Honeybees show lateral asymmetry in both learning about odours associated with reward and recalling memory of these associations. We have extended this research to show that bees exhibit lateral biases in their initial response to odours: viz., turning towards the source of an odour presented on their right side and turning away from it when presented on their left side. The odours we presented were the main component of the alarm pheromone, iso-amyl acetate (IAA), and four floral scents. The significant (...) bias to turn towards IAA odour on the right and away from it on the left is, we argue, a lateralization of the fight-flight response elicited by this pheromone. It contrasts to an absence of any asymmetry in the turning response to an odour of the flowers on which the bees had been feeding prior to testing: to this odour they turned towards when it was presented on either the left or right side. Lemon and orange odours were responded to differently on the left and right sides (towards on the right, away on the left) but no asymmetry was found in responses to rose odour. Our results show that side biases are present even in the initial, orienting response of bees to certain odours. (shrink)

Indirect routes by which gonadal hormones influence sexual differentiation are considered. In rats, differentiation may depend on the way in which the mother responds to the hormonal condition of her pups, and this has implications for the interpretation of the data for humans. Interaction between gonadal hormones and light experience in chicks is compared with the mammalian systems covered in Fitch & Denenberg's review.

Recent evidence in natural and semi-natural settings has revealed a variety of left-right perceptual asymmetries among vertebrates. These include preferential use of the left or right visual hemifield during activities such as searching for food, agonistic responses, or escape from predators in animals as different as fish, amphibians, reptiles, birds, and mammals. There are obvious disadvantages in showing such directional asymmetries because relevant stimuli may be located to the animal's left or right at random; there is no a priori association (...) between the meaning of a stimulus (e.g., its being a predator or a food item) and its being located to the animal's left or right. Moreover, other organisms (e.g., predators) could exploit the predictability of behavior that arises from population-level lateral biases. It might be argued that lateralization of function enhances cognitive capacity and efficiency of the brain, thus counteracting the ecological disadvantages of lateral biases in behavior. However, such an increase in brain efficiency could be obtained by each individual being lateralized without any need to align the direction of the asymmetry in the majority of the individuals of the population. Here we argue that the alignment of the direction of behavioral asymmetries at the population level arises as an “evolutionarily stable strategy” under “social” pressures occurring when individually asymmetrical organisms must coordinate their behavior with the behavior of other asymmetrical organisms of the same or different species. Key Words: asymmetry; brain evolution; brain lateralization; development; hemispheric specialization; laterality; lateralization of behavior; social behavior; theory of games. (shrink)

The present response elaborates and defends the main theses advanced in the target article: namely, that in order to provide an evolutionary account of brain lateralization, we should consider advantages and disadvantages associated both with the individual possession of an asymmetrical brain and with the alignment of the direction of lateralization at the population level. We explain why we believe that the hypothesis that directional lateralization evolved as an evolutionarily stable strategy may provide a better account than alternative hypotheses. We (...) also further our discussion of the influence of stimulation and experience in early life on lateralization, and thereby show that our hypothesis is not deterministic. We also consider some novel data and ideas in support of our main thesis. (shrink)

Combinatory logic and lambda-conversion were originally devised in the 1920s for investigating the foundations of mathematics using the basic concept of 'operation' instead of 'set'. They have now developed into linguistic tools, useful in several branches of logic and computer science, especially in the study of programming languages. These notes form a simple introduction to the two topics, suitable for a reader who has no previous knowledge of combinatory logic, but has taken an undergraduate course in predicate calculus and recursive (...) functions. The key ideas and basic results are presented, as well as a number of more specialised topics, and man), exercises are included to provide manipulative practice. (shrink)

Introduction Combinatory logic deals with a class of formal systems designed for studying certain primitive ways in which functions can be combined to form ...

This paper raises questions about the epistemological foundations of evidence-based medicine . We argue that EBM is based upon reliabilist epistemological assumptions, and that this is appropriate - we should focus on identifying the most reliable processes for generating and collecting medical knowledge. However, we note that this should not be reduced to narrow questions about which research methodologies are the best for gathering evidence. Reliable processes for generating medical evidence might lie outside of formal research methods. We also question (...) the notion of the knower that is assumed by EBM. We argue that EBM assumes an enlightenment conception of knowers as autonomous, substitutable individuals. This conception is troubled by the way that clinicians learn the role of anecdote in health care and the role of patient choice, all of which bring into play features of clinicians and patients as situated individuals with particular backgrounds and experiences. EBM's enlightenment conception of the knower is also troubled by aspects of the way evidence is produced. Given these limitations, we argue that EBM should retain its reliabilist bent, but should look beyond formal research methodologies in identifying processes that yield reliable evidence for clinical practice. We suggest looking to feminist epistemology, with its focus on the standpoints of individual situated knowers, and the role of social context in determining what counts as knowledge. (shrink)

Although little noticed by practicing theorists, narrative voice influences theoretical work. This essay presents a demonstration of voice as method, concentrating on brief segments of works by Garfinkel and Goffman. We attend to two methodological themes: how theorists use voice to establish intellectual autonomy, and how the use of voice influences credibility with readers. Garfinkel maximizes his autonomy by using narrative techniques that isolate him from his readers, and produce little common context with them as a result. Goffman maintains a (...) context for credibility with his readers by using a personal voice, but he uses this voice to request their indulgence as he follows his autonomous muse. Goffman's narrative self-indulgence prevents him from fashioning a coherent theoretical program for his readers, something Garfinkel's distant voice enables him to achieve. (shrink)

Because the main difference between combinatory weak equality and λβ-equality is that the rule \begin{equation*}\tag{\xi} X = Y \vdash \lambda x.X = \lambda x.Y\end{equation*} is valid for the latter but not the former, it is easy to assume that another way of defining combinatory β-equality is to add rule (ξ) to the postulates for weak equality. However, to make this true, one must choose the definition of combinatory abstraction in (ξ) very carefully. If one tries to use one of the (...) more common abstraction algorithms, the result will be an equality, = ξ , that is either equivalent to βη-equality (and so strictly stronger than β-equality) or else strictly weaker than β-equality. This paper will study the relations = ξ for several commonly used abstraction algorithms, distinguish between them, and axiomatize them. (shrink)

(Report assembled for the Workshop of the AMIA Working Group on Formal Biomedical Knowledge Representation in connection with AMIA Symposium, Washington DC, 2005.) Best practices in ontology building for biomedicine have been frequently discussed in recent years. However there is a range of seemingly disparate views represented by experts in the field. These views not only reflect the different uses to which ontologies are put, but also the experiences and disciplinary background of these experts themselves. We asked six questions related (...) to biomedical ontologies to what we believe is a representative sample of ontologists in the biomedical field and came to a number conclusions which we believe can help provide an insight into the practical problems which ontology builders face today. (shrink)

This chapter contains sections titled: Notes.

Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...) +1 transcription start site. The -219 and -491 polymorphic variations have significant association with instance of AD, and -491AA has significant risk even when stratified for the APOEepsilon4 allele. We also show significant effects on reporter gene expression in neuronal cell cultures, and, notably, these effects are modified by species origin of the cells. The -491 and -219 polymorphisms may have an interactive effect in addition to any independent activity. DNA-protein interactions differ between each polymorphic state. We propose SP1 and GATA as candidates for regulatory control of the -491 and -219 polymorphic sites. This work's significance lies in drawing connection among APOE promoter polymorphisms' associations with AD to functional promoter activity differences and specific changes in DNA-protein interactions in cell culture-based assays. Taken together, these results suggest that APOE expression levels are a risk factor for AD irrespective of APOEepsilon4 allele status. (shrink)

Seventeenth-century philosophy scholars come together in this volume to address the Insiders--Descartes, Spinoza, Leibniz, Locke, and Hobbes--and Outsiders--Pierre Gassendi, Kenelm Digby, Theophilus Gale, Ralph Cudworth and Nicholas Malebranche--of the philosocial canon, and the ways in which reputations are created and confirmed. In their own day, these ten figures were all considered to be thinkers of substantial repute, and it took some time for the Insiders to come to be regarded as major and original philosophers. Today these Insiders all feature in (...) the syllabi of most history of philosophy courses taught in western universities, and the papers in this collection, contrasting the stories of their receptions with those of the Outsiders, give an insight into the history of philosophy which is generally overlooked. (shrink)

These collected essays represent a communal attempt, by some of the foremost North American worldview scholars, to respond to some of the pressing questions surrounding the many-sided concept that worldview has become in contemporary Christian discourse. Is worldview too modern a concept? Is it too static a way of considering reality? Is it overly intellectual and an invitation for apologetic abuse? Is it hindering more than helping the enterprise of Christian education to use worldview as the point of integration? These (...) and many other questions are wrestled with in these essays. By looking at both the historical development of the term, its present uses and abuses, and possible future alterations, the thinkers in After Worldview have created a foundational conversation and suggested many intriguing ways to revivify this crucial idea from the deadening effects of over-exposure and under-contemplation. These essays provide serious Christian scholarship in an inviting tone, that wonder and suggests, rather than declares, the good aims and good ends that worldview engagement can and should offer to the Body of Christ. (shrink)

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

1. The Modern Context for a Healing Profession Roger J. Bulger The future of the profession of medicine in America is, at the very least, under serious ...

This article presents the Pilgrimage Model as a template for educators wishing to lead students on site-specific studies of engaged learning. During the 2015–2016 academic year, a group of Georgeto...

In theory, observed correlations between genetic information and behaviour might be useful to members of the WEIRD (western, educated, industrialized, rich, and democratic) populations. Guiding young people to choose educational opportunities that best match their abilities would benefit both the individual and society. In practice, however, such choices are far more profoundly limited by the culture people have inherited than their genes.

The contributors, not identified except by name, are mostly westerners. No bibliography. Paperback edition ($12.95) not seen. Annotation copyrighted by Book News, Inc., Portland, OR.

Parrots prepare for vocalization by a ventro-caudal retraction of the larynx. This laryngeal movement, which “frames” vocal sequences, is similar to a movement used by pigeons as a preparation for suction drinking. The air-pressure events involved in such movements can trigger either suction drinking or vocalization. This suggests a possible evolutionary link between these ingestive and vocal mechanisms.

Recent developments in quantum theory have focused attention on fundamental questions, in particular on whether it might be necessary to modify quantum mechanics to reconcile quantum gravity and general relativity. This book is based on a conference held in Oxford in the spring of 1984 to discuss quantum gravity. It brings together contributors who examine different aspects of the problem, including the experimental support for quantum mechanics, its strange and apparently paradoxical features, its underlying philosophy, and possible modifications to the (...) theory. (shrink)

This book, sure to become a standard reference work, is a comprehensive, lucid, and systematic commentary on Kant's practical philosophy. Kant is arguably the most important moral philosopher of the modern period. Using as nontechnical a language as possible, Professor Sullivan offers a detailed, authoritative account of Kant's moral philosophy - including his ethical theory, his philosophy of history, his political philosophy, his philosophy of religion, and his philosophy of education - and demonstrates the historical, Kantian origins of such important (...) notions as 'autonomy', 'respect for persons', 'rights', and 'duties'. An invaluable resource, this book will be extremely useful to advanced undergraduates, graduates, and professional philosophers alike. (shrink)

I defend the view that the design of the built environment should be a proper part of environmental ethics. An environmentally responsible culture should be one in which citizens take responsibility for the domesticated environments in which they live, as well as for their effects on wild nature. How we build our world reveals both the possibilities in nature and our own stance toward the world. Our constructions and contrivances also objectively constrain the possibilities for the development of a human (...) way of life integrated with wild nature. An environmentally responsible culture should require a built world that reflects and projects care and respect toward nature. (shrink)

An international legal agreement governing the global antimicrobial commons would represent the strongest commitment mechanism for achieving collective action on antimicrobial resistance (AMR). Since AMR has important similarities to climate change—both are common pool resource challenges that require massive, long-term political commitments—the first article in this special issue draws lessons from various climate agreements that could be applicable for developing a grand bargain on AMR. We consider the similarities and differences between the Paris Climate Agreement and current governance structures for (...) AMR, and identify the merits and challenges associated with different international forums for developing a long-term international agreement on AMR. To be effective, fair, and feasible, an enduring legal agreement on AMR will require a combination of universal, differentiated, and individualized requirements, nationally determined contributions that are regularly reviewed and ratcheted up in level of ambition, a regular independent scientific stocktake to support evidence informed policymaking, and a concrete global goal to rally support. (shrink)