The promises of precision medicine are often heralded in the medical and lay literature, but routine integration of genomics in clinical practice is still limited. While the “last mile” infrastructure to bring genomics to the bedside has been demonstrated in some healthcare settings, a number of challenges remain — both in the receptivity of today's health system and in its technical and educational readiness to respond to this evolution in care. To improve the impact of genomics on health and disease (...) management, we will need to integrate both new knowledge and new care processes into existing workflows. This change will be onerous and time-consuming, but hopefully valuable to the provision of high quality, economically feasible care worldwide. (shrink)

This paper provides an analysis of contrary-to-duty reasoning from the proof-theoretical perspective of category theory. While Chisholm’s paradox hints at the need of dyadic deontic logic by showing that monadic deontic logics are not able to adequately model conditional obligations and contrary-to-duties, other arguments can be objected to dyadic approaches in favor of non-monotonic foundations. We show that all these objections can be answered at one fell swoop by modeling conditional obligations within a deductive system defined as an instance of (...) a symmetric monoidal closed category. Using category theory as a foundational framework for logic, we show that it is possible to model conditional normative reasoning and conflicting obligations within a monadic approach without adding further operators or considering deontic conditionals as primitive. (shrink)

Monoidal logics were introduced as a foundational framework to analyse the proof theory of deontic logic. Building on Lambek’s work in categorical logic, logical systems are defined as deductive systems, that is, as collections of equivalence classes of proofs satisfying specific rules and axiom schemata. This approach enables the classification of deductive systems with respect to their categorical structure. When looking at their proof theory, however, one can see that there are similarities between monoidal and substructural logics. The purpose of (...) the present paper is to address this issue and highlight the differences between these two approaches. We argue that monoidal logics provide a more flexible foundational framework that enables a finer analysis of the relationship between negation and other logical connectives. We show that the elimination of double negation is independent from the de Morgan dualities, that monoidal deductive systems are not necessarily weakly distributive and that deduc... (shrink)

In psychology, measurement instruments are constructed from scales, which are obtained on the grounds of exploratory and confirmatory factor analysis. Looking at the literature, one can find various recommendations regarding how these techniques should be used during the scale construction process. Some authors suggest to use exploratory factor analysis on the entire data set while others advice to perform an internal cross-validation by randomly splitting the data set in two and then either perform exploratory factor analysis on both parts or (...) exploratory factor analysis on the first part and confirmatory factor analysis on the other. In spite of all these divergent recommendations, there is no consensus on which method yields the best result. In this paper, we analyze this issue in light of the prediction versus accommodation debate and argue that the answer to this question depends on one’s conception of the criteria that should be used to achieve the goals of the scientific enterprise. (shrink)

Realism is generally assumed as the correct position with regards to psychological research and the measurement of psychological attributes in psychometrics. Borsboom et al., 203–219 2003), for instance, argued that the choice of a reflective measurement model necessarily implies a commitment to the existence of psychological constructs as well as a commitment to the belief that empirical testing of measurement models can justify their correspondence with real causal structures. Hood :739–761 2013) deemphasized Borsboom et al.’s position and argued that the (...) choice of a reflective measurement model does not necessarily require ontological commitments, though, in his view, it does necessitate a commitment to minimal epistemic realism. Although these arguments are formulated with regard to psychological research, they can actually be generalized to other disciplines in social sciences that use similar methodologies and statistical techniques. In Hood’s opinion, empiricism does not suffice to provide an adequate account of the choice of reflective measurement models given that this choice requires an appeal to causal explanations. In this paper, we argue against Hood and answer this challenge, providing epistemic foundations for social science research that do not appeal to realism. (shrink)

Exploratory factor analysis is a statistical method widely used in quantitative psychology for the construction of scales and measurement instruments. It aims to reduce the complexity of a data set and explain the common and unique variance using latent variables. In introductory textbooks, exploratory factor analysis is generally presented in contrast to confirmatory factor analysis as a theory- or a hypothesis-generating process that does not require prior background, theory or hypothesis to be performed. The aim of the present paper is (...) to analyze this claim and clarify in which sense exploratory factor analysis is theory-laden. We provide a careful examination of the concepts it involves and thereby establish a clear limitation of the epistemic scope of exploratory factor analysis. (shrink)

Book Reviews Clayton peterson, Dialogue: Canadian Philosophical Review/Revue canadienne de philosophie, FirstView Article.

In this paper, we argue that Forrester’s paradox, as he presents it, is not a paradox of standard deontic logic. We show that the paradox fails since it is the result of a misuse of , a derived rule in the standard systems. Before presenting Forrester’s argument against standard deontic logic, we will briefly expose the principal characteristics of a standard system Δ. The modal system KD will be taken as a representative. We will then make some remarks regarding , (...) pointing out that its use is restricted to the standard system’s theorems, and cannot be applied to contingent conditionals. Finally, we will show that Forrester’s paradox is not a paradox of standard deontic logic, at least not in the sense he intended it to be. We show that the paradox cannot arise in KD since its semantical model is not rich enough to represent the intuitive validity of the conditional within Forrester’s paradox. We show that the paradox arises within a system that has a finer semantics. (shrink)

Ce texte se veut une analyse critique de l'approche de Thomason quant à la logique déontique. Alors que l'auteur défend que celle-ci doit être formalisée dans le cadre des logiques temporelles, nous soutenons que la temporalité est implicite à l'obligation, et de fait que la logique déontique n'a pas a être traitée dans la cadre d'une logique temporelle. Nous présenterons d'abord la position de Thomason. Il sera question des exemples dont l'auteur se sert pour justifier son point de vue philosophique (...) et du modèle sémantique qu'il propose pour rendre compte de l'obligation. Il sera ensuite sujet d'une critique des exemples de l'auteur et de son modèle sémantique. (shrink)

Cet article se veut une critique de la thèse défendue par [Cleland 1993], laquelle soutient que la thèse de Church doit être rejetée puisque les limites du calcul dépendent de la structure physique du monde. Dans un premier temps, nous offrons un (très) bref aperçu de la thèse de Church puis nous présentons l argument de Cleland. Par la suite, nous proposons une analyse critique de son argument, ce qui nous amènera à faire quelques distinctions conceptuelles par rapport aux notions (...) qui concernent la calculabilité. Finalement, nous montrons que les limites du calcul ne sont pas physiques mais bien logiques. En résumé, notre argument est que les limites du calcul sont déterminées en partie par le fait qu’une procédure effective doit pouvoir être décrite de manière finie. (shrink)

Cet article se veut une critique de la thèse défendue par [Cleland 1993], laquelle soutient que la thèse de Church doit être rejetée puisque les limites du calcul dépendent de la structure physique du monde. Dans un premier temps, nous offrons un bref aperçu de la thèse de Church puis nous présentons l argument de Cleland. Par la suite, nous proposons une analyse critique de son argument, ce qui nous amènera à faire quelques distinctions conceptuelles par rapport aux notions qui (...) concernent la calculabilité. Finalement, nous montrons que les limites du calcul ne sont pas physiques mais bien logiques. En résumé, notre argument est que les limites du calcul sont déterminées en partie par le fait qu’une procédure effective doit pouvoir être décrite de manière finie.Even though Church’s thesis is widely accepted among mathematicians, it is nonetheless controversial. In this paper, we argue against the position of [Cleland 1993], which defends that Church s thesis must be rejected because the limits of computation depend upon the physical structure of the world. We first give a brief overview of Church’s thesis and then we present Cleland s argument. We then propose a critical analysis of Cleland s argu­ment, which will involve some conceptual distinctions regarding the notion of computability, and finally we will show that the limits of computation are not physical but logical. In short, we argue that computation is limited by the fact that an effective procedure must be described in a finite way. (shrink)

Cet article se veut une critique de la thèse défendue par [Cleland 1993], laquelle soutient que la thèse de Church doit être rejetée puisque les limites du calcul dépendent de la structure physique du monde. Dans un premier temps, nous offrons un (très) bref aperçu de la thèse de Church puis nous présentons l argument de Cleland. Par la suite, nous proposons une analyse critique de son argument, ce qui nous amènera à faire quelques distinctions conceptuelles par rapport aux notions (...) qui concernent la calculabilité. Finalement, nous montrons que les limites du calcul ne sont pas physiques mais bien logiques. En résumé, notre argument est que les limites du calcul sont déterminées en partie par le fait qu’une procédure effective doit pouvoir être décrite de manière finie. (shrink)

Ce texte porte sur les principales objections faites à la logique déontique, notamment le dilemme de Jorgensen et les paradoxes de Ross. Pour aborder ces points, nous présenterons d’abord la position de Weinberger quant à la façon dont il considère que la logique doit être appliquée au domaine normatif, ce qui nous permettra d’en arriver à sa critique de la logique déontique. Avant de présenter le dilemme et les paradoxes, nous verrons quelques notions de logique modale afin de faciliter la (...) compréhension des objections et de la critique qui en sera faite. Finalement, nous proposerons une analyse formelle des paradoxes soulevés contre la logique déontique ainsi qu’une critique du présupposé réaliste implicite aux réponses faites au dilemme de Jorgensen. Nous serons alors en mesure de souligner quelques points importants à prendre en compte lors de la formalisation d’un discours. (shrink)

Ce texte porte sur l’analyse sémantique de la logique déontique. Nous analyserons de façon critique un texte de Schotch portant sur une interprétation de la logique déontique dans le cadre d’une sémantique non-kripkéenne. Nous laisserons de côté les choix relatifs à la syntaxe de son système afin de se concentrer sur l’analyse sémantique qu’il expose contre la logique déontique et sur celle qu’il propose en retour. Avant de voir le détail de son raisonnement, nous présenterons brièvement quelques notions de logique (...) modale afin de faciliter la compréhension de l’argument de Schotch. Nous présenterons ensuite l’argument de l’auteur contre la logique déontique afin de pouvoir exposer sa solution, ce qui ouvrira la porte à une lecture critique de son analyse. (shrink)

ABSTRACTMonoidal logics were introduced as a foundational framework to analyze the proof theory of logical systems. Inspired by Lambek's seminal work in categorical logic, the objective is to defin...

This research article revisits Hempel’s logic of confirmation in light of recent developments in categorical proof theory. While Hempel advocated several logical conditions in favor of a purely syntactical definition of a general non-quantitative concept of confirmation, we show how these criteria can be associated to specific logical properties of monoidal modal deductive systems. In addition, we show that many problems in confirmation logic, such as the tacked disjunction, the problem of weakening with background knowledge and the problem of irrelevant (...) conjunction, are also associated with specific logical properties and, incidentally, with some of Hempel’s logical conditions of adequacy. We discuss the raven paradox together with further objections against Hempel’s approach, showing how our analysis enables a clear understanding of the relationships between Hempel’s conditions, the problems in confirmation logic, and the properties of deductive systems. (shrink)

Book Reviews Clayton peterson, Dialogue: Canadian Philosophical Review/Revue canadienne de philosophie, FirstView Article.

Philip Clayton has put forth a clear and important position regarding the mind-body relationship in terms of supervenient and emergent realities. While I agree with Clayton on many points, I argue that there are important problems with current literature on supervenience and emergence. In particular, I distinguish between closed system emergence and open system emergence, suggesting that Clayton’s position is closer to the latter than the former.

Nicholaos Jones argues that theology is not a respectable discipline because of its inability to meet the standards of contemporary science. Although Jones makes a bold claim, I suggest that he has not made his case by focusing on the question of defining science and metaphysics appropriately, the analysis of the literature he cites, and his central claim that theology presupposes the absolute certainty of God.

This brief opening for a special issue of Tradition and Discovery: The Polanyi Society Periodical on Philip Clayton’s thought and its connection with that of Michael Polany introduces Clayton’s essay and the responses by Martinez Hewlett, Gregory R. Peterson, Andy F. Sanders and Waler B. Gulick.

A discussion of epistemic reasons, theoretical rationality, and the relationship between them. Discusses the ontology of reasons and evidence, the relationship between reasons (motivating, normative, possessed, apparent, genuine, etc.) and rationality, the relationship between epistemic reasons and evidence, the relationship between rationality, justification, and knowledge, and many other related topics.

American Academy of Pediatrics (AAP) and American College of Medical Genetics (ACMG) recently provided two recommendations about predictive genetic testing of children. The Clinical Sequencing Exploratory Research Consortium's Pediatrics Working Group compared these recommendations, focusing on operational and ethical issues specific to decision making for children. Content analysis of the statements addresses two issues: (1) how these recommendations characterize and analyze locus of decision making, as well as the risks and benefits of testing, and (2) whether the guidelines conflict or (...) come to different but compatible conclusions because they consider different testing scenarios. These statements differ in ethically significant ways. AAP/ACMG analyzes risks and benefits using best interests of the child and recommends that, absent ameliorative interventions available during childhood, clinicians should generally decline to order testing. Parents authorize focused tests. ACMG analyzes risks and benefits using the interests of the child and other family members and recommends that sequencing results be examined for additional variants that can lead to ameliorative interventions, regardless of age, which laboratories should report to clinicians who should contextualize the results. Parents must accept additional analysis. The ethical arguments in these statements appear to be in tension with each other. (shrink)

This is a defence of externalism about knowledge and also about justification. In this paper, I argue that an important virtue of externalism about these notions is that externalism about justification helps to explain the value of (i.e., importance of) knowledge. I also develop and expand upon some of my earlier arguments for externalism that drew upon what's now known as 'morally loaded cases'. The virtue of externalism is that it's the only view that can both allow for certain kinds (...) of categorical normative requirements while also vindicating the idea that we ought to be guided by the beliefs that we ought to have. (Internalists either have to deny that we ought to be guided by the beliefs that we ought to have (which isn't very internalist!) or, failing that, revise our views about the existence of certain kinds of categorical requirements and tell us that we ought to be guided by our beliefs to do evil things (which isn't very nice!).). (shrink)

This chapter contains section titled: I In What Sense is Dworkin's Liberalism Neutral? II Two Parameters III Liberal Neutrality and the Sacred Acknowledgement.

If I were to say, “Agnes does not know that it is raining, but it is,” this seems like a perfectly coherent way of describing Agnes’s epistemic position. If I were to add, “And I don’t know if it is, either,” this seems quite strange. In this chapter, we shall look at some statements that seem, in some sense, contradictory, even though it seems that these statements can express propositions that are contingently true or false. Moore thought it was paradoxical (...) that statements that can express true propositions or contingently false propositions should nevertheless seem absurd like this. If we can account for the absurdity, we shall solve Moore’s Paradox. In this chapter, we shall look at Moore’s proposals and more recent discussions of Moorean absurd thought and speech. (shrink)

I argue that justification isn't just in the head. The argument is simple. We should be guided by our beliefs. We shouldn't be guided by anything to do what we shouldn't do. So, we shouldn't believe in ways that would guide us to do the things that we shouldn't. Among the various things we should do is discharge our duties (e.g., to fulfil our promissory obligations) and respect the rights of others (e.g., rights not to be harmed or killed by (...) agents acting on bad information). The grounds of our duties and obligations aren't just in the head. Thus, the conditions that bear on the justification of our beliefs cannot be contained wholly in our heads. The internalist might be right about aspects of normativity, but their theories tell us important normative truths without telling us the whole truth. In addition to norms that tell us how to process information, there are norms that tell us how we ought to live together. In information-asymmetry cases, these norms clearly come apart. Important normative questions about what we should do when agents (who, we might suppose, do what they subjectively ought to do) have interests that come into conflict can only be answered by externalist theories that recognise information-transcendent norms and normatively significant relations that don't supervene upon the information of any agent in particular. The internalist picture turns out to be disturbing precisely because it falls silent when we're faced with questions about how to resolve these conflicts. Resolving these conflicts should be a pressing concern for every normative theory. (shrink)

The museum of the colonial moment fused the expansion of knowledge and global contact of North Atlantic powers with the aggressive nationalist pride of their hegemonic positions, building national, cultural, and racial identity through framing. How does Black Panther use the museum scene to illustrate a fear of Black museums and the problems of existence observed through the philosophies of Black existentialism and Africana phenomenology? Killmonger's questioning of Wakanda reveals the truth and effect of Wakanda's isolationist history. Yet, Wakanda is (...) nevertheless shown as a representation of African history, not just in the tribal nature of Wakanda's social structure or in the clothing and physical adornments and jewelry, but also in the rituals and spirituality. (shrink)

Are humans free, or are we determined by our genes and the world around us? The question of freedom is not only one of philosophy’s greatest conundrums, but also one of the most fundamental questions of human existence. It’s particularly pressing in societies like ours, where our core institutions of law, ethics, and religion are built around the belief in individual freedom. Can one still affirm human freedom in an age of science? And if free will doesn’t exist, does it (...) make sense to act as though it does? These are the issues that are presented, probed, and debated in the following chapters. A dozen experts―specialists in medicine, psychology, ethics, theology, and philosophy—grapple with the multiple and often profound challenges presented by today’s brain science. After examining the arguments against traditional notions of free will, several of the authors champion the idea of a chastened but robust free will for today, one that allows us still to affirm the value of first-person experience. (shrink)

What can we learn from cases of knowledge from falsehood? Critics of knowledge-first epistemology have argued that these cases provide us with good reason for rejecting the knowledge accounts of evidence, justification, and the norm of belief. I shall offer a limited defense of the knowledge-first approach to these matters. Knowledge from falsehood cases should undermine our confidence in like-from-like reasoning in epistemology. Just as we should be open to the idea that knowledge can come from non-knowledge, we should be (...) open to the idea that justified beliefs can come from unjustified beliefs. (shrink)

What does everyone in the modern world need to know? Renowned psychologist Jordan B. Peterson's answer to this most difficult of questions uniquely combines the hard-won truths of ancient tradition with the stunning revelations of cutting-edge scientific research. Humorous, surprising and informative, Dr. Peterson tells us why skateboarding boys and girls must be left alone, what terrible fate awaits those who criticize too easily, and why you should always pet a cat when you meet one on the street. (...) What does the nervous system of the lowly lobster have to tell us about standing up straight (with our shoulders back) and about success in life? Why did ancient Egyptians worship the capacity to pay careful attention as the highest of gods? What dreadful paths do people tread when they become resentful, arrogant and vengeful? Dr. Peterson journeys broadly, discussing discipline, freedom, adventure and responsibility, distilling the world's wisdom into 12 practical and profound rules for life. [This book] shatters the modern commonplaces of science, faith and human nature, while transforming and ennobling the mind and spirit of its readers. (shrink)

The internalism-externalism debate is one of the oldest debates in epistemology. Internalists assert that the justification of our beliefs can only depend on facts internal to us, while externalists insist that justification can depend on additional, for example environmental, factors. Clayton Littlejohn proposes and defends a new strategy for resolving this debate. Focussing on the connections between practical and theoretical reason, he explores the question of whether the priority of the good to the right might be used to defend (...) an epistemological version of consequentialism, and proceeds to formulate a new 'deontological externalist' view. On this view, the justificatory status of a belief depends upon whether it is fit for the purposes of practical reasoning. Only beliefs that meet externalist standards are fit for such a purpose. If we want to understand how a wide range of norms (e.g., moral norms) apply to rational agents regardless of what their evidence or outlook is like, we have to embrace an externalist account of the justification. (shrink)

It seems that different epistemic norms can come into conflict and so we might wonder what happens when they do impose incompatible requirements upon us. According to the dilemmic view, they might sometimes generate sets of requirements that cannot be satisfied, ensuring that there is no rationally acceptable way for a thinker to deal with the predicament she’s in. After reviewing the case for the dilemmic view, I introduce an alternative framework that accounts for the appearance of dilemma-like conflicts without (...) committing us to the possibility of genuine dilemmas. I argue that this alternative view has some important explanatory virtues that the dilemmic view lacks and can account for the problematic intuitions that seem to support the dilemmic view. (shrink)