The Euthyphro is generally considered one of Plato’s early dialogues. According to the developmental approach to reading the dialogues, when writing the Euthyphro Plato had not yet developed the sort of elaborate “theory of forms ” that we see presented in the middle dialogues and further refined in the late dialogues. This essay calls the developmental account into question by showing how key elements from the theory of forms that appear in the late dialogues, particularly in the Statesman, are already (...) operative in the Euthyphro. When one identifies the way in which each of Euthyphro ’s definitions of piety fails in light of Socrates’s arguments, one already finds the conception of form that Plato presents in the middle and late dialogues. (shrink)

Plotinus calls the first principle the One and the Good. According to Plotinus, ‘Good’ is an appropriate name for the One because the One is that which all things desire. Since he says that the One is beyond knowledge, beyond language, beyond intellect, and beyond being, however, what philosophical evidence can he provide for his claim that the One is that which all desire? In this article I offer some philosophical evidence, aside from mystical union with the One, for why (...) ‘the Good’ is an appropriate name for the One, and for why calling the One ‘Good’ is not at odds with the fact that it is beyond knowledge, but rather entails it. To this end, after an initial consideration of the relationship between the good and desire in Plato and Aristotle, I focus on the role that desire plays in relation to the Good in Plotinus’ thought. (shrink)

Saint Anselm’s ontological argument is usually interpreted either (1) as an attempt to deductively prove God’s existence or (2) as a form of prayer, which is not intended to “prove” God’s existence, but rather to deepen the devotion of those who already believe. In this paper I attempt to find a mean between these two interpretations, showing that while Anselm’s argument is not a deductive proof, it is nevertheless a proof of God’s existence. I argue that Anselm’s ontological argument is (...) analogous to Aristotle’s to elegktikōs apodeixai (retorsive argument) for the truth of the principle of non-contradiction in Metaphysics IV: an argument that does not move from premises to conclusion, but rather demonstrates the truth of its conclusion by showing that its conclusion is always presupposed. I argue that interpreting Anselm’s ontological argument in this way exempts it from the most common objections against it. (shrink)

Should one use philosophy in service of religion? I argue that Dionysius the Areopagite gives a negative answer to this question. The relevant text is Dionysius’ Letter 7, in which he explains why he does not use philosophy to attack Greco-Roman paganism. Philosophy, according to Dionysius, is something divine. In fact, in Letter 7 he goes so far as to identify philosophy with what St. Paul calls the “wisdom of God.” As a result, philosophy should not be treated as a (...) tool to be used in service of anything, even the true religion, which Dionysius of course identifies with Christianity. In order to elucidate Dionysius’ position, I provide a detailed account of how he understands philosophy, religion (thrêskeia), and use (chraô). (shrink)

Gottlob Frege (1848-1925) was unquestionably one of the most important philosophers of all time. He trained as a mathematician, and his work in philosophy started as an attempt to provide an explanation of the truths of arithmetic, but in the course of this attempt he not only founded modern logic but also had to address fundamental questions in the philosophy of language and philosophical logic. Frege is generally seen (along with Russell and Wittgenstein) as one of the fathers of the (...) analytic method, which dominated philosophy in English-speaking countries for most of the twentieth century. His work is studied today not just for its historical importance but also because many of his ideas are still seen as relevant to current debates in the philosophies of logic, language, mathematics and the mind. The Cambridge Companion to Frege provides a route into this lively area of research. (shrink)

Boethius's Consolation of Philosophy was one of the most widely read and influential texts in medieval Europe, considering questions such as: how can evil exist in a world governed by God? And how is happiness still attainable despite the vicissitudes of fortune? Written as a dialogue between Boethius and Lady Philosophy, and alternating between poetry and prose, the Consolation is of interest not only to philosophers, but to students of classics and literature as well. In this Critical Guide, the first (...) collection of philosophical essays devoted exclusively to the Consolation, thirteen new essays demonstrate its ongoing vitality and break open its riches for a new generation of readers. The essays reflect the diverse array of approaches in contemporary scholarship and attend to both the literary features and the philosophical content of the Consolation. The volume will be invaluable for scholars of medieval philosophy, medieval literature, and the history of ideas. (shrink)

Philosophy in the English-speaking world is dominated by analytic approaches to its problems and projects; but theology has been dominated by alternative approaches. Many would say that the current state in theology is not mere historical accident, but is, rather, how things ought to be. On the other hand, many others would say precisely the opposite: that theology as a discipline has been beguiled and taken captive by 'continental' approaches, and that the effects on the discipline have been largely deleterious. (...) The methodological divide between systematic theologians and analytic philosophers of religion is ripe for exploration. The present volume represents an attempt to begin a much-needed interdisciplinary conversation about the value of analytic philosophical approaches to theological topics. Most of the essays herein are sympathetic toward the enterprise the editors are calling analytic theology; but, with an eye toward balance, the volume also includes essays and an introduction that try to offer more critical perspectives on analytic theology. (shrink)

There are only two places in which Plato explicitly offers a critique of the sort of theory of forms presented in the Phaedo and Republic: at the beginning of the Parmenides and in the argument against the Friends of the Forms in the Sophist. An accurate account of the argument against the Friends, therefore, is crucial to a proper understanding of Plato’s metaphysics. How the argument against the Friends ought to be construed and what it aims to accomplish, however, are (...) matters of considerable controversy. My aim in this article is twofold. First, I show that the two readings of the argument against the Friends that dominate the contemporary literature – the “Cambridge Change” reading and the “Becoming-is-Being” reading – lack sufficient textual support. Second, I offer an alternative reading of the argument against the Friends that better explains both the text of 248a4–249d5 and the role the argument plays within the Stranger’s wider project of demonstrating that non-being is. My thesis is that the Stranger’s argument against the Friends seeks to demonstrate that the forms must be both at rest and moved, where “moved” has the sense of “affected.” To participate in a form is to be affected by that form. I argue that since, according to the Stranger, every form participates in some other forms, every form is “moved” in the sense that it is affected by the forms in which it participates. Likewise, I argue that every form is at rest in the sense that its unique nature remains unaffected by the other forms in which it participates. (shrink)

At Sophist 260e3-261a2, the Eleatic Stranger claims that in order to demonstrate that falsehood is, he and Theaetetus must first track down what speech (logos), opinion (doxa), and appearance (phantasia) are, and then observe the communion (koinōnia) that speech, opinion, and appearance have with non-being. The Stranger, however, never explicitly discusses the communion of speech, opinion, and appearance with non-being. Yet presumably their communion is implicit in his account of falsehood, given his claim that observing that communion is needed in (...) order to demonstrate that falsehood is (260e5-a2). This essay seeks to make the communion that speech has with non-being explicit. I argue that speech has communion with non-being in that the things and actions speech combines together by means of nouns and verbs need not be combined in a way that reveals how the being a given speech is about combines ontologically with other beings. (shrink)

Im Zentrum des Werkes von Michael Oakeshott (1901-1990) steht die Frage nach der Vernunft der Praxis und der Praxis der Vernunft. Dieses klassische Thema der praktischen Philosophie, das heute im Hintergrund verschiedener Debatten in Philosophie und Politikwissenschaft steht, leitete Oakeshott in seiner Auseinandersetzung mit der modernen Politik. Die in dem Sammelband vereinigten Beitrage bieten einen Uberblick uber die internationale Forschungslage; ihr gemeinsamer Angelpunkt ist Oakeshotts Praxisbegriff: Diskutiert wird seine praktische Bedeutung im Durchgang durch die grundlegenden politischen und gesellschaftlichen Problemfragen (...) der Gegenwart, seine theoretische Leistungsfahigkeit ist Gegenstand vergleichender Perspektiven, die vor allem die deutschen Zeitgenossen wie H. Arendt, H.-G. Gadamer, G. Simmel oder L. Strauss einbeziehen. Der vorliegende Band unternimmt es, die seit mehr als zwei Jahrzehnten intensiv gefuhrte, vor allem angelsachsische Debatte um Oakeshotts Denken in die einschlagigen deutschen Diskussionen zu tragen und die Anknupfungspunkte sichtbar zu machen, die sein facettenreiches Werk fur die Verstandigung uber eine humane Praxis in den Konflikten des 21. Jahrhunderts bietet. Mit Beitragen von: Josiah Lee Auspitz, Michael Becker, Wendell John Coats Jr., Peter Finn, Jurgen Gebhardt, Steven A. Gerencser, Michael Grossheim, Michael Henkel, Hans Jorg Hennecke, Bart van Klink, Silviya Lechner, Oliver W. Lembcke, Kenneth B. McIntyre, Efraim Podoksik, Rainer Schmidt, Suvi Soininen, Judith A. Swanson, Martyn P. Thompson. (shrink)

A brief introduction to the first issue of the Journal of Analytic Theology.

In 2012, a new and promising gene manipulation technique, CRISPR-Cas9, was announced that seems likely to be a foundational technique in health care and agriculture. However, patents have been granted. As with other technological developments, there are concerns of social justice regarding inequalities in access. Given the technologies’ “foundational” nature and societal impact, it is vital for such concerns to be translated into workable recommendations for policymakers and legislators. Colin Farrelly has proposed a moral justification for the use of patents (...) to speed up the arrival of technology by encouraging innovation and investment. While sympathetic to his argument, this article highlights a number of problems. By examining the role of patents in CRISPR and in two previous foundational technologies, we make some recommendations for realistic and workable guidelines for patenting and licensing. (shrink)

As Socrates recounts his search for causes (aitiai) in the Phaedo, he identifies the following as genuine causes: intelligence (nous), seeming best, choice of the best, and the forms. I argue that these causes should be understood as norms prescribing the conditions their effects must meet if those effects are to be produced. Thus, my account both explains what Socrates’ causes are and the way in which they cause what they cause.

ABSTRACT The use of broad consent for genomics research raises important ethical questions for the conduct of genomics research, including relating to its acceptability to research participants and comprehension of difficult scientific concepts. To explore these and other challenges, we conducted a study using qualitative methods with participants enrolled in an H3Africa Rheumatic Heart Disease genomics study (the RHDGen network) in Zambia to explore their views on broad consent, sample and data sharing and secondary use. In-depth interviews were conducted with (...) RHDGen participants (n = 18), study staff (n = 5) and with individuals who refused to participate (n = 3). In general, broad consent was seen to be reasonable if reasons for storing the samples for future research use were disclosed. Some felt that broad consent should be restricted by specifying planned future studies and that secondary research should ideally relate to original disease for which samples were collected. A few participants felt that broad consent would delay the return of research results to participants. This study echoes findings in other similar studies in other parts of the continent that suggested that broad consent could be an acceptable consent model in Africa if careful thought is given to restrictions on re-use. (shrink)

The argument by which the Eleatic Stranger differentiates the kinds being and different (255c9-e2) is one of the most controversial in Plato’s Sophist. In it the Stranger introduces the vexed distinction between beings that are auta kath’ hauta, ‘themselves according to themselves’, and those that are pros alla, ‘relative to others’ (255c13-14). Although commentators have developed many interpretations of the argument, there is a key yet hitherto unrecognized ambiguity in the syntax of the counterfactual conditional at 255d4-6, concerning whether the (...) adjunct comparative clause, hōsper to on, should be adjoined to the protasis or apodosis. Editors from Heindorf to Robinson adjoin hōsper to on to the protasis. I argue this is mistaken. Adjoining hōsper to on to the apodosis instead allows for a more straightforward interpretation of the argument and offers a resolution to the controversies surrounding the ‘according to themselves’ / ‘relative to others’ distinction. (shrink)

The use of broad consent for genomics research raises important ethical questions for the conduct of genomics research, including relating to its acceptability to research participants and comprehension of difficult scientific concepts. To explore these and other challenges, we conducted a study using qualitative methods with participants enrolled in an H3Africa Rheumatic Heart Disease genomics study in Zambia to explore their views on broad consent, sample and data sharing and secondary use. In-depth interviews were conducted with RHDGen participants, study staff (...) and with individuals who refused to participate. In general, broad consent was seen to be reasonable if reasons for storing the samples for future research use were disclosed. Some felt that broad consent should be restricted by specifying planned future studies and that secondary research should ideally relate to original disease for which samples were collected. A few participants felt that broad consent would delay the return of research results to participants. This study echoes findings in other similar studies in other parts of the continent that suggested that broad consent could be an acceptable consent model in Africa if careful thought is given to restrictions on re-use. (shrink)

In Plato’s Statesman, the Eleatic Stranger explains that the division of all human beings into Greek and barbarian is mistaken in that it fails to divide reality into genuine classes or forms (eidē). The division fails because “barbarian” names a privative form, that is, a form properly indicated via negation: non-Greek. This paper examines how the Stranger characterizes privative forms in the Sophist. I argue that although the Stranger is careful to define privative forms as fully determinate, he nevertheless characterizes (...) them as having a structure unlike that of their non-privative counterparts. A privative form, in contrast to a non-privative form, is indifferent to the specificity of its members. (shrink)

In their chapter, “In What Sense Does the One Exist? Existence and Hypostasis in Plotinus,” Paul DiRado and Michael Wiitala consider the problem of the One’s existence. Starting with the modern philosophical distinction between the “is” of predication and the “is” of existence, they show that Plotinus does not make such a distinction. The reason for this, they argue, is that Plotinus does not share with modern philosophers a univocal notion of existence. For Plotinus, both the verb “einai” (...) and the word “hypostasis” have variable meanings. Thus Plotinus can, in some contexts, say that “the One is” without being committed to the view that the One is or exists in the same way that other entities lower in the metaphysical hierarchy (Forms, say) exist. To say that “the One is” is to say that the One is the basis for the being of other entities; the Forms, on the other hand, truly “are,” in that they are the subjects of necessary and unchanging real predication. (shrink)

Boethius is unique among Christian authors in late antiquity in that his account of deification makes no explicit reference to Christ. Instead, he develops a distinctly Neo-Platonic notion of deification, which he puts in the mouth of Lady Philosophy. According to Lady Philosophy, human beings are made divine through participation in God, who is understood as happiness itself, goodness itself, and unity itself. On the basis of this identification of happiness and God, Lady Philosophy concludes that the happiness human beings (...) desire can only be attained through deification. Although the argument of the Consolation suggest that a virtuous life, contemplation, and prayer are all necessary for attaining happiness and deification, there is no indication that they are sufficient for happiness and deification; nor does she specify what would be sufficient. The reason for her silence in this regard is presumably Boethius’ orthodox Catholic belief that salvation, and therefore deification, is only attainable through Christ. While Lady Philosophy, as Boethius portrays her, can identify that happiness is only attainable through deification, she cannot on her own sufficiently identify how to achieve deification. (shrink)

In the Nicomachean Ethics, Aristotle seems to take it for granted that the contemplative man is morally virtuous. Yet in certain passages he suggests that morally virtuous actions can impede contemplation (theōria). In this paper I examine the relationship between contemplation and morally virtuous action in Aristotle’s ethics. I argue that, when understood within the context of the motivating power of the kalon, contemplation and morally virtuous action are related to one another in such a way that one cannot be (...) contemplative without being morally virtuous and vice versa. I begin by showing how eudaimonia is used in the Nicomachean Ethics to interpret the erga kai ho bios, that is, lived experience, and to bring to light the kalon as the motive for morally virtuous actions. I argue that since the kalon is also the motive for contemplation, morally virtuous action and contemplation imply one another. (shrink)

Objections to the traditional view that God knows all of time eternally stand or fall on what one means by “eternally.” The widely held supposition, shared by both eternalists and those who oppose them, such as Open Theists, is that to say God knows all of time eternally entails that he cannot know all of time from atemporal perspective. In this paper I show that Boethius’s characterization of God’s eternal knowledge employs a different meaning of “eternal,” which is incompatible with (...) this supposition. I argue that Boethius’s claim that “the most excellent knowledge is that which by its own nature knows not only its own proper object but also the objects of all lower kinds of knowledge” entails that God is not limited by perspective and so eternally and simultaneously knows every temporal event from a temporal as well as a timeless perspective. (shrink)

There is a tendency among contemporary scholars of ancient Greek philosophy to think that Plotinus’ philosophical orientation is significantly different from that of Plato. One such difference is that Plotinus seems to be more interested in systematically presenting and articulating a specific set of philosophical doctrines than Plato was. After all, Plotinus lived and wrote in a context in which there were a number of highly developed philosophical schools—the Stoics, Peripatetics, Gnostics, and Epicureans, just to name a few—and is interested (...) in showing where his own views stand in relation to these. Yet despite these and other differences between the projects of Plato and of Plotinus, in this paper I want to focus on a point of continuity and agreement between the two: namely on their philosophical orientation toward the ‘why’ (dioti) of things. Plotinus’ philosophical orientation, like that of Plato before him, is driven by a search for the ‘why’ of things and a confidence that the goal of every why-inquiry is attainable. I argue that Plotinus understands this search for the ‘why’ to entail that for every object or state of affairs, there must be some principle that explains why that object or state of affairs is the way it is or has the character it does. In particular, I focus on how Plotinus’ confidence that the object of this sort of why-inquiry is attainable leads him to claim that the first principle—the One or Good—is beyond being. (shrink)

Reciprocal altruism involves foregoing an immediate benefit for the sake of a greater long-term reward. It follows that individuals who exhibit a stronger preference for future over immediate rewards should be more disposed to engage in reciprocal altruism – in other words, ‘patient’ people should be more cooperative. The present study tested this prediction by investigating whether participants’ contributions in a public-good game correlated with their ‘discount rate’. The hypothesis was supported: patient people are indeed more cooperative. The paper discusses (...) alternative interpretations of this result, and makes some suggestions for future research. (shrink)

Nudges have become a popular tool for behaviour change; but, some interventions fail to replicate, even when the identical, previously successful intervention is used. One cause of this problem is that people default to using some of or all of the previously-successful existing nudges for any problem—the “kitchen sink” approach. We argue that the success of an intervention depends on understanding people’s current behaviour and beliefs to ensure that any nudge will actually “budge” them from their current beliefs. We introduce (...) the Beliefs–Barriers–Context model, with three components: understanding beliefs, barriers, and context to change behaviour through a budge. Designing a budge has the goal of identifying the psychological mechanism that drives a target behaviour, focusing on the psychology of the target population before attempting to change that behaviour. In contrast to the “kitchen sink” approach, budges are best complemented with mechanism experiments to identify what undergirds behaviour change. Moving away from simply nudging behaviour to budging minds—by understanding beliefs, barriers and context—has the potential to inform both the successes and failures of behavioural interventions. (shrink)

We examine the question of how many Boolean algebras, distinct up to isomorphism, that are quotients of the powerset of the naturals by Borel ideals, can be proved to exist in ZFC alone. The maximum possible value is easily seen to be the cardinality of the continuum $2^{\aleph_{0}}$ ; earlier work by Ilijas Farah had shown that this was the value in models of Martin's Maximum or some similar forcing axiom, but it was open whether there could be fewer in (...) models of the Continuum Hypothesis. We develop and apply a new technique for constructing many ideals whose quotients must be nonisomorphic in any model of ZFC. The technique depends on isolating a kind of ideal, called shallow, that can be distinguished from the ideal of all finite sets even after any isomorphic embedding, and then piecing together various copies of the ideal of all finite sets using distinct shallow ideals. In this way we are able to demonstrate that there are continuum-many distinct quotients by Borel ideals, indeed by analytic P-ideals, and in fact that there is in an appropriate sense a Borel embedding of the Vitali equivalence relation into the equivalence relation of isomorphism of quotients by analytic P-ideals. We also show that there is an uncountable definable wellordered collection of Borel ideals with distinct quotients. (shrink)

In [STU 00, KUT 03] we introduced a family of ‘modal' languages intended for talking about distances. These languages are interpreted in ‘distance spaces' which satisfy some of the standard axioms of metric spaces. Among other things, we singled out decidable logics of distance spaces and proved expressive completeness results relating classical and modal languages. The aim of this paper is to axiomatize the modal fragments of the semantically defined distance logics of [KUT 03] and give a new proof of (...) their decidability. (shrink)

The adaptationist framework is necessary and sufficient for unifying the social and natural sciences. Gintis's “beliefs, preferences, and constraints” (BPC) model compares unfavorably to this framework because it lacks criteria for determining special design, incorrectly assumes that standard evolutionary theory predicts individual rationality maximisation, does not adequately recognize the impact of psychological mechanisms on culture, and is mute on the behavioural implications of intragenomic conflict. (Published Online April 27 2007).

Associative memory is the ability to link together components of stimuli. Previous evidence suggests that prior familiarization with study items affects the nature of the association between stimuli. More specifically, novel stimuli are learned in a more context-dependent fashion than stimuli that have been encountered previously without the current context. In the current study, we first acquired behavioral data from 62 human participants to conceptually replicate this effect. Participants were instructed to memorize multiple object-scene pairs and were then tested on (...) their recognition memory for the objects. Importantly, 1 day prior, participants had been familiarized with half of the object stimuli. During the test phase, the objects were either matched to the same scene as during study or swapped with a different object’s scene. Our results conceptually replicated the context-dependency effect by showing that breaking up a studied object-context pairing is more detrimental to object recognition performance for non-familiarized objects than for familiarized objects. Second, we used functional magnetic resonance imaging to determine whether medial temporal lobe encoding-related activity patterns are reflective of this familiarity-related context effect. Data acquired from 25 human participants indicated a larger effect of familiarization on encoding-related hippocampal activity for objects presented within a scene context compared to objects presented alone. Our results showed that both retrieval-related accuracy patterns and hippocampal activation patterns were in line with a familiarization-mediated context-dependency effect. (shrink)

Research suggests that the mind contains a set of adaptations for detecting alliances: an alliance detection system, which monitors for, encodes, and stores alliance information and then modifies the activation of stored alliance categories according to how likely they will predict behavior within a particular social interaction. Previous studies have established the activation of this system when exposed to explicit competition or cooperation between individuals. In the current studies we examine if shared political opinions produce these same effects. In particular, (...) if participants will spontaneously categorize individuals according to the parties they support, even when explicit cooperation and antagonism are absent, and if party support is sufficiently powerful to decrease participants’ categorization by an orthogonal but typically-diagnostic alliance cue . Evidence was found for both: Participants spontaneously and implicitly kept track of who supported which party, and when party cross-cut race—such that the race of targets was not predictive of party support—categorization by race was dramatically reduced. To verify that these results reflected the operation of a cognitive system for modifying the activation of alliance categories, and not just socially-relevant categories in general, an identical set of studies was also conducted with in which party was either crossed with sex or age . As predicted, categorization by party occurred to the same degree, and there was no reduction in either categorization by sex or by age. All effects were replicated across two sets of between-subjects conditions. These studies provide the first direct empirical evidence that party politics engages the mind’s systems for detecting alliances and establish two important social categorization phenomena: that categorization by age is, like sex, not affected by alliance information and that political contexts can reduce the degree to which individuals are represented in terms of their race. (shrink)

Review of Gerald A. Press, Plato: A Guide for the Perplexed.

This volume has 41 chapters written to honor the 100th birthday of Mario Bunge. It celebrates the work of this influential Argentine/Canadian physicist and philosopher. Contributions show the value of Bunge’s science-informed philosophy and his systematic approach to philosophical problems. The chapters explore the exceptionally wide spectrum of Bunge’s contributions to: metaphysics, methodology and philosophy of science, philosophy of mathematics, philosophy of physics, philosophy of psychology, philosophy of social science, philosophy of biology, philosophy of technology, moral philosophy, social and political (...) philosophy, medical philosophy, and education. The contributors include scholars from 16 countries. Bunge combines ontological realism with epistemological fallibilism. He believes that science provides the best and most warranted knowledge of the natural and social world, and that such knowledge is the only sound basis for moral decision making and social and political reform. Bunge argues for the unity of knowledge. In his eyes, science and philosophy constitute a fruitful and necessary partnership. Readers will discover the wisdom of this approach and will gain insight into the utility of cross-disciplinary scholarship. This anthology will appeal to researchers, students, and teachers in philosophy of science, social science, and liberal education programmes. 1. Introduction Section I. An Academic Vocation Section II. Philosophy Section III. Physics and Philosophy of Physics Section IV. Cognitive Science and Philosophy of Mind Section V. Sociology and Social Theory Section VI. Ethics and Political Philosophy Section VII. Biology and Philosophy of Biology Section VIII. Mathematics Section IX. Education Section X. Varia Section XI. Bibliography. (shrink)

This book critically advances readings of Jacques Derrida to offer a renewed understanding of the problem of decision and its inherent exclusivity. Michael Oliver applies this deconstructive insight to the contexts of justice pursuits and theological negotiations of divine decision, arguing for the necessity of reckoning with difficult decisions.

This book critically advances readings of Jacques Derrida to offer a renewed understanding of the problem of decision and its inherent exclusivity. Michael Oliver applies this deconstructive insight to the contexts of justice pursuits and theological negotiations of divine decision, arguing for the necessity of reckoning with difficult decisions.

ABSTRACT Previous research has consistently highlighted the importance of stakeholder engagement in identifying and developing solutions to ethical challenges in genomic research, especially in Africa where such research is relatively new. In this paper, we examine what constitutes good ethical practice in research, from the perspectives of genomic research participants in Uganda. Our study was part of a multi-site qualitative study exploring these issues in Uganda, Ghana and Zambia. We purposively sampled various stakeholders including genomic research participants, researchers, research ethics (...) committee members, policy makers and community members. This paper presents the findings from in-depth interviews with 27 people with diabetes who had participated in a diabetes genomic study. Data were collected using semi-structured interviews. Manual thematic content analysis was conducted using a framework approach. Findings indicate three key requirements that research participants see as vital for genomic research to be more responsive to research participants’ needs and contextual realities: (1) de-emphasising the role of experts and institutions in the consenting process, (2) clarity about the timing and nature of feedback both of findings relevant to the health of individuals and about the broad progress of the study, and (3) more effective support for research participants during and after the study. (shrink)

Females and males often exhibit conspicuous morphological, physiological and behavioral differences. Similarly, gene expression profiles indicate that a large portion of the genome is sex‐differentially deployed, particularly in the germ line. Because males and females are so fundamentally different, each sex is likely to have a different optimal gene expression profile that is never fully achieved in either sex because of antagonistic selection in females versus males. Males are hemizygous for the X chromosome, which means that recessive male‐favorable de novo (...) mutations on the X chromosome are subject to immediate selection. In females, a recessive female‐favorable mutation on one of two X chromosomes is not available for selection until it becomes frequent enough in the local population to result in homozygous individuals. Given that most mutations are recessive, one would expect that genes or alleles favoring males should accumulate on the X chromosome. Recent microarray work in Drosophila and C. elegans clearly shows the opposite. Why is the X chromosome a highly disfavored location for genes with male‐biased expression in these animals? BioEssays 26:543–548, 2004. Published 2004 Wiley Periodicals, Inc. (shrink)

We examine the question of how many Boolean algebras, distinct up to isomorphism, that are quotients of the powerset of the naturals by Borel ideals, can be proved to exist in ZFC alone. The maximum possible value is easily seen to be the cardinality of the continuum $2^{\aleph_{0}}$ ; earlier work by Ilijas Farah had shown that this was the value in models of Martin's Maximum or some similar forcing axiom, but it was open whether there could be fewer in (...) models of the Continuum Hypothesis. We develop and apply a new technique for constructing many ideals whose quotients must be nonisomorphic in any model of ZFC. The technique depends on isolating a kind of ideal, called shallow, that can be distinguished from the ideal of all finite sets even after any isomorphic embedding, and then piecing together various copies of the ideal of all finite sets using distinct shallow ideals. In this way we are able to demonstrate that there are continuum-many distinct quotients by Borel ideals, indeed by analytic P-ideals, and in fact that there is in an appropriate sense a Borel embedding of the Vitali equivalence relation into the equivalence relation of isomorphism of quotients by analytic P-ideals. We also show that there is an uncountable definable wellordered collection of Borel ideals with distinct quotients. (shrink)

Managing grand challenges demands a relational leader who encourages collaboration, coordination, and trust with various stakeholders. Although leaders appear to play a critical role in addressing grand challenges, relatively little research exists about the factors that inform stakeholder perceptions of leaders during a grand challenge. To address this limitation, we integrate implicit leadership theory and gender role theory to consider stakeholders’ gender prescriptive expectations when evaluating leader effectiveness during the COVID-19 pandemic. We theorize that stakeholders advantage female leaders based on (...) mental schemas of what is required in a pandemic—relational leadership—and stakeholders’ prescriptive expectations of female leaders as more relational. Using a laboratory experiment, we find that female leaders are perceived as more relational, and hence, more effective than their male counterparts. Our findings advance scholars’ and practitioners’ understanding of strategic leadership, stakeholder management, and grand challenges. (shrink)

To achieve the very specific goal of reducing net greenhouse gas emissions to zero by 2050, many technical challenges and conflicts of interest must be overcome. How can a strategy be developed that is politically and socially acceptable? Research is needed to support societal efforts to rethink the links between energy use and human well-being.

ABSTRACT Previous research has consistently highlighted the importance of stakeholder engagement in identifying and developing solutions to ethical challenges in genomic research, especially in Africa where such research is relatively new. In this paper, we examine what constitutes good ethical practice in research, from the perspectives of genomic research participants in Uganda. Our study was part of a multi-site qualitative study exploring these issues in Uganda, Ghana and Zambia. We purposively sampled various stakeholders including genomic research participants, researchers, research ethics (...) committee members, policy makers and community members. This paper presents the findings from in-depth interviews with 27 people with diabetes who had participated in a diabetes genomic study. Data were collected using semi-structured interviews. Manual thematic content analysis was conducted using a framework approach. Findings indicate three key requirements that research participants see as vital for genomic research to be more responsive to research participants’ needs and contextual realities: (1) de-emphasising the role of experts and institutions in the consenting process, (2) clarity about the timing and nature of feedback both of findings relevant to the health of individuals and about the broad progress of the study, and (3) more effective support for research participants during and after the study. (shrink)

ABSTRACT The use of broad consent for genomics research raises important ethical questions for the conduct of genomics research, including relating to its acceptability to research participants and comprehension of difficult scientific concepts. To explore these and other challenges, we conducted a study using qualitative methods with participants enrolled in an H3Africa Rheumatic Heart Disease genomics study (the RHDGen network) in Zambia to explore their views on broad consent, sample and data sharing and secondary use. In-depth interviews were conducted with (...) RHDGen participants (n = 18), study staff (n = 5) and with individuals who refused to participate (n = 3). In general, broad consent was seen to be reasonable if reasons for storing the samples for future research use were disclosed. Some felt that broad consent should be restricted by specifying planned future studies and that secondary research should ideally relate to original disease for which samples were collected. A few participants felt that broad consent would delay the return of research results to participants. This study echoes findings in other similar studies in other parts of the continent that suggested that broad consent could be an acceptable consent model in Africa if careful thought is given to restrictions on re-use. (shrink)

Previous research has consistently highlighted the importance of stakeholder engagement in identifying and developing solutions to ethical challenges in genomic research, especially in Africa where such research is relatively new. In this paper, we examine what constitutes good ethical practice in research, from the perspectives of genomic research participants in Uganda. Our study was part of a multi-site qualitative study exploring these issues in Uganda, Ghana and Zambia. We purposively sampled various stakeholders including genomic research participants, researchers, research ethics committee (...) members, policy makers and community members. This paper presents the findings from in-depth interviews with 27 people with diabetes who had participated in a diabetes genomic study. Data were collected using semi-structured interviews. Manual thematic content analysis was conducted using a framework approach. Findings indicate three key requirements that research participants see as vital for genomic research to be more responsive to research participants’ needs and contextual realities: de-emphasising the role of experts and institutions in the consenting process, clarity about the timing and nature of feedback both of findings relevant to the health of individuals and about the broad progress of the study, and more effective support for research participants during and after the study. (shrink)