This essay contends that while Nancy and Esposito have strikingly similar concepts of the place of the political in post-metaphysical community, their respective articulations of these concepts noticeably diverge. Because of his commitment to excavating the political project of immunity as central to the Western political tradition in and through the category of the legal person, Esposito announces community as impolitical, as the interruptive spacing, and thus alternating displacement, of the political conceived as the site of emancipatory agency. In contrast, (...) in the work of Agamben and in the recent work of Nancy, an articulation of the person and the political in more agential terms can be found. This divergence presents interpretive difficulties insofar as Esposito's discussion of community as impolitical could be read as advancing ontological neutrality or passivity that threatens to separate political activity from its liberating potential. I argue that such ontological neutrality is a product of Esposito's confrontation with the political as dominated by both the logic of immunity and an engagement with the complex legacy of Heidegger's problematic political trajectory. To this extent it is an open question whether Esposito's project leaves room for a new vision of the political and for political agency. (shrink)

Bone marrow is the main site for hematopoiesis in adults. It acts as a niche for hematopoietic stem cells (HSCs) and contains non‐hematopoietic cells that contribute to stem cell dormancy, quiescence, self‐renewal, and differentiation. HSC also exist in resting spleen of several species, although their contribution to hematopoiesis under steady‐state conditions is unknown. The spleen can however undergo extramedullary hematopoiesis (EMH) triggered by physiological stress or disease. With the loss of bone marrow niches in aging and disease, the spleen as (...) an alternative tissue site for hematopoiesis is an important consideration for future therapy, particularly during HSC transplantation. In terms of harnessing the spleen as a site for hematopoiesis, here the remarkable regenerative capacity of the spleen is considered with a view to forming additional or ectopic spleen tissue through cell engraftment. Studies in mice indicate the potential for such grafts to support the influx of hematopoietic cells leading to the development of normal spleen architecture. An important goal will be the formation of functional ectopic spleen tissue as an aid to hematopoietic recovery following clinical treatments that impact bone marrow. For example, expansion or replacement of niches could be considered where myeloablation ahead of HSC transplantation compromises treatment outcomes. (shrink)

This article underlines and draws attention to critical insights that Esposito makes regarding the prospects of rethinking community in a globalized world. Alongside Agamben and Nancy, Esposito challenges the property prejudice found in mainstream models of community. In identity politics, collective identity is converted into a form of communal property. Borders, sovereign territories, and exclusive rights are fiercely defended in the name of communal property. Esposito responds to this problem by developing what I call a “deontological communal contract” where being (...) and ethics are prioritized over having and economics. I examine this new perspective on community in relation to mainstream models found in contemporary and classical social theory. (shrink)

This collection of essays, though dealing with different topics from section to section, is unified by the idea that, at least in the English-speaking world, ...

Jonathan Edwards is known as one of the most respected thinkers in American history and presided over the Great Awakening, one of the formative colonial events. What many don't realize is Edwards lived during a time of widespread conflict, which eventually touched the people of Northampton personally. Through these collected sermons, many of which are unpublished, Edwards sought to instruct, train, and comfort his congregation during a precarious season in provincial life. These sermons demonstrate the scope of Edwards's greatness: (...) a global thinker intimately connected to the British Empire as well as shepherd of the Northampton flock. The first part of this collection presents the sermons Edwards preached while the theater of war centered on the continent and the Caribbean. During this phase, Edwards's sermons leveraged martial language to promote the burgeoning revivals. In 1744, war was transplanted to the colonies in which the Northampton congregation personally participated. After a short hiatus of international conflict, warfare spread throughout the colonies. While he served a frontier mission, Edwards prepared his Indian congregation for yet another season of war. These sermons present Edwards as theologian, historian, philosopher, but most importantly, as pastor. (shrink)

Sentience is the capacity to have feelings, such as feelings of pain, pleasure, hunger, thirst, warmth, joy, comfort and excitement. It is not simply the capacity to feel pain, but feelings of pain, distress or harm, broadly understood, have a special significance for animal welfare law. Drawing on over 300 scientific studies, we evaluate the evidence of sentience in two groups of invertebrate animals: the cephalopod molluscs or, for short, cephalopods (including octopods, squid and cuttlefish) and the decapod crustaceans (...) or, for short, decapods (including crabs, lobsters and crayfish). We also evaluate the potential welfare implications of current commercial practices involving these animals. (shrink)

Discusses how William James’s work suggests a world without will, self, or time and how research supports this perspective. William James is often considered a scientist compromised by his advocacy of mysticism and parapsychology. Jonathan Bricklin argues James can also be viewed as a mystic compromised by his commitment to common sense. James wanted to believe in will, self, and time, but his deepest insights suggested otherwise. “Is consciousness already there waiting to be uncovered and is it a veridical (...) revelation of reality?” James asked shortly before his death in 1910. A century after his death, research from neuroscience, physics, psychology, and parapsychology is making the case, both theoretically and experimentally, that answers James’s question in the affirmative. By separating what James passionately wanted to believe, based on common sense, from what his insights and researches led him to believe, Bricklin shows how James himself laid the groundwork for this more challenging view of existence. The non-reality of will, self, and time is consistent with James’s psychology of volition, his epistemology of self, and his belief that Newtonian, objective, even-flowing time does not exist. (shrink)

South Africa has an education crisis, despite the fact that the government spends the biggest slice of its budget on education, more than any other African country. And yet the crisis persists. Jansen and Blank looked at South African schools that work, in spite of adverse conditions -- schools in poor communities, schools with overcrowded classrooms, schools in both rural and urban environments -- and have drawn out the practical strategies that make them successful. 19 short films (included on (...) DVD) let you visit these schools and understand in the words of their principals, teachers and learners what makes them succeed. Then take look at the 10 key strategies identified and see how to implement them in other schools to effect transformation. As we have come to expect from Jansen, there are no complicated theories, not difficult to implement solutions -- just lots of common sense! (shrink)

Idiots burn books for the same reason philosophers write them – they matter. But why exactly do political philosophy books matter, not to mention the hundreds of articles published every year? In part because they are interesting, but also because they are influential. They are mind-altering and, in turn, world-altering. Political philosophers write their books for the same reason political revolutionaries read them – they change the world. In this short and original book, Jonathan Floyd explains three things: (...) what political philosophy is, how you can do it, and why you might want to. Accessibly written for those coming to the subject for the first time, it is also a must-read for scholars whose research takes in the nature, methods, and purposes of their field. It is also a must-burn for anyone who dreams of a dumber, thicker, less enlightened world. (shrink)

Jerry Gaus is the most important philosopher of public reason since John Rawls. His path-breaking work on this topic has deeply influenced a large group of moral and political philosophers, a group to which I happily belong. In this short paper I examine one feature of the account developed in his incredibly rich and illuminating book, The Order of Public Reason.Gaus (2011), cited hereafter as OPR. I argue Gaus’s theory struggles to resolve a crucial question: how can we be (...) confident that public reason will yield a set of moral rules whose content is minimally acceptable?Gaus’s viewGiven pervasive disagreement about morality, how can we engage in the practice of morality—making demands on others and frequently enforcing those demands with coercive threats—in a way that also manages to respect others as free and equal interpreters of morality? One solution, which Gaus associates with Kant and Rawls, is to bracket all those beliefs or commitments that divide us, and construct a set of mo. (shrink)

Consider people’s ordinary concept of belief. This concept seems to pick out a particular psychological state. Indeed, one natural view would be that the concept of belief works much like the concepts one finds in cognitive science – not quite as rigorous or precise, perhaps, but still the same basic type of notion. But now suppose we turn to other concepts that people ordinarily use to understand the mind. Suppose we consider the concept happiness. Or the concept love. How are (...) these concepts to be understood? One obvious hypothesis would be that they are best understood as being more or less like the concept of belief. Maybe these concepts, too, pick out a particular mental state and thereby enable people to predict, explain and understand others’ behavior. We will argue that this hypothesis is mistaken. Instead, we suggest that the different concepts people use to understand the mind are fundamentally different from each other. Some of these concepts do indeed serve simply to pick out a particular mental state, but others allow a role for evaluative judgments. So, for example, our claim will be that when people are wondering whether a given agent is truly ‘happy’ or ‘in love,’ they are not merely trying to figure out whether this agent has a particular sort of mental state. They are also concerned in a central way with evaluating the agent herself. In short, our aim is to point to a striking sort of difference between the different concepts that people use to pick out psychological attitudes. We will be.. (shrink)

Deep brain stimulation (DBS) is frequently described as a ‘reversible’ medical treatment, and the reversibility of DBS is often cited as an important reason for preferring it to brain lesioning procedures as a last resort treatment modality for patients suffering from treatment-refractory conditions. Despite its widespread acceptance, the claim that DBS is reversible has recently come under attack. Critics have pointed out that data are beginning to suggest that there can be non-stimulation-dependent effects of DBS. Furthermore, we lack long-term data (...) about other potential irreversible effects of neuromodulation. This has considerable normative implications for comparisons of DBS and brain lesioning procedures. Indeed, Devan Stahl and colleagues have recently argued that psychiatric DBS should be subject to the same legal safeguards as other forms of psychosurgery, supporting their position by forcibly criticising the claim that DBS is reversible. In this paper, I respond to these criticisms by first clarifying the descriptive and evaluative elements of the reversibility claim that supporters of DBS might invoke, and the different senses of ‘reversibility’ that we might employ in discussing the effects of medical procedures. I go on to suggest that it is possible to defend a nuanced version of the reversibility claim. To do so, I explain how DBS has some effects that are stimulation dependent in the short term, and argue that these effects can have significant normative implications for patient well-being and autonomy. I conclude that we should not abandon a nuanced version of the reversibility claim in the DBS debate. (shrink)

Jonathan Walkan challenges cognitive science's dominant model of mental representation and proposes a novel, well-devised alternative. The traditional view in the cognitive sciences uses a linguistic model of mental representation. That logic-based model of cognition informs and constrains both the classical tradition of artificial intelligence and modeling in the connectionist tradition. It falls short, however, when confronted by the frame problem---the lack of a principled way to determine which features of a representation must be updated when new information (...) becomes available. So far, proposed alternatives, including the imagistic model, have not resolved the problem. Waskan proposes the Intrinsic Cognitive Models hypothesis, according to which representational states can be concpetualized as the cognitive equivalent of scale models.Waskan argues further that the proposal that humans harbor and manipulate cognitive counterparts to scale models offers the only viable explanation for what most clearly differentiates humans from other creatures: the capacity to engage in truth-preserving manipulation of representations. The ICM hypothesis, he claims, can be distinguished from sentence-based accounts of truth preservation in a way that is fully compatible with what is known about the brain. (shrink)

A tropel is a particular property: the redness of a rose, the roundness of the moon. It is generally supposed that tropes are individuated by primitive quantity: this redness, that roundness. I argme that the trope theorist is far better served by individuating tropes by spatiotemporal relation: here redness, there roundness. In short, tropes are not this-suches but here-suches.

How must knowledge be formed, if made in the image of assertion? That is, given that knowledge plays the normative role of governing what one may assert, what can be inferred about the structure of the knowledge relation from this role? I will argue that what one may assert is sensitive to the question under discussion, and conclude that what one knows must be relative to a question. In short, knowledge in the image of assertion is question-relative knowledge.

Simple extrapolation is the orthodox approach to extrapolating from clinical trials in evidence-based medicine: extrapolate the relative effect size from the trial unless there is a compelling reason not to do so. I argue that this method relies on a myth and a fallacy. The myth of simple extrapolation is the idea that the relative risk is a ‘golden ratio’ that is usually transportable due to some special mathematical or theoretical property. The fallacy of simple extrapolation is an unjustified argument (...) from ignorance: we conclude that the relative effect size is transportable in the absence of evidence to the contrary. In short, simple extrapolation is a deeply problematic solution to the problem of extrapolation. (shrink)

This Very Short Introduction brings together the latest research in neuroscience and psychology - weaving in case-studies, anecdotes, literature, and philosophy - to explore and explain the science of memory - how it works, and why we can't live without it.

Cooperation is rife in the microbial world, yet our best current theories of the evolution of cooperation were developed with multicellular animals in mind. Hamilton’s theory of inclusive fitness is an important case in point: applying the theory in a microbial setting is far from straightforward, as social evolution in microbes has a number of distinctive features that the theory was never intended to capture. In this article, I focus on the conceptual challenges posed by the project of extending Hamilton’s (...) theory to accommodate the effects of gene mobility. I begin by outlining the basics of the theory of inclusive fitness, emphasizing the role that the concept of relatedness is intended to play. I then provide a brief history of this concept, showing how, over the past fifty years, it has departed from the intuitive notion of genealogical kinship to encompass a range of generalized measures of genetic similarity. I proceed to argue that gene mobility forces a further revision of the concept. The reason in short is that, when the genes implicated in producing social behaviour are mobile, we cannot talk of an organism’s genotype simpliciter; we can talk only of an organism’s genotype at a particular stage in its life cycle. We must therefore ask: with respect to which stage(s) in the life cycle should relatedness be evaluated? For instance: is it genetic similarity at the time of social interaction that matters to the evolution of social behaviour, or is it genetic similarity at the time of reproduction? I argue that, strictly speaking, it is neither of these: what really matters to the evolution of social behaviour is diachronic genetic similarity between the producers of fitness benefits at the time they produce them and the recipients of those benefits at the end of their life-cycle. I close by discussing the implications of this result. The main payoff is that it makes room for a possible new mechanism for the evolution of altruism in microbes that does not require correlated interaction among bearers of the genes for altruism. The importance of this mechanism in nature remains an open empirical question. (shrink)

Deep Brain Stimulation is currently being investigated as an experimental treatment for patients suffering from treatment-refractory AN, with an increasing number of case reports and small-scale trials published. Although still at an exploratory and experimental stage, initial results have been promising. Despite the risks associated with an invasive neurosurgical procedure and the long-term implantation of a foreign body, DBS has a number of advantageous features for patients with SE-AN. Stimulation can be fine-tuned to the specific needs of the particular patient, (...) is relatively reversible, and the technique also allows for the crucial issue of investigating and comparing the effects of different neural targets. However, at a time when DBS is emerging as a promising investigational treatment modality for AN, lesioning procedures in psychiatry are having a renaissance. Of concern it has been argued that the two kinds of interventions should instead be understood as rivaling, yet “mutually enriching paradigms” despite the fact that lesioning the brain is irreversible and there is no evidence base for an effective target in AN. We argue that lesioning procedures in AN are unethical at this stage of knowledge and seriously problematic for this patient group, for whom self-control is particularly central to wellbeing. They pose a greater risk of major harms that cannot justify ethical equipoise, despite the apparent superiority in reduced short term surgical harms and lower cost. (shrink)

How should we understand good philosophical inquiry? Ernest Sosa has argued that the key to answering this question lies with virtue-based epistemology. According to virtue-based epistemology, competences are prior to epistemic justification. More precisely, a subject is justified in having some type of belief only because she could have a belief of that type by exercising her competences. Virtue epistemology is well positioned to explain why, in forming false philosophical beliefs, agents are often less rational than it is possible to (...) be. False philosophical beliefs are often unjustified—and the agent is thereby less rational for having them—precisely because these beliefs could not be formed by exercising competences. But, virtue epistemology is not well positioned to explain why, in failing to form some true philosophical beliefs, agents are less rational than it is possible to be. In cases where agents fall short by failing to believe philosophical truths, the problem is not that they believe things they shouldn’t, but that they lack beliefs they ought to have. We argue that Timothy Williamson's recent critique of the a priori/a posteriori distinction falls prey to similar problem cases. Williamson fails to see that a type of belief might be a priori justified if and only if, even without any special confirming experiences, agents fall short by failing to have this type of belief. We conclude that there are types of beliefs that are deeply a priori justified for any agent regardless of what epistemic competences the agent has. However, we also point out that this view has a problem of its own: it appears to make the acquisition of a priori knowledge too easy. We end by suggesting that a move back towards virtue-based epistemology is necessary. But in order for this move to be effective, epistemic competences will have to be understood very differently than in the reliabilist tradition. (shrink)

Epistemology - the theory of knowledge and of justified belief - has always been of central importance in philosophy. Progress in other areas of philosophical research has often depended crucially on epistemological presuppositions. This Companion, with well over 250 articles ranging from summary discussions to major essays on topics of current controversy, is the first complete reference work devoted to the subject. All the main theoretical positions in epistemology are discussed and analysed, tougher with the different categories of knowledge itself (...) - scientific, historical, mathematical, a priori, moral and so on - and the special problems associated with these. There are also many entries covering individual concepts, arguments and problems, short definitions of technical terms, and biographical articles. With its unrivalled coverage of the field, supported by a comprehensive index and an extensive cross-referencing, the Companion is likely to remain the standard reference work in epistemology from undergraduate level upward for the foreseeable future. (shrink)

Thinking is the essence of what it means to be human and defines us more than anything else as a species. Jonathan Evans explores cognitive psychological approaches to understanding the nature of thinking and reasoning, problem solving, and decision making.

Recent developments in experimental philosophy (‘x-phi’) suggest that there is a new way in which the empirical and normative dimensions of bioethics can be brought into successful dialogue with one another. It revolves around conceptual analysis – though not the kind of conceptual analysis one might perform in an armchair. Following Édouard Machery, this is Conceptual Analysis Rebooted. In short, morally-pertinent medical concepts like ‘treatment’, ‘euthanasia’ and ‘sanctity of life’ can each have several meanings that underwrite inferences with different (...) moral implications. X-phi shows us that an experimental approach to conceptual analysis can make explicit the implicit structures that underpin our thinking about such concepts. By presenting concrete examples, I aim to offer a glimpse of an empirically-grounded, practically-normative 'bioxphi' that demystifies and distinguishes medical concepts, assesses the normative inferences these concepts dispose us to draw and revises those inferences that are deficient. (shrink)

In this amazingly prophetic work, done late in his career, Herbert Spencer offers an approach to ethics that anticipates developments throughout the twentieth century. He moves away from the twin evils of ethical doctrines bequeathed to us by an ancient past that are simply no longer feasible but also avoids modern standards of ethical conduct that are simply impossible to attain. "By association with rules that cannot be obeyed," Spencer writes, "rules that can be obeyed lose their authority." The volume (...) opens with three chapters on conduct: its evolution, good and bad, and ways of judgment. This is followed by a series of chapters that examine ethics from a variety of scientific perspectives: physics, biology, psychology, and sociology. The work then moves on to specific issues of deep human concern: the relativity of pleasures and pain, egoism versus altruism in explaining actions, and trial and compromise in decision-making about ethical concerns. Spencer's work anticipates the movement toward pragmatic, naturalistic, and even positivist approaches to ethics. He emphasizes that a relativist approach while in keeping with the spirit of the industrial age, also poses a variety of problems that admit only of empirical solutions. He understands that his critical stance on absolutism should not blind researchers to the ideals assumed by the ancients that assist people in their everyday living. In short, this is a remarkable work, entirely modern, and yet containing a sharp evaluation of how ethical data serve to enhance ethical conduct. (shrink)

Historians of science have long been agreeing: what many textbooks of evolutionary biology say, about the histories of Darwinism and the New Synthesis, is just too simple to do justice to the complexities revealed to critical scholarship and historiography. There is no current consensus, however, on what grand narratives should replace those textbook histories. The present paper does not offer to contribute directly to any grand, consensual, narrational goals; but it does seek to do so indirectly by showing how, in (...) just one individual case, details of intellectual biography connect with big picture issues. To this end, I examine here how very diverse scientific and metaphysical commitments were integrated in Sewall Wright’s own personal synthesis of biology and philosophy. Taking as the decisive text the short final section of Wright’s long 1931 paper on ‘Evolution in Mendelian populations,’ I examine how his shifting balance theory related to his optimum breeding strategy research, his physiological genetics, his general theory of homogenising and heterogenesing causation and his panpsychist view of mind and matter; and I discuss how understanding these relations can clarify Wright’s place in the longue durée of evolutionary thought. (shrink)

Theory of Science provides an accessible but systematic survey of perspectives on science and rationality through the arguments and ideas of leading thinkers of the 20th century, including Einstein, Carnap, Popper, Kuhn, Feyerabend, Hempel, Gadamer, Foucault, and Harding. The book also gives a critical introduction to scientific methodology, including the relationship between theory and observation, the problem of induction, hypothetic-deductive method, truth and progress, and explanation in natural and human science. The book covers the theory of science â?? part of (...) the syllabus in Examen Philosophicum at The Norwegian University of Science and Technology (NTNU) â?? for which there has hitherto been no unitary text book in English. Theory of Science is also suited to use in other courses at various levels, as well as being of interest to a wider audience concerned with the philosophical and social problems of science. (shrink)

This is a paper about trust, with a specific focus on the ways in which trust is investigated in the business literature and the commercial sector. The lens through which the topic is approached is distinctively philosophical. We use philosophical tools to demonstrate the paucity of some of the accounts of trust that are given in the business and management literature, as well as the empirically informed literature that has flowed from them. We close with a discussion of some work (...) on trust drawn from the commercial sector that would, as we shall demonstrate, benefit from a clearer understanding of the nature of trust. We take this to be important. Trust is a key moral and ethical component of transactional relationships. Without a clear understanding of the notion, we will be missing a central concept in our attempts to understand the commercial world that we inhabit. The paper proceeds in four parts. In the first part of the paper we introduce some reasonably standard philosophical distinctions between different kinds of trust, as well as saying a little more about our methods. In the second, we demonstrate that a reasonably widely held account of trust in the business and management literature fails to capture the nuance reflected by the philosophical literature. On the basis of this, in the third section, we suggest that various pieces of empirical work require reassessment. In the final part of the paper we explore some non-academic discussions of trust drawn from the commercial sector arguing that, there too, we require a more precise understanding of trust. In short, though, our overarching argument is simply this: if we can give a more precise analysis of trust, it follows that both our empirical research and current commercial activity can be improved. (shrink)

How do our engagements with fictions and other products of the imagination compare to our experiences of the real world? Are the feelings we have about a novel's characters modelled on our thoughts about actual people? If it is wrong to feel pleasure over certain situations in real life, can it nonetheless be right to take pleasure in analogous scenarios represented in a fantasy or film? Should the desires we have for what goes on in a make-believe story cohere with (...) what we want to happen in the actual world? In Apt Imaginings, Jonathan Gilmore develops a new framework to pursue these questions, marshalling a wide range of research in aesthetics, the science of the emotions, moral philosophy, neuroscience, cognitive psychology, and film and literary theory. Gilmore argues that, while there is a substantial empirical continuity in our feelings across art and life, the norms that govern the appropriateness of those responses across the divide are discontinuous. In this view, the evaluative criteria that determine the fit, correctness, or rationality of our emotions and desires for what is internal to a fiction can be contrary to those that govern our affective attitudes toward analogous things in the real world. In short, it can be right to embrace within a story what one would condemn in real life. The theory Gilmore defends in this volume helps to explain our complex and sometimes conflicted attitudes toward works of the imagination; challenges the popular view that fictions serve to refine our moral sensibilities; and exposes a kind of autonomy of the imagination that can render our responses to art immune to standard real-world epistemic, practical, and affective kinds of criticism. (shrink)

An important obstacle to lawhood in the special sciences is the worry that such laws would require metaphysically extravagant conspiracies among fundamental particles. How, short of conspiracy, is this possible? In this paper we'll review a number of strategies that allow for the projectibility of special science generalizations without positing outlandish conspiracies: non-Humean pluralism, classical MRL theories of laws, and Albert and Loewer's theory. After arguing that none of the above fully succeed, we consider the conspiracy problem through the (...) lens of our preferred view of laws, an elaboration of the MRL view that we call the Better Best System (BBS) theory. BBS offers a picture on which, although all events supervene on a fundamental level, there is no one unique locus of projectibility; rather there are a large number of loci corresponding to the different areas (ecology, economics, solid-state chemistry, etc.) in which there are simple and strong generalizations to be made. While we expect that some amount of conspiracy-fear-inducing special science projectibility is inevitable given BBS, we'll argue that this is unobjectionable. It follows from BBS that the laws of any particular special or fundamental science amount to a proper subset of the laws. From this vantage point, the existence of projectible special science generalizations not guaranteed by the fundamental laws is not an occasion for conspiracy fantasies, but a predictable fact of life in a complex world. (shrink)

Suppose that, while you are dreamlessly asleep, the sizes of and distances between all objects in the world are uniformly multiplied. Would you be able to detect this global inflation? Intuitively, no. But would your experience of size remain accurate? Intuitively, yes. On these grounds, some have concluded that our experiences do not represent size and instead represent modes of presentation of size. We are, in this sense, ‘cut off’ from the sizes of things in the external world. Here, I (...) argue for a more modest conclusion: undetectable inflation reveals that our experiences represent only relative size. Call this view austere phenomenal relativism––or austere relativism, for short. I develop a framework to contrast austere relativism with its competitors, give an extended argument for the view, and then defuse a potential dilemma concerning the units in which our experiences represent size. (shrink)

While many have argued that moral disagreement poses a challenge to moral knowledge, the precise nature of this challenge is controversial. Indeed, in the moral epistemology literature, there are many different versions of ‘the’ argument from moral disagreement to moral scepticism. This paper contributes to this vast literature on moral disagreement by arguing for two theses: 1. All (or nearly all) moral disagreement arguments share an underlying structure; and, 2. All moral disagreement arguments that satisfy this underlying structure cannot establish (...) moral scepticism because this underlying structure leads to a previously unrecognized reductio ad absurdum. In short, I argue that this reductio argument (very likely) refutes all versions of the moral disagreement to moral scepticism argument in one fell swoop. (shrink)

Relatively little has been written about the ethics of conducting early phase clinical trials involving subjects from the developing world. Below, I analyze ethical issues surrounding one of gene transfer’s most widely praised studies conducted to date: in this study, Italian investigators recruited two subjects from the developing world who were ineligible for standard of care because of economic considerations. Though the study seems to have rendered a cure in these two subjects, it does not appear to have complied with (...) various international guidelines that require that clinical trials conducted in the developing world be responsive to their populations’ health needs. Nevertheless, policies devised to address large scale, late stage trials, such as the AZT short‐course placebo trials, map somewhat awkwardly to early phase studies. I argue that interest in conducting translational research in the developing world, particularly in the context of hemophilia trials, should motivate more rigorous ethical thinking around clinical trials involving economically disadvantaged populations. (shrink)

International institutions are being transformed by the twinned appearance of new non-governmental organizations and new technologies. How do these processes co-evolve? If we were limited to three words to describe the new interactive technologies of the Web, we would highlight the following logics: link, search, interact. Whereas in other systems these logics are additive, on the Web they can be recombinatory. Search, for example, can be conducted based on the structure of links, leading to new patterns of interaction, new links (...) and new methods of search. Of greatest interest are the kinds of search where you don’t know what you’re looking for but will recognize it when you find it. In short, innovation is promoted by networked organizational forms. New technologies do not determine these innovative outcomes, but they can facilitate them. The article explores the prospect of shifts among NGOs from autarky to collaboration, and from information transmission to knowledge networks in the virtual public sphere. (shrink)

This is a short introductory article. I focus on three questions: What is instrumental rationality? What are the principles of instrumental rationality? Could instrumental rationality be all of practical rationality?

The influence of Aristotle, the prince of philosophers, on the intellectual history of the West is second to none. In this book, Jonathan Barnes examines Aristotle's scientific researches, his discoveries in logic and his metaphysical theories, his work in psychology and in ethics and politics, and his ideas about art and poetry, placing his teachings in their historical context.

Suppose that, while you are dreamlessly asleep, the sizes of and distances between all objects in the world are uniformly multiplied. Would you be able to detect this global inflation? Intuitively, no. But would your experience of size remain accurate? Intuitively, yes. On these grounds, some have concluded that our experiences do not represent size and instead represent modes of presentation of size. We are, in this sense, ‘cut off’ from the sizes of things in the external world. Here, I (...) argue for a more modest conclusion: undetectable inflation reveals that our experiences represent only relative size. Call this view austere phenomenal relativism––or austere relativism, for short. I develop a framework to contrast austere relativism with its competitors, give an extended argument for the view, and then defuse a potential dilemma concerning the units in which our experiences represent size. (shrink)

Modernist philosophy and psychology have pursued a variety of methods and models for understanding the universal inclination of human persons toward moral self-deception. We tend, as the Scriptures reveal and as recent empirical studies have confirmed, to think more highly of ourselves and our personal moral caliber than we ought. Whereas, Freud, Sartre, and others have offered solutions to the “paradox” of self-deception—that is, how one can be both deceiver and deceived—their solutions ultimately fall short in terms of both (...) coherence and explanatory power. From a Christian perspective, secular frameworks are bound to falter because they do not account for humanity’s status as fallen and sinful before a holy God. The gospel of Jesus Christ, on the other hand, offers means not only of understanding, but overcoming, moral self-deception. Historically, no movement of Christian spirituality has been more rigorously skeptical of the human ability to “know thyself” truly than the Puritans. This analysis of Puritan pastoral theology provides a helpful lens through which to view, and undermine, the deceitfulness of the human heart. (shrink)

ABSTRACTRelatively little has been written about the ethics of conducting early phase clinical trials involving subjects from the developing world. Below, I analyze ethical issues surrounding one of gene transfer’s most widely praised studies conducted to date: in this study, Italian investigators recruited two subjects from the developing world who were ineligible for standard of care because of economic considerations. Though the study seems to have rendered a cure in these two subjects, it does not appear to have complied with (...) various international guidelines that require that clinical trials conducted in the developing world be responsive to their populations’ health needs. Nevertheless, policies devised to address large scale, late stage trials, such as the AZT short‐course placebo trials, map somewhat awkwardly to early phase studies. I argue that interest in conducting translational research in the developing world, particularly in the context of hemophilia trials, should motivate more rigorous ethical thinking around clinical trials involving economically disadvantaged populations. (shrink)

This paper introduces some of the major themes of An Unwritten Future: Realism and Uncertainty in World Politics, and provides a short illustration of how the analytical apparatus elaborated there can offer fruitful insights into understanding enduring puzzles in international relations. An Unwritten Future explores, illuminates and interrogates Classical Realism, an approach to the study of world politics that is contrasted with Structural Realism and with the ‘hyper-rationalist’ perspective associated with the ‘Rationalist Explanations for War’ school of thought. It (...) elucidates the fundamental flaws of those two highly influential paradigms, and explains why Classical Realism, with its emphasis on what Structural Realism and Hyper-rationalism forbid—content, purpose, history, and irreducible uncertainty—provides a more promising and productive point of departure for students of international relations. (shrink)