The dichotomy between Nature and Nurture, which has been dismantled within the framework of development, remains embodied in the notions of plasticity and evolvability. We argue that plasticity and evolvability, like development and heredity, are neither dichotomous nor distinct: the very same mechanisms may be involved in both, and the research perspective chosen depends to a large extent on the type of problem being explored and the kinds of questions being asked. Epigenetic inheritance leads to transgenerationally extended plasticity, and developmentally-induced (...) heritable epigenetic variations provide additional foci for selection that can lead to evolutionary change. Moreover, hereditary innovations may result from developmentally induced large-scale genomic repatterning events, which are akin to Goldschmidtian “systemic mutations”. The epigenetic mechanisms involved in repatterning can be activated by both environmental and genomic stress, and lead to phylogenetic as well as ontogenetic changes. Hence, the effects and the mechanisms of plasticity directly contribute to evolvability. (shrink)

This paper applies the conceptual toolkit of Evolutionary Developmental Biology (evo‐devo) to the evolution of the genome and the role of the genome in organism development. This challenges both the Modern Evolutionary Synthesis, the dominant view in evolutionary theory for much of the 20th century, and the typically unreflective analysis of heredity by evo‐devo. First, the history of the marginalization of applying system‐thinking to the genome is described. Next, the suggested framework is presented. Finally, its application to the evolution of (...) genome modularity, the evolution of induced mutations, the junk DNA versus ENCODE debate, the role of drift in genome evolution, and the relationship between genome dynamics and symbiosis with microorganisms are briefly discussed. (shrink)

A biographical sketch of the Hologenome Theory.

This article describes how empirical discoveries in the 1930s–1950s regarding population variation for chromosomal inversions affected Theodosius Dobzhansky and Richard Goldschmidt. A significant fraction of the empirical work I discuss was done by Dobzhansky and his coworkers; Goldschmidt was an astute interpreter, with strong and unusual commitments. I argue that both belong to a mechanistic tradition in genetics, concerned with the effects of chromosomal organization and systems on the inheritance patterns of species. Their different trajectories illustrate how scientists’ commitments affect (...) how they interpret new evidence and adjust to it. Dobzhansky was moved to revised views about selection, while Goldschmidt moved his attention to different genetic phenomena. However different, there are significant connections between the two that enrich our understanding of their views. I focus on two: the role of developmental considerations in Dobzhansky’s thought and the role of neutrality and drift in Goldschmidt’s evolutionary account. Dobzhansky’s struggle with chromosomal variation is not solely about competing schools of thought within the selectionist camp, as insightfully articulated by John Beatty, but also a story of competition between selectionist thinking and developmental perspectives. In contraposition, Goldschmidt emphasized the role of low penetrance mutations that spread neutrally and pointed out that drift could result from developmental canalization. This account adds to the dominant story about Goldschmidt’s resistance to the splitting of development from genetics, as told by Garland Allen and Michael Dietrich. The story I tell illustrates how developmental thinking and genetic thinking conflicted and influenced researchers with different convictions about the significance of chromosomal organization. (shrink)

We discuss two inference patterns for inferring the coevolution of two characters based on their properties at a single point in time and determine when developmental interactions can be used to deduce evolutionary order. We discuss the use of the inference patterns we present in the biological literature and assess the arguments’ validity, the degree of support they give to the evolutionary conclusion, how they can be corroborated with empirical evidence, and to what extent they suggest new empirically addressable questions. (...) We suggest that the developmental argument is uniquely applicable to cognitive-cultural coevolution. (shrink)

This volume joins a growing list of books, monographs, and proceedings from scientific meetings that attempt to consolidate the wide spectrum of approaches emphasizing the role of development in evolution into a coherent and productive synthesis, often called evo-devo. Evo-devo is seen as a replacement or amendment of the modern synthesis that has dominated the field of evolution since the 1940s and which, as even its architects confessed, was fundamentally incomplete because development remained outside its theoretical framework (Mayr and Provine (...) 1980).As the volume attests, there is now a strong feeling that the time is ripe for the onsolidation of evo-devo, and that the field is mature enough so that mapping the theoretical terrain and experimental approaches is both feasible and scientifically productive. Now is an appropriate time to try to weave the strands of reasoning leading to the developmental perspective and offer a synthesis. (shrink)

The notion of structure of evolution is proposed to capture what it means to say that two situations exhibit the same or similar constellations of factors affecting evolution. The key features of holobiont evolution and the hologenome theory are used to define a holobiont structure of evolution. Finally, Cultural Group Selection, a set of hypotheses regarding the evolution of human cognition, is shown to match the holobiont structure closely though not perfectly.

An argument is presented according to which exposing pseudo-scientific medical claims may be ethically wrong. It is then suggested that this argument gives an interesting explanation why the successful outing of pseudo-science may lead to an increase in medical pseudo-science overall.

Organisms inherit various kinds of developmental information and cues from their parents. The study of inheritance systems is aimed at identifying and classifying the various mechanisms and processes of heredity, the types of hereditary information that is passed on by each, the functional interaction between the different systems, and the evolutionary consequences of these properties. We present the discussion of inheritance systems in the context of several debates. First, between proponents of monism about heredity (gene-centric views), holism about heredity (Developmental (...) Systems Theory), and those stressing the role of multiple systems of inheritance. Second, between those analyzing inheritance solely in terms of replication and transmission, and views that stress the multi-generation reproduction of phenotypic traits. A third debate is concerned with different criteria that have been proposed for identifying and delimiting inheritance systems. A fourth controversy revolves around the significance of the “Lamarckian” aspects of some of the inheritance systems that have been identified, such as epigenetic inheritance and behavioral inheritance, that allow the transmission of environmentally induced characters (i.e., “soft inheritance”). (shrink)

This article is arranged around two general claims and a thought experiment. I begin by suggesting that the genome should be studied as a developmental system, and that genes supervene on genomes (rather than the other way around). I move on to present a thought experiment that illustrates the implications a dynamic view of the genome has for central concepts in biology, in particular the information content of the genome, and the notion of responses to stress.

Statistical reasoning is an integral part of modern scientific practice. In The Seven Pillars of Statistical Wisdom Stephen Stigler presents seven core ideas, or pillars, of statistical thinking and the historical developments of each of these pillars, many of which were concurrent with developments in biology. Here we focus on Stigler’s fifth pillar, regression, and his discussion of how regression to the mean came to be thought of as a solution to a challenge for the theory of natural selection. Stigler (...) argues that the purely mathematical phenomenon of regression to the mean provides a resolution to a problem for Darwin’s evolutionary theory. Thus, he argues that the resolution to the problem for Darwin’s theory is purely mathematical, rather than causal. We show why this argument is problematic. (shrink)

Both von Neumann and Wiener were outsiders to biology. Both were inspired by biology and both proposed models and generalizations that proved inspirational for biologists. Around the same time in the 1940s von Neumann developed the notion of self reproducing automata and Wiener suggested an explication of teleology using the notion of negative feedback. These efforts were similar in spirit. Both von Neumann and Wiener used mathematical ideas to attack foundational issues in biology, and the concepts they articulated had lasting (...) effect. But there were significant differences as well. Von Neumann presented a how-possibly model, which sparked interest by mathematicians and computer scientists, while Wiener collaborated more directly with biologists, and his proposal influenced the philosophy of biology. The two cases illustrate different strategies by which mathematicians, the “professional outsiders” of science, can choose to guide their engagement with biological questions and with the biological community, and illustrate different kinds of generalizations that mathematization can contribute to biology. The different strategies employed by von Neumann and Wiener and the types of models they constructed may have affected the fate of von Neumann’s and Wiener’s ideas – as well as the reputation, in biology, of von Neumann and Wiener themselves. (shrink)

Many natural and biological phenomena can be depicted as networks. Theoretical and empirical analyses of networks have become prevalent. I discuss theoretical biases involved in the delineation of biological networks. The network perspective is shown to dissolve the distinction between regulatory architecture and regulatory state, consistent with the theoretical impossibility of distinguishing a priori between “program” and “data”. The evolutionary significance of the dynamics of trans-generational and inter-organism regulatory networks is explored and implications are presented for understanding the evolution of (...) the biological categories development-heredity; plasticity-evolvability; and epigenetic-genetic. (shrink)

Richard Goldschmidt famously rejected the notion of atomic and corpuscular genes, arranged on the chromosome like beads-on-a-string. I provide an exegesis of Goldschmidt’s intuition by analyzing his repeated and extensive use of metaphorical language and analogies in his attempts to convey his notion of the nature of the genetic material and specifically the significance of chromosomal pattern. The paper concentrates on Goldschmidt’s use of metaphors in publications spanning 1940-1955. -/- .

The review focuses on Huxley’s debt to Richard Goldschmidt and Cyril Darlington. I discuss the conceptions of the genome developed by Goldschmidt and Darlington and their continuing relevance.

The aim of the book is to explore common concerns regarding methodological individualism in different fields of the life sciences broadly construed. It will address conceptual problems regarding individuals and their relation and dependence on the collectivities they are part of and consider innovative new viewpoints, grounded in specific scientific projects that question the present descriptions and understanding and raise challenges. A wide variety of recent, influential contributions in the life sciences utilize notions of collectivity, sociality, rich interactions and emergent (...) phenomena, as essential explanatory tools to handle numerous persistent scientific questions in the life sciences. -/- Examples range from gene expression and regulation, the dynamics of bacterial populations, the ecological developmental biology of symbiosis, levels of selection, to communication, motion and patterns of behavior in diverse life forms, the role of social institutions and cultural dynamics in human evolution, and the psychological basis for social norms. The book is being structured so that fruitful and rewarding disciplinary interactions take place among researchers and scholars who have been concerned with overcoming methodological individualism. -/- The books includes a section of four papers on holobionts and the hologenome theory and a special memorial article on the work of the late Prof. Eshel Ben-Jacob authored by Herbert Levine. (shrink)

Recent and not so recent advances in our molecular understanding of the genome make the once prevalent view of the genome as a passive container of genetic information (i.e., genes) untenable, and emphasize the importance of the internal organization and re-organization dynamics of the genome for both development and evolution. While this conclusion is by now well accepted, the construction of a comprehensive conceptual framework for studying the genome as a dynamic system, capable of self-organization and adaptive behavior is still (...) underway. This work deals with the effect of such a conceptual shift on evolutionary thought. Specifically, I try to articulate the conceptual commitments and obligations of views that privilege explanatorily or causally the genome, its dynamics and mechanisms, over genes. I refer to this class of views as belonging to ‘the genome perspective’. (shrink)

German theologian F. D. E. Schleiermacher's doctrine of God-the first to be developed in the post-Kantian era-fundamentally changed the course of Christian theology. The degree to which his doctrine of God was influenced by the philosophy of Benedict de Spinoza remains in dispute, however. This study examines the ways in which Schleiermacher actively adopted elements of Spinoza's thought in the development of his own theological doctrine of God. Julia Lamm's analysis of little-known but seminal essays by Schleiermacher reveals his (...) young creative genius in daring to go beyond the neo-Spinozism of Herder and the post-Kantianism of Fichte by developing his own post-Kantian Spinozism. Schleiermacher's unique simultaneous appropriation of Kant and Spinoza is characterized by four themes: an organic monism, an ethical determinism, a critical realism, and a nonanthropomorphic view of God, which Lamm traces through his two major theological works, On Religion: Speeches to Its Cultured Despisers and The Christian Faith. Ultimately, Lamm finds that Schleiermacher departs from Spinoza in significant ways. Most notably, he talks about "the living God" who is best expressed through the divine attributes of love and wisdom. This living God is what Schleiermacher refers to as the "third alternative" to, on the one hand, the anthropomorphized God of orthodox Protestantism and, on the other hand, Spinoza's natura naturans. (shrink)

German theologian F. D. E. Schleiermacher's doctrine of God-the first to be developed in the post-Kantian era-fundamentally changed the course of Christian theology. The degree to which his doctrine of God was influenced by the philosophy of Benedict de Spinoza remains in dispute, however. This study examines the ways in which Schleiermacher actively adopted elements of Spinoza's thought in the development of his own theological doctrine of God. Julia Lamm's analysis of little-known but seminal essays by Schleiermacher reveals his (...) young creative genius in daring to go beyond the neo-Spinozism of Herder and the post-Kantianism of Fichte by developing his own post-Kantian Spinozism. Schleiermacher's unique simultaneous appropriation of Kant and Spinoza is characterized by four themes: an organic monism, an ethical determinism, a critical realism, and a nonanthropomorphic view of God, which Lamm traces through his two major theological works, On Religion: Speeches to Its Cultured Despisers and The Christian Faith. Ultimately, Lamm finds that Schleiermacher departs from Spinoza in significant ways. Most notably, he talks about "the living God" who is best expressed through the divine attributes of love and wisdom. This living God is what Schleiermacher refers to as the "third alternative" to, on the one hand, the anthropomorphized God of orthodox Protestantism and, on the other hand, Spinoza's natura naturans. (shrink)

This paper contributes to the ongoing discussion of sustainability behaviors by introducing the construct of perceived organizational support toward the environment. We propose and empirically test an integrated model whereby we test the association of POS-E with employees’ organizational citizenship behaviors toward the environment as well as to job attitudes. Results indicated that POS-E was positively related to OCB-E, job satisfaction, organizational identification, and psychological empowerment, and negatively related to turnover intentions. We also found that psychological empowerment partially mediated the (...) relationship between POS-E and the dependent variables. We discuss the theoretical implications as well as practical implications for managers seeking to encourage sustainability in their organizations. (shrink)

The literature regarding social and environmental sustainability of business focuses primarily on rationales for adopting sustainability strategies and operational practices in support of that goal. In contrast, we examine sustainability from a perspective that has received far less research attention—attitudes that inform managerial decision-making. We develop a conceptual model that identifies six elemental categories of attitudes that can be held independently or aggregated to yield a meta-attitude representing the legitimacy of sustainability. Our model distinguishes among three types of internally held (...) attitudes and externally perceived subjective norms: pragmatic, moral, and cognitive. We propose a refinement of Ajzen's (In: Kuhl J, Beckmann J (eds) Action control: from cognition to behavior, 1985; Organ Behav Hum Decis Process 50:179-211, 1991) Theory of planned behavior (TPB) that incorporates these sub-categories of personal attitudes and subjective norms. Practical implications are discussed including how organizations considering adopting sustainability programs might use the model as a conceptual tool to help achieve and assess program success. (shrink)

Research explored methods for “shortening the food links” or developing the “local foodshed” by connecting farmers with food service buyers (for restaurants and institutions) in Colorado. Telephone interviews were used to investigate marketing and purchasing practices. Findings include that price is not a significant factor in purchasing decisions; that food buyers prioritize quality as their top purchasing criterion but are not aware that local farmers can provide higher quality, that institutions are interested in buying locally; that small farms can offer (...) comparable or higher quality produce andservice; and that farmers need to show buyers what the quality of produce and service they can provide. (shrink)

President Clinton, already facing formidable obstacles in reforming the health care system, denies that it will involve any rationing. This is politically understandable, but wrong. Infinite needs are rapidly overtaking finite resources. Most health providers recognize that the genius of modern medicine has outpaced our ability to pay. But the public still has unlimited expectations and a blind faith that everything can be provided to everyone by simply eliminating "waste, fraud, and abuse." Rationing is inherent in any health care system. (...) As government undertakes to define what is "medically necessary or appropriate," it will unavoidably undertake a series of rationing decisions. Health care is being transformed from a private good to a public good. Government, when it reforms the health care system, must inevitably ask: How do we buy the most health for the public? Keywords: Clinton Health Plan, public good, rationing CiteULike Connotea Del.icio.us What's this? (shrink)

I end with another parable, but it is also a true story. Harvey Gushing, the famous surgeon after whom the Gushing Lectures are named, made an international reputation in his allegiance to quality. He badgered his profession to a higher standard of self-effacement and railed against the debasement of clinical skills and overemphasis on research and pursuit of personal gain. We honor him to this day because those were, and remain, important points. Yet, Harvey Gushing served as a surgeon during (...) World War I and at Ypres. Although the Allied mortality was as much as 50,000 soldiers a day, not counting the wounded, Gushing refused to operate on any more than two patients each day, arguing that to do so would have lowered his standard of care for his patients a – standard that made sense in one time but that became strikingly insensitive, and I suggest even unethical, in another when confronted with a different reality. (shrink)

Can democracy resolve the new set of survival problems we face? Our greatest challenge is to modify or perhaps even reverse what has worked well. Our economic system must adapt to our ecological system. Genetic values that allowed Homo sapiens to prosper may be counterproductive today. Four preconceptions that hinder the United States in facing challenges: 1) It has a divine destiny; 2) Problem solving machinery and institutions are equal to the challenges; (the influence of money on politics undermines this); (...) 3) Our political system and democracy are sustainable; 4) Population and economic growth are good. Nations must ask: How many people can we support? We cannot be growth maximizers and ecological realists at the same time. Both the Rio Declaration and the Brundtland Commission set utopian but unachievable goals. (shrink)

The single greatest challenge facing managers in the developed countries of the world is to raise the productivity of knowledge and service workers. This challenge, which will dominate the management agenda for the next several decades, will ultimately determine the competitive performance of companies. Even more important, it will determine the very fabric of society and the quality of life of every industrialized nation. … Unless this challenge is met, the developed world will face increasing social tensions, increasing polarization, increasing (...) radicalization, possibly even class war. (shrink)

Too often, the limits of our language are the limits of our thinking. “If thought corrupts language, language can also corrupt thought,” warned George Orwell. How we label something too often controls how we think about it. We get particular concepts in our head and they are hard to change. They govern how we think and how we act. “Disease” and “death” used to be considered as “God's will,” and it took hundreds of years and no small number of martyrs (...) to get that corrected. It was very hard to develop modern medicine when so many subjects were thought of as outside of human control. Similarly, the number of children a woman had was thought to be “God's will,” and that has made the development of contraception controversial to this day. Human control over any part of human destiny is usually opposed vigorously. Humankind has the tendency to confuse the familiar with the necessary. (shrink)

Zusammenfassung Sprechen Wissenschaftler üblicherweise vom Platonischen Charakter der Dialektik Schleiermachers, meinen sie deren grundlegend Sokratisch-dialogischen Charakter, zumal Schleiermacher Dialektik als „die Kunst des Diskurses oder des Dialogs“ definierte. Problematisch daran ist nun, daß Platons Dialoge mehr als eine Art von Dialektik aufweisen. Der Aufsatz beginnt mit einem Überblick auf die, in der „Allgemeinen Einleitung“ dargelegten fünf Grunddeutungsprinzipien, die Schleiermachers Interpretation der platonischen Dialektik untermauern, leiten und einschränken sollen. Der Beitrag wendet sich dann den Einleitungen der einzelnen Dialoge zu, um zu (...) überprüfen, wie Schleiermacher diese Prinzipien auf konkrete Situationen bei seiner Bearbeitung eines jeden Dialogs anwendet. Schleiermacher scheint manchmal einfach die eher spekulativen Züge der Platonischen Dialektik zu ignorieren, wie seine Interpretation des Phaidros zeigt. Gelingt es ihm nicht diese spekulativen Züge zu ignorieren, unterdrückt er sie, indem er einen zwingenden Bezug zur dialogischen Form der Dialektik herstellt, wie seine Interpretationen des Sophistes und des Phaidon zeigen. Läßt er dann schließlich einen bestimmten unabhängigen Status der spekulativen Dialektik Platons zu, marginalisiert Schleiermacher die entsprechenden Passagen so, daß er sie ihrer Bedeutung beraubt, wie seine Interpretation der Bücher V–VII der Politeia zeigt. (shrink)

A thorough distinction between explanatory and descriptive concepts reveals a radical explanatory and a trivial descriptive doctrine in current neuroscientific research. The explanatory approach examines the neuronal substrates of the mind, whereas the descriptive one deals only with its correlates.