In the last two decades we have witnessed considerable efforts directed towards making electronic healthcare records comparable and interoperable through advances in record architectures and (bio)medical terminologies and coding systems. Deep semantic issues in general, and ontology in particular, have received some interest from the research communities. However, with the exception of work on so-called ‘controlled vocabularies’, ontology has thus far played little role in work on standardization. The prime focus has been rather the rapid population of terminologies at the (...) level of fine detail. In this paper, we argue that more efforts are needed on the side of both research and standardization to ensure that the coding systems used in electronic healthcare records enjoy a semantics that is coherent with the semantics of the record. We propose realist ontology as a method to bring about this coherence by means of a robust system of top-level ontological categories. (shrink)

Strawson's attempt to refute scepticism about the existence of other minds has itself been a popular target of sceptical criticism. But the very persistence of the attacks suggests that no clinching rebuttal has yet been produced. One of the earliest and still one of the most effective responses to Strawson is Ayer's celebrated paper ‘The Concept of a Person’, in which he reasserts the position of classical empiricist scepticism on the existence of other minds. By reinterpreting and partly reconstructing Strawson's (...) arguments I shall try to show that the sceptical position represented by Ayer is indeed incoherent, as Strawson maintains, and I shall suggest why a conclusive rebuttal of Strawson's anti-sceptical arguments has not been and is unlikely to be produced. (shrink)

Mill's feminism has been attacked as being logically incoherent. The general verdict has been that Mill can easily be defended from the charge. However, both sides in the debate have ignored the fact that his feminism is part of a broader theory of liberal empiricism. Placing The Subjection of Women in this context re–opens the question of its logical credentials and reveals a basic weakness in Millian feminism.

A market may be defined as a set of competitive relationships in which agents strive, within limits set by ground rules, to better their own economic positions, not necessarily at the expense of other people, but not necessarily not at their expense either. A degree of indifference to the market fates of others is, manifestly, an inevitable feature of the market practice, so defined. But though indifference is clearly logically endemic to markets, it has been denied that selfishness is necessarily (...) involved in the raw competition of market activity. Thus, Hayek maintains that market behaviour is not selfish on the grounds that the market is a competitive non zero-sum ‘wealth-creating game’ in which individuals ‘use their own knowledge for their own ends’ in a system whose operations,viathe ‘Invisible Hand’, also produce unintended benefits for others. But for behaviour to be selfish it clearly need not necessarily disbenefit other people; it is enough that it is pursued, or persisted in, regardless of its effects upon others. And this is precisely what the institutional ‘indifference’ of market activity amounts to. Admittedly individuals who understand the Hayekian logic of the market know that the long-run chances of everyone's benefiting are maximized by acting in a rigorously competitive manner, and so they at least in one sense act with a ‘regard for others’. Butipso factothis category of market agents has an even stronger reason than the ignorantly selfish for disregarding thespecificinterests of all theparticularindividuals with whom they have economically to do. ‘Market selfishness’, the disregard for others' market interests, is thus a logically inevitable feature of market activity. (shrink)

The principles of historical materialism involve Marx in making two crucial claims about freedom. The first is that the revolutionary proletariat is, in an important sense, more free than its class antagonist the bourgeoisie. The second is that the beneficiaries of a successful proletarian revolution—the members of a solidly established communist society—enjoy a greater freedom than even proletarians engaged in revolutionary praxis. It is perhaps natural to take Marx to be operating here with what might be called a logically continuous (...) notion of freedom, established communists enjoying to perfection what revolutionary proletarians merely imperfectly experience and what the bourgeoisie entirely misses. But whatever one's views might be about what Marx in fact says about freedom this cannot be what he ought to say for his theory of freedom to work. The kind of line Marx need to take finds a significant precedent in his economics where we find a theory implying two quite distinct logical dimensions in that the principles and concepts designed to apply to the transactions of capitalism necessarily lack descriptive purchase on communist economic reality. The existence of these two dimensions, and particularly Marx's comparative silence as to the nature of the second, reflect his conviction that the transition between the two systems must be marked by a profound conceptual as well as material break. Consequently it is not unreasonable, perhaps, to look for an analogous discontinuity in his metaphysics and to expect to find two distinct varieties of freedom, the one reflecting the nature of class society, the other of human community. (shrink)

The principles of historical materialism involve Marx in making two crucial claims about freedom. The first is that the revolutionary proletariat is, in an important sense, more free than its class antagonist the bourgeoisie. The second is that the beneficiaries of a successful proletarian revolution—the members of a solidly established communist society—enjoy a greater freedom than even proletarians engaged in revolutionary praxis. It is perhaps natural to take Marx to be operating here with what might be called a logically continuous (...) notion of freedom, established communists enjoying to perfection (or as near as maybe) what revolutionary proletarians merely imperfectly experience and what the bourgeoisie entirely misses. But whatever one's views might be about what Marx in fact says about freedom this cannot be what he ought to say for his theory of freedom to work. The kind of line Marx (and Marxists) need to take finds a significant precedent in his economics where we find a theory implying two quite distinct logical dimensions in that the principles and concepts designed to apply to the transactions of capitalism (commodity, capital, wage-labour, surplus-value, and so on) necessarily lack descriptive purchase on communist economic reality. The existence of these two dimensions, and particularly Marx's comparative silence as to the nature of the second, reflect his conviction that the transition between the two systems must be marked by a profound conceptual as well as material break. Consequently it is not unreasonable, perhaps, to look for an analogous discontinuity in his metaphysics and to expect to find two distinct varieties of freedom, the one reflecting the nature of class society, the other of human community. (shrink)

Writing in the foreword to Allan Bloom's The Closing of the American Mind and speaking of his upbringing in Chicago between the wars Saul Bellow attests that …as a Midwesterner, the son of immigrant parents, I recognized at an early stage that I was called upon to decide for myself to what extent my Jewish origins, my surroundings [‘the accidental circumstances of Chicago’], my schooling, were to be allowed to determine the course of my life. I did not intend to (...) be wholly dependent upon history and culture. Full dependency must mean that I was done for. The commonest teaching of the civilized world in our time can be stated simply: ‘Tell me where you come from and I'll tell you what you are’. (shrink)

This volume brings together J.S. Mills On Liberty and a selection of important essays by such eminent scholars as Isaiah Berlin, Alan Ryan, John Rees, C.L. Ten and Richard Wollheim. As well as providing authoritative commentary upon On Liberty , the essays reflect a broader debate about the philosophical foundations of Mill's liberalism, particularly the question of the connection betweenMill's professed utilitarianism and his commitment to individual liberty. Introduced and edited by John Gray and G.W. Smith, the book will (...) be of interest to students of Mill, to ethical and political philosophers and to anyone interested in the contemporary status of liberalism. (shrink)

This volume brings together J.S. Mills _On Liberty_ and a selection of important essays by such eminent scholars as Isaiah Berlin, Alan Ryan, John Rees, C.L. Ten and Richard Wollheim. As well as providing authoritative commentary upon _On Liberty_, the essays reflect a broader debate about the philosophical foundations of Mill's liberalism, particularly the question of the connection betweenMill's professed utilitarianism and his commitment to individual liberty. Introduced and edited by John Gray and G.W. Smith, the book will be (...) of interest to students of Mill, to ethical and political philosophers and to anyone interested in the contemporary status of liberalism. (shrink)

This volume brings together J.S. Mills _On Liberty_ and a selection of important essays by such eminent scholars as Isaiah Berlin, Alan Ryan, John Rees, C.L. Ten and Richard Wollheim. As well as providing authoritative commentary upon _On Liberty_, the essays reflect a broader debate about the philosophical foundations of Mill's liberalism, particularly the question of the connection betweenMill's professed utilitarianism and his commitment to individual liberty. Introduced and edited by John Gray and G.W. Smith, the book will be (...) of interest to students of Mill, to ethical and political philosophers and to anyone interested in the contemporary status of liberalism. (shrink)

ABSTRACTOne of the most powerful claims of disability theology is that the rejection of persons with disabilities somehow correlates with a rejection of God. This ‘correlative rejection’ is, however, frequently just stated rather than explored in detail, something this article therefore seeks to remedy by examining one example of the correlative rejection that draws together the ethical concerns of theologians writing on intellectual disability with Meister Eckhart’s teaching on the human relationship with God. Here, the correlative rejection is exposed as (...) an inevitable result of the narrow emphasis on autonomy and rationality in human self-perception which shape the habituated, even ritualised ways that we try to know persons with intellectual disabilities and God. By contrast, truly knowing and relating to persons with intellectual disabilities, God, and finally also ourselves, relies on a reconciliation with the dependence, vulnerability, and non-rational forms of exchange that a narrow attachment to a... (shrink)

v. 1. Nicomachean ethics. Politics. The Athenian Constitution. Rhetoric. On Poetics.--v. 2. Logic.--v. 3. Physics. Metaphysics. On the soul. Short physical treaties.--v. 4. On the heavens. On generation and corruption. Meteorology. Biological treatises.

Introduction, W G Runciman Social Evolution in Primates: The Role of Ecological Factors and Male Behaviour, Carel P van Schaik Determinants of Group Size in Primates: A General Model, R I M Dunbar Function and Intention in the Calls of Non-Human Primates, Dorothy L Cheney & Robert M Seyfarth Why Culture is Common, but Cultural Evolution is Rare, Robert Boyd & Peter J Richerson An Evolutionary and Chronological Framework for Human Social Behaviour, Robert A Foley Friendship and the Banker?s Paradox: (...) Other Pathways to the Evolution of Adaptations for Altruism, John Tooby & Leda Cosmides The Early Prehistory of Human Social Behaviour: Issues of Archaeological Inference and Cognitive Evolution, Steven Mithen The Emergence of Biologically Modern Populations in Europe: A Social and Cognitive ?Revolution??, Paul Mellars Responses to Environmental Novelty: Changes in Men?s Marriage Strategies in a Rural Kenyan Community, Monique Borgerhoff Mulder Genetic Language Impairment: Unruly Grammars, M Gopnik, J Dalalakis, S E Fukuda, S Fukuda & E Kehayia The Emergence of Cultures among Wild Chimpanzees, Christophe Boesch Terrestriality, Bipedalism and the Origin of Language, Leslie C Aiello Conclusions, John Maynard Smith. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)