Cells fine‐tune their DNA repair, selecting some regions of the genome in preference to others. In the paradigm case, excision of UV‐induced pyrimidine dimers in mammalian cells, repair is concentrated in transcribed genes, especially in the transcribed strand. This is due both to chromatin structure being looser in transcribing domains, allowing more rapid repair, and to repair enzymes being coupled to RNA polymerases stalled at damage sites; possibly other factors are also involved. Some repair‐defective diseases may involve repair‐transcription coupling: three (...) candidate genes have been suggested.However, preferential excision of pyrimidine dimers is not uniformly linked to transcription. In mammals it varies with species, and with cell differentiation. In Drosophila embryo cells it is absent, and in yeast, the determining factor is nucleosome stability rather than transcription.Repair of other damage departs further from the paradigm, even in some UV‐mimetic lesions. No selectivity is known for repair of the very frequent minor forms of base damage. And the most interesting consequence of selective repair, selective mutagenesis, normally occurs for UV‐induced, but not for spontaneous mutations. The temptation to extrapolate from mammalian UV repair should be resisted. (shrink)

Aesthetics of Music: Musicological Approaches is an anthology of fourteen essays, each addressing a single key concept or pair of terms in the aesthetics of music, collectively serving as an authoritative work on musical aesthetics that remains as close to 'the music' as possible. Each essay includes musical examples from works in the 18th, 19th, and into the 20th century. Topics have been selected from amongst widely recognised central issues in musical aesthetics, as well as those that have been somewhat (...) neglected, to create a collection that covers a distinctive range of ideas. All essays cover historical origins, sources, and developments of the chosen idea, survey important musicological approaches, and offer new critical angles or musical case studies in interpretation. (shrink)

We argue that Madole & Harden's distinction between shallow versus deep genetic causes can bring some clarity to causal claims arising from genome-wide association studies (GWASs). However, the authors argue that GWAS only finds shallow genetic causes, making GWAS commensurate with the environmental studies they hope to supplant. We also assess whether their distinction applies best to explanations or causes.

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

Alison Gopnik and Andrew Meltzoff have argued for a view they call the ‘theory theory’: theory change in science and children are similar. While their version of the theory theory has been criticized for depending on a number of disputed claims, we argue that there is a fundamental problem which is much more basic: the theory theory is multiply ambiguous. We show that it might be claiming that a similarity holds between theory change in children and (i) individual scientists, (ii) (...) a rational reconstruction of a Superscientist, or (iii) the scientific community. We argue that (i) is false, (ii) is non-empirical (which is problematic since the theory theory is supposed to be a bold empirical hypothesis), and (iii) is either false or doesn’t make enough sense to have a truth-value. We conclude that the theory theory is an interesting failure. Its failure points the way to a full, empirical picture of scientific development, one that marries a concern with the social dynamics of science to a psychological theory of scientific cognition. (shrink)

In Overcoming America / America Overcoming, Stephen Rowe shows how the moral disease and political paralysis that plague America are symptomatic of the fact that America herself has been overtaken by the modern values which she exported to the rest of the world. He points to a way out of this current and potentially fatal malaise: join other societies which are also struggling to move beyond the modern and consciously reappropriate those elements of tradition which have to do with (...) cultivation of the mature human being. To avoid fundamentalism, Rowe discusses how this reappropriation must be undertaken in dialogue with those who also have come to recognize the unsustainable quality of the modern life, and who have been able to live beyond the nihilistic wish to tear it down. This book supports the call for an emerging global ethic and spirituality, providing resources of articulation and interpretation that allow for an ongoing dialogue between traditional and modern values—both worthy and problematic in their own ways—through which reliable policy and healthy living become possible. (shrink)

Youths with disruptive behavior disorders and psychopathic traits showed reduced amygdala responses to fearful expressions under low attentional load but no indications of increased recruitment of regions implicated in top- down attentional control. These findings suggest that the emotional deficit observed in youths with disruptive behavior disorders and psychopathic traits is primary and not secondary to increased top- down attention to nonemotional stimulus features.

Hume's Enlightenment Tract is the first full book-length study for forty years of David Hume's Enquiry concerning Human Understanding. The Enquiry has, contrary to its author's expressed wishes, long lived in the shadow of its predecessor, A Treatise of Human Nature. Stephen Buckle presents the Enquiry in a fresh light, and aims to raise it to its rightful position in Hume's work and in the history of philosophy. He argues that the Enquiry is not, as so often assumed, a (...) mere collection of watered-down extracts from the earlier work. It is, rather, a coherent work with a unified argument; and, when this argument is grasped as a whole, the Enquiry shows itself to be the best introduction to the lineaments of its author's general philosophy. Buckle offers a careful guide through the argument and structure of the work. He shows how the central sections of the Enquiry offer a critique of the dogmatic empiricisms of the ancient world, and set in place an alternative conception of human powers based on the sceptical principles of habit and probability. These principles are then put to work, to rule out philosophy's metaphysical ambitions and their consequences: religious systems and their attendant conception of human beings as semi-divine rational animals. Hume's scepticism, experimentalism, and naturalism are thus shown to be different aspects of the one unified philosophy - a sceptical version of the Enlightenment vision. (shrink)

Hume's Enlightenment Tract is the first full book-length study for forty years of David Hume's Enquiry concerning Human Understanding. The Enquiry has, contrary to its author's expressed wishes, long lived in the shadow of its predecessor, A Treatise of Human Nature. Stephen Buckle presents the Enquiry in a fresh light, and aims to raise it to its rightful position in Hume's work and in the history of philosophy. He argues that the Enquiry is not, as so often assumed, a (...) mere collection of watered-down extracts from the earlier work. It is, rather, a coherent work with a unified argument; and, when this argument is grasped as a whole, the Enquiry shows itself to be the best introduction to the lineaments of its author's general philosophy. Buckle offers a careful guide through the argument and structure of the work. He shows how the central sections of the Enquiry offer a critique of the dogmatic empiricisms of the ancient world, and set in place an alternative conception of human powers based on the sceptical principles of habit and probability. These principles are then put to work, to rule out philosophy's metaphysical ambitions and their consequences: religious systems and their attendant conception of human beings as semi-divine rational animals. Hume's scepticism, experimentalism, and naturalism are thus shown to be different aspects of the one unified philosophy - a sceptical version of the Enlightenment vision. (shrink)

Plato. Aristotle. Augustine. Hume. Kant. Hegel. Every student of philosophy needs to know the history of the philosophical discourse such giants have bequeathed us. Philosopher C. Stephen Evans brings his expertise to this daunting task as he surveys the history of Western philosophy, from the Pre-Socratics to Nietzsche and postmodernism—and every major figure and movement in between.

This book explores a wide range of philosophical issues in their connection with theism, including views of free will, ethical theories, theories of mind, naturalism, and karma-plus-reincarnation. In this clear and logical guide, C. Stephen Layman takes up eight important philosophical questions about God: Does God exist? Why does God permit evil? Why think God is good? Why is God hidden? What is God's relationship to ethics? Is divine foreknowledge compatible with human free will? Do humans have souls? Does (...) reincarnation provide the best explanation of suffering? Based on more than thirty years of experience in teaching undergraduates and in leading philosophical discussions related to God, Layman has arranged the text to deal with each of these eight questions in one or two chapters apiece. Many philosophical works take up questions about God, but the chapters of this book plunge the reader very quickly into the arguments relevant to each question. Layman presents the arguments cogently and simply, yet without oversimplifying the issues. The book emphasizes strengths and weaknesses of both theism and its metaphysical rivals. Readers will gain a clearer understanding of theism and naturalism, and of their sometimes surprising implications. (shrink)

The four volume work of which this book is a part has been praised as one of the great monuments of theoretical scholarship in sociology of the century. The praise has come largely from the older generation of students of Parsons and Merton. A great deal of dispraise has come from Alexander's own generation. Alan Sica's (1983) brilliant, biting review of Volume I speaks for many of Alexander's peers. Volume II is likely to be even more controversial. This volume begins (...) the substantive task of the text, the reinterpretation of the 'theoretical logic' of the classical sociologists, a reinterpretation governed by the intention of transcending the errors and limitations of the 'presuppositional' reasoning of the classical thinkers. For Alexander's sociological audience the second volume is the beginning of what really counts, and Volume II is indeed quite a different affair from the first, 'philosophical' volume: the prose tightens, and the air of getting down to work is palpable. (shrink)

Who are the new Atheists and what are they saying? -- The value of natural theology -- The concept of a natural sign for God -- Natural signs for God and Theistic arguments -- Can we trust the natural signs for God? -- Recognizing God's self-revelation -- Criteria for a genuine revelation from God -- Making the case for Christian faith.

God and moral obligations -- What is a divine command theory of moral obligation? -- The relation of divine command theory to natural law and virtue ethics -- Objections to divine command theory -- Alternatives to a divine command theory -- Conclusions: The inescapability of moral obligations.

Is there such a thing as natural knowledge of God? C. Stephen Evans presents the case for understanding theistic arguments as expressions of natural signs in order to gain a new perspective both on their strengths and weaknesses. Three classical, much-discussed theistic arguments - cosmological, teleological, and moral - are examined for the natural signs they embody. At the heart of this book lie several relatively simple ideas. One is that if there is a God of the kind accepted (...) by Christians, Jews, and Muslims, then it is likely that a 'natural' knowledge of God is possible. Another is that this knowledge will have two characteristics: it will be both widely available to humans and yet easy to resist. If these principles are right, a new perspective on many of the classical arguments for God's existence becomes possible. We understand why these arguments have for many people a continued appeal but also why they do not constitute conclusive 'proofs' that settle the debate once and for all. Touching on the interplay between these ideas and contemporary scientific theories about the origins of religious belief, particularly the role of natural selection in predisposing humans to form beliefs in God or gods, Evans concludes that these scientific accounts of religious belief are fully consistent, even supportive, of the truth of religious convictions. (shrink)

C. Stephen Evans explains and defends Kierkegaard's account of moral obligations as rooted in God's commands, the fundamental command being `You shall love your neighbour as yourself'. The work will be of interest not only to those interested in Kierkegaard, but also to those interested in the relation between ethics and religion, especially questions about whether morality can or must have a religious foundation. As well as providing a comprehensive reading of Kierkegaard as an ethical thinker, Evans puts him (...) into conversation with contemporary moral theorists. Kierkegaard's divine command theory is shown to be an account that safeguards human flourishing, as well as protecting the proper relations between religion and state in a pluralistic society. (shrink)

Attempts to unlock the Climacus section of Kierkegaard's pseudonymous literature. This book offers a sustained analysis of the key concepts discussed in the works: existence and the ethical, truth and subjectivity, indirect communication, guilt and suffering, irony and humour, reason and paradox, and faith and history.

This book is an explanation and defence of a veiw of faith and reason that is found in the writings of Kierkegaard, a view often termed as fideism. The author distinguishes indefensible forms of fideism that involve a rejection of reason from a fideism that requires that reason becomeself-critical. An understanding of the limits of reason requires both an understanding of faith as above reason, as in Aquinas and Kant, and also as against what is taken as rational by most (...) human beings.The fiedeistic view of faith as involving a critique of reason is illustrated by concrete discussions of three traditional topics in the philosophy of religion: knowledge of God's existence, the problem of evil and the question as to how someone could know that a particular religion could be basedon a revelation from God.The book presents a careful distinction between different kinds of fideism, with a critical rejection of some kinds and a defence of others. The author shows that fideism does not have to be understood as a rejection of reason, rather as a critique of the limits of reason. (shrink)

This volume in the Reason & Religion series provides an explanation and defense of a view of faith and reason found in the writings of Soren Kierkegaard and others that is often called "fideism", a belief in faith beyond reason.

C. Stephen Evans provides a clear, readable introduction to Søren Kierkegaard as a philosopher and thinker. His book is organised around Kierkegaard's concept of the three 'stages' or 'spheres' of human existence, which provide both a developmental account of the human self and an understanding of three rival views of human life and its meaning. Evans also discusses such important Kierkegaardian concepts as 'indirect communication', 'truth as subjectivity', and the Incarnation understood as 'the Absolute Paradox'. Although his discussion emphasises (...) the importance of Christianity for understanding Kierkgaard, it shows him to be a writer of great interest to a secular as well as a religious audience. Evans' book brings Kierkegaard into conversation with western philosophers past and present, presenting him as one who gives powerful answers to the questions which philosophers ask. (shrink)

General preface -- Preface to the second edition -- What is philosophy of religion? -- Philosophy of religion and other disciplines -- Philosophy of religion and philosophy -- Can thinking about religion be neutral? -- Fideism -- Neutralism -- Critical dialogue -- The theistic God : the project of natural theology -- Concepts of God -- The theistic concept of God -- A case study : divine foreknowledge and human freedom -- The problem of religious language -- Natural theology -- (...) Proofs of God's existence -- Classical arguments for God's existence -- Ontological arguments -- Cosmological arguments -- Teleological arguments -- Moral arguments -- Conclusions: The value of theistic argument -- Religious experience -- Types of religious experience -- Models for understanding experience -- Experience of God as direct and mediated -- Are religious experiences veridical? -- Checking experiential claims -- Special acts of God : revelation and miracles -- Special acts -- Theories of revelation -- Is the traditional view defensible? -- What is a miracle? -- Is it reasonable to believe in miracles? -- Can a revelation have special authority? -- Religion, modernity, and science -- Modernity and religious belief -- Naturalism -- Do the natural sciences undermine religious belief? -- Objections from the social sciences -- Religious uses of modern atheism -- The problem of evil -- Types of evil, versions of the problem, and types of response -- The logical form of the problem -- The evidential form of the problem -- Horrendous evils and the problem of hell -- Divine hiddenness -- Faith(s) and reason -- Faith : subjectivity in religious arguments -- The evidentialist challenge to religious belief -- Reformed epistemology -- The place of subjectivity in forming beliefs -- Interpretive judgments and the nature of a cumulative case -- Can faith be certain? -- Faith and doubt : can religious faith be tested? -- What is faith? -- Could one religion be true? (shrink)

Johannes Climacus, Søren Kierkegaard's pseudonymous author of Philosophical Fragments, "invents" a religion suspiciously resembling Christianity as an alternative to the assumption that humans possess the Truth within themselves. Through this literary device, Climacus raises in a fresh and audacious way age-old questions about the relation of Christian faith to human reason. Is the idea of a human incarnation of God logically coherent? Is religious faith the product of a voluntary choice? In a comprehensive discussion of one of Kierkegaard's most important (...) books, C. Stephen Evans elucidates Kierkegaard's novel explanation that the tension between faith and reason must be understood as a consequence of the passionate character of reason itself. Passionate Reason situates Kierkegaard's philosophy in the context of postmodern religious thought, providing a contemporary reading of Fragments as a challenge to both the modern Enlightenment critique of reason and the postmodern abandonment of truth. (shrink)

A compelling account of Kierkegaard's ethical views, seeing him against the backdrop of nineteenth-century European society but showing the relevance of his thought for the twenty-first century. Kierkegaard's view of morality as grounded in God's command to love our neighbours as ourselves has clear advantages over contemporary secular rivals.

This paper is a reflection on two ontological analogies that have played a role in discussion about the Trinity---the Modalist and Social analogies. I argue that the Modal analogy commits one to a view of the divine persons that comports poorly with Scripture. I then consider two arguments to the effect that the doctrine of the Trinity commits one to tritheism. I argue that the Social analogy contains better resources for handling these arguments than the more traditional position, which involves (...) denying that the divine persons are substances. (shrink)

This book contains a vigorous argument, constructed with the help of Kierkegaard, that the Kantian ideal of autonomy in ethics is misplaced, and that the most adequate forms of the ethical life see ethics as requiring a religious foundation. The ideal of an ethic that is grounded in "pure, impartial reason" is a chimera; no justification for ethical living can be given that does not see ethical knowledge as stemming from a "committed" or "situated" perspective that eschews the disengaged "view (...) from nowhere." The ideal of disengagement, when universalized, produces skepticism in epistemology and amoralism in ethics. Since this ideal is itself a type of ethical stance, Rudd agrees with Kierkegaard that it cannot be "objectively" refuted, but can and must be rejected. In exploring Kierkegaard’s epistemology, Rudd correctly sees that this Kierkegaardian emphasis on "subjectivity" as necessary for knowledge by no means implies any kind of relativism or subjectivism about truth. (shrink)

At the risk of a tremendous over-simplification, I believe it is helpful to categorize views of Christianity which have appeared in the west in the last two hundred years into three major groups. First there are the unbelievers, those for whom Christianity is straightforwardly untrue, unknowable, or unbelievable . This group would include those who try to salvage some form of essentially humanistic religion as well as those who simply turn away from religious belief altogether, either to put their ultimate (...) hopes in political ideology, or science, or simply to attempt to limit themselves to hopes which are finite and non-ultimate in character. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 1':'3 for an integrated life (197). But he does not mention that for Plato the desire for knowledge and understanding, drawn to its objects, the Forms, is part of what accounts for this compulsion and its intensity. Listening to the Cicadas is an outstanding example of a philosophically sensitive, literary reading of a Platonic dialogue. Ferrari writes demandingly but beautifully, and his dialectical reading often has just (...) the effect he desires, to draw the reader into the Phaedrus's world. In addition, he is familiar with contemporary moral philosophy, moral psychology, and philosophy of action, and employs notions from Williams, Frankfurt, and others in sensible and helpful ways. The book should be accessible to a wide audience; the Greek is transliterated and translated, with virtually all technical discussion confined to notes. But although the series in which the book appears is well known to specialists in classics and classical philosophy, it is probably not familiar to philosophers generally and literary theorists. This is unfortunate, for Ferrari's work is an important one for all of these audiences. Micn^~t. L. MORCAN Indiana University, Bloomington Walter G. Englert. Epicurus on the Swerve and Voluntary Action. American Philological Assocation. American Classical Studies. Atlanta: Scholars Press, 1987. Pp. x + 215. Cloth, $~ 1-95. Paper, $1 ~-95Though he has fallen from top billing (Aristotle and Epicurus on Voluntary. Action was the work's original title as a x981 Stanford dissertation), Aristotle has retained his prominence in Englert's only slightly revised text. Englert's thesis, in fact, is that the Epicurean "swerve was first developed in response to Aristotelian challenges to atomism in cosmology, physics, psychology, and physiology, and in particular, was meant to be the atomic equivalent of Aristotle's sumphuton pneuma in Epicurus's analysis of the voluntary actions of all living creatures" (145). My skepticism toward this assertion is based not so much on the doubtful availability of Aristotelian texts to Hellenistic philosophers (though Englert's depiction of Epicurus responding to specific passages of the De caelo, Physics, and De motu animalium certainly invites this objection) as on the following considerations: (a) Englert's Epicurus posits weight as an atomic property to counter Aristotle's objection that Democritean atoms have no natural motion with which forced motion might contrast. But why would Epicurus think Aristotle's objection any more forceful than we do? If Epicurus insists that atoms fall down, it is not from a metaphysical conviction that every body must have a natural locomotive tendency, but because of his empirical observation that things in fact fall. (b) Englert's Epicurus, casting about for a third cause of motion besides collisions and weight, stumbles upon Aristotle's description of "the accidental" (to sumbebekos) as an event without definite cause happening at an indeterminate time and place, and conceives of the swerve. But the similarity of the two doctrines is entirely superficial. The accident, for Aristotle, is the nonessential: man is not pale by nature, for instance, 124 JOURNAL OF THE HISTORY OF PHILOSOPHY 28"1 JANUARY 1990 but "by accident," e.g., if he happens to stay indoors. If there is an analogue for this in Epicurus, it's in his notion ofsuraptomata. But what has this to do with the swerve? (c) Finally, Englert's Epicurus posits the swerve as an atomistic adaptation of the workings of Aristotle's sumphuton pneuma. (Does this mean the pneuma's motion is accidental? The relation of this thesis to the last is unclear.) The analogy of the expanding pneuma and the swerving atom is supposed to be that both are physical bodies whose motion marks a more or less "fresh start," breaking the otherwise deterministic causal chain. More or less? Englert speaks of a "delicate balance" in Aristotle's account "between a purely passive causal sequence" (from the stimulus of phantasia to the agent's response) and a "sequence involving a completely new beginning of motion" (93)- But what is this balance if not Stoic compatibilism, an endless causal chain balanced against the ascription of responsibility for personal initiative? Is Aristotle then a proto-Stoic? That is, does Aristotle believe that stimulus plus character determines response? Englert wants to say... (shrink)

Evangelical scholars have recently offered criticisms of mind-body dualism from the disciplines of theology, philosophy, and neuroscience. We offer several arguments as to why these reasons for abandoning mind-body dualism fail. Additionally, we offer a positive thesis, a dualism that brings together the best aspects of the Cartesian view and the Thomistic view of human persons. The result is a substance dualism that treats the nature of embodiment quite seriously. This view explains why we, as souls, require a resurrected body (...) as well as accounting for the great good of our embodiment in general. A human person is at the same time wholly soul and yet fully bodily. (shrink)