See	discussions,	stats,	and	author	profiles	for	this	publication	at:	https://www.researchgate.net/publication/294728934 How	can	Neuroscience	contribute	to	Moral Philosophy,	Psychology	and	Education	based	on Aristotelian	Virtue	Ethics? Article in International	Journal	of	Ethics	Education	*	October	2016 DOI:	10.1007/s40889-016-0016-9 CITATIONS 2 READS 125 1	author: Some	of	the	authors	of	this	publication	are	also	working	on	these	related	projects: Predicting	long-term	outcomes	of	interventions	using	machine	learning	and	computational	simulation View	project Purpose,	Morality,	Prosociality,	and	Positive	Youth	Development	View	project Hyemin	Han University	of	Alabama 29	PUBLICATIONS 86	CITATIONS SEE	PROFILE All	content	following	this	page	was	uploaded	by	Hyemin	Han	on	16	February	2016. The	user	has	requested	enhancement	of	the	downloaded	file.	All	in-text	references	underlined	in	blue	are	added	to	the	original	document and	are	linked	to	publications	on	ResearchGate,	letting	you	access	and	read	them	immediately. Running Head: Neuroscience and Aristotelian Virtue Ethics 1 How can Neuroscience contribute to Moral Philosophy, Psychology and Education based on Aristotelian Virtue Ethics?1 Hyemin Han Stanford University Abstract The present essay discusses the relationship between moral philosophy, psychology and education based on virtue ethics, contemporary neuroscience, and how neuroscientific methods can contribute to studies of moral virtue and character. First, the present essay considers whether the mechanism of moral motivation and developmental model of virtue and character are well supported by neuroscientific evidence. Particularly, it examines whether the evidence provided by neuroscientific studies can support the core argument of virtue ethics, that is, motivational externalism. Second, it discusses how experimental methods of neuroscience can be applied to studies in human morality. Particularly, the present essay examines how functional and structural neuroimaging methods can contribute to the development of the fields by reviewing the findings of recent social and developmental neuroimaging experiments. Meanwhile, the present essay also considers some limitations embedded in such discussions regarding the relationship between the fields and suggests directions for future studies to address these limitations. Keywords Virtue ethics, Moral philosophy, Moral education, Moral development, Neuroscience Introduction Moral philosophers and psychologists have proposed diverse perspectives to deal with the debates regarding the definition of morality. First, we may consider outcome-oriented or rule-based moral philosophical viewpoints 1 This is the postprint of the accepted manuscript, which was finally accepted by editors. The final version of this manuscript is available through the publisher's webpage (Springer). Running Head: Neuroscience and Aristotelian Virtue Ethics 2 (Barnett et al. 2005). Basically, these standpoints are mainly interested behavioural outcomes (consequentialism) or moral rules (deontology) instead of an actor's disposition or character while making moral judgment (SinnottArmstrong 2011; Alexander and Moore 2012). Consequently, moral psychological models based on this philosophical vantage point, such as the Kohlbergian model, which employs ideas of Kantian, Rawlsian and utilitarian moral philosophy (Kohlberg 1981; Blum 1988) to establish its philosophical framework, tend to emphasize the role of moral cognition and moral reasoning that are essential in evaluating norms, rules and predicted behavioural outcomes in moral judgment. According to this viewpoint, moral behaviour or motivation is defined as a behaviour or motivation originated from the obedience to moral principle (in case of deontology) or that maximizes goods (in case of consequentialism) (Nunner-Winkler 1997; De Colle and Werhane 2008). On the other hand, the proponents of virtue ethics have proposed significant counterarguments against the outcome-oriented or rule-based viewpoints (Hursthouse 2012). Unlike previously mentioned viewpoints, those proponents argue that happiness or flourishing (eudaimonia) of a person is most fundamental in morality (Snow 2008; Kraut 2014). They contend that moral virtue, which becomes the basis of morality, can be regarded as a long-term, habituated and internalized disposition that eventually leads us to eudaimonia with the guidance of practical wisdom (phronesis) (Curzer 2012; Silverstein and Trombetti 2013; Kristjánsson 2014). Phronesis, or practical wisdom, is defined as reasoning enabling us to make an appropriate decision in a certain situation, which leads us to the middle way (Sanderse 2012). A developmental and psychological model based on this philosophical vantage point argues that the process of early habituation and later cultivation of phronesis are fundamentally required (Kristjánsson 2007a; Carr 2008; Han 2015); it particularly underscores the development of integrative moral character (Arthur 2003; Hartman 2006) enabling us to make an appropriate moral decision and to adjust our emotional and motivational forces at an appropriate level guided by phronesis (Kristjánsson 2000; Molewijk et al. 2011), rather than the development of a specific moral function, such as moral reasoning in the case of Kohlbergian theory. Based on these aspects of virtue ethics and virtue ethical moral psychology and education, the present study will delve into the relationship between virtue ethics and neuroscience. First, the present essay, which is interested in moral education as well as moral philosophy, surmises that the theoretical framework of virtue moral philosophy seems to be more coherent with the recent integrative moral educational approach that aims to foster students' moral character, which embraces all aspects of human morality-i.e., moral reasoning, moral affection and moral behaviour (Lickona 1996; Berkowitz 2002; Blasi 2005; Narvaez and Lapsley 2005; Althof and Berkowitz 2006)- Running Head: Neuroscience and Aristotelian Virtue Ethics 3 comparing to other moral philosophical viewpoints. Moral psychological models originating from outcome-oriented or rule-based moral philosophy tend to focus on the development of certain aspects of moral functioning, particularly moral reasoning in the case of Kohlbergian moral psychology (Kohlberg 1981; Kohlberg 1984), so they are not likely to be suitable for directly applying to moral education aiming at developing holistic moral character. Instead, a more inclusive theoretical framework, virtue ethics, equally underscores the role of moral habit, disposition and phronesis (Kristjánsson 2013; Kraut 2014). Second, its developmental model (Sanderse 2014) would provide more useful insights to scholars and educators. Finally, the naturalistic aspect of Aristotelian virtue ethics would make it be better supported by scientific evidence comparing to other moral philosophical perspectives (Kristjánsson 2007a; Jeong and Han 2013; Jacobs 2014). Therefore, the present essay will concentrate on virtue ethics and its psychological and educational models among diverse theoretical frameworks while exploring the connection between recent neuroscience and studies of human morality. Neuroscientists have sought the neural substrate of human morality, which establishes biological basis of moral behaviour, using various methods, such as functional and structural neuroimaging and non-invasive brain stimulation methods (Poldrack 2008; Young et al. 2010; Tassy et al. 2012; Jeurissen et al. 2014). They have demonstrated how activity in brain regions associated with affection, cognition, motivation and other moral psychological processes are related to moral functioning. These neuroscientific studies of human morality have significantly and pervasively influenced other traditional disciplines dealing with morality including, but not limited to, moral philosophy, moral psychology and moral education (Narvaez and Vaydich 2008; Han 2014). For instance, previous neuroimaging studies investigating the involvement of affective processes in moral cognition proposed a novel idea about moral psychological mechanisms of deontological and utilitarian moral decision-making, which provided a new vantage point to moral philosophy (Greene et al. 2001; Greene et al. 2004; Greene 2007). The present essay will start with discussing how the recent neuroscience can support moral philosophical and psychological accounts of human morality proposed by virtue theorists by reviewing empirical evidence. In the first section, the present essay will focus on whether the moral philosophical basis of Aristotelian virtue ethics is coherent with neuroscientific evidence and how well the evidence can explain its psychological and developmental models. Furthermore, the second section will consider the future directions of neuroimaging studies focusing on moral virtue and character. More specifically, this essay will concentrate on how neuroimaging methods can Running Head: Neuroscience and Aristotelian Virtue Ethics 4 contribute to the scientific investigation of virtue, character development, and finally, the development of educational methods based on this viewpoint. Exploring the Relationship between Aristotelian Virtue Theory and Neuroscience This section consists of two sub-sections dealing with the core philosophical basis (first part) and developmental processes (second part) proposed by Aristotelian ethics. First, I discuss whether the core philosophical element of Aristotelian moral philosophy, that is, motivational externalism (Kristjánsson 2012), which argues the necessity of emotional and motivational elements, which are independent from moral reasoning for moral action (Zagzebski 1996), can be supported by neuroscientific evidence. Second, I discuss whether findings in developmental neuroscience correspond to the model of amoral developmental theory proposed by Aristotelian ethics, which especially underscores the habituation of virtue as well as the cultivation phronesis (Hursthouse 2012; Kristjánsson 2014). Motivational Externalism and Social Neuroscience There have been continuous controversies regarding the relationship between moral reasoning and moral behaviour. More specifically, scholars have debated whether moral decision based on moral reasoning does necessarily result in actual behaviour. There are two distinctive points of view explaining the relationship: motivational internalism and motivational externalism. The proponents of motivational internalism, motivational internalists, argue that moral judgment itself generates motivation for behaviour (Rosati 2006). On the other hand, motivational externalists proposing motivational externalism contend that moral judgment does not necessarily generate moral behavioural outcome; instead, they argue that other motivational factors, such as a strong will, are required to bridge the gap between judgment and behaviour (Rosati 2006). In this section, the present essay will discuss why motivational externalism seems to be more convincing and better explain the reality compared to motivational internalism based on empirical evidence in the fields of psychology and neuroscience. Of course, motivational internalism perhaps is perhaps better than motivational externalism in terms of its structure. Motivational internalism explains the mechanism of moral behaviour with a relatively simple and straightforward model (Mele 1989; Shafer-Landau 2000; Bjorklund et al. 2012); it does not require the complicated involvement of diverse psychological constructs or components, such as a will, to explain how motivation is Running Head: Neuroscience and Aristotelian Virtue Ethics 5 generated. Also, as shown by the Kohlbergian model of moral reasoning development (Kohlberg 1981; Kohlberg 1984), the internalism model was perhaps supported by empirical evidence. However, since the foundation of internalism is being threatened by the recent findings from psychological and neuroscientific studies, the present essay will discuss why externalism is a more plausible framework explaining the mechanism of moral behaviour. Social neuroscience suggests that motivation for moral behaviour does not originate directly from the result of moral judgment, as argued by motivational internalists. Instead, it implies that other psychological processes, particularly affective and rewarding processes, are inevitably involved in the formation of moral motivation and action, as proposed by motivational externalists. Motivational internalism argues, "a person cannot sincerely make a moral judgment without being motivated at least to some degree to abide by her judgment" (Rosati 2006). Although there are two types of internalism, strong and weak, both acknowledge that moral judgment is necessary in moral motivation and action (Rosati 2006). Several neuroscientific experiments are not consistent with those standpoints. First, brain lesion studies focusing on human morality significantly threaten the validity of strong internalism. The case study of Phineas Gage demonstrated that the lesion in the prefrontal cortex caused significant deficiency in socio-moral adjustment (Barker 1995). Although his intellectual ability to make judgments was intact for a while, his socio-moral character and behavioural tendency were severely regressed immediately after the accident (Kihlstrom 2010). Moreover, a recent experiment investigated more directly the association between the lesion in the medial prefrontal cortex, which deals with affection, and the integration of motivational force (Tranel 2002), moral reasoning, and moral motivation (Saver and Damasio 1991). This experiment demonstrated that, for patients whose medial prefrontal cortex was damaged during their adulthood, although their average moral judgment score was not significantly worse than that of normal participants, they showed severe socio-moral maladjustment, embodied by a morally inappropriate behavioural tendency. Given these experiments, strong motivational internalism can be refuted, because although those presented patients were able to make sound moral judgments and their moral reasoning was intact, their moral motivation and behavioural tendency were significantly deficient. Thus, moral judgment cannot be a sufficient condition for moral motivation and behaviour. Second, the validity of weak internalism can also be criticized by neuroscientific evidence. Although weak internalism endorses that mental illness or another motivational force can override the result of sound moral judgment, it still maintains the position that sound moral judgment is at least a necessary condition for moral Running Head: Neuroscience and Aristotelian Virtue Ethics 6 motivation and behaviour (Brink 1997). Thus, counterexamples, demonstrating that moral motivation and behaviour can be generated without moral judgment, can threaten this version of internalism. In fact, behavioural and developmental neurosciences focusing on moral motivation and behaviour in infancy show us the possibility of moral motivation and behaviour without sophisticated formal moral judgment (Decety and Howard 2013). For instance, even very young infants, such as 3-months-olds (Hamlin et al. 2010) or 6-months-olds (Hamlin et al. 2007), are motivated to prefer prosocial and moral behaviour over antisocial and anti-moral behaviour, although they are not capable of making sound and sophisticated moral judgments (Piaget 1948; Kohlberg 1984). Scholars suggest that this phenomenon occurs due to the presence of hard-wired morality in infants' brains (Bloom 2012). Because Aristotelian virtue ethics acknowledges that children can have rudimentary forms of moral virtues, although those virtues are not full virtues moderated by phronesis (Kraut 2014), the results of these scientific experiments may indicate that moral motivation and behaviour, at least in their rudimentary forms, can exist even among infants. Hence, those counterexamples can threaten the validity of weak motivational internalism, and support the core of Aristotelian ethics, that is, motivational externalism. However, some may contend that we should consider other components on top of explicit behavioural outcome itself while we are evaluating the moral aspect of behaviour. For instance, although Phineas Gage's behaviour was socially inappropriate and can be considered to be anti-moral, his behaviour may not be completely anti-moral because he may not possess a mental ability to take moral responsibility due to the brain injury; if he lacked such a mental ability, we cannot blame him for behaving anti-morally (Fischer and Ravizza 2000). Moreover, children's prosocial behavioural tendency presented in psychological studies may also not be regarded as moral behavioural tendency. Since moral philosophers have argued that we should evaluate the moral aspect of certain behaviour based on not only its behavioural outcome itself but also its intention (Anscome 1958; Pellegrino 1995), it would be inappropriate to say that children's prosocial behaviour initially generated by instinct is moral. Thus, we should consider these factors, i.e., responsibility and intention, while evaluating certain behaviour. Then, how the components of responsibility and intention in moral behaviour is related to the prior discussion of the validity of motivational externalism? The present study intends to review previous psychological studies examining the psychological mechanism and neural correlates of moral responsibility and intention. Previous social psychological works have shown that people may withdraw themselves from moral behaviour even when they made Running Head: Neuroscience and Aristotelian Virtue Ethics 7 a sound moral judgment due to moral disengagement originating from the lack of the sense of responsibility (Bandura 1990; Bandura 1999). Also, previous neuroimaging studies have demonstrated that a brain circuitry associated with self-agency and possibility the sense of responsibility was significantly activated in moral decisionmaking task conditions (Moll et al. 2007), and it significantly interacted with brain regions associated with moral judgment (Han et al. 2016). Furthermore, a recent experiment demonstrated that the factor of intention influenced behavioural outcome on top of decision-making processes (Greene et al. 2009); a neuroimaging study also found the neural correlates of intention judgment by setting the type of intention as an independent variable (Borg et al. 2006). Given these previous studies, the present essay shall conclude that the psychological and neural mechanism of responsibility and intention are perhaps independent from those of moral reasoning itself in the generation of behavioural motivation, and they would empirically support motivational externalism, not motivational internalism. Development of moral virtue and developmental neuroscience Findings in developmental neuroscience also support the developmental model of Aristotelian ethicists. Both early habituation and internalization of moral virtue, as well as cultivation of phronesis, which moderates motivational forces to be appropriately exerted in a given situation, are necessary for the achievement of the ultimate purpose of human life, that is, eudaimonia (Aristotle 2000; Wall 2003; Kristjánsson 2014), according to Aristotelian perspective. First, the previous lesion study demonstrated that the average moral judgment interview score among patients with early-onset prefrontal damage was significantly worse than that of normal participants. This study proposed that patients with such damage were not able to internalize moral norms into their brain reward system, hindering their further development of moral reasoning, given the somatic marker hypothesis (Saver and Damasio 1991; Damasio 1994). It can support the standpoint of Aristotelian moral development, which emphasizes the importance of early habituation of moral norms for the acquisition of moral virtue and eudaimonia. Of course, a continent person, who has developed moral reasoning without early-habituation of moral virtue, can behave morally because she knows well what is morally appropriate (Kristjánsson 2013; Fowers 2014); however, because moral norm and affection are not completely integrated into her selfhood, they become a sort of external imperative for her, not a natural trait, and can hardly serve for her moral flourishing and happiness (Stocker 2003). Thus, the neuroscientific investigation Running Head: Neuroscience and Aristotelian Virtue Ethics 8 corresponds to this Aristotelian account on moral development, which emphasizes the importance of early internalization of moral virtue for the future development of moral character, including moral reasoning. Second, developmental brain studies have shown that the Aristotelian version of the moral developmental course, which consists of the habituation of norms and cultivation of wisdom, may occur in the physical reality. According to this idea, the early habituation and internalization of moral norms through repetitive behavioural training, followed by the cultivation of phronesis, are required for the development of moral character (Carr 2008; Kristjánsson 2014). Some neuroimaging studies have demonstrated that one of the most salient aspects of moral development at the neural level during early-childhood through early-adolescence is that brain regions associated with the motivational and reward system (e.g., amygdala, nucleus accumbens, orbitofrontal cortex, ventral striatum), which engages in the habituation and internalization of rules (Wilson and Rolls 2005; Blair 2007), develop earlier than regions associated with sophisticated reasoning (Galvan et al. 2006; Hare et al. 2008; Decety et al. 2012). This aspect would also be supported by neuroimaging studies demonstrating that habituation actually influences the neural mechanism of affection and motivation (Tricomi et al. 2009; Lingawi and Balleine 2012; de Wit et al. 2012). Then, in regions correlated with reasoning based on prudence, self-control, and sophisticated self-reflective processes (e.g., lateral prefrontal cortex, posterior cingulate cortex) (Moll et al. 2007; Buckner et al. 2008; Immordino-Yang et al. 2012), that correspond to the concept of phronesis in Aristotelian philosophy, the activity becomes salient beyond adolescence (Casey et al. 2008; Wright et al. 2008; Harenski et al. 2012). This neural-level developmental trend suggests that the moral developmental course proposed by Aristotelian ethics may actually occur in the human brain. Although there have been no neuroscientific studies that directly focused on the neural-level effect of moral educational interventions, some experiments can shed light on this issue. First, training programs designed for the habituation of certain actions, such as juggling, induced myelination in regions associated with the function (Scholz et al. 2009). Second, even for the cultivation of reasoning, which is more sophisticated than the case of habituation, interventions, such as board games (B. Lee et al. 2010), reasoning exercises (Mackey et al. 2012), working memory training (Olesen et al. 2004; Takeuchi et al. 2010), and meditation programs (Lazar et al. 2005), promoted significant structural changes in brain regions associated with cognition and reasoning. These results would support the idea that Aristotelian ways for moral education-i.e., habituation and phronesis cultivation-actually influences Running Head: Neuroscience and Aristotelian Virtue Ethics 9 the brain structure according to the idea of neuroplasticity (LeDoux 2002) and previous neuroscientific studies demonstrating the neural-level effect of habituation and learning (Tricomi et al. 2009; Lingawi and Balleine 2012; de Wit et al. 2012). Utilizing Neuroscientific Methods to Investigate Moral Development Moral virtue has been an important issue in the fields of moral psychology and education. Moral psychologists and educators who aim to develop students' character as a whole tend to pay their attention to the concept of integrative moral virtue rather than individual moral function, such as moral cognition or affection (C. Lee and Taylor 2013). To accurately diagnose the current developmental status and evaluate the effects of educational endeavours, scholars need a well-developed measurement of moral virtue. Then what are possible ways to measure the development of moral virtue? It seems to be difficult to properly measure this conceptual construct because we, human, cannot have a perfect insight into a subjects' mind with scientific methods; we can only have proxies to the mind, instead of "mind reading strategies," to conduct a scientific investigation of moral virtue. Aristotle gave us a hint about one possible proxy of moral virtue. If a man once acquires reason, that makes a difference in action; and his state, while still like what it was, will then be virtue in the strict sense. (Aristotle 2000) Behavioural observation would be a possible way to assess whether a person possesses a certain moral virtue in his/her self, given the quote of Aristotle. In fact, this method has been frequently utilized by developmental psychologists, particularly who are interested in early childhood development (Woodhead and Paulkner 2000). However, there are significant limitations in this method. First, a mere presence of moral behaviour cannot prove that the actor of the behaviour possesses moral virtue. According to Aristotle's account on the habituation of moral virtue and moral character, the repetition and consistency of the moral behaviour are more important than a mere presence of the behaviour (Aristotle 2000). Thus, the observation of moral behaviour in an empirical study, which is usually conducted during a short period, does not necessarily confirm that a participant has completely integrated moral virtue into his/her self. In addition, we should be aware of the possibility of social and desirability biases. Participants do not behave as they actually behave in their everyday lives because they want to show that they Running Head: Neuroscience and Aristotelian Virtue Ethics 10 behave in a moral and socially desirable manner to observers (Adair 1984). Because of these reasons, thus, the reliability and credibility of behavioural observation to measure moral virtue would be severely threatened. These limitations are also common to the questionnaire method, which is usually being utilized by moral psychologists and educators (Kristjánsson 2013). The desirability bias is also an important issue in this case. For instance, if we ask our participants to rate the importance of keywords, which include both moral and non-moral ones, to them, they would naturally tend to rate moral keywords are important to them regardless of whether the moral values and virtues embedded in the keywords are really important to them, and integrated into their selfhood because they want to show that they are moral people. In addition, validity would not also be guaranteed; in other words, we are not sure about whether we can measure moral virtue, which is inevitably internal and covert, with a paper-and-pencil questionnaire. Therefore, moral philosophers and psychologists need a more direct approach to internal psychological processes that enables them to properly measure the development of moral virtue. Neuroimaging methods, which have been rapidly developed during last couple of decades, would address the problems of previous methods. The neuroimaging methods present significant advantages over current methods for assessing moral development such as self-reporting, which (1) do not give scientists insight into the substructures that process moral virtue and that underlie manifest behaviour; and which (2) are biased by respondents' subjectivity (Ito and Cacioppo 2007). Neuroimaging Methods to Measure Moral Virtue The neuroscientific investigations of moral virtue can start by examining moral exemplars who are realizing moral virtue in their lives. Colby and Damon (1992) emphasized that empirical studies of moral exemplars can provide us with useful insights regarding the nature of human morality, which could not be completely examined by traditional moral psychological studies targeted at ordinary people. Because the moral exemplars are a paragon of moral virtue, it would be informative to investigate their developmental and psychological characteristics. In fact, this "reverseengineering method" shows us how moral virtue works in reality through the real exemplars (Walker 2013). Thus, comparing brains between moral exemplars that have already acquired moral virtue and ordinary people is a good starting point of our endeavours to measure the internal mechanism of moral virtue. Running Head: Neuroscience and Aristotelian Virtue Ethics 11 Functional neuroimaging. Given the theoretical framework of virtue ethics and character psychology, the integration of moral virtue into a person's selfhood is an important goal in character development (Kristjánsson 2007b). Thus, it is reasonable to research the link between moral virtue to an individual's sense of "self" to examine the development of moral virtue. At the neural level, this research can be conducted by measuring the connectivity between brain regions associated with moral virtue and self-related processes, such as self-reflection and self-referencing (Buckner et al. 2008). The neuroimaging studies of the default mode network (DMN), which is closely associated with psychological processes regarding the selfhood, self-referential and autobiographic processes (Immordino-Yang et al. 2012) are particularly informative for our research on the mechanisms of selfhood and self-related psychological processes at the neural level. In these DMN studies, scientists have reported that certain brain regions were deactivated while participants were consciously involved in cognitive tasks. On the contrary, these regions were activated when the participants were in resting state. This pattern significantly differed from the pattern usually reported in previous neuroimaging studies. The regions included the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), precuneus, and inferior parietal lobule (IPL). The scientists named the network of these regions, which has only been activated during resting state, as the DMN; and they hypothesized that this network would be related to introspective self-related psychological processes, instead of goal-driven cognitive functions (Buckner et al. 2008). As the scientists hypothesized, an interesting aspect of the DMN is that this network is extensively activated when participants are requested to do a sort of self-related tasks. For instance, the DMN was significantly more activated during the self-adjective association ask condition than other-adjective task association condition (Zhu et al. 2007). In addition, when a part of this network, the precuneus, was disrupted by the transcraniel magnetic stimulation (TMS), the efficiency of the self-adjective association task declined and became identical to that of the otheradjective association task (Lou et al. 2010). Thus, given these findings, the DMN is the neural network extensively associated with the selfhood and its related psychological processes. In fact, recent neuroimaging studies that examined the neural substrate of admiration showed that the PCC and precuneus in the DMN were particularly activated under the moral virtue admiration condition compared with the physical excellence admiration condition (Immordino-Yang et al. 2009; Englander et al. 2012). In addition, previous functional neuroimaging studies have consistently demonstrated that the ventromedial prefrontal cortex (VMPFC) Running Head: Neuroscience and Aristotelian Virtue Ethics 12 and orbitofrontal cortex (OFC), which constitute the DMN, were significantly associated with prosocial and moral emotion and moral cognition (Moll et al. 2007; Moll and de Oliveira-Souza 2007; Reniers et al. 2012; Han et al. 2014; Sevinc and Spreng 2014; Han et al. 2016). Given these findings, the DMN is the core of moral self, and the region of interest in virtue ethics and character psychology. We will be able to quantify the degree of the development of moral virtue at the neural level, and to approach the inner psychological processes of virtue and character, which has not been completely investigated, by investigating the strength and robustness of the functional connectivity between these DMN regions and other regions associated with individual moral functions, such as moral compassion and moral indignation. We can examine the strength of the neural connectivity between brain regions associated with self-related processes and moral functions. The neural connectivity is calculated from the series of functional brain images that are acquired while participants are watching visual stimuli that induce moral emotional responses closely associated with moral virtue, or solving moral dilemmas. In addition to the brain connectivity under the task conditions, the connectivity measured during resting state is also informative as shown in previous DMN studies (e.g., Buckner et al., 2008). Finally, because it is usually expected that moral exemplars are successfully integrate moral virtue into their selfhood, their functional connectivity between brain regions dealing with moral and self-related functions would significantly differ from that among ordinary people. This approach can also contribute to the development of a more effective moral educational program by evaluating the effectiveness of the newly invented program. The quality of the program can be evaluated by measuring whether the program induces significant change in the functional connectivity specified by the functional neuroimaging project comparing ordinary people and moral exemplars. Structural neuroimaging. Structural neuroimaging studies have shown that various trainings including both physical and cognitive skill trainings induced significant changes in brains at the structural level (e.g., Scholz, Klein, Behrens, & Johansen-Berg, 2009; Takeuchi et al., 2010). For instance, long-term trained players of the game of "Baduk (Go)," an Asian board game, showed a significantly different brain anatomy in the frontal, cinglulum, and striato-thalamic areas dealing with attentional control, working memory, executive regulation, and problem-solving, compared with non-experts (B. Lee et al. 2010). Thus, given this fact, we can expect that moral exemplars that have Running Head: Neuroscience and Aristotelian Virtue Ethics 13 successfully habituated and internalized moral virtue would show significantly different structural characteristics in brain regions associated with moral and self-related functions compared with ordinary people. Therefore, we can utilize the grey matter thickness measurement. It measures the thickness of grey matters in the region of interest using high-resolution structural brain images, and enables researchers to investigate developmental or pathological changes from the quantified thickness (Fischl and Dale 2000). For instance, O'Donnell, Noseworthy, Levine, and Denis (2005) examined the developmental changes in the frontopolar area, which is associated with cognitive function, from childhood to adolescence using this method. Given the findings of previous studies using this method, the structural characteristics of grey matters were continuously affected by both internal (e.g., aging), and external (e.g., environment and training) factors (Lazar et al. 2005; O'Donnell et al. 2005). In addition, the diffusion-tensor imaging (DTI) can also be used to examine changes in brain regions. This method quantifies diffusion anisotropy effects in white matters, and investigates the microstructure of the human brain (Assaf and Pasternak 2008). The DTI method has also been applied to investigate the influences of both internal and external factors on the brain structure (e.g., Lee et al., 2010; Molinuevo et al., 2012; Scholz et al., 2009; Takeuchi et al., 2010). Particularly, the structural changes in brain regions associated with moral function and the DMN to examine character development at the level of brain structure are important. In addition, researchers will be able to discover other brain regions that would be related to moral virtue, which have not been yet reported by previous studies, through the comparison in the brain anatomy between exemplars and ordinary people. In fact, structural changes were usually observed in a brain region that is directly associated with a function of interest in the previous studies of the brain structure (e.g., Lazar et al., 2005; Lee et al., 2010), so brain regions associated with moral virtue would show significantly different brain structures between moral exemplars and ordinary people. Again, we can expect that the habituation and internalization of moral virtue, which are the most important characteristics of moral exemplars, would be reflected in the structural feature of the regions. Furthermore, we will be able to apply the structural neuroimaging methods to evaluate the longitudinal effect of a newly invented moral educational program. The educational effect at the neural level can be measured by focusing on the degree of the structural change in regions selected by the exemplar-based experiment that is potentially induced by the program. Limitations and future directions Running Head: Neuroscience and Aristotelian Virtue Ethics 14 However, we have to be aware of several limitations of the methods. First, we have to take into account that the majority of previous neuroimaging studies examining human morality have utilized hypothetical moral dilemmas instead of real problems (Christensen and Gomila 2012). If we do not seriously consider how to employ realistic dilemmas that can be implemented in neuroimaging settings, we cannot properly investigate the neural correlates of moral virtue and character because the development of moral virtue and character can only be completely evaluated if we investigate all of moral reasoning, moral affection, moral motivation, and moral behaviour (Curren and Kotzee 2014; Fowers 2014). Particularly, the core concept of virtue ethics, phronesis, cannot be properly understood by considering only cognitive aspect of human morality; the exercise of phronesis is inevitably associated with emotion, motivation and behaviour on top of moral reasoning (Stovall 2011; Hursthouse 2012; Kristjánsson 2014). Thus, we should develop a measurement of moral virtue and character that employs realistic situations inducing activation of all aspects of human moral functioning on top of moral reasoning, which has been mainly examined by previous neuroimaging studies using hypothetical dilemmas. Unfortunately, due to the restricted circumstance in MR scanners, the potential measurement would be inevitably textand/or picture-based similar to previous moral dilemma tasks. Thus, recently developed text-based measurements based on virtue ethics, such as a prototype of gratitude measurement (Morgan et al. 2014), measurement for virtuous law practice (Arthur et al. 2014) and measurement for virtuous medical practice (Arthur et al. 2015), would be most promising candidates that can be utilized in neuroimaging studies. These measurements can also be applied to measure the longitudinal effect of a newly developed virtue ethics-based moral educational program at the neural level. Second, because neuroscientific studies of human morality have employed diverse experimental paradigms and tasks, they would not produce totally comparable and coherent results; it would significantly hinder the interpretation of the results. In fact, there have been concerns regarding the possibility of statistical idiosyncrasies that would be produced by the differences in methods while interpreting a set of results of multiple neuroimaging experiments (Wager et al. 2004). Thus, we should carefully consider how to address the possible idiosyncrasies, which would be problematic during the interpretation of multiple individual neuroimaging experiments, and how to properly find out the psychological and educational implications from them. One possible way is to utilize a metaanalysis of multiple neuroimaging studies; for instance, the Activation Estimated Likelihood (ALE) method implemented in GingerALE (Laird et al. 2005; Eickhoff et al. 2009) is a feasible meta-analysis method easily applied to analysis of neuroimaging studies in socio-moral neuroscience (Bzdok et al. 2012; Sevinc and Spreng Running Head: Neuroscience and Aristotelian Virtue Ethics 15 2014). Although the experiments included in the meta-analysis model would not be completely comparable or coherent with each other, the process of the meta-analysis is effective to reduce the statistical idiosyncrasies possibly embedded in individual experiments and to produce statistically reliable and valid outcomes (e.g., common activation foci, common neural correlates of a function of interest) (Wager et al. 2004; Etkin and Wager 2007; Costafreda 2009). Of course, the meta-analysis is also the most feasible method to increase the statistical power, which is likely to be week in each individual neuroimaging study due to its small sample size (Cacioppo et al. 2013). Scholars who are interested in neuroimaging studies of moral virtue and character can utilize this analysis method once multiple neuroimaging experiments, which might seem to be primarily incomparable, are conducted. They will be able to get statistically reliable, valid and powerful results by meta-analysing multiple experiments, and finally, to approach the neural-level mechanism of moral virtue and character. This kind of meta-analysis can also be applied to compare the effect of diverse moral educational approaches once neuroimaging studies examining the longitudinal effect of educational methods are performed and the findings are accumulated in a database. Concluding Remarks The present essay reviewed the relationship between virtue ethics and contemporary neuroscience and how methods in neuroscience can contribute to the studies in moral philosophy, moral psychology, and moral education. First, the present essay discussed how and why virtue ethics and its psychological model are more coherent with contemporary neuroscience than are other ethical theories by considering the philosophical account of moral motivation and developmental model. Second, we sought how to apply neuroscientific methods, particularly functional and structural neuroimaging methods, to studies in moral philosophy, psychology and education based on virtue ethics while discussing their limitations and how to deal with the limitations. Given these discussions, the present essay concludes that virtue ethics and its psychological and educational models will be able to be well supported by experiments on the neural mechanism of morality and neuroscientific methods. Of course, although scientific findings seem to support Aristotelian moral philosophy and psychology, we must not attempt merely to reduce the philosophical and developmental theories into activity of biological substances, or incautiously equate philosophy, psychology, and natural sciences. Then, what would be appropriate ways to address this issue? 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