Department of Economics, University of Calgary, 2500 University Dr NW, Calgary AB, T2N 1N4, Canada. Tel.: +1403220 5861; Fax: +1403220 5861; Email: ahollis{at}ucalgary.ca ' + u + '@' + d + ' '//--> . Abstract The Health Impact Fund has been proposed as an optional, comprehensive advance market commitment system offering financial payments or ‘prizes’ to patentees of new drugs, which are sold globally at an administered low price. The Fund is designed to offer payments based on the therapeutic impact (...) of the drugs or vaccines, so that innovators will have efficient incentives to develop drugs that maximize health gains. Consumers would have improved access to such drugs because of low prices. CiteULike Connotea Del.icio.us What's this? (shrink)

Antibiotic resistance presents a classic example of the “tragedy of the commons.” In this eponymous tragedy, the commons — shared, public access lands — are overgrazed because farmers can send their livestock onto the land at a zero price. The “tragedy” occurs because overgrazing destroys the land and reduces its ability to provide fodder. The application to antibiotics is obvious: the use of antibiotics creates selection pressure leading to increased proportions of resistant bacteria in the patient and the environment. The (...) increase in frequency of resistant organisms diminishes the effectiveness of antibiotics in treating future infections; thus, the long-term value of the antimicrobial resource is reduced. (shrink)

In a widely cited 2003 article, DiMasi, Hansen, and Grabowski estimated the cost of pharmaceutical research and development to be $1.1 billion per new medicine coming onto the market in 2001. They also estimate that this cost is going up at a real rate of 7.4% annually. According to these estimates, the innovation cost per new medicine today is about $2.1 billion or $2.65 billion.

This paper offers an economic rationale for compulsory licensing of needed medicines in developing countries. The patent system is based on a trade-off between the “deadweight losses” caused by market power and the incentive to innovate created by increased profits from monopoly pricing during the period of the patent. However, markets for essential medicines under patent in developing countries with high income inequality are characterized by highly convex demand curves, producing large deadweight losses relative to potential profits when monopoly firms (...) exercise profit-maximizing pricing strategies. As a result, these markets are systematically ill-suited to exclusive marketing rights, a problem which can be corrected through compulsory licensing. Open licenses that permit any qualified firm to supply the market on the same terms, such as may be available under licenses of right or essential facility legal standards, can be used to mitigate the negative effects of government-granted patents, thereby increasing overall social welfare. (shrink)

Not all intellectual property rights grant the right to exclude that is indicative of “property rules,” as that term was used by Guido Calabresi and A. Douglas Melamed in their seminal article. Some intellectual property rights are “liability rules,” in which the right holder has an entitlement to compensation for use of the protected invention, not a right to preclude the use. Although patent laws normally grant a right to exclude others from use of the protected invention as a default, (...) most countries’ laws allow the government to convert the patent property rule into a liability rule through a compulsory license. It has been noted, for example, that by the end of the 1950s, the U.S. had issued compulsory licenses covering 40 to 50 thousand patents, including substantial portions of the patent portfolios of AT&T, General Electric, IBM, and Xerox. The U.S. Supreme Court recently expressed a willingness to accept liability rules over injunctions in some patent infringement cases. (shrink)

Frege's Puzzle is a founding problem in analytic philosophy. It lies at the intersection of central topics in the philosophy of language and mind: the theory of reference, the nature of propositional attitudes, the nature of semantic theorizing, the relation between semantics and pragmatics, etc. This chapter is an overview of the puzzle and of the space of contemporary approaches to it.

Economics is probably the most subtle, precise and powerful of the social sciences and its theories have deep philosophical import. Yet the dominant alliance between economics and philosophy has long been cheerfully simple. This is the textbook alliance of neo-Classicism and Positivism, so crucial to the defence of orthodox economics against by now familiar objections. This is an unusual book and a deliberately controversial one. The authors cast doubt on assumptions which neo-Classicists often find too obvious to defend or, indeed, (...) to mention. They set out to disturb an influential concensus and to champion an unpopular cause. Although they go deeper into both philosophy and economics than is usual in interdisciplinary works, they start from first principles and the text is provokingly clear. This will be a stimulating book for all economic theorists and philosophers interested in the philosophy of science and social science. (shrink)

I highlight a metaphysical concern that stands in the way of more widespread adoption of causal modeling techniques such as causal Bayes nets. Researchers in some fields may resist adoption due to concerns that they don't 'really' understand what they are saying about a system when they apply such techniques. Students in these fields are repeated exhorted to be cautious about application of statistical techniques to their data without a clear understanding of the conditions required for those techniques to yield (...) genuine insight into the data. They are acutely aware that anyone can chuck some data into a software package and get what looks like an answer, even though these tests may not be well-defined for the data on which they can apparently be run. This is thus a healthy skepticism for uptake of causal modeling methods, which points directly to the need for a metaphysical understanding of causation in order to successfully use the modeling methods. Without a clear understanding of what the methods are committing to, including what it means to say that there exists a causal relationship, researchers have limited ability to identify potentially bad output, or to independently verify results. (shrink)

Even in areas of philosophy of science that don’t involve formal treatments of truth, one’s background view of truth still centrally shapes views on other issues. I offer an informal way to think about truth as trueing, like trueing a bicycle wheel. This holist approach to truth provides a way to discuss knowledge products like models in terms of how well-trued they are to their target. Trueing emphasizes: the process by which models are brought into true; how the idealizations in (...) models are not false but rather like spokes in appropriate tension to achieve a better-trued fit to target; and that this process is not accomplished once and done forever, but instead requires upkeep and ongoing fine-tuning. I conclude by emphasizing the social importance of being a pragmatist about truth in order to accurately answer questions about science such as, “but do we really know that…”. (shrink)

Losing an arm to rescue a child from a burning building is supererogatory. But is losing an arm to save two children more supererogatory than losing two arms to save a single child? What factors make one act more supererogatory than another? I provide an innovative account of how to compare which of two acts is more supererogatory, and show the superiority of this account to its chief rival.

This chapter examines the relationship between laws and mechanisms as approaches to characterising generalizations and explanations in science. I give an overview of recent historical discussions where laws failed to satisfy stringent logical criteria, opening the way for mechanisms to be investigated as a way to explain regularities in nature. This followed by a critical discussion of contemporary debates about the role of laws versus mechanisms in describing versus explaining regularities. I conclude by offering new arguments for two roles for (...) laws that mechanisms cannot subsume, one epistemically optimistic and one pessimistic, both broadly Humean. Do note that this piece is not primarily Hume exegesis; it is more of a riff in the key of Hume. (shrink)

Does it make sense to refer to bird song - a complex vocalization, full of repetitive and transformative patterns that are carefully calculated to woo a mate - as art? What about a pack of wolves howling in unison or the cacophony made by an entire rain forest? Redefining music as "the art of possibly animate things," Musical Vitalities charts a new path for music studies that blends musicological methods with perspectives drawn from the life sciences. In opposition to humanist (...) approaches that insist on a separation between culture and nature--approaches that appear increasingly untenable in an era defined by human-generated climate change--Musical Vitalities treats music as one example of the cultural practices and biotic arts of the animal kingdom rather than as a phenomenon categorically distinct from nonhuman forms of sonic expression. The book challenges the human exceptionalism that has allowed musicologists to overlook music's structural resemblances to the songs of nonhuman species, the intricacies of music's physiological impact on listeners, and the many analogues between music's formal processes and those of the dynamic natural world. Through close readings of Austro-German music and aesthetic writings that suggest wide-ranging analogies between music and nature, Musical Vitalities seeks to both rekindle the critical potential of nineteenth-century music and rejoin the humans at the center of the humanities with the nonhumans whose evolutionary endowments and planetary fates they share. (shrink)

This chapter examines the philosophical discussion concerning the relationship between time, memory, attention, and consciousness, from Locke through the Scottish Common Sense tradition, in terms of its influence on James' development of the specious present doctrine. The specious present doctrine is the view that the present moment in experience is non punctate, but instead comprises some nonzero amount of time; it contrasts with the mathematical view of the present, in which the divide between past and future is merely a point (...) or a line with no thickness. The anonymous source for the term 'specious present' is revealed as a retired businessman-turned-amateur philosopher. The more likely source for the idea itself is a little-known philosopher, Shadworth Hollway Hodgson, who was not merely a significant influence on James but also on Husserl's development of the tripartite account of internal time consciousness. I conclude by demonstrating how James' changing views on the relationship between concepts and experience meant that by the later period of his writings, including those in which he develops his own views on pragmatism, James would have not merely noted the contrast between a mathematical conception of the present and our actual experience of it, he would have taken a further step and condoned the thick experience of the present as demonstrating the inadequacy of the intellectualized mathematical characterization. (shrink)

.Deep disagreements are those involving a disagreement about (relatively) fundamental epistemic principles. This paper considers the bearing of testimonial injustice, in Miranda Fricker’s sense, on the depth of disagreements, and what this can teach us about the nature and significance of deep disagreements. I start by re-evaluating T. J. Lagewaard’s recent argument that disagreements about the nature, scope, and impact of oppression will often be deepened by testimonial injustice, since the people best placed to offer relevant testimony will be subject (...) to testimonial injustice, pushing the disagreement into one about the bearing of certain epistemic sources on the original debate. I take issue with this last step, but I build on the argument to bring attention to unappreciated and worrying ways in which prejudices can make a disagreement deep in ways that can be hidden from one or more of the participants and from observers. Finally, I revisit some of the ways that deep disagreement has been thought to be problematic for the proper functioning of a democracy, and I examine whether the kinds of hidden deep disagreements I argue for in the paper make these problems any worse, concluding that they likely do. (shrink)

This chapter contains sections titled: Introduction The Mathematical Theory of Probability The Philosophical Theory of Probability Conclusion References.

'Alain Badiou: Between Theology and Anti-theology' provides one of the first comprehensive analyses of the relationship between Badiou's philosophy and theology. Examining the full range of Badiou's writings, this provocative study explores how Badiou's philosophy relies on theology even if he claims otherwise and actively attempts to work against theology. Despite the complex questions discussed - ranging across ontology, the theory of truth and the subject, philosophy and its conditions, and anti-philosophy - this book presents a clear and accessible overview (...) of the theological, religious and biblical themes which animate Badiou's philosophy. (shrink)

David Malament argued that Hartry Field's nominalisation program is unlikely to be able to deal with non-space-time theories such as phase-space theories. We give a specific example of such a phase-space theory and argue that this presentation of the theory delivers explanations that are not available in the classical presentation of the theory. This suggests that even if phase-space theories can be nominalised, the resulting theory will not have the explanatory power of the original. Phase-space theories thus raise problems for (...) nominalists that go beyond Malament's initial concerns. Thanks to Mark Steiner, Jens Christian Bjerring, Ben Fraser, John Mathewson, and two anonymous referees for helpful comments on an earlier draft of this paper. CiteULike Connotea Del.icio.us What's this? (shrink)

According to a tradition reaching back to Plato, questions about the nature of knowledge are to be answered by offering an analysis in terms of truth, belief, justification, and other factors presumed to be in some sense more basic than knowledge itself. In light of the apparent failure of this approach, knowledge first philosophy instead takes knowledge as the starting point in epistemology and related areas of the philosophies of language and mind. Knowledge cannot be analyzed in the traditional sense, (...) but this does not make it mysterious or unimportant. On the contrary, we are freed to use our grasp of what knowledge is to elucidate the nature of belief, justification, evidence, the speech act of assertion, and the demands on action and practical reasoning, and to treat knowledge as a purely mental state in its own right. Knowledge First? offers the first overview and critical evaluation of knowledge first philosophy as a whole. (shrink)

When scientists act unethically, their actions can cause harm to participants, undermine knowledge creation, and discredit the scientific community. Responsible Conduct of Research training i...

Proponents of the predicate view of names explain the reference of an occurrence of a name N by invoking the property of bearing N. They avoid the charge that this view involves a vicious circularity by claiming that bearing N is not itself to be understood in terms of the reference of actual or possible occurrences of N. I argue that this approach is fundamentally mistaken. The phenomenon of ‘reference transfer’ shows that an individual can come to bear a name (...) in virtue of the referential practices of a group of speakers. I develop a picture of name-bearing which captures this fact by treating the extension of name as a function of the way that extension is represented in the presuppositions of groups of speakers. I show that though there is a form of circularity inherent in this approach, it is not vicious circularity. (shrink)

This paper is about how to interpret and evaluate purported evidence for predicativism about proper names. I aim to point out some underappreciated thorny issues and to offer both predicativists and non-predicativists some advice about how best to pursue their respective projects. I hope to establish three related claims: that non-predicativists have to posit relatively exotic, though not entirely implausible, polysemic mechanisms to capture the range of data that predicativists have introduced ; that neither referentialism nor extant versions of predicativism (...) can offer a very plausible account of the interpretive possibilities for singular unmodified definite descriptions containing names ; and that the most plausible version of predicativism would treat bare names as non-anaphoric definite descriptions. (shrink)

Respect for patient autonomy can apply at two levels: ensuring that patient care reflects their considered values and wishes and honoring patient preferences about how to make momentous decisions. Caregivers who seek to respect patient autonomy in the context of some end-of-life decisions face a dilemma. Because these decisions are fraught, patients may prefer to approach them sequentially, only making decisions at the time they arise. However, respecting patients’ preferences for a sequential approach can increase the likelihood that surrogates and (...) care teams wind up in situations in which they lack information needed to ensure patients receive care that conforms to their considered values after they are no longer competent to make decisions for themselves. Sequential decision-making can thus conflict with the goal of ensuring care reflects the wishes of patients. After illustrating how this dilemma can arise in the use of life-sustaining “bridge” technologies, we argue that care teams may be warranted in requiring patients to articulate their wishes in an advance care plan before treatment begins. In some cases, care teams may even be permitted to refuse to undertake certain courses of care, unless patients articulate their wishes in an advance care plan. (shrink)

This article argues that the quiet politics of informal business-state interaction explains the political determinants of growth regimes. Building on the business power literature within the study of comparative capitalism, it shows that the noisy politics of elections often leads to changes of government but rarely to fundamental changes in the growth regime. Rather, growth models can be traced to the interactions and interests of dominant corporations within a country and its policymaking elites. The argument is developed through a comparative (...) case study research design, using the case of foreign direct investment–led growth in Ireland and Hungary. FDI-led growth regimes are a universe of cases that rely on state-led industrial and enterprise policies targeting the capital investment of foreign-owned multinational firms. Despite periods of noisy electoral politics challenging basic tenets of the FDI-led growth model in both Hungary and Ireland, the continuity of FDI-oriented growth is traced to the corporate politics of business-state elite deals. (shrink)

This paper criticises Miranda Fricker's account of the primary harm of testimonial injustice as a kind of epistemic objectification, where the latter is understood on the model provided by Martha Nussbaum's influential analysis of sexual objectification and where it is taken to involve the denial of someone's epistemic agency. I examine the existing objections to Fricker's account of the primary harm, criticising some while accepting the force of others, and I argue that one of Fricker's own central examples of testimonial (...) injustice in fact offers the basis of a particularly telling objection. While Fricker's other critics have mostly concluded that we need to look at alternative theoretical resources to offer an account of the primary harm of testimonial injustice, I aim to show that this is premature; both Fricker and her critics have underestimated the resources provided by Nussbaum's analysis of objectification when offering an account of the primary harm, and something very much in the spirit of Fricker's account survives the objections. (shrink)

A main thread of the debate over mathematical realism has come down to whether mathematics does explanatory work of its own in some of our best scientific explanations of empirical facts. Realists argue that it does; anti-realists argue that it doesn't. Part of this debate depends on how mathematics might be able to do explanatory work in an explanation. Everyone agrees that it's not enough that there merely be some mathematics in the explanation. Anti-realists claim there is nothing mathematics can (...) do to make an explanation mathematical ; realists think something can be done, but they are not clear about what that something is. I argue that many of the examples of mathematical explanations of empirical facts in the literature can be accounted for in terms of Jackson and Pettit's [1990] notion of program explanation, and that mathematical realists can use the notion of program explanation to support their realism. This is exactly what has happened in a recent thread of the debate over moral realism. I explain how the two debates are analogous and how moves that have been made in the moral realism debate can be made in the mathematical realism debate. However, I conclude that one can be a mathematical realist without having to be a moral realist. (shrink)

Frege's puzzle is a fundamental challenge for accounts of mental and linguistic representation. This piece surveys a family of recent approaches to the puzzle that posit representational relations. I identify the central commitments of relational approaches and present several arguments for them. I also distinguish two kinds of relationism—semantic relationism and formal relationism—corresponding to two conceptions of representational relations. I briefly discuss the consequences of relational approaches for foundational questions about propositional attitudes, intentional explanation, and compositionality.

Twentieth century philosophers introduced the distinction between “objective rightness” and “subjective rightness” to achieve two primary goals. The first goal is to reduce the paradoxical tension between our judgments of what is best for an agent to do in light of the actual circumstances in which she acts and what is wisest for her to do in light of her mistaken or uncertain beliefs about her circumstances. The second goal is to provide moral guidance to an agent who may be (...) uncertain about the circumstances in which she acts, and hence is unable to use her standard moral principle directly in deciding what to do. This paper distinguishes two important senses of “moral guidance”; proposes criteria of adequacy for accounts of subjective rightness; canvasses existing definitions for “subjective rightness”; finds them all deficient; and proposes a new and more successful account. It argues that each comprehensive moral theory must include multiple principles of subjective rightness to address the epistemic situations of the full range of moral decision-makers, and shows that accounts of subjective rightness formulated in terms of what it would reasonable for the agent to believe cannot provide that guidance. (shrink)

In archival footage uploaded online of a concert at the University of the Western Cape in 1988 musician Robbie Jansen declared that the next composition to be performed was named 'Freedom Where Have You Been'.1 Before counting the band in, Jansen offered a short discourse on the meaning of the phrase hoya chibongo. Hearing the Afrikaans hoorie (meaning listen here) in the expression hoya, Jansen proceeded to split up the word chibongo to accentuate chi- as aurally reminiscent of the suffix (...) -tjie that is used in Afrikaans to mark the diminutive. bongo, in this context as Jansen remarked, is the drum, leading Jansen to exclaim that the phrase hoya chibongo means to 'listen to the (small) drum', the drum that is, according to Jansen, 'the truth'. In Jansen's exact words, 'the drum speaks the truth and the drum has always been our language before these funny words that we are speaking now'. Jansen's translation was markedly oral, not only in its expression of speech and languaging but also in its invocation of a historicity through the oral; an oral tradition, for all intents and purposes. In its locatedness in a musically expressive and performative moment, Jansen expressed a duality of sound that exceeds the oral itself: calling attention to how language might be a conduit for the instrument, and how in some sense the drum might speak across time and space. It usefully deepens the often cliché proclamation rehearsed in and out of music studies in particular that music is universal, or that sound might be thought of as a kind of connective tissue that allows a specific sense-making of the social.2 In Jansens invocation of 'before' in his statement about the drum as language, and in debates around the meaning of sound to the social, it is history - or, a representation of pastness - that is called upon to bring about a set of futures where sound mediates the experience of a temporal matrix where truth, or freedom, might be found. What Jansen does/did was not necessarily an act of translation into a local vernacular as it is the blurring of the oral and the aural in a moment that might express the relation between sound, its interpretation, and its social life, obliquely. The truth for Jansen was what the drum expressed; but it was also the drum itself. The oral is aural, as the aural is oral. (shrink)

Among the virtues of relationist approaches to Frege’s puzzle is that they put us in a position to outline structural features of the puzzle that were only implicit in earlier work. In particular, they allow us to frame questions about the relation between the explanatory roles of sense and sameness of sense. In this paper, I distinguish a number of positions about that relation which have not been clearly distinguished. This has a few pay-offs. It allows us to shed light (...) on recent controversies about the ‘essential indexical’, and it also allows us to see what’s at stake between relationists and their opponents. When we see what’s at stake, we can see that we have reason to adopt an account of cognitive significance that incorporates elements of both relationist and Fregean approaches. (shrink)

Predicativists hold that proper names have predicate-type semantic values. They face an obvious challenge: in many languages names normally occur as, what appear to be, grammatical arguments. The standard version of predicativism answers this challenge by positing an unpronounced determiner in bare occurrences. I argue that this is a mistake. Predicativists should draw a distinction between two kinds of semantic type—underived semantic type and derived semantic type. The predicativist thesis concerns the underived semantic type of proper names and underdetermines a (...) view about the semantic type of bare occurrences. I’ll argue that predicativists should hold that bare names are derived individual-denoting expressions. I end by considering what this result means for the relationship between predicativism and other metalinguistic theories of names. (shrink)

Fregeanism and Relationism are competing families of solutions to Frege’s Puzzle, and by extension, competing theories of propositional representation. My aim is to clarify what is at stake between them by characterizing and evaluating a Relationist argument. Relationists claim that it is cognitively possible for distinct token propositional attitudes to be, in a sense, qualitatively indistinguishable: to differ in no intrinsic representational features. The idea of an ‘intrinsic representational feature’ is not, however, made especially clear in the argument. I clarify (...) it here and, having done so, offer reason to doubt the argument. This will put us in a position to draw some lessons about the relation between object-directed and representation-internal aspects of cognitive significance. (shrink)

Recently two distinct forms of rule-utilitarianism have been introduced that differ on how to measure the consequences of rules. Brad Hooker advocates fixed-rate rule-utilitarianism, while Michael Ridge advocates variable-rate rule-utilitarianism. I argue that both of these are inferior to a new proposal, optimum-rate rule-utilitarianism. According to optimum-rate rule-utilitarianism, an ideal code is the code whose optimum acceptance level is no lower than that of any alternative code. I then argue that all three forms of rule-utilitarianism fall prey to two fatal (...) problems that leave us without any viable form of rule-utilitarianism. (shrink)

Call an account of names satisfactionalist if it holds that object o is the referent of name a in virtue of o’s satisfaction of a descriptive condition associated with a. Call an account of names minimally descriptivistif it holds that if a competent speaker finds ‘a=b’ to be informative, then she must associate some information with ‘a’ which she does not associate with ‘b’. The rejection of both positions is part of the Kripkean orthodoxy, and is also built into extant (...) versions of the file-picture of reference. In this paper, I argue that the rejection of minimal descriptivism only follows from the rejection of satisfactionalism given certain implausible assumptions about the nature of competence with a proper name. I do this by showing that considerations internal to the file-picture - in particular the idea that competence with a proper name constitutes an ‘epistemically rewarding’ relation to its bearer - motivate an acceptance of minimal descriptivism. (shrink)