Strategic leadership and corporate sustainability have recently come together in conspicuously explicit fashion through the emergence of top management team positions with dedicated corporate sustainability responsibilities. These TMT positions, commonly referred to as “Chief Sustainability Officers,” have found their way into the upper echelons of many of the world’s largest corporations alongside more traditional TMT positions including the CEO and CFO. We explore this phenomenon and consider the following two questions: Why are corporate sustainability positions being installed to the TMT?What (...) effects do corporate sustainability TMT positions have at their organizations? We consider these questions through strategic leadership and neoinstitutional theoretical frameworks. Through the latter, we also engage with Weberian considerations of bureaucracy. We find that the reasons why corporate sustainability TMT positions are installed can be in response to a crisis at the corporation for which its legitimacy is challenged. We also find the corporate sustainability TMT position can be installed proactively in an effort to realize external opportunities that may have otherwise gone unrealized without concerted attention and coordination afforded by a strategic level position. Regarding effects, we determine the position can relate to the establishment of bureaucratic structures dedicated to corporate sustainability within the corporation through which formalized processes and key performance indicators to drive corporate sustainability performances are established. In the face of our finding that many corporate sustainability TMT positions are being removed despite having only relatively recently been introduced to their respective TMTs, we find that the successful implementation of bureaucratic machinery can help considerations to sustainability extend beyond the tenure of a corporate sustainability position within the TMT. (shrink)

Scandinavia is routinely cited as a global leader in corporate social responsibility and sustainability. In this article, we explore the foundation for this claim while also exploring potential contributing factors. We consider the deep-seated traditions of stakeholder engagement across Scandinavia including the claim that the recent concept of “creating shared value” has Scandinavian origins, institutional and cultural factors that encourage strong CSR and sustainability performances, and the recent phenomenon of movement from implicit to explicit CSR in a Scandinavian context and (...) what this may entail. In sum, we depict the state of the art in CSR and sustainability in Scandinavia. We intend for this to serve as a basis to help establish a globally recognized research paradigm dedicated to considering CSR and sustainability in a Scandinavian context. (shrink)

This article examines corporate responsibility in the supply chains of four of the largest Scandinavian multinational corporations - IKEA, Nokia, Novo Nordisk, and StatoilHydro - and offers two key findings. First, these Scandinavian companies have all implemented responsible supply chain practices where suppliers in developing nations, and the communities of these suppliers, are engaged as key stakeholders and treated as partners. Second, these supply chain practices all share the common bond of having honesty and the establishment of trust-based relationships at (...) their foundation. As a result, these Scandinavian companies have developed a "cooperative advantage" in their ability to form successful, long-term partnerships in their respective supply chains. (shrink)

I present a review of the top management teams (TMTs) of the largest public corporations in the U.S. and Scandinavia (one thousand in total) to identify corporations that have a TMT position with “corporate social responsibility” (CSR) or a “CSR synonym” like sustainability or citizenship explicitly included in the position title. Through this I present three key findings. First, I establish that a number of CSR TMT positions exist and I list all identified corporations and associated position titles. Second, I (...) show that Scandinavian corporations are significantly more likely than U.S. corporations to have such CSR TMT positions. This finding serves as evidence that the U.S. may have been surpassed by a subset of Europe, i.e., Scandinavia, in at least one relevant measure of explicit CSR, whereby this study may serve witness to a noteworthy juncture post Matten and Moon’s (Academy of Management Review, 33(2):404–424, 2008) “Implicit & Explicit CSR” article. And third, I show that corporations with a CSR TMT position are three times more likely to be included in the Dow Jones Sustainability Index (DJSI) than corporations with none. A range of further research opportunities stemming from these findings include exploring whether explicit attention to CSR by the corporation is indicative of a longer term trend that has to do with attention to responsible business and whether a move away from the expression ‘CSR’ toward the expression ‘sustainability’ is underway and what this may entail. (shrink)

In this article, we first provide evidence that Scandinavian contributions to stakeholder theory over the past 50 years play a much larger role in its development than is presently acknowledged. These contributions include the first publication and description of the term “stakeholder”, the first stakeholder map, and the development of three fundamental tenets of stakeholder theory: jointness of interests, cooperative strategic posture, and rejection of a narrowly economic view of the firm. We then explore the current practices of Scandinavian companies (...) through which we identify the evidence of relationships to these historical contributions. Thus, we propose that Scandinavia offers a particularly promising context from which to draw inspiration regarding effective company-stakeholder cooperation and where ample of examples of what is more recently referred to as “creating shared value” can be found. We conclude by endorsing the expression “Scandinavian cooperative advantage” in an effort to draw attention to the Scandinavian context and encourage the field of strategic management to shift its focus from achieving a competitive advantage toward achieving a cooperative advantage. (shrink)

In this article, we first provide evidence that Scandinavian contributions to stakeholder theory over the past 50 years play a much larger role in its development than is presently acknowledged. These contributions include the first publication and description of the term “stakeholder”, the first stakeholder map, and the development of three fundamental tenets of stakeholder theory: jointness of interests, cooperative strategic posture, and rejection of a narrowly economic view of the firm. We then explore the current practices of Scandinavian companies (...) through which we identify the evidence of relationships to these historical contributions. Thus, we propose that Scandinavia offers a particularly promising context from which to draw inspiration regarding effective company-stakeholder cooperation and where ample of examples of what is more recently referred to as “creating shared value” can be found. We conclude by endorsing the expression “Scandinavian cooperative advantage” in an effort to draw attention to the Scandinavian context and encourage the field of strategic management to shift its focus from achieving a competitive advantage toward achieving a cooperative advantage. (shrink)

In this article, we first provide evidence that Scandinavian contributions to stakeholder theory over the past 50 years play a much larger role in its development than is presently acknowledged. These contributions include the first publication and description of the term “stakeholder”, the first stakeholder map, and the development of three fundamental tenets of stakeholder theory: jointness of interests, cooperative strategic posture, and rejection of a narrowly economic view of the firm. We then explore the current practices of Scandinavian companies (...) through which we identify the evidence of relationships to these historical contributions. Thus, we propose that Scandinavia offers a particularly promising context from which to draw inspiration regarding effective company-stakeholder cooperation and where ample of examples of what is more recently referred to as “creating shared value” can be found. We conclude by endorsing the expression “Scandinavian cooperative advantage” in an effort to draw attention to the Scandinavian context and encourage the field of strategic management to shift its focus from achieving a competitive advantage toward achieving a cooperative advantage. (shrink)

In this article, we first provide evidence that Scandinavian contributions to stakeholder theory over the past 50 years play a much larger role in its development than is presently acknowledged. These contributions include the first publication and description of the term “stakeholder”, the first stakeholder map, and the development of three fundamental tenets of stakeholder theory: jointness of interests, cooperative strategic posture, and rejection of a narrowly economic view of the firm. We then explore the current practices of Scandinavian companies (...) through which we identify the evidence of relationships to these historical contributions. Thus, we propose that Scandinavia offers a particularly promising context from which to draw inspiration regarding effective company-stakeholder cooperation and where ample of examples of what is more recently referred to as “creating shared value” can be found. We conclude by endorsing the expression “Scandinavian cooperative advantage” in an effort to draw attention to the Scandinavian context and encourage the field of strategic management to shift its focus from achieving a competitive advantage toward achieving a cooperative advantage. (shrink)

There is a contradiction in our ideas about moral responsibility. In one strand of our thinking, we believe that a person can become more blameworthy by luck. Consider some examples in order to make that idea concrete. Two reckless drivers manage their vehicles in the same way, and one but not the other kills a pedestrian. Two corrupt judges would each freely take a bribe if one were offered. By luck of the courthouse draw, only one judge is offered (...) a bribe, and so only one takes a bribe. Luck is the salient difference between the agents in each case. After all, the spatial location of the pedestrian is outside of each driver’s control, and being offered a bribe is outside of each judge’s control. But we blame the killer driver more than the merely reckless driver, and we blame the bribe-taker more than the mere would-be bribe-taker. This is because we believe that the killer driver and the bribe-taker are more blameworthy than each of their counterparts. Nevertheless, the idea that luck affects moral responsibility contradicts another feature of our thinking captured in this moral principle: A person’s blameworthiness cannot be affected by that which is not within her control. This moral principle yields the verdict that the drivers are equally blameworthy and that the judges are equally blameworthy. So, to put the contradiction in concrete terms, our thinking about moral responsibility implies that the drivers are and are not equally blameworthy, and the same is true for the judges. -/- I argue that only the first strand of our thinking is correct. Certain kinds of luck in results, circumstances, and character can partially determine a person’s praiseworthiness and blameworthiness. In terms of the examples, I argue that the killer driver and the bribe-taker are more blameworthy than each of their counterparts. But if I am to make genuine progress in the moral luck debate, my arguments cannot appeal to case intuitions such as ‘the killer driver is more blameworthy,’ because the problem of moral luck is fundamentally a clash of intuitions. So, I offer arguments from diverse areas in philosophy in order to ensure that they do not bottom out in standard pro-moral luck intuitions. (shrink)

With the publication of A Theory of Justice in 1971, John Rawls not only rejuvenated contemporary political philosophy but also defended a Kantian form of Enlightenment liberalism called “justice as fairness.” Enlightenment liberalism stresses the development and exercise of our capacity for autonomy, while Reformation liberalism emphasizes diversity and the toleration that encourages it. These two strands of liberalism are often mutually supporting, but they conflict in a surprising number of cases, whether over the accommodation of group difference, the design (...) of civic education, or the promotion of liberal values internationally. During the 1980’s, however, Rawls began to jettison key Kantian characteristics of his theory, a process culminating in the 1993 release of Political Liberalism and completing the transformation of justice as fairness into a Reformation liberalism. -/- Reconstructing Rawls argues that this transformation was a tragic mistake because it jeopardized the most important features of his theory, viz. the lexical priorities of right, liberty, and fair equality of opportunity as well as the difference principle. Controversially, this book contends that Rawls’s so-called “political turn,” motivated by a newfound interest in diversity and the accommodation of difference, has been unhealthy for autonomy-based liberalism and has pushed liberalism more broadly towards cultural relativism, be it in the guise of liberal multiculturalism or critiques of cosmopolitan distributive-justice theories. The book then demonstrates that the central elements of justice as fairness can only be defended within the context of a Kantian Enlightenment liberalism and that Rawls’s hope for a more pluralistic grounding for his theory, endorsed by a wide variety of belief systems present in modern democratic societies, is illusory. -/- Reconstructing Rawls is the first book to systematically compare Rawls’s and Kant’s theories and the first to offer an internal critique and reconstruction of justice as fairness, reconceiving it as a comprehensive, universalistic Kantian liberalism. By doing so, it gives us both the vision of a liberal world order—“a republicanism of all states, together and separately,” as Kant put it—and a mode of justification addressed to all men and women, not as members of particular nations, races, and faiths, but as human beings, as citizens of the world. In short, it reclaims Rawls for the Enlightenment. (shrink)

The ATM protein kinase is centrally involved in the cellular response to ionizing radiation (IR) and other DNA double‐strand‐break‐inducing insults. Although it has been well established that IR exposure activates the ATM kinase domain, the actual mechanism by which ATM responds to damaged DNA has remained enigmatic. Now, a landmark paper provides strong evidence that DNA‐strand breaks trigger widespread activation of ATM through changes in chromatin structure.1 This review discusses a checkpoint activation model in which chromatin perturbations lead (...) to the conversion of inactive ATM domains to phosphorylated, active ATM monomers. The new findings underscore the critical importance of epigenetic events in genome function and surveillance in mammalian cells. BioEssays 25:627–630, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In this reflection I address one of the critical questions this monograph is about: How to justify proposing yet another semantic theory in the light of Wittgenstein’s strong warnings against it. I see two clear motives for Wittgenstein’s semantic nihilism. The first one is the view that philosophical problems arise from postulating hypothetical entities such as “meanings”. To dissolve the philosophical problems rather than create new ones, Wittgenstein suggests substituting “meaning” with “use” and avoiding scientism in philosophy together with the (...) urge to penetrate in one's investigation to unobservable depths. I believe this first motive constitutes only a weak motive for Wittgenstein’s quietism, because there are substantial differences between empirical theories in natural sciences and semantic theories in philosophy that leave Wittgenstein’s assimilation of both open to criticism. But Wittgenstein is right, on the second motive, that given the dynamic character of linguistic practice, the classical project of semantic theory is a disease that can be removed or ameliorated only by heeding the advice to replace concern with meaning by concern with use. On my view, this does not preclude, however, a different kind of theoretical approach to meaning that avoids the pitfalls of the Procrustean enterprise Wittgenstein complained about. (shrink)

This article criticizes radical labor republicanism on republican grounds. I show that its demand for universal workplace democracy via workers’ cooperatives conflicts with republican freedom along three different dimensions: first, freedom to choose an occupation…and not to choose one; second, freedom within the very cooperatives that workers are to democratically govern; and third, freedom within the newly proletarian state. In the conclusion, I ask whether these criticisms apply, at least in part, to the more modest, incrementalist strand of labor (...) republicanism. To the extent that they do, delaboring republicanism might be the best response. (shrink)

In Michel Tournier’s 1967 novel Vendredi ou les Limbes du Pacifique—published in English under the abbreviated title Friday—the protagonist, stranded on an isla.

Reflection on the history of skepticism shows that philosophers have often conjoined as a single doctrine various theses that are best kept apart. Some of these theses are incredible – literally almost impossible to accept – whereas others seem quite plausible, and even verging on the platitudinous. Mixing them together, one arrives at a view – skepticism – that is as a whole indefensible. My aim is to pull these different elements apart, and to focus on one particular strand (...) of skepticism that deserves sustained and respectful attention. The strand I have in mind I will refer to as epistemic defeatism. Roughly, in its most global form, it is the view that, in the final analysis, we have no good evidence for the truth of any proposition. Working through various historical texts, I attempt to untangle epistemic defeatism from neighboring views, and in particular to establish its independence from questions about knowledge. Having thus established the view's autonomy, I turn to the options for self-consciously accepting defeat. One may despair or one may have faith. But I will ultimately propose that the most attractive option – the option that preserves the most of our epistemic integrity – is to have hope. (shrink)

Sidgwick saw egoism as important and undefeated. Not long afterward, egoism is largely ignored. Immediately after Sidgwick, many arguments were given against egoism – most poor – but one argument deserves attention as both influential and plausible. Call it the “grounds objection.” It has two strands. It objects that there are justifying reasons for action other than that an action will maximize my self-interest. It also objects that sometimes, what makes an action right is a fact other than its maximizing (...) my self-interest. I briefly explain and criticize many of the arguments given against egoism in the period, then explain and defend the grounds objection. (shrink)

Projects of human improvement take both individual and intergenerational forms. The biosciences provide many technologies, including prenatal screening and the latest gene editing techniques, such as CRISPR, that have been viewed as providing the means to human improvement across generations. But who is fit to furnish the next generation? Historically, eugenics epitomizes the science-based attempt to improve human society through distinguishing kinds of people and then implementing social policies—from immigration restriction to sexual sterilization and euthanasia—that influence and even direct what (...) sorts of people populate our future. Despite recognition of the horrors of the eugenic extremes of the past and of the subhumanizing of those sufficiently below appearance or ability norms to be viewed as “defective” or “unfit”, many people continue to be drawn to strands of eugenic thinking. (shrink)

This article is concerned with the shape of the story of seventeenth- and eighteenth-century moral philosophy as told by J. B. Schneewind in The Invention of Autonomy. After discussion of alternative possible shapes for such a story, the focus falls on the question to what extent, in Schneewind's account, strands of empiricist voluntarism and rationalist intellectualism are interwoven in Kant. This in turn leads to consideration of different types of voluntarism and their roles in early modern ethical theory. Correspondence:c1 (...) class='Hi'>robert[email protected]. (shrink)

[INTRODUCTION] Like the terms 'dialectic', 'Aufhebung' (or 'sublation'), and 'Geist', the term 'concrete universal' has a distinctively Hegelian ring to it. But unlike these others, it is particularly associated with the British strand in Hegel's reception history, as having been brought to prominence by some of the central British Idealists. It is therefore perhaps inevitable that, as their star has waned, so too has any use of the term, while an appreciation of the problematic that lay behind it has (...) seemingly vanished: if the British Idealists get any sort of mention in a contemporary metaphysics book (which is rarely), it will be Bradley's view of relations or truth that is discussed, not their theory of universals, so that the term has a rather antique air, buried in the dusty volumes of Mind from the turn of the nineteenth century. This is not surprising: the episode known as British Idealism can appear to be a period that is lost to us, in its language, points of historical reference (Lotze, Sigwart, Jevons), and central preoccupations (the Absolute). Even while interest in Hegel continues to grow, interest in his Logic has grown more slowly than in the rest of his work, with Book III of the Logic remaining as the daunting peak of that challenging text - while it is here that the British Idealists focussed their attention and claimed to have uncovered that 'exotic' but 'vanished specimen', the concrete universal. Finally, as the trend of reading Hegel pushes ever further in a non-metaphysical direction, it might be thought that the future of the concrete universal is hardly likely to be brighter than its recent past - for it may seem hard to imagine how a conception championed by the British Idealists, who were apparently shameless in their metaphysical commitments, can find favour in these more austere and responsible times. In this paper, however, I want to make a case for holding that there is something enlightening to be found in how some of the British Idealists approached the 'concrete universal', both interpretatively and philosophically. At the interpretative level, I will argue that while not everything these Idealists are taken to mean by the term is properly to be found in Hegel, their work nonetheless relates to a crucial and genuine strand in Hegel's position, so that their discussion of this issue is an important moment in the reception history of his thought. At a philosophical level, I think that the question that concerned Hegel and these British Idealists retains much of its interest, as does their shared approach to it: namely, how far does our thought involve a mere abstraction from reality, and what are the metaphysical and epistemological implications if it turns out it does not? As such, I will suggest, taking seriously what these British Idealists have to say about the concrete universal can help us both in our understanding of Hegel, and in our appreciation of the contribution Hegel's position can make to our thinking on the issues that surround this topic. (shrink)

What happens when neuroscientific knowledges move from laboratories and clinics into therapeutic settings concerned with the care of children? ‘Brain-based parenting’ is a set of discourses and practices emerging at the confluence of attachment theory, neuroscience, psychotherapy and social work. The neuroscientific knowledges involved understand affective states such as fear, anger and intimacy as dynamic patterns of coordination between brain localities, as well as flows of biochemical signals via hormones such as cortisol. Drawing on our own attempts to adopt brain-based (...) parenting, and engaging with various strands and critiques of new materialism and affect theory, we explore the ways in which the social sciences and humanities might fruitfully engage with neuroscientific concepts and affects. How does science-affected indeterminacy, with all its promises of ontological and experiential agency, help us to observe, wait, bind or hold together volatile mixtures of habit, speech and action? (shrink)

The films of Michael Haneke, so some critics argue, exploit the nihilism of a media-saturated culture, indulging in a dubious manipulation of audience expectations and our fascination with violence. Such criticisms, however, misunderstand or distort the complex moral, political, and aesthetic purpose of Haneke’s work. Indeed, his films are better understood as examining the socially disorienting and subjectively disintegrating effects of our post-humanist world of mass-mediatised experience. At the same time, they are highly reflexive cinematic works that force us to (...) reflect – both morally and aesthetically – upon our relationship with cinematic and media images. These two strands of Haneke’s work comprise a sustained meditation on what we might call the “post-humanist condition”: a cinematic critique of the disintegration and fragmentation of affect and subjectivity, a disintegration closely linked with contemporary forms of mediatised spectacle and the cynical consumption of images of violence. Given the mediatised nature of contemporary social experience, the only effective way to engage in cinematic critique is by means of the very images that capture and captivate us. (shrink)

In addition to empirical adequacy and compatibility with other current theories, scientific theories are commonly judged on three criteria â simplicity, elegance, and fertility. Fertility has received comparatively little attention in the philosophical literature. A definition of a certain sort of fertility, called P-fertility, proposed by Ernan McMullin, is that it consists in the capacity of a theory to be successfully modified over time to explain new experimental data or theoretical insights. McMullin made the major claim that he has a (...) novel and perhaps the sole argument for Scientific Realism. His argument involves two strands (i) theories must be considered diachronically and it is an historical fact that long standing successful scientific theories are P-fertile, and (ii) the correct explanation of this fact is that these theories reflect the realities of a mind-independent world. A rebuttal of McMullinâs position given in the literature is considered and rejected. His argument therefore requires further consideration. The plausible first strand of McMullinâs argument is accepted for the purposes of discussion, and thus the observation requires explanation, either along McMullinâs own lines or otherwise. The concept of diachronicity and the implications of accepting a diachronic view of scientific theories are considered. The identity of theory across time can be understood both from a Realist and an Anti-realist perspective via the concept of significant claims in the successive versions of the long standing successful theories. This defuses a possible objection to McMullinâs argument, namely that by assuming diachronicity he begs the question against the Anti-realist. Explanations of the conjunction of success and P-fertility are examined from the perspective of Scientific Realism and the major current Anti-realist stances â Entity Realism, Structural Realism, Instrumentalism, and Internal Realism. 3 To justify the second strand of McMullinâs argument, a notion of the approximate truth or of the verisimilitude of theories is required. Inter alia it is argued that a distinction must be made between the approximate truth of a scientific theory and that of a simple assertion or a simple narrative. The concepts of the approximate truth of scientific theories and their verisimilitude are explored and some serious difficulties are identified. First, it is difficult to accommodate differences in respect as well as in degree in delineating the nature of an approximately true theory. Second, it is difficult to give a satisfactory account of the metric used to assess the verisimilitude of theories. It is argued that in any case no version of these concepts can adequately support the second strand of McMullinâs thesis. This is because, at best, approximate truth and verisimilitude can only support a pragmatic claim â the improved empirical adequacy of successive versions of the long standing theory. In contrast, McMullinâs thesis requires that successor versions generally are better theories. Third, there is an intractable theory dependent weighting problem posed by the open ended nature of scientific theories in contrast with the closed narratives describing idealized models. The role of the approximate truth of scientific theories is explored, within the frameworks of Realism and Anti-realism, with regard to the possible responses to the existence of two highly successful, well corroborated, but incompatible theories â general relativity and quantum mechanics. It is suggested that Scientific Realism itself, not only McMullinâs argument for Scientific Realism, requires the notion of approximate truth or verisimilitude of theories. Putnamâs Internal Realism is considered, and, if as I suggest, no adequate account of the concepts of the approximate truth or verisimilitude of scientific theories can be given, Internal Realism (which need not draw on these concepts because of its denial that there is a unique correct description of the world) is more plausible than the full blooded Scientific Realism advocated by McMullin, despite granting the claim of the historical observation of the conjunction between long standing successful theories and their P-fertility. (shrink)

The essay "Physique de croyant" is an important statement of Pierre Duhem's position on the relation between his science and his religion. Duhem trod a difficult path, some might say an impossible one, in Republican France because he was both a physicist and a devout Catholic. In this essay, using "Physique de croyant" as a touchstone, I explore the way in which he tried to reconcile his conflicting allegiances. There are several strands in Duhem's strategy that need to be teased (...) out. First, Duhem sought to defend his science against the charge that it was materialist and atheist. He did this with his claim, usually called the autonomy thesis, that physics and metaphysics are fundamentally different enterprises—that physics, properly conducted, has no metaphysical implications and requires no metaphysical support. This did not deny metaphysics its rightful territory. Second, Duhem used his segregationist position to defend the Roman Catholic Church against the assaults of the positivist scientism then in favor with the Republicans. Third, he also sought to protect his science against fellow Catholics who wanted to use it for polemical purposes. I develop and evaluate these lines of defense. (shrink)

Bernard Williams has argued that on a consequentialist moral theory, individuals cannot possess what he calls "integrity." I argue that one central strand of this criticism concerns how persons must think about life-shaping decisions. I interpret "integrity" as a pattern of continuity in an agent's moral decision-making. In order to have integrity an agent must possess a stable character which unifies one's choices. Since a sophisticated consequentialist moral structure can properly value the having of a character on the basis (...) of which agents guide their lives, it can successfully address this criticism. (shrink)

There are two distinct strands within modern philosophical ethics that are relevant to environmental philosophy: an empiricist strand that seeks a naturalist account of human conduct and a humanist strand rooted in a conception of transcendent human freedom. Each strand has its appeal, but each also raises both strategic and theoretical problems for environmental philosophers. Based on a reading of Kant's critical solution to the antinomy of freedom and nature, I recommend that environmental philosophers consider the possibility (...) of a Darwinian humanism, through which moral agents are understood as both free and causally intertwined with the natural world. (shrink)

Nichols’ Bound presents interesting new angles on traditional debates about free will and moral responsibility, relating them to the latest empirical research in psychology, social sciences and experimental philosophy. In experimental philosophy, he cites numerous recent studies showing that there are strong incompatibilist strands in folk intuitions about free will and responsibility, taking issue with other recent studies claiming that folk intuitions are predominantly compatibilist. But he also argues that incompatibilist folk intuitions are based on faulty reasoning and cannot be (...) realized. We are left with a choice between an eliminativism about free will and moral responsibility or revising ordinary beliefs and practices in a compatibilist direction. Though Nichols sees problems with both these positions, he ultimately opts for the latter. Despite agreeing with Nichols on many points, I argue in this paper that he takes the libertarian view of free will off the table too precipitously, leaving us with too narrow a choice of options. I argue that we can make sense of an incompatibilist view of free will and responsibility without reducing it to mere chance or mystery and that it remains an open scientific question whether we can have such a free will. (shrink)

Chromosomal origins of DNA replication in higher eukaryotes differ significantly from those of E. coli (oriC) and the tumor virus, SV40 (ori sequence). Initiation events appear to occur throughout broad zones rather than at specific origin sequences. Analysis of four chromosomal origin regions reveals that they share common modular sequence elements. These include DNA unwinding elements, pyrimidine tracts that may serve as strong DNA polymerase‐primase start sites, scaffold associated regions, transcriptional regulatory sequences, and, possibly, initiator protein binding sites and inherently (...) destabilized regions. Based on the novel organization of chromosomal origin regions, we propose a model for initiation of DNA replication in higher eukaryotes. Unwinding of duplex DNA during initiation may be uncoupled, both temporally and spatially, from DNA synthesis, resulting in transient single‐stranded intermediates that function in lieu of conventional replication forks during chromosomal DNA replication. DNA synthesis begins subsequently at multiple sites Within the unwound regions rather than at specific origin sequences. (shrink)

Thinkers heavily indebted to Foucault—such as Wendy Brown, Judith Butler, Jodi Melamed and Jasbir Puar—are at the fore of a contemporary interrogation of queerness and racialized empire. This paper critically surveys this terrain, differentiates several strands of it, and attempts a theoretical reframing such that we may be better equipped to gain new vantage on the central problematic. I argue that the current conviviality of queerness and empire is best understood not only through a univocal ‘homonationist’ lens, but also requires (...) situating in the context of multiple languages of civilizational superiority and liberal tolerance. In particular, it requires the deployment of arguments about the ‘benchmark of civilization,’ in which whole societies are ranked along a unilinear trajectory of development according to standards set by the most powerful among them. One relatively recent addition to the criteria of civilizational adjudication is the capacity of societies to ‘tolerate’ new forms of societal difference. In this case, I argue, the most important of these are the strange pairing of sexual and religious dispositifs. (shrink)

This book, by one of the most innovative and challenging contemporary thinkers, consists of an extensive essay from which the book takes its title and five shorter essays that are internally related to “Being Singular Plural.” One of the strongest strands in Nancy’s philosophy is his attempt to rethink community and the very idea of the social in a way that does not ground these ideas in some individual subject or subjectivity. The fundamental argument of the book is that being (...) is always “being with,” that “I” is not prior to “we,” that existence is essentially co-existence. Nancy thinks of this “being-with” not as a comfortable enclosure in a pre-existing group, but as a mutual abandonment and exposure to each other, one that would preserve the “I” and its freedom in a mode of imagining community as neither a “society of spectacle” nor via some form of authenticity. The five shorter essays impressively translate the philosophical insight of “Being Singular Plural” into sophisticated discussions of national sovereignty, war and technology, identity politics, the Gulf War, and the tragic plight of Sarajevo. The essay “Eulogy for the Mêlée,” in particular, is a brilliant discussion of identity and hybridism that resonates with many contemporary social concerns. As Nancy moves through the exposition of his central concern, being-with, he engages a number of other important issues, including current notions of the “other” and “self” that are relevant to psychoanalytic, political, and multicultural concepts. He also offers astonishingly original reinterpretations of major philosophical positions, such as Nietzsche’s doctrine of “eternal recurrence,” Descartes’s “cogito,” and the nature of language and meaning. (shrink)

:This article analyses some of the aesthetic and philosophical strands of Lars von Trier's Melancholia, focusing in particular on the film's remarkable Prelude, arguing that it performs a complex ethical critique of rationalist optimism in the guise of a neo-italictic allegory of world-destruction. At the same time, I suggest that Melancholia seeks to “work through” the loss of worlds – cinematic but also cultural and natural – that characterises our historical mood, one that might be described as a deflationary apocalypticism (...) or melancholy modernity. From this perspective, Melancholia belongs to a genealogical lineage that links it with two earlier films important for von Trier: Ingmar Bergman's Shame [Skammen] and Andrei Tarkovsky's The Sacrifice . All three films share a concern with apocalypticism, world-sacrifice, and historical melancholia; but they also explore different responses to the imagined experience of a catastrophic loss of world. By examining these films in relation t.. (shrink)

This paper provides an overview of recent literature on the history of epidemics in East Asia, with a primary focus on modern and contemporary China, but including some discussion of the scholarship in English on epidemics in Korea and Japan. Key research strands are identified within the field: local and regional histories, disease biographies, histories of public health campaigns, global connections, and cultural representations. The paper argues that studies of epidemic disease have been central to debates about East Asian modernity, (...) transformations of the state, the formation of a post-imperial citizenry, postcolonial science and technology studies, and East Asia’s role in globalizing processes. The paper concludes by reflecting on the COVID-19 pandemic and the issues it raises for future research. (shrink)

Genes are functional cell segments of DNA within an organism, as well as basic physical units of biological inheritance, which have consequences for human dignity and public interest. Genes and genetic material (DNA strands of nucleotides, genetically altered plants and animals e.g., see Appendix B) are patentable. In the US and around the globe, governments grant genetic patents for new, non-obvious, and useful gene inventions. A wide range of interest groups such as religious leaders, scientists, biotech pharmaceuticals, medical practitioners, health (...) care providers, venture capitalists, medical patients and persons have interests in defining what is subject to patents. Yet, it is at least questionable that genetic inventions, and the ownership of discoveries of gene mutations leading to possible diseases, should be subject to influence by interest groups. Although some genes (cDNA) are currently legally patentable, the question in this examination is whether gene patents should be legally and morally justified. In this work I examine whether gene patents should legally and morally be justified, given the principles of biomedical ethics such as human Beneficence /Autonomy and Justice. I argue that gene patenting is not justifiable, and I consider what can be done to create a system that delivers access to genetic information in the current genetic Intellectual Patent system. This interdisciplinary work is more complex than whether bio-science researchers and corporate entities should hold gene patents, or differentiating the legal question of whether genes are an invention or a discovery in the human genome. Mere responses to these questions would not ultimately solve the genetic justice problem. The justification for genetic appropriation is more complexity, since it is grounded in axiological claims about human dignity and public interest set in an ever changing biomedical/biogenetic technology. To address this complexity, I will draw upon the ideas of “the capability approach” to genetic justice found in the work of Nussbaum and Sen. This work is an interdisciplinary examination of the proper appropriation of natural genetic material and its impact on human dignity. It is argued that genetic material and information should be accessible to all, via heath care, for example. We must look to new ways to achieve genetic justice that promote human flourishing as a public good. (shrink)

The technique of ‘examining meditative topics’ is one of the emblematic practices of the ‘Zen’ traditions of East Asia. An emblematic feature of this technique is the generation of a sense of inquiry, or more literally a ‘feeling’ or ‘sensation of doubt’. This inquiry creates an intense introspective focus that, in some strands of the practice, may be accompanied by palpable physical sensations; these sensations seem to be analogous to the experience of ‘excitation’ or ‘rapture’ described in contemporary samatha/śamatha and (...) vipassanā/vipaśyanā practice. I explore the treatment of prīti in Abhidharma theory and suggest that, where prīti is not classified as a discrete dharma, it might best be classified as a type of otherworldly vedanā that is ‘free from carnality’. I conclude with a discussion of an explicit questioning dimension in commentarial discussions of satipaṭṭhāna practice in the Pāli tradition, where inquiring ‘Who goes? Whose is this going?’ helps to transform the act of walking into an act of mindfulness. This questioning dimension suggests possible parallels with the Zen notion of ‘doubt’. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Strands of System: The Philosophy of Charles PeirceRobert W. BurchStrands of System: The Philosophy of Charles Peirce, by Douglas R. Anderson; xiv & 204pp. West Layfayette, Indiana: Purdue University Press, 1995, $24.95 cloth, $13.95 paper.The Purdue University Press Series in the History of Philosophy was created to “present well-edited basic texts to be used in courses and seminars and for teachers looking for a succinct exposition of the (...) results of recent research.” Anderson’s contribution to this series matches the aim of the series to near perfection.Strands of System is a general introduction to both the life and the work of the American scientist-mathematician-philosopher Charles S. Peirce. Many, though by no means all, of the main themes of Peirce’s philosophy are touched. Anderson’s exposition is succinct and—usually—at a basic, introductory level; virtually no specialist knowledge of Peirce’s thinking is required to follow it. References to recent research on Peirce are ample and up-to-date. Anderson’s account falls well within the mainstream of current understanding of Peirce, and accordingly it should occasion no distasteful surprises for the teacher who desires a solid introductory survey.Besides a preface and appendices, the book contains four chapters. The first is a biographical sketch; the second is an overview of certain themes in Peirce’s philosophy; the third is the full text of and a commentary upon the rather early essay “The Fixation of Belief”; and the fourth chapter is the full text of and a commentary upon the rather late essay “A Neglected Argument for the Existence of God.”Chapter Two, entitled “Strands of System,” is perhaps the heart of Anderson’s [End Page 384] exposition of what he regards as Peirce’s somewhat-less-than-monolithic philosophical system—a system in which, as Anderson sees it, a host of diverse themes start and stop, twist and turn, and cross and recross each other like the different strands making up a rope. A wide variety of Peircean topics are briefly discussed: the classification of the sciences, mathematics, philosophy, phenomenology, normative sciences, aesthetics, ethics, logic, and metaphysics. Most of the major concepts of Peircean thought are taken up: synechism, tychism, the categories of firstness and secondness and thirdness, the theory of signs, and some features of the notion of semeiosis.Despite its apparent thoroughness, Anderson’s book mostly lacks a presentation of the technical-scientific-mathematical-logical side of Peirce’s thought. In ignoring this side of Peirce’s intellectual endeavor, however, Anderson is not very different from most other contemporary discussants of Peirce; and the omission is perhaps justified in an introductory survey. All in all, Anderson’s volume should make an excellent, if somewhat partial, introduction to the thought of Peirce, an introduction that I can highly recommend for use in a first course or seminar in the thought of this extremely important American thinker.Robert W. BurchTexas A&M UniversityCopyright © 1995 The Johns Hopkins University Press... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Beyond Ratzinger's Republic:Communio's Postliberal TurnSam Zeno Conedera S.J. and Vincent L. Strand S.J.Is the political future of the West a postliberal one? For the past decade, numerous prominent thinkers in America and Europe have been debating this question. Matters that not long ago were merely of historical interest, such as Pope Gelasius I's understanding of the relation between sacral authority and royal power, Thomas Aquinas's thought on monarchy (...) and Robert Bellarmine's theory of the pope's indirect authority in temporal matters are now increasingly studied for their potential answers to contemporary political questions. This development, which would have been nearly unimaginable just a decade earlier, unsurprisingly has been led by Catholics. We say "unsurprisingly" in view of the long pre-modern tradition of Catholic political thought, as well as the Church's long struggle against liberalism during the nineteenth and early twentieth centuries. Some of the current postliberal writers explicitly connect themselves to both of these aspects by using the term "integralist" to describe their position.1 [End Page 889]This "new integralism" represents a radical departure from the mainstream of Catholic political discourse of the last half century, which has largely sought rapprochement with Western liberalism. A group of writers, led by John Courtney Murray, George Weigel, Michael Novak, and Robert George, have held that the American constitutional order is rooted in the natural law tradition, and therefore is basically friendly to Catholic political thought. The Church's role in American life, they say, is upholding the natural law as a public moral philosophy, while embracing the non-establishment clause of the First Amendment as a matter of principle, in accordance with the teachings of the Second Vatican Council. This "Whig Thomism," which for decades represented the predominant outlook of conservative American Catholics, must now face the challenge of a different sort of Thomism represented by the integralists.2While the engagement between Whig Thomists and integralists has received most of the attention from scholars and journalists alike, another postliberal option has emerged in recent years. Its source is a group of Catholic thinkers associated with the Communio theological movement. Their political vision, which has no single name or label, has a complex and subtle relationship with the thought of earlier Communio writers, most of whom shared the Whig Thomist desire for reconciliation with Western liberalism. [End Page 890] The appearance of a Communio postliberalism therefore represents a significant development within this intellectual tradition. The most important representative of the earlier Communio perspective on political questions is Joseph Ratzinger / Pope Benedict XVI, who has recently been lauded as the "most important Catholic thinker of the twentieth century" on matters at the intersection of theology and politics.3In an article titled "Ratzinger's Republic" that appeared in these pages in 2020, we identified a significant tension in his thought about the Church's contribution to political life.4 Exploring Ratzinger's writings on natural law, we demonstrated that two currents are present. In accord with his fundamental theological commitments about nature and grace and about faith and reason, Ratzinger often questioned the effectiveness of arguments from natural law. He claimed that, since reason is historically conditioned, and therefore in the current order marked by sin, reason needs grace and faith to function properly. Yet, on other occasions, Ratzinger strongly endorsed arguments from natural law, highlighting its role as the foundation of a just democratic political order. We traced this ambivalence about natural law back to a dilemma at the heart of Ratzinger's political thought. On the one hand, in accord with his thinking about the relations of nature and grace and faith and reason, Ratzinger argued that the state needs the Church to supply moral values that the state cannot furnish on its own. On the other hand, he believed it belongs to the very nature of the Church to be separate from the state, and he endorsed nonconfessional, religiously pluralistic states.5 In light of these two commitments, Ratzinger argued that the contribution Christians are to make to the state is to supply moral values that were discerned under the influence of grace and divine revelation but... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Strands of System: The Philosophy of Charles PeirceRobert W. BurchStrands of System: The Philosophy of Charles Peirce, by Douglas R. Anderson; xiv & 204pp. West Layfayette, Indiana: Purdue University Press, 1995, $24.95 cloth, $13.95 paper.The Purdue University Press Series in the History of Philosophy was created to “present well-edited basic texts to be used in courses and seminars and for teachers looking for a succinct exposition of the (...) results of recent research.” Anderson’s contribution to this series matches the aim of the series to near perfection.Strands of System is a general introduction to both the life and the work of the American scientist-mathematician-philosopher Charles S. Peirce. Many, though by no means all, of the main themes of Peirce’s philosophy are touched. Anderson’s exposition is succinct and—usually—at a basic, introductory level; virtually no specialist knowledge of Peirce’s thinking is required to follow it. References to recent research on Peirce are ample and up-to-date. Anderson’s account falls well within the mainstream of current understanding of Peirce, and accordingly it should occasion no distasteful surprises for the teacher who desires a solid introductory survey.Besides a preface and appendices, the book contains four chapters. The first is a biographical sketch; the second is an overview of certain themes in Peirce’s philosophy; the third is the full text of and a commentary upon the rather early essay “The Fixation of Belief”; and the fourth chapter is the full text of and a commentary upon the rather late essay “A Neglected Argument for the Existence of God.”Chapter Two, entitled “Strands of System,” is perhaps the heart of Anderson’s [End Page 384] exposition of what he regards as Peirce’s somewhat-less-than-monolithic philosophical system—a system in which, as Anderson sees it, a host of diverse themes start and stop, twist and turn, and cross and recross each other like the different strands making up a rope. A wide variety of Peircean topics are briefly discussed: the classification of the sciences, mathematics, philosophy, phenomenology, normative sciences, aesthetics, ethics, logic, and metaphysics. Most of the major concepts of Peircean thought are taken up: synechism, tychism, the categories of firstness and secondness and thirdness, the theory of signs, and some features of the notion of semeiosis.Despite its apparent thoroughness, Anderson’s book mostly lacks a presentation of the technical-scientific-mathematical-logical side of Peirce’s thought. In ignoring this side of Peirce’s intellectual endeavor, however, Anderson is not very different from most other contemporary discussants of Peirce; and the omission is perhaps justified in an introductory survey. All in all, Anderson’s volume should make an excellent, if somewhat partial, introduction to the thought of Peirce, an introduction that I can highly recommend for use in a first course or seminar in the thought of this extremely important American thinker.Robert W. BurchTexas A&M UniversityCopyright © 1995 The Johns Hopkins University Press... (shrink)

The simian virus 40 chromosome, a model for the mammalian replicon, is a uniquely powerful system for the study of drugs and treatments which target enzymes of the mammalian replication apparatus. High resolution gel electrophoretic analysis of normal and aberrant viral replication intermediates can be used effectively to understand the molecular events of replication failure. These events include breakage of replication forks, aberrant topoisomerase action, failure to separate daughter chromosomes, protein‐DNA crosslinking, single and double strand DNA breakage, alterations in (...) topology and inactivation of replication intermediates. The SV40 replication system can also be used to study the recombinational events which often follow drug‐induced replication failure. (shrink)

Fritz Marti is a “true believer” in the transcendental method of philosophy pioneered by Fichte and modified by Schelling. With it he links the Augustinian religious theme that at the very center of our own self-conscious life we can encounter God who is our ground. Marti ranges freely between these Augustinian and idealist anchors, reading intervening figures such as Descartes and Kant in their terms. The result is his own vital personal testimony, a philosophico-religious “profession of faith” that illumines the (...) powerful attraction this strand of German idealism had, and still has, for many. Marti began his philosophical education with Fichte, and still employs Fichte’s insights to carry out transcendentally the analysis of the free, self-conscious “I” that Augustine initiated. But Marti also turns to Schelling for what Fichte’s analysis largely neglects, namely, a developed idealistic account of God as ground of the self’s freedom, and serious attention to human encounters with God in the history of religion. (shrink)

The relationship between political judgment and science-based expertise is a troubled one. In the media three cliché images compete. The business-as-usual political story is that, in spite of appearances to the contrary, politics is safely ‘on top’ and experts are still ‘on tap’. The story told by scientists is that power-less but inventive scholars only ‘speak truth to power’. But there is plenty of room for a more cynical interpretation. It sees scientific advisers as following their own interests, unless better (...) paid by other interests, and politicians as asking for advice only to support and legitimize their pre-formed political decisions. To the extent this cynical perspective gains ascendancy, politics and science lose credibility. If we think the three clichés cloak a more complex reality, we should embark upon a quest for other, possibly better models of the science/politics nexus. That is exactly the purpose of this article. Its claim is that a mutual transgression of the knowledge utilization strand of research in policy studies and the study of science, technology and society will provide us with more sophisticated images of science/politics boundary arrangements. Building upon Habermas’ well-known distinctions and Wittrock’s historical-institutional approach in the construction of a property space, eight models are presented. We should try to discover the conditions under which some of these models may claim greater verisimilitude. This may allow us to rethink the role of scientific expertise in policymaking and generate a model that guides experts and policymakers in their day-to-day boundary work. (shrink)

In the 1930s Warburg's spare prose and disciplined respect for the facts set the style for a new generation of biochemists who had not known the conceptual revolutions of earlier years. Led by Warburg, they rejected the excesses of the colloid school and the false starts of the teens and twenties. Talk of active structure virtually disappeared as chemists began to identify enzymes, coenzymes, vitamins, and hormones. In the gradual transformation of the Atmungsferment from an ironcolloid complex to a specific (...) haem-protein, the roots of Warburg's inspiration were readily forgotten-the richer and more varied intellectual currents of the early decades of biochemistry. Experimental cytology and pharmacology were important strands. Most of what Warburg was doing on narcosis from 1908 to 1912 was typical of this school. He was deeply influenced by Loeb and his theory of the fertilization membrane. In the period from 1900 to 1914 the ups and down of belief in Hofmeister's enzyme theory was an important trend which helped determine the style of biochemistry in later decades. Warburg's conception of the Atmungsferment was shaped by the general reaction c. 1910 against Buchner's optimistic view. Warburg's Heidelberg lecture was framed as an answer to Hofmeister's lecture of 1901 and turned out almost as an imitation or second edition of it. It was a style that was soon out of fashion. The affinity between the early concept of enzymes and the old concept idea of “living protein” should not be neglected in discussions of Warburg's distaste for “enzymology.” The colloid school is too easily dismissed as a mere impediment to the chemical triumphs of the 1930s. Warburg's Atmungsferment was obviously colored by the colloidal cast of biochemical thought in 1912. The Atmungsferment represented, in short, a hybrid transition from the romantic biochemistry of the period 1900–1925 to the mature, classical of the 1930s. It is fascinating precisely because it reflects, and refracts through a unique and powerful mind, the varied local traditions of the early history of modern biochemistry. (shrink)

For well over two decades, Andy Clark has been gleaning theoretical lessons from the leading edge of cognitive science, applying a combination of empirical savvy and philosophical instinct that few can match. Clark’s most recent book, Supersizing the Mind: Embodiment, Action, and Cognitive Extension, brilliantly expands his oeuvre. It offers a well-informed and focused survey of research in the burgeoning field of situated cognition, a field that emphasizes the contribution of environmental and non-neural bodily structures to the production of intelligent (...) behavior. The situated research program, fledgling though it may be in some respects, has reached an age at which its philosophical stock can reasonably be taken; and Clark is just the person to take it. Supersizing the Mind consists of three main divisions. The first develops the case for the distinctively extended view of cognition, according to which the human mind or cognitive system literally comprises elements beyond the boundary of the human organism. The second responds to critics of the extended outlook: Frederick Adams, Kenneth Aizawa, Keith Butler, Brie Gertler, Rick Grush, and me, among others. The third major division evaluates nonextended strands in the situated program, in particular, those that emphasize the role of the non-neural body in cognition. (shrink)

In the discourse of 18th-century British intellectuals the term 'luxury' held a well-recognized and much disputed place. Dispute arose chiefly around the problem of disentangling the economic, moral-theological and political strands of the term. The object of the present paper is to trace forward the history of debate over the concept along one develop ing line of specialization - that of 19th-century political economy. It will be seen how the term luxury (and related terms: necessity, decency, productive, unproductive, etc.) adjusted (...) meaning(s) as the economic, social and intellectual contexts in which it was embedded themselves mutated. In particular, it is argued, the changing significance attached to the term illustrates the extent to which a key 19th-century intellec tual elite managed to accommodate the implications of a transition from a society based on assumptions of scarcity and hierarchy to one that was beginning to contemplate the possibility of mass market abun dance. While the profession's leaders did develop a sharpened interest in aspiration to luxury consumption as a legitimate motor of economic growth, all registered their disapproval of certain forms of the aspira tion, revealing in the process a variety of class, gender and 'race' pre occupations - including (from J. S. Mill onwards) a particular distaste for positional or status-related consumption. (shrink)

This paper studies some normative relations that hold between actions, their preconditions and their effects, with particular attention to connecting what are often called ‘ought to be’ norms with ‘ought to do’ norms. We use a formal model based on a form of transition system called a ‘coloured labelled transition system’ (coloured LTS) introduced in a series of papers by Sergot and Craven. Those works have variously presented a formalism (an ‘action language’) nC+ for defining and computing with a (coloured) (...) LTS, and another, separate formalism, a modal language interpreted on a (coloured) LTS used to express its properties. We consolidate these two strands. Instead of specifying the obligatory and prohibited states and transitions as part of the construction of a coloured LTS as in nC+, we represent norms in the modal language and use those to construct a coloured LTS from a given regular (uncoloured) one. We also show how connections between norms on states and norms on transitions previously treated as fixed constraints of a coloured LTS can instead be defined within the modal language used for representing norms. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:In Kant’s Wake: Philosophy in the Twentieth CenturyRobert HannaTom Rockmore. In Kant’s Wake: Philosophy in the Twentieth Century. Oxford: Blackwell Publishing, 2006. Pp. 213. Paper, $24.95.In In Kant's Wake, Tom Rockmore sets himself the almost impossibly ambitious task of telling a coherent story about the sprawling set of thinkers, doctrines, arguments, journal articles, books, social institutions, teachings, and other intellectual practices that make up philosophy in the twentieth century. (...) His highly plausible unifying hypothesis is that twentieth-century philosophy is a series of creative and reactive footnotes to Kant's Critical Philosophy as encapsulated in the Critique of Pure Reason, and in particular, to Kant's transcendental idealism. Of course the same unifying hypothesis is equally plausible of the nineteenth century. In this sense, the history of philosophy since Kant is just the history of post-Kantian philosophy.Rather than telling a single long story, Rockmore tells five shorter stories. He begins his narrative with a chapter on Kant's metaphysics and immediate responses to the Critique of Pure Reason (ch. 2). Then he focuses, in turn, on the diachronic developments of Marxism (ch. 3), pragmatism, (ch. 4), phenomenology (ch. 5), and analytic philosophy (ch. 6). The five stories are framed by a methodological chapter on the problem of interpreting twentieth-century philosophy (ch. 1), and a concluding chapter on the relation between Kant and the overall shape of philosophy in the twentieth century (ch. 7).Three more or less explicitly-stated interpretive principles run through each of Rockmore's historical narratives. The first, as I have already mentioned, is the grand unifying hypothesis of the essentially protean character of Kant's first Critique and the metaphysics of transcendental idealism. The second is that each distinct philosophical movement is [End Page 676] fundamentally organized around the teachings and writings of a few "master" or "strong" thinkers (14). And the third is that the history of philosophy is nothing but a multi-voiced Socratic conversation (13). Everyone knows how even the most intensely animated intellectual conversation can end with an inconclusive whimper instead of a conclusive bang. According to Rockmore, that is basically what happened to the great philosophical conversation of the twentieth century.In the chapter on Kant, Rockmore usefully distinguishes between two strands of transcendental idealism that Kant regarded as fully complementary, but which tended to run and pull in sharply opposite directions in post-Kantian philosophy: (1) the representationalist strand, and (2) the constructivist strand (36). Now Kant's transcendental idealism says four things. First, cognition is the mental representation of objects. Second, the objects we cognize are nothing but appearances or phenomena and never things-in-themselves or noumena. Third, the generic structure of the objects and the world we cognize is identical to the non-empirical or a priori generic structure of the innate cognitive capacities or faculties of our minds. And fourth, the human mind is spontaneously active in producing the specific structures of the very objects we cognize when our faculties are triggered by particular sensory inputs. The first and second theses of transcendental idealism constitute its representationalist strand, and the third and fourth theses constitute its constructivist strand.The decomposition of the orginal Kantian vector into its representationalist and constructivist components helps Rockmore in his interpretation of the four main sub-movements of twentieth-century philosophy. Marxism or dialectical materialism, organized of course around the teachings and writings of Karl Marx, is an economic, social, and political version of post-Kantian constructivism focused on the concrete struggles of alienated individuals and groups to achieve liberation and self-realization in collective action. So too pragmatism, organized around the teachings and writings of C. S. Peirce, William James, and John Dewey, is another version of post-Kantian constructivism, this time focused on the idea that the meaning and truth of concepts and propositions is strictly determined by the practical pay-offs of applying those concepts and propositions.By contrast, phenomenology and analytic philosophy are both versions of representationalism. Phenomenology is organized around the teaching and writings of Edmund Husserl, Martin Heidegger, Jean-Paul Sartre, and Maurice Merleau-Ponty, and focuses on the structures of consciousness and object-directedness... (shrink)

This article introduces the Chinese conception of wisdom by a focus mainly on the famous discussion in Mencius. It emphasizes that everything is a change, that changes toward wisdom are natural (or in the case of Xunzi, humane), and that people are always changing toward or away from what is wise. In contrast to much Western thought, wisdom is a response to external things, not to an internal marker. Moreover, it is nearly always a commentary on conjoint actions as in (...) a game, or ritual. The essay continues some strands of Chinese thinking about wisdom through Xunzi and up to Zhu Xi. My position as a Westerner is commented on at the end. (shrink)

Hereditary breast and ovarian cancers are frequently attributed to germline mutations in the tumor suppressor genes BRCA1 and BRCA2. BRCA1/2 act to repair double‐strand breaks (DSBs) and suppress the demise of unstable replication forks. Our work elucidated a dynamic interplay between BRCA2 and the WRN DNA helicase/exonuclease defective in the premature aging disorder Werner syndrome. WRN and BRCA2 participate in complementary pathways to stabilize replication forks in cancer cells, allowing them to proliferate. Whether the functional overlap of WRN and (...) BRCA2 is relevant to replication at gaps between newly synthesized DNA fragments, protection of telomeres, and/or metabolism of secondary DNA structures remain to be determined. Advances in understanding the mechanisms elicited during replication stress have prompted the community to reconsider avenues for cancer therapy. Insights from studies of PARP or topoisomerase inhibitors provide working models for the investigation of WRN's mechanism of action. We discuss these topics, focusing on the implications of the WRN‐BRCA2 genetic interaction under conditions of replication stress. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Theater of Nature: Jean Bodin and Renaissance Science by Ann BlairPeter DearAnn Blair. The Theater of Nature: Jean Bodin and Renaissance Science. Princeton: Princeton University Press, 1997. Pp. xiv + 382. Cloth, $45.00.Jean Bodin’s Universae naturae theatrum (1596) is the least celebrated of all the major publications by this outstanding figure of the French renaissance. It lacks the apparent political, historiographical, and philosophical relevance of Bodin’s well-known (...) earlier works (the Methodus ad facilem historiarum cognitionem of 1566, Les six livres de la République of 1576, and De la démonomanie des sorciers of 1580, all receiving much more attention then as now). Ann Blair focuses our attention on the Theatrum, as a text whose significance for her book exists on at least three interrelated levels: there is its relation to Bodin’s views in the more famous texts; its advantage as a treatise on natural philosophy about whose author we know much more (intellectually) than those of most such works; and in connection with the last, there is above all its value as a distinguished representative of a genre of natural philosophical writings that was prominent in the late sixteenth and early seventeenth centuries.It is the third consideration that motivates Blair’s book most centrally. She declares her wish to enrich our view of the history of science with works, like the Theatrum, that were not made by subsequently regarded stars such as Galileo or Descartes; the very typicality of its genre makes the Theatrum, she argues, a valuable window on contemporary understandings of what natural knowledge was and should be about. Bodin’s enterprise possessed a religious core: natural philosophy was for him a tool to be used in shoring up broadly irenical positions (of the kind associated with the Colloquium heptaplomeres, usually attributed, as here, to Bodin). This kind of “natural theology” avant la lettre characterized a good number of different thinkers and writers on natural philosophy in this period, many of them German (besides their discussion here, Blair is considering such people, and their project of pia philosophia, more fully in her current work). It is a subject that, more than anything, stands at the heart of her study.Bodin, rather conventionally, tried to establish a close liaison between natural philosophy and religious knowledge—that is, between those things to be inferred from experience of the natural world and the central dogmas of faith. Less conventionally, he attempted to demonstrate on occasion truths that were far from orthodox. Regardless of whether Bodin was “really” a Catholic or a Protestant (and Blair observes the great interest in the Theatrum shown by German Calvinists in the first few decades after its original publication), his general religious stance was one of accommodation. Thus good philosophizing could demonstrate (in the weak, rhetorical sense of that term) such doctrines as the existence and providence of God; contentious issues, such as the correct interpretation of the Eucharist, were left aside. Nonetheless, Bodin also argued, at such length and with such vigor as to have the propositions condemned by the Catholic church, that human souls and angels (as well as, more usually, demons) were corporeal beings. The importance to Bodin of this position stemmed from its sociopolitical implications: in particular, if human souls were incorporeal, it became unclear how rewards and punishments—necessary sanctions for restoring the social order threatened by the Wars of Religion—could be meted out after death. Curiously, such a view seems to imply that pleasure and pain are inextricably connected to bodies alone. [End Page 363]Among the historiographical strands informing Blair’s approach is recent literature on the “history of the book,” best known through the work of Roger Chartier. Accordingly, Blair discusses the vicissitudes of production of Bodin’s book in its various editions and emissions, and carefully considers, along with the likely reading practices by the aid of which Bodin came to compose it, the various uses to which its first readers put it. Her major interpretive trope is that of the commonplace book. While acknowledging the lack of direct material evidence for Bodin’s use of such a technique as his chief means of... (shrink)

LeRoy Walters was a central figure in debates about federal policy regarding genetics and biotechnology—a neutral, publicly engaged philosopher and religious studies academic who put his skills to work in national service. His career spanned the emergence of biotechnology as a field in the 1970s until his retirement. His interests reached from moral philosophical theory to Holocaust studies to practical concerns about public policy in genetics. We focus here on the role of bioethics in policy related to the advent of (...) human gene transfer, the Human Genome Project, and the emergence of biotechnology as a commercial enterprise. We focus on his role as an academic influencing the government strand of the “triple helix”... (shrink)