Human–nonhuman chimeras have been the focus of ethical controversies for more than a decade, yet some related issues remain unaddressed. For example, little has been said about the relationship between the origin of transferred cells and the morally relevant capacities to which they may give rise. Consider, for example, a developing mouse fetus that receives a brain stem cell transplant from a human and another that receives a brain stem cell transplant from a dolphin. If both chimeras acquire morally relevant (...) capacities as a result of transplantation, and if those capacities are indistinguishable, should the difference in cell origin matter to how we classify these creatures? I argue that if morally relevant capacities are easy to detect, cell origin is irrelevant to how the chimera ought to be treated. However, if such capacities are hard to detect, cell origin should play a role in considerations about how to treat the chimera. (shrink)

Extrapolation from a well-understood base population to a less-understood target population can fail if the base and target populations are not sufficiently similar. Differences between laboratory mice and humans, for example, can hinder extrapolation in medical research. Mice that carry a partial or complete human physiological system, known as humanized mice, are supposed to make extrapolation more reliable by simulating a variety of human diseases. But what justifies our belief that these mice are similar enough to their human counterparts to (...) simulate human disease? I argue that, unless three requirements are met in the process of humanizing mice, very little does. My requirements are not meant to provide necessary and sufficient conditions that guarantee a particular outcome. Instead, they serve as a heuristic for guiding scientific judgments involving extrapolation. In developing each requirement, I engage with philosophical issues concerning the nature of model-based science and the mechanistic approach (and its limits) to making generalizations in the life sciences. (shrink)

What’s the basis for considering an egg donor a genetic parent but not a mitochondrial donor? I will argue that a closer look at the biological facts will not give us an answer to this question because the process by which one becomes a genetic parent, i.e., the process of reproduction, is not a concept that can be settled by looking. It is, rather, a concept in need of philosophical attention. The details of my argument will rest on recent developments (...) in biological technology, but the persuasiveness of my argument will turn on the history of another biological concept, death. Given some important similarities between the two concepts, the way in which ‘death’ evolved in the recent past can provide guidance on how we should think about ‘reproduction.’. (shrink)

Research ethics committees must sometimes deliberate about objects that do not fit nicely into any existing category. This is currently the case with the “gastruloid,” which is a self-assembling blob of cells that resembles a human embryo. The resemblance makes it tempting to group it with other members of that kind, and thus to ask whether gastruloids really are embryos. But fitting an ambiguous object into an existing category with well-worn pathways in research ethics, like the embryo, is only a (...) temporary fix. The bigger problem is that we no longer know what an embryo is. We haven’t had a non-absurd definition of ‘embryo’ for several decades and without a well-defined comparison class, asking whether gastruloids belong to the morally relevant class of things we call embryos is to ask a question without an answer. What’s the alternative? A better approach needs to avoid what I’ll refer to as “the potentiality trap” and, instead, rely on the emergence of morally salient facts about gastruloids and other synthetic embryos. (shrink)

Depression is a widespread and debilitating disorder, but developing effective treatments has proven challenging. Despite success in animal models, many treatments fail in human trials. While various factors contribute to this translational failure, standardization practices in animal research are often overlooked. This paper argues that certain standardization choices in behavioral neuroscience research on depression can limit the generalizability of results from rodents to humans. This raises ethical and scientific concerns, including animal waste and a lack of progress in treating human (...) patients. To address these issues, animal ethics committees can establish reasonable expectations for preclinical research and highlight the impact of standardization on generalizability. Such efforts can help improve translation from animal models to human patients and ultimately benefit those suffering from depression. (shrink)

Media reporters often announce that we are on the verge of bringing back the woolly mammoth, even while there is growing consensus among scientists that resurrecting the mammoth is unlikely. In fact, current “de-extinction” efforts are not designed to bring back a mammoth, but rather adaptations of the mammoth using close relatives. For example, Harvard scientists are working on creating an Asian elephant with the thick coat of a mammoth by merging mammoth and elephant DNA. But how should such creatures (...) be classified? Are they elephants, mammoths, or both? Answering these questions requires getting clear about the concept of reproduction. What I hope to show is that with an appropriate notion of reproduction—one for which I will argue—resurrecting a member of Mammuthus primigenius is a genuine possibility. (shrink)

Human embryo models formed from stem cells—known as embryoids—allow scientists to study the elusive first stages of human development without having to experiment on actual human embryos. But clear ethical guidelines for research involving embryoids are still lacking. Previously, a handful of researchers put forward new recommendations for embryoids, which they hope will be included in the next set of International Society for Stem Cell Research guidelines. Although these recommendations are an improvement over the default approach, they are nonetheless unworkable, (...) because they rely on a poorly conceived notion of an embryoid’s ‘potential’ to trigger stringent research regulations. (shrink)

With an increasing number of ways to ‘assist’ reproduction, some bioethicists have started to wonder what it takes to become a genetic parent. It is widely agreed that sharing genes is not enough to substantiate the parent–offspring relation, but what is? Without a better understanding of the concept of reproduction, our thinking about parent–offspring relations and the ethical issues surrounding them risk being unprincipled. Here, I address that problem by offering a principled account of reproduction—the Overlap, Development and Persistence account—which (...) I believe best captures the meaning of ‘genetic parenthood’. (shrink)

Comparative genomicists seem to be convinced that the unit of measurement employed in their studies is a gene that drives the function of cells and ultimately organisms. As a result, they have come to some substantive conclusions about how similar humans are to other organisms based on the percentage of genetic makeup they share. I argue that the actual unit of measurement employed in the studies corresponds to a structural rather than a functional gene concept, thus rendering many of the (...) implications drawn from comparative genomic studies largely unwarranted, if not completely mistaken. †To contact the author, please write to: Department of Philosophy, University of Utah, 215 South Central Campus Drive, Carolyn Tanner Irish Humanities Building, 4th Floor, Salt Lake City, UT 84112; e‐mail: monika.piotrowska@utah.edu. (shrink)

According to Haber and Benham (2012), a sufficient condition for full moral consideration is that a creature bears a genealogical relation to the Homo sapiens lineage. Since part-humans do not bear such a relation, they are not due full moral consideration on that basis. Given this argument, my aim in this commentary is twofold. First, I want to challenge its soundness by showing that it is possible for part-humans to bear a genealogical relation to the H. sapiens lineage. Second, I (...) want to argue that Haber and Benham's attempt at avoiding moral confusion by reframing ethical concerns about part-humans doesn’t work. (shrink)

New discoveries are improving the odds of human cells surviving in host animals, prompting regulatory and funding agencies to issue calls for additional layers of ethical oversight for certain types of human–animal chimeras. Of interest are research proposals involving chimeric animals with humanized brains. But what is motivating the demand for additional oversight? I locate two, not obviously compatible, motivations, each of which provides the justificatory basis for paying special attention to different sets of human–animal chimeras. Surprisingly, the sets of (...) animals that actually get flagged for special scrutiny by research and funding guidelines do not correlate with either of the sets of animals that arise when we think about what is motivating additional oversight. What this shows is that existing research policies and funding guidelines are disconnected from their motivation: the rationale for flagging certain types of human–animal chimeras as requiring special oversight is ignored in execution. (shrink)

Although neurological disease and mental illness can cause terrible human suffering, strategies for researching their causes and cures are not obvious. Invasive brain research on actual human being...

I begin with a description of the benefits and limits of DNA barcoding as presented by its advocates not its critics. Next, I argue that due to the mutually dependent relationship between defining and delimiting species, all systems of classification are grounded in theory, even if only implicitly. I then proceed to evaluate DNA barcoding in that context. In particular, I focus on the barcoders’ use of a sharp boundary by which to delimit species, arguing that this boundary brings along (...) additional theoretical commitments inconsistent with the way taxonomists conceive of species, viz., as entities that have vague boundaries and that cannot be defined by any single attribute other than ancestry. Given these inconsistencies, I conclude that even if groupings based on DNA barcodes match those of an existing taxonomy, the two systems of classification are not necessarily tracking the same entities, i.e., species. (shrink)

I am grateful to the authors who commented on my article (Piotrowska 2014) for their careful examination of my argument. They have presented a variety of stimulating ideas and suggestions, with which I largely agree and which I would like to discuss further, but in the interest of brevity, I shall try to concentrate only on points of contention.

Much of the book is aimed at persuading the reader that genes are not ‘the prime movers in all biological processes’ and that ‘postgenomic genes’ are better understood in a functional sense, as ‘things an organism can do with its genome.' With the main argument in place, the authors examine its impact on a number of philosophical debates. I will discuss three of them: causation, information, and reduction.

Unfounded—conspiracy and health—beliefs about COVID-19 have accompanied the pandemic worldwide. Here, we examined cross-nationally the structure and correlates of these beliefs with an 8-item scale, using a multigroup confirmatory factor analysis. We obtained a two-factor model of unfounded (conspiracy and health) beliefs with good internal structure (average CFI = 0.98, RMSEA = 0.05, SRMR = 0.04), but a high correlation between the two factors (average latent factor correlation = 0.57). This model was replicable across 50 countries (total N = 13,579), (...) as evidenced by metric invariance between countries (CFI = 0.96, RMSEA = 0.06, SRMS = 0.07) as well as scalar invariance across genders (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03) and educational levels (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03). Also, lower levels of education, more fear of COVID-19, and more cynicism were weakly associated with stronger conspiracy and health beliefs. The study contributes to knowledge about the structure of unfounded beliefs, and reveals the potential relevance of affective (i.e., fear of COVID-19) and cognitive (i.e., cynicism) factors along with demographics, in endorsing such beliefs. In summary, we obtained cross-cultural evidence for the distinctiveness of unfounded conspiracy and health beliefs about COVID-19 in terms of their structure and correlates. (shrink)

The book is divided into four sections, and contains two central arguments. The goal of the first argument is to show that generally accepted concepts in moral theory have an irreducibly second-personal character and that it is impossible to fully understand many central moral ideas without it. Here, by evaluating a broad range of literature in moral theory and articulating the second-personal aspect of each, Darwall elaborates on the interpersonal nature of moral obligation. The detailed discussion presents some well-known moral (...) theories, and while emphasizing the Deontological perspective, highlights the second-personal character of all moral theories; a perspective that has, in the past, gone unnoticed. However, as Darwall himself acknowledges, the first argument cannot vindicate the very ideas it analyzes. He thus dedicates the second part of the book to a reverse-strategy: instead of arguing for the existence of a second-person foundation in moral theory, Darwall sets out to show that the presuppositions of the second-person standpoint include the moral law in them. In this second argument, Darwall explains that the second-personal standing can only be justified within a circle of four interrelated ideas (claim, accountability, second-personal reason, and second-personal authority), and that this circle necessarily excludes instances of coercion. (shrink)

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

This book is the first presentation in Polish scientific literature of the views and concepts of social constructivists on the complex and varied problems of the philosophy of science with particular consideration of mathematics. It is based on numerous publications and comments of the founders and supporters of social constructivism.

Previous research examining the relationship between religion and attitudes about death have yielded mixed results due to over-simplified conceptualizations of constructs, lack of theory, and an over-reliance on Western samples. To overcome these issues, the present study examined the relationship between three types of religious orientation and two types of death attitudes among a sample of 532 college students in Poland. The results demonstrated unique relations between religion and death attitudes, as well emphasized the importance of considering religious engagement as (...) a moderating variable. Although the results were generally consistent with Terror Management Theory, other theoretical perspectives were considered as well. (shrink)

Anthropologie und Moralphilosophie wurden von Kant ausfuhrlicher und differenzierter behandelt als bisher angenommen. Daruber hinaus sind beide Disziplinen notwendig voneinander abhangig und aufeinander bezogen. Seine Konzeption des Verhaltnisses von Anthropologie und Moralphilosophie weist Kant aus als wurdigen Gesprachspartner in der modernen Anthropologie- und Moralphilosophie-Diskussion.".

The notion of empathy has been explicated in different ways in the current debate on how to understand others. Whereas defenders of simulation-based approaches claim that empathy involves some kind of isomorphism between the empathizer’s and the target’s mental state, defenders of the phenomenological account vehemently deny this and claim that empathy allows us to directly perceive someone else’s mental states. Although these views are typically presented as being opposed, I argue that at least one version of a simulation-based approach—the (...) account given by de Vignemont and Jacob—is compatible with the direct-perception view. My argument has two parts: My first step is to show that the conflict between these accounts is not—as it seems at first glance—a disagreement on the mechanism by which empathy comes about. Rather, it is due to the fact that their proponents attribute two very different roles to empathy in understanding others. My second step is to introduce Stein’s account of empathy. By not restricting empathy to either one of these two roles, her process model of empathy helps to see how the divergent intuitions that have been brought forward in the current debate could be integrated. (shrink)

It has become increasingly common to talk about the second person in the theory of mind debate. While theory theory and simulation theory are described as third person and first person accounts respectively, a second person account suggests itself as a viable, though wrongfully neglected third option. In this paper I argue that this way of framing the debate is misleading. Although defenders of second person accounts make use of the vocabulary of the theory of mind debate, they understand some (...) of the core expressions in a different way. I will illustrate this claim by focusing on Reddy’s and Gallagher’s accounts and argue that these authors use the notions of knowing and of understanding other minds differently than traditionally assumed. As a consequence, second person accounts thus conceived do not directly address the questions that gave rise to the theory of mind debate. They invite us, however, to critically reflect upon the way the debate has been set up. (shrink)

Comprehensive study of the Vākyapadīya of Bhartr̥hari, work on semantics and philosophy of Sanskrit grammar.

Introducing the first macro-sociological perspective on the concept of creativity this book includes a review of ten domains which have studied creativity. It also explores the results of a six-year on-going research project comparing students' ideas on creativity with employers' and industry professionals' views.

Die Autorin zeigt anhand der Texte von Locke, Leibniz, Kant, Fichte, Novalis und Jean Paul, wie Motive aus der nachkopernikanischen und newtonschen Astronomie zu Schlüsselmetaphern werden. Die Denker und Dichter erörtern mit diesen die Möglichkeiten eines neuen Grundlagendenkens und -handelns im Angesicht der Verwissenschaftlichung des Weltbildes.

The concept of vulnerability is widely used in human rights policy documents, reports, and case law focusing on the impacts of climate change on human rights. In academic discussions, the concept, however, has also sparked a discussion on its benefits and challenges for the advancement of human rights, especially concerning the principles of equality and non-discrimination. This article aims at contributing to this debate from a frame-analytical perspective. In social sciences, frame-analysis is a form of discourse analysis which focuses on (...) the consequences of different concepts for legal, political, and social discussions and norms. With the example of selected UN documents on different human rights issues in the context of climate change, the article, firstly, analyzes whether and how the concept of vulnerability is defined in the documents and why it is used in the documents. Secondly, it is elaborated to which individuals and groups the concept is applied. Thirdly, it is discussed how vulnerability is conceptualized in relation to or in distinction to the concepts of inequality and discrimination. In a further section it is analyzed what narratives are mobilized by the frame of vulnerability. The article concludes that from a discourse-analytical perspective the frame of vulnerability mobilizes problematic narratives which has gendered and racialized implications for those labeled vulnerable. (shrink)

Willing and Understanding elucidates a variety of issues in and approaches to debating the will-intellect interplay in the late Middle Ages. Authored by prominent scholars in the field, the contributions offer different perspectives on the development of late medieval theories of the will. Charting a dense map of voluntarist and epistemological ideas - entrenched leitmotifs of late medieval philosophy, seminal insights sparking original trends, and ephemeral novelties - the volume is a testimony to the conceptual multidimensionality and ethical complexity of (...) the past and present iterations of the debate on the will. Contributors are Pascale Bermon, Magdalena Bieniak, Michael W. Dunne, Riccardo Fedriga, Giacomo Fornasieri, Tobias Hoffmann, Severin V. Kitanov, Monika Michałowska, Riccardo Saccenti, Sonja Schierbaum, Michael Szlachta, Łukasz Tomanek, and Francesco Omar Zamboni. (shrink)

Van Goghs Malerei vollzieht den Wandel vom traditionellen Verständnis des Bildes als Repräsentation zum Bild als einer a-mimetischen, eigengesetzlichen Wirklichkeit, der sich äusserst anregend auf den Expressionismus und auf die abstrakte Malerei ausgewirkt hat. Weniger bekannt ist die Tatsache, dass sein Werk auch zur Entstehung von modernen Dichtungs- und Kunsttheorien beitrug. So wies es Rilke den Weg zur Sachlichkeit des Sagens, Hofmannsthal ermöglichte es ein neues Verständnis von Wirklichkeit, Heidegger unterstützte es bei der Erweiterung und Verwandlung der Metaphysik, während es (...) Jaspers zur Entwicklung seiner künftigen Existenzphilosophie anstiess. (shrink)

The Latin text Disputatio nova contra Mulieres, Qua probatur eas Homines non esse, published at the end of the sixteenth century, proved immensely popular in the years to come. Today, this book, the title of which raises doubts about the humanity of women, falls within the context of the longstanding historical debate known as the querelle des femmes. We have two French translations of this Latin text: the first one by Anne-Gabriel Meusnier de Querlon made in 1744, the second by (...) Charles Clapiès in 1766. The two translation texts perfectly exemplify the discussion regarding the relative merits of free translation and literal translation in the Age of Enlightenment. Comparing these two translations yields important insights related to fidelity and transposition in translation. (shrink)

In dieser Studie untersucht Monika Palowski das kontrovers diskutierte Phänomen der Klassenwiederholung erstmals aus Perspektive der Wissenssoziologischen Diskursanalyse. Anhand von insgesamt über 700 Texten aus Erziehungswissenschaft und Printmedien werden machtvolle Diskursstränge und -formationen rekonstruiert, die nicht nur die Wahrnehmung von Klassenwiederholung und schulischer Selektion, sondern auch der betroffenen Subjekte je spezifisch präfigurieren und dadurch Klassenwiederholung teils auch legitimieren. Die Ergebnisse der Analyse sind daher einerseits für die erziehungswissenschaftliche Auseinandersetzung mit schulischer Selektion und Bildungsungerechtigkeit relevant, andererseits aber auch für die (...) Diskurs- und Subjektivierungsforschung. (shrink)

The series Studien zur deutschen Literatur (Studies in German Literature) presents outstanding analyses of German-speaking literature from the early modern period to the present day. It particularly embraces comparative, cultural and historical-epistemological questions and serves as a tradition-steeped forum for innovative literary research. All submitted manuscripts undergo a double peer-review process.

This volume discusses the definitional problems and conceptual strategies involved in defining the human. By crossing the boundaries of disciplines and themes, it offers a transdisciplinary platform for exploring the new ideas of the human and adjusting to the dynamic in which we are plunged. The emerging cyborgs and transhumans call for an urgent reconsideration of humans as individuals and collectives. The identity of the human in the 21st century eludes definitions underpinned by simplifying and simplified dichotomies. Affecting all the (...) spheres of life, the discoveries and achievements of recent decades have challenged the bipolar categorizations of human/nonhuman and human/machine, real/virtual and thus opened the door to transdisciplinary considerations. Ours is a new world where the boundaries of normality and abnormality, a legacy of the long history of philosophy, medicine, and science need dismantling. We are now on our way to re-examine, re-understand, and re-describe what normal-abnormal, human-nonhuman, and I-we-they mean. We find ourselves facing what resembles the liminal stage of a global ritual, a stage of being in-between—between the old anthropocentric order and a new position of blurred boundaries. The volume addresses philosophical, bioethical, sociological, and cognitive approaches developed to transcend the binaries of human-nonhuman, natural-artificial, individual-collective, and real-virtual. (shrink)