employed determinately (and not merely indeterminately). I then show that Maimon also formulates the distinction and the problem in the same way, and that his interpretation will shape how Fichte, Schelling, and Hegel each construe and address Kant's question, How are synthetic judgments possible a priori ? (shrink)

If I understand him correctly, Derek Parfit’s views place us, philosophically speaking, in a very small box. According to Parfit, normativity is an irreducible non-natural property that is independent of the human mind. That is to say, there are normative truths - truths about what we ought to do and to want, or about reasons for doing and wanting things. The truths in question are synthetic a priori truths, and accessible to us only by some sort of rational intuition. (...) Parfit supposes that if we are to preserve the irreducibility of the normative, this is just about all we can say, at least until we bring in some actual intuitions to supply the story with some content. (shrink)

The aim of this paper1 is to attack Quine’s views on the analytic-synthetic distinction (ASD), but more than half of it will be devoted to arguing that an attack is still required. This preliminary thesis is based on the claim that what Quine presents as (1) an attack on the ASD, followed by (2) some remarks about confirmation and disconfirmation, offers a more formidable obstacle to the adherent of the traditional ASD if (2) is built into (1) as a (...) positive but unwelcome theory of the.. (shrink)

I want to analyse the Quine-Carnap discussion on analyticity with regard to logical, mathematical and set-theoretical statements. In recent years, the renewed interest in Carnap’s work has shed a new light on the analytic-synthetic debate. If one fully appreciates Carnap’s conventionalism, one sees that there was not a metaphysical debate on whether there is an analytic-synthetic distinction, but rather a controversy on the expedience of drawing such a distinction. However, on this view, there can be no longer a (...) single analytic-synthetic distinction, because several kinds of statements could be regarded as analytic (L-determinate). L-equivalence between extra-logical linguistic predicates has already been heavily debated. The recent consensus states that Quine’s rejection of this analytic-synthetic is pragmatically grounded in his linguistic behaviorism. However, Carnap’s logical frameworks also contain other kinds of statements, and it is worthwhile to compare both Quine and Carnap’s grounds for considering these statements as analytic or not analytic. First, I will discuss logical statements. I will argue that Quine draws a very sharp distinction between first order logic and set theory, which should be regarded as a (pragmatic) analytic-synthetic distinction (as Quine admits in an interview, see Theoria, 40, 1994, p. 199). In fact, Quine’s major worry is whether identity statements are analytic. Second, I will discuss mathematical statements. In Carnap’s Foundations of Logic and Mathematics, it is clear that mathematical statements are analytic. For Quine, all mathematical statements are reducible to set-theoretical statements. Third, I discuss the analyticity of set-theoretical statements. For Quine, the membership predicate should be regarded as an interpreted extra-logical predicate. Quine’s work in set theory and his later philosophy of set theory naturally lead to the view that set-theoretical statements cannot be analytic. A major complication for the Quine-Carnap comparison is that Carnap has no elaborate reflections on set theory, while the influence of set theory on Quine’s views can hardly be underestimated. I conclude with some lessons for the contemporary debate on analyticity. (shrink)

This paper concentrates on some aspects of the history of the analytic-synthetic distinction from Kant to Bolzano and Frege. This history evinces considerable continuity but also some important discontinuities. The analytic-synthetic distinction has to be seen in the first place in relation to a science, i.e. an ordered system of cognition. Looking especially to the place and role of logic it will be argued that Kant, Bolzano and Frege each developed the analytic-synthetic distinction within the same conception (...) of scientific rationality, that is, within the Classical Model of Science: scientific knowledge as cognitio ex principiis . But as we will see, the way the distinction between analytic and synthetic judgments or propositions functions within this model turns out to differ considerably between them. (shrink)

Roderick Chisholm appears to agree with Kant on the question of the existence of synthetic a priori knowledge. But Chisholm’s conception of the a priori is a traditional Aristotelian conception and differs markedly from Kant’s. Closer scrutiny reveals that their agreement on the question of the synthetic a priori is merely verbal: what Kant meant to affirm, Chisholm denies. Curiously, it looks as if Chisholm agreed on all substantive issues with the empiricist rejection of Kant’s synthetic a (...) priori. In the end, it turns out that Chisholm disagrees with both, empiricism and Kant, over a fundamental question: whether mere understanding of the contents of our thoughts must always remain within the circle of our own ideas or can provide us with genuine knowledge of matters of fact. (shrink)

Two of W. V. Quine''s most familiar doctrines are his endorsement of the distinction between underdetermination and indeterminacy, and his rejection of the distinction between analytic and synthetic truths. The author argues that these two doctrines are incompatible. In terms wholly acceptable to Quine, and based on the underdetermination/indeterminacy distinction, the author draws an exhaustive and exclusive distinction between two kinds of true sentences, and then argues that this corresponds to the traditional analytic/synthetic distinction. In an appendix the (...) author expands on one aspect of the underdetermination/indeterminacy distinction, as construed here, and discusses, in passing, some of Quine''s more general views on truth. (shrink)

It is often assumed that there is a close connection between Quine's criticism of the analytic/synthetic distinction, in 'Two dogmas of empiricism' and onwards, and his thesis of the indeterminacy of translation, in Word and Object and onwards. Often, the claim that the distinction is unsound (in some way or other) is taken to follow from the indeterminacy thesis, and sometimes the indeterminacy thesis is supported by such a claim. However, a careful scrutiny of the indeterminacy thesis as stated (...) by Quine, and the varieties of the analytic/synthetic distinction, reveals that the two claims are mutually independent. Neither does the claim that the distinction is unsound follow from the indeterminacy thesis, nor that thesis from unsoundness claim, under any of the common interpretations of the analytic/synthetic distinction. (shrink)

The emergent new science of synthetic biology is challenging entrenched distinctions between, amongst others, life and non-life, the natural and the artificial, the evolved and the designed, and even the material and the informational. Whenever such culturally sanctioned boundaries are breached, researchers are inevitably accused of playing God or treading in Frankenstein’s footsteps. Bioethicists, theologians and editors of scientific journals feel obliged to provide an authoritative answer to the ambiguous question of the ‘meaning’ of life, both as a scientific (...) definition and as an explication with wider existential connotations. This article analyses the arguments mooted in the emerging societal debates on synthetic biology and the way its practitioners respond to criticism, mostly by assuming a defiant posture or professing humility. It explores the relationship between the ‘playing God’ theme and the Frankenstein motif and examines the doctrinal status of the ‘playing God’ argument. One particularly interesting finding is that liberal theologians generally deny the religious character of the ‘playing God’ argument—a response which fits in with the curious fact that this argument is used mainly by secular organizations. Synthetic biology, it is therefore maintained, does not offend so much the God of the Bible as a deified Nature. While syntheses of artificial life forms cause some vague uneasiness that life may lose its special meaning, most concerns turn out to be narrowly anthropocentric. As long as synthetic biology creates only new microbial life and does not directly affect human life, it will in all likelihood be considered acceptable. (shrink)

In this paper we examine the following problems: How many concepts of function are there in biology, social science, and technology? Are they logically related and if so, how? Which of these function concepts effect a functional explanation as opposed to a mere functional account? What are the consequences of a pluralist view of functions for functionalism? We submit that there are five concepts of function in biology, which are logically related in a particular way, and six function concepts in (...) social science and technology. Only two of them may help effect a genuine functional explanation. Finally, our synthetic approach allows us to distinguish four different varieties of functionalism in biology, psychology, social science, and technology: formalist, black boxist, adaptationist, and teleological. And only one of them is explanatory in the strong sense defended here. (shrink)

W. V. O. Quine’s assault on the analytic/synthetic distinction is one of the most celebrated events in the history of twentieth century philosophy. This paper shines a light on Quine’s own understanding of the history of this distinction. More specifically, this paper argues, contrary to what seems to be the received view, that Quine explicitly recognized a kindred subversive spirit in David Hume.

The Analytic/Synthetic distinction did not originate in Kant, but in Port-Royal's logical theory. The key for the doctrine is the explicite recognition of two different kinds of relative clauses, e.g. explicative and determinative. In the middle eighteenth century the distinction becomes a topic within the grammars. Although we can find by grammarians different criteria for the distinction, these criteria (for which we can find medieval sources) are for the main predictable from the original theory of ideas, which was presented (...) in Port-Royal's logical writings. The topic of the two relative clauses (somewhat broader than the analytic/synthetic distinction) can be used to give empirical criteria for analyticity and also for revisiting Quine's criticism of the topic. Analyticity yet appears as a master piece of classical linguistic philosophy and not as being the empty dogma of modern empiricism. (shrink)

The phrase ‘synthetic biology’ is used to describe a set of different scientific and technological disciplines, which share the objective to design and produce new life forms. This essay addresses the following questions: What conception of life stands behind this ambitious objective? In what relation does this conception of life stand to that of traditional biology and biotechnology? And, could such a conception of life raise ethical concerns? Three different observations that provide useful indications for the conception of life (...) in synthetic biology will be discussed in detail: 1. Synthetic biologists focus on different features of living organisms in order to design new life forms, 2. Synthetic biologists want to contribute to the understanding of life, and 3. Synthetic biologists want to modify life through a rational design, which implies the notions of utilising, minimising/optimising, varying and overcoming life. These observations indicate a tight connection between science and technology, a focus on selected aspects of life, a production-oriented approach to life, and a design-oriented understanding of life. It will be argued that through this conception of life synthetic biologists present life in a different light. This conception of life will be illustrated by the metaphor of a toolbox. According to the notion of life as a toolbox, the different features of living organisms are perceived as various rationally designed instruments that can be used for the production of the living organism itself or secondary products made by the organism. According to certain ethical positions this conception of life might raise ethical concerns related to the status of the organism, the motives of the scientists and the role of technology in our society. (shrink)

Social scientific and humanistic research on synthetic biology has focused quite narrowly on questions of epistemology and ELSI. I suggest that to understand this discipline in its full scope, researchers must turn to the objects of the field—synthetic biological artifacts—and study them as the objects in the making of a science yet to be made. I consider one fundamentally important question: how should we understand the material products of synthetic biology? Practitioners in the field, employing a consistent (...) technological optic in the study and construction of biological systems, routinely employ the mantra ‘biology is technology’. I explore this categorization. By employing an established definition of technological artifects drawn from the philosophy of technology, I explore the appropriateness of attributing to synthetic biological artifacts the four criteria of materiality, intentional design, functionality, and normativity. I then explore a variety of accounts of natural kinds. I demonstrate that synthetic biological artifacts fit each kind imperfectly, and display a concomitant ontological ‘messiness’. I argue that this classificatory ambivalence is a product of the field’s own nascence, and posit that further work on kinds might help synthetic biology evaluate its existing commitments and practices. (shrink)

The Presidential Commission for the Study of Bioethical Issues released its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, on December 16, 2010.1 President Barack Obama had requested this report following the announcement last year that the J. Craig Venter Institute had created the world’s first self-replicating bacterial cell with a completely synthetic genome. The Venter group’s announcement marked a significant scientific milestone in synthetic biology, an emerging field of research that aims to (...) combine the knowledge and methods of biology, engineering, and related disciplines in the design of chemically synthesized DNA to create organisms with novel or enhanced .. (shrink)

This paper contends that the first argument of Hume's "Of scepticism with regard to reason" entails that humans have no knowledge as Hume understands knowledge. In defending this claim, we also see how Hume's argument anticipates an important aspect of an extremely influential 20th century development: the collapse of the analytic/synthetic distinction.

Van den Belt recently examined the notion that synthetic biology and the creation of ‘artificial’ organisms are examples of scientists ‘playing God’. Here I respond to some of the issues he raises, including some of his comments on my previous discussions of the value of the term ‘life’ as a scientific concept.

Artificial life can take two forms: synthetic and virtual. In principle, the materials and properties of synthetic living systems could differ radically from those of natural living systems yet still resemble them enough to be really alive if they are grounded in the relevant causal interactions with the real world. Virtual (purely computational) "living" systems, in contrast, are just ungrounded symbol systems that are systematically interpretable as if they were alive; in reality they are no more alive than (...) a virtual furnace is hot. Virtual systems are better viewed as "symbolic oracles" that can be used (interpreted) to predict and explain real systems, but not to instantiate them. The vitalistic overinterpretation of virtual life is related to the animistic overinterpretation of virtual minds and is probably based on an implicit (and possibly erroneous) intuition that living things have actual or potential mental lives. (shrink)

A somewhat simplified version of Jerrold J. Katz's theory of the analytic/synthetic distinction for natural languages is presented. Katz's account is criticized on the following grounds. (1) the antonymy operator is not well defined; it leaves certain sentences without readings. (2) The account of negation is defective; it has the consequence that certain nonsynonymous sentences are marked as synonymous. (3) The account of entailment is defective; it has the consequence that analytic sentences entail synthetic ones. (4) Katz's account (...) of indeterminable sentences is criticized; it has the consequence that certain logical truths are not marked as analytic. (5) Katz's semantics provides no account of truth, so that he is unable to show that analytic sentences are true and that indeterminable sentences are not. (shrink)

Not all research in machine consciousness aims to instantiate phenomenal states in artefacts. For example, one can use artefacts that do not themselves have phenomenal states, merely to simulate or model organisms that do. Nevertheless, one might refer to all of these pursuits -- instantiating, simulating or modelling phenomenal states in an artefact -- as 'synthetic phenomenality'. But there is another way in which artificial agents (be they simulated or real) may play a crucial role in understanding or creating (...) consciousness: 'synthetic phenomenology'. Explanations involving specific experiential events require a means of specifying the contents of experience; not all of them can be specified linguistically. One alternative, at least for the case of visual experience, is to use depictions that either evoke or refer to the content of the experience. Practical considerations concerning the generation and integration of such depictions argue in favour of a synthetic approach: the generation of depictions through the use of an embodied, perceiving and acting agent, either virtual or real. Synthetic phenomenology, then, is the attempt to use the states, interactions and capacities of an artificial agent for the purpose of specifying the contents of conscious experience. This paper takes the first steps toward seeing how one might use a robot to specify the non- conceptual content of the visual experience of an (hypothetical) organism that the robot models. (shrink)

It is a most commonly accepted hypothesis that life originated from inanimate matter, somehow being a synthetic product of organic aggregates, and as such, a result of some sort of prebiotic synthetic biology. In the past decades, the newly formed scientific discipline of synthetic biology has set ambitious goals by pursuing the complete design and production of genetic circuits, entire genomes or even whole organisms. In this paper, I argue that synthetic biology might also shed some (...) novel and interesting perspectives on the question of the origin of life, and that, in addition, it might challenge our most commonly accepted definitions of life, thereby changing the ways we might think about life and its origin. (shrink)

In his essay “Logical Empiricism”, in the anthology Twentieth Century Philosophy, Professor Feigl writes: “All forms of empiricism agree in repudiating the existence of synthetic a priori knowledge.” Schlick makes the same point even more forcibly: “The empiricism which I represent believes itself to be clear on the point that, as a matter of principle, all propositions are either synthetic a posteriori or tautologous; synthetic a priori propositions seem to it to be a logical impossibility.” The denial (...) of synthetic a prioris is a major thesis of the logical empiricist position, being found in the writings of most of the leaders of the movement. The reason for its importance is fairly clear. It provides a formula on which the empiricists can base their critique of traditional philosophy. To use Ayer's phrase, denial of the synthetic a priori results in “the elimination of metaphysics”. The philosophical tradition to which the empiricists are opposed and whose “metaphysics” they wish to eliminate can be called, somewhat loosely, rationalism. (shrink)

One of the indisputable signs of the progress made in organic chemistry over the last two hundred years is the increased ability of chemists to manipulate, control and design chemical reactions. The technological expertise manifest in contemporary synthetic organic chemistry is, at least in part, due to developments in the theory of organic chemistry. By appealing to a notable chemist’s attempts to articulate and codify the heuristics of synthetic design, this paper investigates how understanding theoretical organic chemistry facilitates (...) progress in synthetic organic chemistry. The picture that emerges of how the applications of organic chemistry are grounded in its theory is contrasted with both standard and some more contemporary philosophical accounts of the applications of science. (shrink)

Hans Reichenbach is well known for his limiting frequency view of probability, with his most thorough account given in The Theory of Probability in 1935/1949. Perhaps less known are Reichenbach’s early views on probability and its epistemology. In his doctoral thesis from 1915, Reichenbach espouses a Kantian view of probability, where the convergence limit of an empirical frequency distribution is guaranteed to exist thanks to the synthetic a priori principle of lawful distribution. Reichenbach claims to have given a purely (...) objective account of probability, while integrating the concept into a more general philosophical and epistemological framework. A brief synopsis of Reichenbach’s thesis and a critical analysis of the problematic steps of his argument will show that the roots of many of his most influential insights on probability and causality can be found in this early work. (shrink)

Popper uses the "Humean challenge" as a justification for his falsificationism. It is claimed that in his basic argument he confuses two different doubts: (a) the Humean doubt (Popper's problem of induction), and (b) the "Popperean" doubt whether - presupposing that there are laws of nature - the laws we accept are in fact valid. Popper's alleged solution of the problem of induction does not solve the problem in a straightforward way (as Levison and Salmon have remarked before). But if (...) Popper's solution of the Humean challenge is re-interpreted as being close to Kant's it makes sense. Even though Popper explicitly rejects Kant's synthetic judgements a priori, it is claimed here that this is so because he misinterprets Kant's argument. If he had understood Kant correctly he should have been a modern "Kantianer"! (shrink)

Synthetic biology, an emerging field of science and technology, intends to make of the natural world a substrate for engineering practice. Drawing inspiration from conventional engineering disciplines, practitioners of synthetic biology hope to make biological systems standardized, calculable, modular, and predictably functional. This essay develops a Heideggerian reading of synthetic biology as a useful perspective with which to identify and explore key facets of this field, its knowledge, its practices, and its products. After overviews of synthetic (...) biology and Heidegger’s account of technology, I discuss calculability, utility, function, setting-upon, and ordering, with the aim of discussing the manner in which synthetic biology works to render the biological world intelligible as something to be used, rather than something that is in and of itself. Having developed this Heideggerian reading, I proffer a number of corrections to his account that enable a more accurate, nuanced understanding of synthetic biology. Specifically, I discuss the notion of Ge-stell and submit that multiple systems of “enframing” may help to make Heidegger’s argument more robust. I suggest that synthetic biology may work to reveal the natural world as a standing-reserve of function. (shrink)

Some religious believers may see synthetic biology as usurping God's creative role. The Catholic Church has yet to issue a formal teaching on the field (though it has issued some informal statements in response to Craig Venter's development of a ‘synthetic’ cell). In this paper I examine the likely reaction of the Catholic Magisterium to synthetic biology in its entirety. I begin by examining the Church's teaching role, from its own viewpoint, to set the necessary backround and (...) context for the discussion that follows. I then describe the Church's attitude to science, and particularly to biotechnology. From this I derive a likely Catholic theology of synthetic biology.The Church's teachings on scientific and biotech research show that it is likely to have a generally positive disposition to synbio, if it and its products can be acceptably safe. Proper evaluation of, and protection against, risk will be a significant factor in determining the morality of the research. If the risks can be minimized through regulation or other means, then the Church is likely to be supportive. The Church will also critique the social and legal environment in which the research is done, evaluating issues such as the patenting of scientific discoveries and of life. (shrink)

THERE IS A CLEAR DISTINCTION BETWEEN ANALYTIC AND SYNTHETIC SENTENCES IF WE DEFINE AN ANALYTIC SENTENCE AS ONE WHICH ENTAILS A SELF-CONTRADICTION. THE PAPER SHOWS THAT ALTHOUGH THIS DEFINES "ANALYTIC" BY TERMS WHICH ARE THEMSELVES ALSO MODAL TERMS, THESE LATTER TERMS CAN BE EXPLAINED BY DEFINITIONS USING LESS TECHNICAL TERMS AND BY EXAMPLES, IN SUCH A WAY AS TO GIVE "ANALYTIC" AS CLEAR A MEANING AS IS POSSESSED BY MOST OTHER TERMS OF OUR LANGUAGE. THE FACT THAT THERE ARE (...) BORDER-LINE CASES OF ANALYTIC SENTENCES, AND THAT APPARENTLY SOME OBVIOUS CASES OF ANALYTIC SENTENCES TURN OUT TO BE SYNTHETIC IS NO GOOD OBJECTION TO THE CLARITY OF THE DISTINCTION. IF WE DEFINE AN ANALYTIC SENTENCE AS ONE REDUCIBLE TO A TRUTH OF LOGIC BY SUBSTITUTION OF SYNONYMS, THIS DEFINITION PICKS OUT A DIFFERENT CLASS OF SENTENCES AS ANALYTIC, BUT IT ALSO ALLOWS US TO MAKE A CLEAR DISTINCTION BETWEEN THE ANALYTIC AND THE SYNTHETIC. (shrink)

Synthetic biologists aim to generate biological organisms according to rational design principles. Their work may have many beneficial applications, but it also raises potentially serious ethical concerns. In this article, we consider what attention the discipline demands from bioethicists. We argue that the most important issue for ethicists to examine is the risk that knowledge from synthetic biology will be misused, for example, in biological terrorism or warfare. To adequately address this concern, bioethics will need to broaden its (...) scope, contemplating not just the means by which scientific knowledge is produced, but also what kinds of knowledge should be sought and disseminated. (shrink)

Most of the reports on synthetic biology include not only familiar topics like biosafety and biosecurity but also a chapter on ‘ethical concerns’; a variety of diffuse topics that are interrelated in some way or another. This article deals with these ‘ethical concerns’. In particular it addresses issues such as the intrinsic value of life and how to deal with ‘artificial life’, and the fear that synthetic biologists are tampering with nature or playing God. Its aim is to (...) analyse what exactly is the nature of the concerns and what rationale may lie behind them. The analysis concludes that the above-mentioned worries do not give genuine cause for serious concern. In the best possible way they are interpreted as slippery slope arguments, yet arguments of this type need to be handled with care. It is argued that although we are urged to be especially vigilant we do not have sufficiently cogent reasons to assume that synthetic biology will cause such fundamental hazards as to warrant restricting or refraining from research in this field. (shrink)

This dissertation is a critique of synthetic ethical naturalism (SEN). SEN is a view in metaethics that comprises three key theses: first, there are moral properties and facts that are independent of the beliefs and attitudes of moral appraisers (moral realism); second, moral properties and facts are identical to (or constituted only by) natural properties and facts (ethical naturalism); and third, sentences used to assert identity or constitution relations between moral and natural properties are expressions of synthetic, a (...) posteriori necessities. The last of these theses, which distinguishes SEN from other forms of ethical naturalism, is supported by a fourth: the semantic contents of the central moral predicates such as 'morally right' and 'morally good' are fixed in part by features external to the minds of speakers (moral semantic externalism). Chapter 1 introduces SEN and discusses the most common motivations for accepting it. The next three chapters discuss the influential "Moral Twin Earth" argument against moral semantic externalism. In Chapter 2, I defend this argument from the charge that the thought experiment upon which it depends is defective. In Chapters 3 and 4, I consider two attempts to amend SEN so as to render it immune to the Moral Twin Earth argument. I show that each of these proposed amendments amounts to an abandonment of SEN. Chapter Five explores Richard Boyd's proposal that moral goodness is a "homeostatic property cluster." If true, Boyd's hypothesis could be used to support several metaphysical, epistemological, and semantic claims made on behalf of SEN. I advance three arguments against this account of moral goodness. In the sixth chapter, I argue that moral facts are not needed in the best a posteriori explanations of our moral beliefs and moral sensibility. Because of this, those who accept a metaphysical naturalism ought to deny the existence of such facts or else accept skepticism about moral knowledge. In Chapter 7, I consider a counterargument on behalf of SEN to the effect that moral facts are needed in order to explain the predictive success of our best moral theories. I show that this argument fails. (shrink)

Recent developments in synthetic biology are described and characterized as moving the era of biotechnology into platform technologies. Platform technologies enable rapid and diffuse innovations and simultaneous product development in diffuse markets, often targeting sectors of the economy that have traditionally been thought to have little relationship to one another. In the case of synthetic biology, pharmaceutical and biofuel product development are occurring interactively. But the regulatory and ethical issues associated with these two applications share very little overlap. (...) As such, there is some risk that focus on traditional medical applications, for which the ethical expertise is highly developed, will overshadow the ethical issues that arise in connection with land use and its attendant socioeconomic consequences, especially in the developing world. The 2010 report of the Presidential Commission for the Study of Bioethics exhibits this tendency. (shrink)

Synthetic biology aims at designing biological systems, at building ‘living machines’. The emergence of synthetic biology has reignited the cycle of public debate. The old biotechnology debate is being reiterated and the controversies are deepened. The societal debate follows the technological hype cycle. A new technology with a high visibility and high expectations also raises high controversies. For synthetic biology, this hype is currently near its peak and the first signs of disillusionment are getting visible. In policy (...) development, on the other hand, synthetic biology is in the early stages. Governments examine the need for adaptations to existing regulatory frameworks. There is a gap between the visibility of the technological developments and policy formulation. This gap is crucial for technology assessment: while the hype in public attention is over, essential policy steps are taken. In order to close this gap, technology assessment needs to facilitate the societal–ethical debate when media attention, and thus the visibility of the technological developments, declines. (shrink)

I describe two approaches to modelling the universe, the one having its origin in topos theory and differential geometry, the other in set theory. The first is synthetic differential geometry. Traditionally, there have been two methods of deriving the theorems of geometry: the analytic and the synthetic. While the analytical method is based on the introduction of numerical coordinates, and so on the theory of real numbers, the idea behind the synthetic approach is to furnish the subject (...) of geometry with a purely geometric foundation in which the theorems are then deduced by purely logical means from an initial body of postulates. The most familiar examples of the synthetic geometry are classical Euclidean geometry and the synthetic projective geometry introduced by Desargues in the 17th century and revived and developed by Carnot, Poncelet, Steiner and others during the 19th century. The power of analytic geometry derives very largely from the fact that it permits the methods of the calculus, and, more generally, of mathematical analysis, to be introduced into geometry, leading in particular to differential geometry (a term, by the way, introduced in 1894 by the Italian geometer Luigi Bianchi). That being the case, the idea of a “synthetic” differential geometry seems elusive: how can differential geometry be placed on a “purely geometric” or “axiomatic” foundation when the apparatus of the calculus seems inextricably involved? To my knowledge there have been two attempts to develop a synthetic differential geometry. The first was initiated by Herbert Busemann in the 1940s, building on earlier work of Paul Finsler. Here the idea was to build a differential geometry that, in its author’s words, “requires no derivatives”: the basic objects in Busemann’s approach are not differentiable manifolds, but metric spaces of a certain type in which the notion of a geodesic can be defined in an intrinsic manner. I shall not have anything more to say about this approach. The second approach, that with which I shall be concerned here, was originally proposed in the 1960s by F.. (shrink)

Kant’s Critique of Pure Reason (KrV) presents a priori knowledge of synthetic truths as posing a philosophical problem of great import whose only possible solution vindicates the system of transcendental idealism. The work does not accord any such significance to a priori knowledge of analytic truths. The intelligibility of the contrast rests on the well-foundedness of Kant’s analytic–synthetic distinction and on his claim to objectively or correctly classify key judgments with respect to it. Though the correctness of Kant’s (...) classification is vital to his philosophical project, it has been vigorously challenged since he introduced his famous distinction of judgments. The aim of this essay is to explore several .. (shrink)

Computation and philosophy intersect three times in this essay. Computation is considered as an object, as a method, and as a model used in a certain line of philosophical inquiry concerning the relation of mind to matter. As object, the question considered is whether computation and related notions of mental representation constitute the best ways to conceive of how physical systems give rise to mental properties. As method and model, the computational techniques of artificial life and embodied evolutionary connectionism are (...) used to conduct prosthetically enhanced thought experiments concerning the evolvability of mental representations. Central to this essay is a discussion of the computer simulation and evolution of three-dimensional synthetic animals with neural network controllers. The minimally cognitive behavior of finding food by exhibit- ing positive chemotaxis is simulated with swimming and walking creatures. These simulations form the basis of a discussion of the evolutionary and neurocomputa- tional bases of the incremental emergence of more complex forms of cognition. Other related work has been used to attack computational and representational theories of cognition. In contrast, I argue that the proper understanding of the evolutionary emergence of minimally cognitive behaviors is computational and representational through and through. (shrink)

In this essay we show how certain tendencies of theself are enhanced and hindered by technologicallyorganized places. We coordinate a cognitive andbehavioral technology for the control of personalidentity with the technologically totalizedenvironments that we call synthetic sites. Weproceed by describing Mihaly Csikszentmihalyi''sstrategy for intensifying experience and organizingthe self. Walt Disney World is then considered as theexample, par excellence, of a synthetic sitethat promotes ordered experience via self-shrinkage. Finally, we reflect briefly on problems andpossibilities of human life lived in (...) a world that canbe described with increasing accuracy as anarchipelago of synthetic sites. (shrink)

For the last couple of years, The Hastings Center has been running a research project titled “The Ethical Issues of Synthetic Biology” (funded by the Alfred P. Sloan Foundation) that is focused primarily on whether the prospect of altering microorganisms to meet human ends is intrinsically troubling. “Synthetic biology” is not necessarily limited to the alteration of microorganisms, but the applications now under development—such as yeast that produce a precursor of the antimalarial drug artemisinin or blue-green algae that (...) produce fuel—are certainly limited to that. A set of essays in this issue of the Report features a variety of different takes on the field. For the last six months of the project .. (shrink)

Kant’s analytic-synthetic distinction is often construed in terms of the question of whether or not the predicate is contained in or can be derived from the concept of the subject. Few have observed that Kant has another formulation of the distinction, a formulation that is based on the determinate-indeterminate distinction. In fact, it is this formulation that will shape the development of one of the main tasks of post-Kantian German idealism. It is my aim to explain how Kant, Maimon, (...) and Fichte each define and address the problem of the synthetic a priori in terms of the determinate-indeterminate distinction. (shrink)

The term \synthetic phenomenology" refers to: 1) any attempt to characterize the phenomenal states possessed, or modeled by, an artefact (such as a robot); or 2) any attempt to use an artefact to help specify phenomenal states (independently of whether such states are possessed by a naturally conscious being or an artefact). The notion of synthetic phenomenology is clari¯ed, and distinguished from some related notions. It is argued that much work in machine consciousness would bene¯t from being more (...) cognizant of the need for synthetic phenomenology of the ¯rst type, and of the possible forms it may take. It is then argued that synthetic phenomenology of the second type looks set to resolve some problems confronted by standard, nonsynthetic attempts at characterizing phenomenal states. An example of the second form of synthetic phenomenology is given. (shrink)

The topic of synthetic life has long been a subject for science fiction writers, philosophers, and even scientists. With the announcement in 2010 by renowned biologist J. Craig Venter that he and a team of scientists from the J. Craig Venter Institute (JCVI) had created a bacterial cell with chemically synthesized genome, discussions of synthetic life were no longer just conjecture.Humans had assembled nonliving components to make a living cell (Gibson et al. 2010). I was one of the (...) leaders of that endeavor, and this article will be a first-person account of how we made our cell, along with my conjectures about what will come next in the new fields of synthetic biology and synthetic genomics.Scanning electron .. (shrink)

: This essay addresses the difficulties that sociology as a discipline continues to experience in grasping the relations between technology, science and the social. I argue that these difficulties stem from a resolute centering of sociology on the social, which follows a generically Durkheimian blueprint. I elaborate a response to these difficulties which derives from recent lines of work in science and technology studies, and which entails a decentering of the social relative to the material and the conceptual, in terms (...) of both objects of analysis and explanatory formats. In order to display the direct sociological relevance of this approach, I move to the macro level, developing the conceptual apparatus of a decentered social theory via the discussion of a historical example of major sociological significance—the systematic gearing together of scientific research, technological innovation and industrial production that originated in the synthetic dye industry in the second half of the nineteenth century. Besides the interest of the topic itself, the aim is thus to exemplify in some detail what a decentered sociology might look like, both empirically and conceptually. (shrink)

This article is devoted to the question: does the Duhemian argument support the position taken by those contemporary philosophers who--like W. V. O. Quine and M. White--reject the distinction between analytic and synthetic statements? The term "Duhemian argument" is used to refer to the following statement: it is impossible to put to the test one isolated empirical statement; testing empirical statements involves testing a whole group of hypotheses. An analysis of the logical structure of reductive reasoning leads to the (...) conclusion that the Duhemian argument is valid and that it entails the following statements: (1)--experience alone cannot compel us absolutely to the acceptance of any isolated empirical statement whatsoever, independently of our acceptance or rejection of some other statements, and (2)--no isolated empirical statement can be conclusively falsified by experience, independently of our acceptance or rejection of some other statements. The Duhemian argument seems then to establish conclusively the cogency of the claim that, in principle, it is possible to reject or to maintain any particular empirical statement, provided we make appropriate changes in the system of hypotheses which is put to test. The philosophers who reject the distinction between analytic and synthetic statements--in particular Quine--claim that the same line of reasoning supports their contention. It is alleged that: (1)--the Duhemian argument makes impossible a definition of statement synonymy and, consequently, a definition of analyticity in terms of synonymy, and (2)--that the unit of empirical significance is the whole of science or the total science, and (3)--that it is a folly to seek a boundary between synthetic and analytic statements, because all our statements are equally open to revision. The article tries to show that these conclusions do not follow from the Duhemian argument. In particular it is shown: (1)--that the Duhemian argument does not exclude the definition of statement synonymy, (2)--that this argument does not support the contention that the enigmatic entity called "the whole of science" or the "total science" is involved in each and every testing procedure, (3)--that the principle of fundamental revisability of every statement does not change the fact that in scientific practice the situation is never so hopeless as the Duhemian argument seems to imply, because even inconclusive arguments may differ in their adequacy, and (4)--that the term "revision" is ambiguous and only this ambiguity lends an air of plausibility to Quine's formulations. The conclusion is that the Duhemian line of reasoning does not support the contention of philosophers who reject the distinction between analytic and synthetic statements. (shrink)

In this paper, I suggest that the important philosophy of the future will increasingly be found neither in the “continental” nor in the “analytic” traditions but, instead, in the transcending sublation of (all) traditions I call “synthetic philosophy.” I mean “synthetic” both in a sense that encourages the bold combinatorial mélange of existing styles, traditions, and issues, and also in the Hegelian sense of sublating dichotomous oppositions, appropriating the distinctive insights of both sides while eliminating their errors and (...) exaggerations, and thereby creating new syntheses in which the old oppositions are transcended. (shrink)

Zhong 中 is a very important philosophical concept in early Confucianism. Both the received ancient Confucian classics and the newly discovered ancient bamboo manuscripts tell us that adhering to the principle of zhong was an important charge that had been transmitted and inherited by early ancient Chinese political leaders from generation to generation. Confucius and his followers adopted the concept of zhong and further developed it into a sophisticated doctrine, which is usually called zhongdao 中道 (the Way of zhong) or (...) zhongyong 中庸. Being a polysemous word, zhong has several different but philosophically related meanings. However, for a long time, people usually understood zhong in the sense of only one of its meanings, and zhongdao or zhongyong has been commonly interpreted as “the doctrine of the mean.” My argument in this paper is that a synthetic interpretation, which includes all the semantic meanings of zhong is necessary in order to acquire a deep and well-rounded comprehension of the philosophical significance of the Way of zhong. The Way of zhong features a dialectal view of the relationship between heaven and human beings, mind and materials, subjective desire and the available objective conditions, self and others, centrality and diversity, and so on. The Way of zhong has become a widely applied philosophical methodology in Confucianism, as well as a political principle and a kind of personal moral merit in early Confucian doctrines. Today, it still has relevance in contemporary Chinese social and cultural contexts. (shrink)

This article addresses Kant's distinction between a synthetic and an analytic method in philosophy. I will first consider how some commentators have accounted for Kant's distinction and analyze some passages in which Kant defined the analytic and the synthetic method. I will suggest that confusion about Kant's distinction arises because he uses it in at least two different senses. I will then identify a specific way in which Kant accounts for this distinction when he is differentiating between mathematical (...) and philosophical syntheses. I will examine Kant's arguments in the Critique of Pure Reason with the latter sense of the distinction in mind. I will evaluate if he uses the analytic or the synthetic method and if the synthetic method is able to identify, without a previous consideration of some sort of given knowledge, sufficient conditions for deriving some aspects of our knowledge. (shrink)

One of the indisputable signs of the progress made in organic chemistry over the last two hundred years is the increased ability of chemists to manipulate, control, and design chemical reactions. The technological expertise manifest in contemporary synthetic organic chemistry is, at least in part, due to developments in the theory of organic chemistry. By appealing to a notable chemist's attempts to articulate and codify the heuristics of synthetic design, this paper investigates how understanding theoretical organic chemistry facilitates (...) progress in synthetic organic chemistry. The picture that emerges of how the applications of organic chemistry are grounded in its theory is contrasted with both standard and some more contemporary philosophical accounts of the applications of science. (shrink)

Paul Thompson argues that current synthetic biology amounts to synthetic genomics, comprising a ?platform? technology, and that Christopher Preston's deontological objections based on its supposed rejection of the historical process of evolution miscarry. This makes it surprising that Thompson's normative ethic consists in a deontological appeal to Kantian duties of imperfect obligation. Construed as obligations subject to choice, such constraints risk being excessively malleable where the ethical objections to deployment of this technology concern land rights and/or exploitation. Thompson's (...) advocacy of processes ?more beneficial? (to poor people) well illustrates another vulnerability; processes more beneficial than ones that undermine livelihoods could be best avoided themselves, although ones more beneficial than the status quo may not. He well argues that non-deontological arguments should not be confined to human survival, but neglects stances that are either biocentric, consequentialist, or both. Yet a truly synthetic bioethics would be likely to embody these characteristics. (shrink)

This paper attempts to sort out some of the current tensions and ambiguities inherent in the field of bioethics as it continues to mature. In particular it focuses on the question of the methodological relevance of theory or ethical principles to the domain of clinical ethics. I offer an approach to reasoning about moral conflict that combines the insights of contemporary moral theorists, the philosophy of American pragmatism, and the skills of rhetorical deliberation. This synthetic approach locates a proper (...) role for moral theory in the practice of clinical ethics, thus linking abstract philosophical ideas about morality, humanity, suffering, and health to specific deeds, actions, and decisions in the concrete lives of particular individuals. The aim of this synthetic approach of bioethical inquiry is a rapprochement between theoretical knowledge in moral philosophy and the contextualized, relational, and practical understanding of what morality demands of us in our daily lives. I argue for a conception of bioethical inquiry that takes morality to be a study of certain practical, socially embedded concerns about matters of right and wrong, good and evil, as well as a study of the moral theories by which these actual concerns can be explored and critically evaluated. (shrink)

Hare shares with other critics an objection to the use of moral judgments in the method of reflective equilibrium. However, the reasoning behind his criticismdistinguishes it from the more common criticisms that the use of moral judgments is unwarranted because of their suspect origin. While these objections challenge the epistemic worth of moral beliefs, Hare’s objection goes beyond to also critique the deeper theoretical commitments of the method. Hare’s acceptance of a strict differentiation between the meaning and applications of words (...) and consequent rejection of holistic justification follow from his acceptance of the analytic/synthetic distinction, while Rawls’s holistic method of theory justification requires a rejection of the analytic/synthetic distinction. In this essay, I explain how Hare’s criticism of the method of reflective equilibrium and his acceptance of the meaning/application distinction result from his acceptance of the analytic/synthetic distinction and draw from this specific discussion more general conclusions regarding the implications of accepting or rejecting the analytic/synthetic distinction for the use of moral judgments in moral theory justification. I conclude that an acceptance of the distinction precludes the use of moral judgments, while its rejection leaves open the possibility that they could be used, if the issue of their epistemic status can be successfully resolved. (shrink)

The artificial creation of life arises both strong fascination by scientists and strong concerns, if not abhorrence, by critics of science. What appears to be the crowning achievement of synthetic biology is at the same time considered a major evil. That conflict, which perhaps epitomizes many of the cultural conflicts about science in Western societies, calls for a deeper analysis. Standard ethical analyses, which would try to relate such conflicts to a difference in fundamental values, are difficult to apply (...) here, because it is unclear what the underlying values of such emotions as fascination and abhorrence are. These emotions or affects, rather than just referring to what is morally right or wrong, seem to be rooted in our cultural heritage of desires and taboos of transgression. My analysis in this paper is primarily of historical nature. By investigating ideas about the creation of life from the earliest times to the present, I aim to clarify the cultural origins of those emotions. I argue that both the fascination and the abhorrence regarding the creation of life have a common religious basis. Moreover, unlike many commentators of 19th-century mad-scientist classics, from Mary Shelley to H.G. Wells, I argue that this basis has no ancient model in religious or mythological traditions but emerged only in the 19th century from an exchange between science and religion. As long as these emotions dominate public debates, ethical deliberations about synthetic biology are likely to be neglected. (shrink)

Cognition and behavior are the result of neural processes occurring at multiple levels of organization. Synthetic computational approaches are capable of bridging the gaps between multiple organizational levels and contribute to our understanding of how neural structures give rise to specific dynamical states. Such approaches are indispensable for formulating the theoretical foundations of cognitive neuroscience.

A connectionist system that is capable of learning about the spatial structure of a simple world is used for the purposes of synthetic epistemology: the creation and analysis of artificial systems in order to clarify philosophical issues that arise in the explanation of how agents, both natural and artificial, represent the world. In this case, the issues to be clarified focus on the content of representational states that exist prior to a fully objective understanding of a spatial domain. In (...) particular, the criticisms of (Chrisley, 1993) that were raised in (Holland, 1994) are addressed: how can we determine that a system’s spatial representations are more objective than before? And under what conditions (tasks, training regimes, environments) do such increases in objectivity occur? After analysing the results of experiments that attempt to shed light on these questions, the study concludes by comparing and contrasting this work with related research. (shrink)

The integration of computer science, biology, and engineering has resulted in the emergence of rapidly growing interdisciplinary fields such as bioinformatics, bioengineering, DNA computing, and systems and synthetic biology. Ideas derived from computer science and engineering can provide innovative solutions to biological problems and advance research in new directions. Although interdisciplinary research has become increasingly prevalent in recent years, the scientists contributing to these efforts largely remain specialists in their original disciplines and are not fully capable of covering the (...) many facets of multidisciplinary problems, which impedes the development of truly integrated solutions. It would be .. (shrink)

The construction of synthetic life might appear to be the natural objective of the emerging discipline of synthetic biology. The situation, though, is not that simple. Plans to synthesize life appeared quite early, at the beginning of the 20th century (Bensaude-Vincent 2009; Deichmann 2009; Fox Keller 2002; Pereto and Catala 2007). Nor can synthetic biology be identified with work on the origin of life. Nevertheless, it is remarkable that a new, more integrated approach to the origin of (...) life appeared exactly when synthetic biology was emerging (Szostak, Bartel, and Luisi 2001).Most synthetic biologists have the more limited ambition of modifying existing organisms by giving them new functionalities. Synthetic .. (shrink)

Several paleontologists have recently challenged the explanatory adequacy of the modern synthetic theory of evolution. Their position is that, contrary to the prevailing view that evolutionary change is gradual, the fossil record manifests long periods of species stasis (equilibrium) punctuated by periods of rapid species formation. And, they argue, this punctuated equilibria pattern challenges the gradualist, adaptationist and extrapolationist assumptions of the modern synthetic theory of evolution and supports a hierarchical, non-extrapolationist (non-reductionist) view of evolution. In this paper (...) I argue that the challenge rests on an inadequate characterization of the modern synthetic theory and that, even accepting punctuated equilibria and an irreducible evolutionary hierarchy, the modern synthetic theory is adequate to explain evolutionary change at all levels of the hierarchy. (shrink)

This article opens with a disclaimer: I am not a scientist, and the science of synthetic biology is beyond my comprehension. I am a philosopher and an ethicist interested in moral issues in reproductive medicine. In my past research I have raised theoretical questions about the normative constraints on the creation of human beings, especially in the context of the debates on genetic screening and genetic engineering, on both the individual level and the collective, namely that pertaining to the (...) intervention in the human genome.Moral norms usually apply to our relations with other human beings. The questions of reproductive medicine are problematic, since although they relate to human beings, these human beings are .. (shrink)

The aim of synthetic biology is to rationally design devices, systems, and organisms with desired innovative and useful functions (Slusarczyk, Lin, and Weiss 2012). To achieve this aim, synthetic biology uses a concept similar to engineering sciences: well-characterized and standardized modular biological building blocks are reassembled in a systematic and rational manner to generate complex devices and systems with a predicted function. In the past, molecular biological research in combination with intense work in new research areas like systems (...) biology and functional genomics revealed a large inventory of multifaceted modular biological parts that are now in the toolboxes of synthetic biologists. Due to .. (shrink)

This article focuses on the frontier between the technological domain of production of artefacts and the naturalistic domain of the sciences of life and cognition. It shows that, since the 1940s, this frontier has become the place of production of an innovative kind of scientific knowledge??synthetic knowledge.? The article describes the methodology and the main characteristics of synthetic knowledge, and formulates a hypothesis on its epistemological genealogy. Accordingly, it characterizes synthetic knowledge as one of the most advanced (...) expressions of a heterodox tradition of research which, since the 1930s, has been promoting the development of a ?non-representationalist???constructivist??science. (shrink)

In England, Higher Education institutions, together with the schools whose staff they train, are being required to incorporate synthetic phonics as one of the key approaches to the teaching of reading. Yet even if synthetic phonics can be identified as one of the component ‘skills’ of reading, an assumption vigorously contested in this paper, it does not follow that it can or should be taught explicitly and independently of reading for meaning. Imposing such a ‘method’ is, at a (...) deep level, incompatible with teachers acting as teachers and potentially constitutes a kind of abuse of early readers. Moreover, because of the conceptual difficulties confronting any attempt to specify synthetic phonics as an approach, there cannot exist, in principle, empirical research that actually supports its value. Current policy in England since the Rose Report, at least, assumes the opposite. All this cannot be dismissed as a little local difficulty for England concerning the teaching of reading English with all its spelling irregularities: there are broader implications for the relationship between research and teaching, together with continuing tendencies to impose ‘teacher proof’ approaches on schools and their staff in many countries. (shrink)

The paper presents an example of unified theory bearing interest from both a historical and systematic point of view. The example is chosen from evolutionary population genetics (neo-Darwinian synthetic theory). It exhibits various aspects of theoretical change in science that have been shown in Part I (Geiger, 1988) to be characteristic of syntheses of theories.

To illustrate dramatically the progress and potential in the field of synthetic biology, one can begin the story with the 2011 winner of the Lasker Clinical Medical Research Award (Youyou 2011). She was an 81-year-old Chinese scientist, Dr. Tu Youyou, who was given an assignment in 1969 by the Chinese government to find a treatment for malaria from among Chinese herbal medicines. She investigated more than 2,000 Chinese herbal preparations, winnowed them down to some 640 possibilities, obtained 380 extracts (...) from about 200 Chinese herbs, and tested them against a mouse model of malaria. She found one extract, of the Artemisia plant, effective in mice, but she could not reproduce the results consistently. So she .. (shrink)

Peirce did not achieve a final systematization of his work. Beyond the difficulties in explaining so many philosophical tools that he introduced—suffice it to mention semiotic, abductive logic, a heuristic based on continuity, scholastic realism—, there is a theoretical reason for this incompletion. All those new philosophical tools indicated a conception of synthesis very different from the one he received from Kant. Peirce did not realize the profound direction of his enquiry so that he did not directly question neither Kant’s (...) legacy on this issue nor the idea of necessity that presides over it. Starting from Peirce’s conception of continuity and change, this paper will give a new definition of synthetic and analytic judgments and reasoning, completing the picture with a third “vague” judgment and reasoning. In this new definition a synthetic judgment is a judgment that recognizes identity through changes. An analytical judgment is a judgment that loses identity through changes. A vague judgment is a judgment that it is blind to identity through changes. How do we perform synthetic reasoning? Following Peirce’s semiotic study of elements of Gamma Graphs as the sheet of assertion and the line of identity, the paper will first individuate the semiotic characteristics necessary for the recognition of identity. These characteristics lead us to discover “complete gesture” as the tool that we use in our every-day reasoning in order to acquire new knowledge synthetically. “Complete gestures” are actions through which we carry and recognize significant meanings. This new paradigm should provide an improved account of common-sense knowledge as well as of particular creative and hypothetic stages of conception in both scientific and humanistic thought. (shrink)

The analytic/synthetic distinction looks simple. It is a distinction between two different kinds of sentence. Synthetic sentences are true in part because of the way the world is, and in part because of what they mean. Analytic sentences--like all bachelors are unmarried and triangles have three sides--are different. They are true in virtue of meaning, so no matter what the world is like, as long as the sentence means what it does, it will be true. This distinction seems (...) powerful because analytic sentences seem to be knowable in a special way. One can know that all bachelors are unmarried, for example, just by thinking about what it means. But many twentieth-century philosophers, with Quine in the lead, argued that there were no analytic sentences, that the idea of analyticity didn't even make sense, and that the analytic/synthetic distinction was therefore an illusion. Others couldn't see how there could fail to be a distinction, however ingenious the arguments of Quine and his supporters. But since the heyday of the debate, things have changed in the philosophy of language. Tools have been refined, confusions cleared up, and most significantly, many philosophers now accept a view of language--semantic externalism--on which it is possible to see how the distinction could fail. One might be tempted to think that ultimately the distinction has fallen for reasons other than those proposed in the original debate. In Truth in Virtue of Meaning, Gillian Russell argues that it hasn't. Using the tools of contemporary philosophy of language, she outlines a view of analytic sentences which is compatible with semantic externalism and defends that view against the old Quinean arguments. She then goes on to draw out the surprising epistemological consequences of her approach. (shrink)

On behalf of the editors of Perspectives in Biology and Medicine, I am pleased to introduce the editors and venue of the Symposium on Synthetic Life: Scientific, Historical, and Ethical Perspectives, which occupies much of the current issue of our journal. We are very pleased that Professors Ute Deichmann, Michel Morange, and Anthony S. Travis planned, organized, and edited the proceedings of the workshop on this topic, held on March 5-6, 2012, at the Jacques Loeb Centre for the History (...) and Philosophy of the Life Sciences and the NIBN at Ben-Gurion University of the Negev in Beer Sheva, Israel.Professor Deichmann has been the founding director of the Centre since it was created in 2007. Although she trained in .. (shrink)

The philosophical interest of verbal disputes is twofold. First, they play a key role in philosophical method. Many philosophical disagreements are at least partly verbal, and almost every philosophical dispute has been diagnosed as verbal at some point. Here we can see the diagnosis of verbal disputes as a tool for philosophical progress. Second, they are interesting as a subject matter for first-order philosophy. Reflection on the existence and nature of verbal disputes can reveal something about the nature of concepts, (...) language, and meaning. In this article I first characterize verbal disputes, spell out a method for isolating and resolving them, and draw out conclusions for philosophical methodology. I then use the framework to draw out consequences in first-order philosophy. In particular, I argue that the analysis of verbal disputes can be used to support the existence of a distinctive sort of primitive concept and that it can be used to reconstruct a version of an analytic/synthetic distinction, where both are characterized in dialectical terms alone. (shrink)

In the past two or three decades, complexity not only has been a hot research topic but has caught the popular imagination. Terms such as chaos and bifurcation become so common they find their way into Hollywood movies. What is complexity? What is the theory of complexity or the science of complexity? I do not think there is such a thing as the theory of complexity. Not even a rigid definition of complexity exists in the natural sciences. There are many (...) theories trying to address various complex systems. What I try to do is to extract some general ideas that are implicit in these theories, and more generally, in the way that scientists face and think about complicated situations. (shrink)

Inspired by Kant, Merleau-Ponty and Sellars, I illustrate and identify certain kinds of unity which are typical (if not universal) features of our conscious experience, and argue that Kant was right to claim that such unities are produced by unconscious processes of synthesis: A perceptual experience of succession is not reducible to a succession of perceptual experiences. The experience of perceiving one object as having several features is not reducible to a conjunction of perceptual experiences of those features. A cross-modal (...) perceptual experience is not reducible to a conjunction of single-modality perceptual experiences. Incoming perceptual information is synthesized into a single scene-a representation of the world as perceived from a spatio-temporal point of view. Any two of the simultaneous features of the experience of a subject S can be thought of together by S. Many of the experiences of a subject S can be thought of by S at a later time as part of his or her history of experience. These can be summarized in the general principle: An experience of a complex is not a complex of experiences. This is consistent with Sellars' principle that: A sense-impression of a complex is a complex of impressions because the latter applies at the sub-personal, unconceptualized level, and the former at the conscious level of conceptualized experiences. (shrink)

This is a review of Peter Hylton's Quine (Routledge, 2007). The review highlights three aspects of the book that make are somewhat novel in the literature: (1) Hylton points out that Quine does not reject the analytic-synthetic distinction altogether, but merely its epistemological use by Carnap and others; (2) that the thesis of indeterminacy of translation is not a central doctrine in Quine's philosophy; and (3) that besides a naturalized epistemology, Quine's philosophy contains also a "naturalized metaphysics".