This paper is a rejoinder to a critique by richard hull in a previous issue. hull denied the legitimacy of moving from the thesis that there are certain one-to-one correlations between mental and physical properties to the thesis that the mental and physical are one and the same. i argue that the move can be justified if it is taken not as deductive but as inductive. given the right sort of correlations, it may be fruitful to conceive of the mental (...) as identical with the physical. (shrink)

This is an extremely rich, wide ranging book, filled with insightful discussions of a large number of issues related to the general topic of the emotions. Its value lies not in its conclusions but in the details, which do not lend themselves easily to summarizing. So it must be said at the outset that this review will not do justice to the subtlety, complexity, and wit of this book.

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Objectives: To describe the concerns and priorities of key stakeholders in a developing country regarding ethical obligations held by researchers and perceptions of equity or “what is fair” for study participants in an HIV/AIDS clinical drug trial. Design: Qualitative study with focus groups. Setting: Teaching and referral hospital and rural health centre in western Kenya. Participants: Potential HIV/AIDS clinical trial participants, clinician researchers, and administrators. Results: Eighty nine individuals participated in a total of 11 focus groups over a four month (...) period. The desire for continued drug therapy, most often life long, following an HIV/AIDS clinical trial was the most common priority expressed in all focus groups. Patients with and without HIV/AIDS also thought subsidisation of drug therapies and education were critical forms of compensation for clinical trial participation. Financial incentives were considered important primarily for purchasing drug therapy as well as obtaining food. Patients noted a concern for the potential mismanagement of any money offered. Clinician researchers and administrators felt strongly that researchers have a moral obligation to participants following a trial to provide continued drug therapy, adverse event monitoring, and primary care. Finally, clinician researchers and administrators stressed the need for thorough informed consent to avoid coercion of study participants. Conclusions: Kenyan patients, clinician researchers, and administrators believe that it would be unfair to stop antiretroviral therapy following an HIV/AIDS clinical trial and that researchers have a long term obligation to participants. (shrink)

It is wholly uncontroversial that measurements-or, more properly, propositions that are measurement reports-are often paradigmatically good cases of propositions that serve the function of evidence. In normal cases it is also obvious that stating such a report is an utterly pedestrian case of successful assertion. So, for example, there is nothing controversial about the following claims: (1) that a proposition to the effect that a particular thermometer reads 104C when properly used to determine the temperature of a particular patient is (...) evidence that the patient in question has a fever and (2) that there is nothing wrong with asserting the proposition that a particular thermometer reads 104C for appropriate reasons of communication, etc. when the thermometer has been properly used to determine the temperature of a particular patient. Here it will be shown that Timothy Williamson’s commitments to a number of principles about knowledge and assertion imply that a whole class of utterly ordinary statements like these that are used as evidence are not really evidence because they are not knowledge and so are (perversely) unassertable according to his principled commitments. This paper deals primarily with the second of these two problems and an alternative account of the norms of assertion is introduced which allows for the assertability of such measurement reports. (shrink)

Kagan ponders a series of important nodes of debate while challenging us to examine what we know and why we know it. Most critically he presents an elegant argument for functions of mind that cannot be replaced with sentences about brains while acknowledging that mind emerges from brain activity. He relies on the evidence to argue that thoughts and emotions are distinct from their biological and genetic bases. In separate chapters he deals with the meaning of words, kinds of knowing, (...) the powerful influence of social class, the functions of education, emotion, morality, and other issues. And without fail he sheds light on these ideas while remaining honest to their complexity." -- Publisher's description. (shrink)

What do the airplane, the escalator, the vacuum cleaner, and the Polaroid camera have in common? It took many, many attempts to perfect these inventions. But the people who invented them persevered and did not give up on their ideas. With TIME For Kids content, this nonfiction book will engage students in reading about inventions as they build their comprehension, vocabulary, and literacy skills. The Reader's Guide and culminating activity direct students back to the text as they develop their higher-order (...) thinking skills. Check It Out! provides resources for additional reading and learning. With text features such as a glossary, index, and table of contents, this book aligns with national and state standards and will keep students engaged in reading. (shrink)

A manifesto for the humanities in the digital age, A New Republic of Letters argues that the history of texts, together with the methods by which they are preserved and made available for interpretation, are the overriding subjects of humanist study in the twenty-first century. Theory and philosophy, which have grounded the humanities for decades, no longer suffice as an intellectual framework. Jerome McGann proposes we look instead to philology--a discipline which has been out of fashion for many decades (...) but which models the concerns of digital humanities with surprising fidelity. For centuries, books have been the best way to preserve and transmit knowledge. But as libraries and museums digitize their archives and readers abandon paperbacks for tablet computers, digital media are replacing books as the repository of cultural memory. While both the mission of the humanities and its traditional modes of scholarship and critical study are the same, the digital environment is driving disciplines to work with new tools that require major, and often very difficult, institutional changes. Now more than ever, scholars need to recover the theory and method of philological investigation if the humanities are to meet their perennial commitments. Textual and editorial scholarship, often marginalized as a narrowly technical domain, should be made a priority of humanists' attention. (shrink)

Second, this collection of cognitive programs evolved in the Pleistocene to solve the adaptive problems regularly faced by our hunter-gatherer ancestors-...

Living in the Borderland addresses the evolution of Western consciousness and describes the emergence of the "Borderland," a spectrum of reality that is beyond the rational yet is palpable to an increasing number of individuals. Building on Jungian theory, Jerome Bernstein argues that a greater openness to transrational reality experienced by Borderland personalities allows new possibilities for understanding and healing confounding clinical and developmental enigmas." "Living in the Borderland challenges the standard clinical model, which views normality as an absence (...) of pathology and which equates normality with the rational. Jerome S. Bernstein describes how psychotherapy itself often contributes to the alienation of Borderland personalities by misperceiving the difference between the pathological and the sacred. The case studies included illustrate the potential this has for causing serious psychic and emotional damage to the patient." "This challenge to the orthodoxies and complacencies of western medicine's concept of pathology will interest Jungian Analysts, Psychotherapists, Psychiatrists and other physicians, as well as educators of children. (shrink)

"No soy de los que deploran la especialización; en todo caso, dudo que sea posible, aunque fuere deseable, frenar la persecución de un saber especializado, en complejas sociedades. Pero es que la filosofía del Derecho ha descansado tradicionalmente en una perspectiva muy amplia, y hay que lamentar de modo especial la pérdida de sus funciones unitivas debido a la extraordinaria necesidad presente de comprender y mejorar las instituciones jurídicas. La situación actual no clama por la desvalorización de la especialización, sino (...) que, por el contrario, desafía a los estudiosos a trascender las especializaciones de la filosofía del Derecho, y cualquiera fuere la utilidad que con ello pudiera lograrse, a construir una jusfilosofía que satisfaga más adecuadamente las presentes demandas". Jerome Hall. (shrink)

Proceedings of a conference held in Sept. 2009 in London, England.