The author replies to a letter to the editor from Felicitas Sofia Holzer concerning Wenner’s article “The Social Value Requirement in Research: From the Transactional to the Basic Structure Model of Stakeholder Obligations,” in the Hastings Center Report’s January‐February 2019 issue.

Relational autonomy theorists attempt to accommodate social embeddedness within a conception of autonomy. These attempts are conceptually messy, at best, and category errors, at worst. Rejecting the liberal conception of autonomy due to feminist concerns is more helpfully answered by the neorepublican notion of freedom as nondomination. The conception of freedom as nondomination captures the values that motivate the relational turn in moral and political theory and does so in a conceptually neater way than attempting to accommodate those concerns in (...) our accounts of autonomy. (shrink)

It has long been taken for granted that clinical research involving human subjects is ethical only if it holds out the prospect of producing socially valuable knowledge. Recently, this social value requirement has come under scrutiny, with prominent ethicists arguing that the social value requirement cannot be substantiated as an ethical limit on clinical research, and others attempting to offer new support. In this paper, I argue that both criticisms and existing defenses of the social value requirement are predicated on (...) what I call the “transactional model of stakeholder obligations”. I go on to problematize this framework, and to introduce an alternative framework for conceptualizing ethical obligations within clinical research. In defending this framework, which I call the “basic structure model of stakeholder obligations”, I also demonstrate how it provides a stronger grounding for the social value requirement that is not vulnerable to critiques grounded in the transactional model. (shrink)

Ethicists have long recognized that two necessary features of ethical research are scientific validity and social value. Yet despite a significant literature surrounding the validity component of this dictate, until recently there has been little attention paid to unpacking what the social value component might require. This article introduces a framework for assessing the social value of research, and in particular, for determining whether a given research program is likely to have significant social value of the kind necessary to fulfill (...) the social value requirement. The article goes on to illustrate how this framework can provide a clearer account of the responsiveness requirement, an ethical dictum that is oft-repeated but whose content and value as a guideline in international research remains contested. Although I introduce this conception of social value in the context of the responsiveness requirement, the account offered can, and is intended to, stand alone as a tool for the assessment of the social value of research. As such it can be usefully applied to discussions about the value of comparative effectiveness trials, the assessment of the continued proliferation of me-too drugs and the research done to develop them, the demand for public access to study-generated data, and persistent deficits in the publication of negative results. (shrink)

Ethical oversight of clinical research is one of the primary means of ensuring that human subjects are protected from the natural bias of researchers and research institutions in favor of experimentation. At a minimum, effective oversight should ensure that risks are minimized and reasonable in relation to anticipated benefits, protect vulnerable subjects from potential coercion or undue influence, ensure full and informed consent, and promote the equitable distribution of the risks and benefits of research. Because these assessments often involve value (...) judgments for which there are no agreed-upon objective standards, we rely on deliberative procedures thought to have the greatest likelihood of producing the right or best outcomes. Concerns about the potential for improperly functioning IRBs to waste scarce human and institutional resources and impede biomedical progress have motivated a surge in empirical research assessing their procedures and outcomes. Yet within this literature, there has been minimal attention paid to the social scientific evidence regarding how individuals and deliberating groups make decisions, nor how those data might inform IRB practice. This essay seeks to fill that gap, locating recent empirical data on IRB composition and process within the context of data regarding what I call “deliberative pathologies,” or instances when deliberation fails to live up to one or more aspect of the deliberative ideal because of systematic biases in the ways participants interact. The paper goes on to make evidence-based recommendations to reduce the vulnerability of IRB deliberations to the kinds of pathologies discussed and indicate directions for future research. (shrink)

In light of the growth in the conduct of international clinical research in developing populations, this paper seeks to explore what is owed to developing world communities who host international clinical research. Although existing paradigms for assigning and assessing benefits to host communities offer valuable insight, I criticize their failure to distinguish between those benefits which can justify the conduct of research in a developing world setting and those which cannot. I argue that the justification for human subjects research is (...) fundamentally grounded in the social value of knowledge, and that this value is context-dependent in a manner which should inform our ethical evaluation of the conduct of research in specific settings. I propose a new framework for the assessment of research benefits assigned to developing world host communities, a natural implication of which is to limit the types of research projects which may permissibly be conducted in developing world settings. (shrink)

This paper examines the moral force of exploitation in developing world research agreements. Taking for granted that some clinical research which is conducted in the developing world but funded by developed world sponsors is exploitative, it asks whether a third party would be morally justified in enforcing limits on research agreements in order to ensure more fair and less exploitative outcomes. This question is particularly relevant when such exploitative transactions are entered into voluntarily by all relevant parties, and both research (...) sponsors and host communities benefit from the resulting agreements. I show that defenders of the claim that exploitation ought to be permitted rely on a mischaracterization of certain forms of interference as unjustly paternalistic and two dubious empirical assumptions about the results of regulation. The view I put forward is that by evaluating a system of constraints on international research agreements, rather than individual transaction-level interference, we can better assess the alternatives to permitting exploitative research agreements. (shrink)

Patient-funded trials are gaining traction as a means of accelerating clinical translation. However, such trials sidestep mechanisms that promote rigor, relevance, efficiency, and fairness. We recommend that funding bodies or research institutions establish mechanisms for merit review of patient-funded trials, and we offer some basic criteria for evaluating PFT protocols.

Within bioethics as well as in broader clinical practice, support for transgender and gender‐questioning adolescent access to pubertal suppression has often relied heavily on the desire to prevent risky, self‐destructive, and suicidal behavior. We argue that framing justifications for access to puberty suppression in this way can actually be harmful to both individual patients as well as to the broader trans population. This justification for access to care makes such access precarious, limits its scope, and introduces perverse incentives to the (...) patient population that is being served. We go on to offer an alternative, positive defense of access to puberty‐blocking treatment for transgender youth grounded in the child's right to an open future. We argue that decisions related to pubertal suppression are both importantly weighty and potentially irreversible, and show why this justification is preferable to so‐called “informed consent” approaches. (shrink)

Volume 19, Issue 9, September 2019, Page 60-62.

Pratt, Zion, and Loff (2012) correctly point out that most international clinical research (ICR) is not intended to address the vast inequities in access to health care between developed and develo...

A growing proportion of clinical research funded by pharmaceutical companies, high-income country research agencies, and not-for-profit funders is conducted in low- and middle-income settings. Disparities in wealth and access to healthcare between the populations where new interventions are often tested and those where many of them are ultimately marketed raise concerns about exploitation. This chapter examines several ethical requirements frequently advanced as mechanisms for protecting research subjects in underserved communities from exploitation and evaluates the effectiveness of those mechanisms as responses (...) to exploitation worries. It goes on to highlight where the conceptual frameworks relied upon by research ethicists must be improved if we are to fully understand the nature of the moral claims and obligations that arise in research conducted in underserved communities. (shrink)

The global impact of Dobbs v. Jackson Women’s Health Organization and the backlash towards reproductive justice that it represents warrant a global feminist response informed by broad theoretical and geopolitical lenses. We consider how a solidaristic, transnational feminist movement might learn from Latin American feminist movements that have been successful in uniting broad coalitions in the fight for reproductive justice as situated within far-reaching political goals. The success of such a global movement must be decolonial and must contend with the (...) fact that overlapping realities of global inequality, severe poverty, extractivism, and western-backed violence are fundamentally implicated in reproductive justice. (shrink)

There has been a growing concern over establishing norms that ensure the ethically acceptable and scientifically sound conduct of clinical trials. Among the leading norms internationally are the World Medical Association's Declaration of Helsinki, guidelines by the Council for International Organizations of Medical Sciences, the International Conference on Harmonization's standards for industry, and the CONSORT group's reporting norms, in addition to the influential U.S. Federal Common Rule, Food and Drug Administration's body of regulations, and information sheets by the Department of (...) Health and Human Services. There are also many norms published at more local levels by official agencies and professional groups.Any account of international standards should cover both scientific and ethical norms at once – the two are conceptually intertwined. Recent sources recognize that “[s]cientifically unsound research on human subjects is unethical in that it exposes research subjects to risks without possible benefit.”. (shrink)

California has focused on health equity in the state’s COVID-19 reopening plan. The Blueprint for a Safer Economy assigns each of California’s 58 counties into 1 of 4 tiers based on 2 metrics: test positivity rate and adjusted case rate. To advance to the next less-restrictive tier, counties must meet that tier’s test positivity and adjusted case rate thresholds. In addition, counties must have a plan for targeted investments within disadvantaged communities, and counties with more than 106 000 residents must (...) meet an equity metric. California's explicit incorporation of health equity into its reopening plan underscores the interrelated fate of its residents during the COVID-19 pandemic and creates incentives for action. This article evaluates the benefits and challenges of this novel health equity focus, and outlines recommendations for other US states to address disparities in their reopening plans. (shrink)

Danielle Wenner has crafted novel arguments in defense of republican accounts of freedom. I learned a lot from her discussion of how Philip Pettit's neorepublican account of freedom as nondomination does a better job than standard accounts of freedom as noninterference of explaining how power over an agent can restrict their freedom to act autonomously. The real crux of Wenner's argument, however, is that freedom as nondomination can do this work in a way that those who defend (...) an account of relational autonomy cannot. I will start with Wenner's defense of freedom as nondomination and of what it can do as the background for assessing her critique of relational autonomy. The upshot of my comments will be that Wenner... (shrink)

In this book Daniel Wegner offers a novel understanding of the relation of consciousness, the will, and our intentional and voluntary actions. Wegner claims that our experience and common sense view according to which we can influence our behavior roughly the way we experience that we do it is an illusion.

The science of well-being studies an evaluative kind, well-being, which raises natural worries about the ability of empirical research to deliver. This paper argues that well-being research can provide important information about how people are doing without entangling itself very deeply in controversial normative claims. Most life satisfaction research, for instance, purports only to tell us how people see their lives going relative to what they care about ? something most people can agree is important, whatever their theory of well-being. (...) At the same time, such research can mislead if it does not in fact have the significance it seems to have. Life satisfaction measures in fact have this problem: life satisfaction attitudes have deep in-principle limitations in their ability to reflect the subjective quality of people's lives, for instance because they are only weakly constrained by the facts about how people see their lives going. You might, e.g., reasonably be satisfied with your life even if you think it's going badly for you. I propose largely replacing such measures with aggregate life evaluation measures, which dispense with both the global judgment and ?satisfaction? elements of life satisfaction. (shrink)

This essay defends the controversial and indeed counterintuitive claim that there is a good argument to be made from a Lockean perspective for government action to guarantee access to health care. The essay maintains that this argument is in some regards more robust than the well-known argument in defense of universal health care spelled out by Norman Daniels, which this essay also examines in some detail. Locke's view that government should protect people's lives, property, and freedom–where freedom is understood as (...) independence and self-determination–justifies government action to ensure access to health care, because (roughly), just as individuals cannot protect themselves from crime and foreign invasion, so individuals are unable to provide for their own health care. Defense from disease is as important as defense from crime, and–although this is arguable–government action to guarantee access to health care does not itself undermine freedom. (shrink)

This essay surveys a number of prominent, recurring, and new directions in the growing scholarly discourse on the theme “Heidegger and Judaism” arranged under three headings. The first, the contrastive framing, encompasses cases in which the relationship between Heidegger and Judaism is perceived as antithetical. The second, the conjunctive framing, encompasses views claiming the existence of affinities and parallels between Heidegger and Judaism, grouped under three subheadings: “Heidegger and biblical thinking,” “Heidegger and Kabbalah,” and “Heidegger and the Jewish nation.” The (...) third, historical perspectives, uses the approach of intellectual history to explore visions of Judaism that are developed as part of engagements with Heidegger’s philosophy. (shrink)

In this paper I review recent philosophical work in English on the nature of emotion. I begin with the well-known attacks of Bedford, Kenny and Pitcher on what I call the traditional (i.e., Cartesian) view of the nature of emotion. I then trace and discuss the successive alternative views that have been developed in the past thirty years. My aim is both to review the development of these alternative views and to indicate what particular problems have come to be considered (...) the central problems in this area. A comprehensive bibliography of recent work in English is appended. (shrink)

This chapter contains sections titled: Economics and Philosophy of Economics Six Central Methodological Problems Inexactness, Ceteris Paribus Clauses, and “Unrealistic Assumptions” Contemporary Directions in Economic Methodology Conclusion References.

If rhetoric is the art of speaking, who is listening? In Being-Moved, Daniel M. Gross provides an answer, showing when and where the art of speaking parted ways with the art of listening-and what happens when they intersect once again. Much in the history of rhetoric must be rethought along the way. And much of this rethinking pivots around Martin Heidegger's early lectures on Aristotle's Rhetoric, where his famous topic, Being, gives way to being-moved. The results, Gross goes on to (...) show, are profound. Listening to the gods, listening to the world around us, and even listening to one another in the classroom-all of these experiences become different when rhetoric is reoriented from the voice to the ear. (shrink)

Includes a foreword by Kevin M. Gilmartin, PhD, author of the bestselling Emotional Survival for Law Enforcement: A Guide for Officers and Their Families. This book offers practical, research-based strategies to help police officers improve wellness, strengthen ethical commitments, and boost resilience both on and off-duty. Your power as a police officer does not come from your badge, gear, or tactical skills. It comes from your POWER: police officer wellness, ethics, and resilience. This book offers a research-based approach to dealing (...) with the daily challenges you face in your law enforcement job. It describes personal and professional steps you can take, on-duty and off-duty, to optimize your health and maintain your performance. When you proactively practice the skills, tips, and exercises outlined in this book, you will be better prepared to defuse crisis situations before they happen, and more capable of coping with them when they do. As a law enforcement officer, you deal with enormous challenges on a daily basis. Policing involves daily risks and stressors that can compromise your health, shorten your career, and make life harder on your loved ones. Even if you have a gym or access to counseling at work, you need a personal plan to maintain your overall wellness-physical, cognitive, emotional, social, and spiritual. (shrink)

Der Funktionsbegriff spielt fur die Kunsttheorie in Geschichte und Gegenwart eine wichtige Rolle: Sei es, dass die Funktionslosigkeit von Kunst emphatisch behauptet oder eingefordert wird; sei es, dass die Auseinandersetzung mit Kunst uber deren Funktionen gerechtfertigt wird; sei es, dass der Kunstbegriff selbst funktional definiert wird. Funktionen von Kunst bereichern auch die Inhalte und das methodische Instrumentarium traditionell kunstferner Disziplinen. Die Beitrage des Bandes behandeln Fragen der Funktionalitat von Kunst, indem sie die Ansatze unterschiedlicher Facher in interdisziplinarer Perspektive mit Fallstudien (...) aus den Kunsten vereinen.". (shrink)

The sun -- The silence of art : Bataille's babbling sacrifice -- A map, of sorts -- Life's grave traces -- The clarity of method and its demands -- Truths of displacement -- Aristotle and the trace of phenomenology -- Encompassing flow or receding deformation ... a first tracing -- The formal force of presence -- The creative force of form -- The force of an impotent demand -- Limitation and light : creatures of the possible -- The intellect moves (...) as the necessity of exchange -- The trace as the force of the absent -- The trace and the gravity of words -- The trace as the absence and the motion of the intelligible -- Affirmation and absence -- The sense of a gesture -- Deformation of one hand rather than another -- The difficulty of gestures -- The subject as the site of the representation of possibility -- The unity of the place of a doubled reflection -- The displacing and transcending logic -- Of the power of representation -- On the place of the subject -- The beginning of the subjective -- Movement and method -- Belonging to the necessity of the element -- The divine task of beginning -- The necessity of the hand -- The difficult gesture of abandon -- The presence of an object, the force of a gesture -- The black box -- The vanishing compulsion -- The philosophical stakes of aesthetic form -- The dark gestures of the hand -- The presence of the frame ... and its gestures -- The originality of trust -- The silence evoked. (shrink)

In der Tradition der Musik ist diese selbst immer wieder als eine Kunstform verstanden worden, die in einem besonders innigen Verhältnis zu dem steht, was uns auszeichnet: unsere Identität. Die Beiträge des Bandes spielen in unterschiedlicher Weise den Gedanken durch, dass Musik an der Konstitution von Subjekten sowie der Gestaltung individueller und kollektiver Selbstverständnisse in geschichtlichen Lebensformen beteiligt ist. Dabei wird vor allem nach der Rolle musikalischer Praktiken und Erfahrungen für die Konstitution, Transformation und Reflexion unserer Selbst als Subjekte gefragt (...) und das Verhältnis von Musik und Subjekt konstruktiv thematisiert. (shrink)

Table at Dimitri's Taverna : on seeking a philosophy of old age -- Old Greek's olive trees : on Epicurus's philosophy of fulfillment -- Deserted terrace : on time and worry beads -- Tasso's rain-spattered photographs : on solitary reflection -- Sirocco of youth's beauty : on existential authenticity -- Tintinnabulation of sheep bells : on mellowing to metaphysics -- Iphigenia's guest : on stoicism and old old age -- Burning boat in Kamini Harbor : on the timeliness of spirituality (...) -- Returning home : on a mindful old age. (shrink)

This book offers a comprehensive overview of the structure, strategy and methods of assessment of orthodox theoretical economics. In Part I Professor Hausman explains how economists theorise, emphasising the essential underlying commitment of economists to a vision of economics as a separate science. In Part II he defends the view that the basic axioms of economics are 'inexact' since they deal only with the 'major' causes; unlike most writers on economic methodology, the author argues that it is the rules that (...) economists espouse rather than their practice that is at fault. Part III links the conception of economics as a separate science to the fact that economic theories offer reasons and justifications for human actions, not just their causes. With its lengthy appendix introducing relevant issues in philosophy of science, this book is a major addition to philosophy of economics and of social science. (shrink)

La modernità incompiuta e l'ermeneutica dell'umano: sulla filosofia di Domenico Jervolino -- Sulla mortalità dell'essere morale: note su ontologia e diritto con Gabriel Marcel -- Matrimonio e "diritto naturale vignete" in Sergio Cotta -- La molteplicità degli ordinamenti giuridici nella riflessione di Giuseppe Capograssi -- Last not last.

As a young college student studying philosophy, Klein filled a notebook with short quotes from the world's greatest thinkers, hoping to find some guidance on how to live the best life he could. As he revisits the wisdom he relished in his youth, each extract is annotated with Klein's inimitable charm and insights. He tackles life's biggest questions-- and leaves us chuckling and enlightened.

Dan Haybron presents an illuminating examination of well-being, drawing on important recent work in the science of happiness. He shows that we are remarkably prone to error in judgements of our own personal welfare, and suggests that we should rethink traditional assumptions about the good life and the good society.

This book is about preferences, principally as they figure in economics. It also explores their uses in everyday language and action, how they are understood in psychology and how they figure in philosophical reflection on action and morality. The book clarifies and for the most part defends the way in which economists invoke preferences to explain, predict and assess behavior and outcomes. Hausman argues, however, that the predictions and explanations economists offer rely on theories of preference formation that are in (...) need of further development, and he criticizes attempts to define welfare in terms of preferences and to define preferences in terms of choices or self-interest. The analysis clarifies the relations between rational choice theory and philosophical accounts of human action. The book also assembles the materials out of which models of preference formation and modification can be constructed, and it comments on how reason and emotion shape preferences. (shrink)

This book, by one of the pre-eminent philosophers of science writing today, offers the most comprehensive account available of causal asymmetries. Causation is asymmetrical in many different ways. Causes precede effects; explanations cite causes not effects. Agents use causes to manipulate their effects; they don't use effects to manipulate their causes. Effects of a common cause are correlated; causes of a common effect are not. This book explains why a relationship that is asymmetrical in one of these regards is asymmetrical (...) in the others. Hausman discovers surprising hidden connections between theories of causation and traces them all to an asymmetry of independence. This is a major book for philosophers of science that will also prove insightful to economists and statisticians. (shrink)

Anger, disgust, elevation, sympathy, relief. If the subjective experience of each of these emotions is the same whether elicited by moral or nonmoral events, then what makes moral emotions unique? We suggest that the configuration of moral emotions is special—a configuration given by the underlying structure of morality. Research suggests that people divide the moral world along the two dimensions of valence (help/harm) and moral type (agent/patient). The intersection of these two dimensions gives four moral exemplars—heroes, villains, victims and beneficiaries—each (...) of which elicits unique emotions. For example, victims (harm/patient) elicit sympathy and sadness. Dividing moral emotions into these four quadrants provides predictions about which emotions reinforce, oppose and complement each other. (shrink)

Three studies test eight hypotheses about (1) how judgment differs between people who ascribe greater vs. less moral relevance to choices, (2) how moral judgment is subject to task constraints that shift evaluative focus (to moral rules vs. to consequences), and (3) how differences in the propensity to rely on intuitive reactions affect judgment. In Study 1, judgments were affected by rated agreement with moral rules proscribing harm, whether the dilemma under consideration made moral rules versus consequences of choice salient, (...) and by thinking styles (intuitive vs. deliberative). In Studies 2 and 3, participants evaluated policy decisions to knowingly do harm to a resource to mitigate greater harm or to merely allow the greater harm to happen. When evaluated in isolation, approval for decisions to harm was affected by endorsement of moral rules and by thinking style. When both choices were evaluated simultaneously, total harm -- but not the do/allow distinction -- influenced rated approval. These studies suggest that moral rules play an important, but context-sensitive role in moral cognition, and offer an account of when emotional reactions to perceived moral violations receive less weight than consideration of costs and benefits in moral judgment and decision making. (shrink)