The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Introduction The unusually wide range of John Stuart Mill's interests and abilities does much to make him an intellectually live figure a century after his ...

Introduction 1 Part 1: Conceptual and Practical 19 1. Liberalism 21 2. Freedom 45 3. Culture and Anxiety 63 4. The Liberal Community 91 5. Liberal Imperialism 107 6. State and Private, Red and White 123 7. The Right to Kill in Cold Blood: Does the Death Penalty Violate Human Rights? 139 Part 2: Liberty and Security 157 8. Hobbes’s Political Philosophy 159 9. Hobbes and Individualism 186 10. Hobbes, Toleration, and the Inner Life 204 11. The Nature of Human (...) Nature in Hobbes and Rousseau 220 12. Locke on Freedom: Some Second Thoughts 233 Part 3: Liberty and Progress, Mill to Popper 255 13. Mill’s Essay On Liberty 257 14. Sense and Sensibility in Mill’s Political Thought 279 15. Mill in a Liberal Landscape 292 16. Utilitarianism and Bureaucracy: The Views of J. S. Mill 326 17. Mill and Rousseau: Utility and Rights 346 18. Bureaucracy, Democracy, Liberty: Some Unanswered Questions in Mill’s Politics 364 19. Bertrand Russell’s Politics: 1688 or 1968? 381 20. Isaiah Berlin: Political Theory and Liberal Culture 395 21. Popper and Liberalism 413 Part 4: Liberalism in America 427 22. Alexis de Tocqueville 429 23. Staunchly Modern, Nonbourgeois Liberalism 456 24. Pragmatism, Social Identity, Patriotism, and Self-Criticism 473 25. Deweyan Pragmatism and American Education 489 26. John Rawls 505 Part 5: Work, Ownership, Freedom, and Self-Realization 521 27. Locke and the Dictatorship of the Bourgeoisie 523 28. Hegel on Work, Ownership, and Citizenship 538 29. Utility and Ownership 556 30. Maximizing, Moralizing, and Dramatizing 573 31. The Romantic Theory of Ownership 586 32. Justice, Exploitation, and the End of Morality 600 33. Liberty and Socialism 617 Notes 631. (shrink)

First published in 1974. As logician, economist, political theorist, practical politician and active champion of social freedom, John Stuart Mill is a figure of continuing importance. In this book the author does full justice to the range of Mill’s achievements, providing an introductory guide to his most important and best known writings including _Autobiography_,_ A System of Logic_,_ Utilitarianism_,_ Liberty, _and _The Subjugation of Women_. In their treatment of his works, the author seeks to emphasise Mill’s approach to those issues (...) — education, the conflict between social order and individual freedom, the unresolved state of the social sciences, rights and duties of citizens in a democratic state — which remain most alive to us today. At the same time Mill is seen as part of his own age, responding to the anxieties that beset his contemporaries. This book will be of interest to students of politics and philosophy. (shrink)

First published in 1974. As logician, economist, political theorist, practical politician and active champion of social freedom, John Stuart Mill is a figure of continuing importance. In this book the author does full justice to the range of Mill's achievements, providing an introductory guide to his most important and best known writings including Autobiography,A System of Logic,Utilitarianism,Liberty, and The Subjugation of Women. In their treatment of his works, the author seeks to emphasise Mill's approach to those issues -- education, the (...) conflict between social order and individual freedom, the unresolved state of the social sciences, rights and duties of citizens in a democratic state -- which remain most alive to us today. At the same time Mill is seen as part of his own age, responding to the anxieties that beset his contemporaries. This book will be of interest to students of politics and philosophy. (shrink)

In Sherrington's Loom, Alan McComas provides a historical account of the research that has led to recognition of key mechanisms underlying consciousness. Evidence is assembled from a rich variety of sources--neurological patients, animal behavior, laboratory studies, and especially brain stimulation and recording in humans and animals. Among the remarkable advances in the field has been the ability to identify nerve cells in the human brain that store memories of specific people, places, and objects. In addition to dealing with the (...) issue of "free will," the book assembles the information into possible working models for sensations, intentions, and actions. McComas concludes by considering the possibility of consciousness in artificially intelligent systems. (shrink)

Machine generated contents note: Table of ContentsIntroduction -- 1. Kierkegaard's Audience and Approach -- 2. Against Hegelianism: Kierkegaard on Creation and Christology -- 3. Karl Barth and the Legacy of the Enlightenment: Cultural Religion, Nationalism, and Idealism -- 4. God's Relationship with Us in Time: The Kierkegaard-Barth Trajectory -- 5. Barth's Appropriation of Kierkegaard -- 6. The Kierkegaard-Barth Trajectory and the Challenge of the "Socratic": What Should Christian Engagement with Secular Society Presuppose? -- 7. Beyond Immanence -- Conclusion -- Bibliography (...) . (shrink)

Critical insights into Kierkegaard's influence on Barth's theology. Karl Barth was often critical of Søren Kierkegaard's ideas as he understood them. But close reading of the two corpora reveals that Barth owes a lot to the melancholy Dane. Both conceive of God as infinitely qualitatively different from humans, and both emphasize the shocking nearness of God in the incarnation. As public intellectuals, they used this theological vision to protect Christocentric faith from political manipulation and compromise. For Kierkegaard, this meant criticizing (...) the state church; for Barth, this entailed resisting Nazism. Meticulously crafted by a father-son team of renowned systematic theologians, Beyond Immanence demonstrates that Kierkegaard and Barth share a theological trajectory--one that resists cynical manipulation of Christianity for political purposes in favor of uncompromising devotion to a God who is radically transcendent yet established kinship with humanity in time. (shrink)

In this case, it is noted that while DNA testing and methylation are being studied as biomarkers for high-grade squamous intraepithelial lesions in the anal canal, their efficacy is no...

The most relevant and plausible conceptions of economic rationality, interpersonal liberty, human welfare, and private-property anarchy do not conflict in theory or practice. Using philosophy and social science, Escape from Leviathan defends this bold, non-normative, thesis from contrary positions in the scholarly literature. Writers considered include David Friedman, John Gray, R. M. Hare, Robert Nozick, Karl Popper, John Rawls, Murray Rothbard, Alan Ryan, Amartya Sen, and Bernard Williams. *** The rationality assumptions of neoclassical and Austrian School economics are (...) reconciled and related to liberty and welfare. A new pre-propertarian theory of interpersonal liberty as the absence of (initiated or proactively) imposed cost is argued to be libertarian. Human welfare is defended as the satisfaction of unimposed wants. Practical anarchy is simply unconstrained private property. Related topics include free will, weakness of will, the nature of moralizing, intellectual property, and restitution and retribution. Critical-rationalist epistemology (theories can only be criticized and tested, not justified or supported) is applied throughout. This is a ground-breaking work that is also an excellent introduction to libertarianism and social thought. (shrink)

Interpretations of human nature driven by scientific analyses of the origin and development of the human species often assume metaphysical naturalism. This generates restrictive and distortive accounts of key facets of human life and ethics. It fails to make sense of human altruism, and it operates within a wider philosophical framework that lacks explanatory power. The accounts of theistic evolution that seek to redress this, however, too easily fail to take sufficient account of the unique contribution of interpretations from a (...) specifically Christian epistemic base. The latter involve a Christological and, hence, eschatological approach which is intrinsic to the interpretation of human nature in light of the purpose and intentionality of the Creator. Phenomenological approaches to the nature of humanity lack the categories to distinguish between human nature as the object of divine intentionality and its present dysfunctional and, ultimately, subhuman state. (shrink)

Surveys the current political situation worldwide and proposes emergent paradigms.

The increasing use of transnational standard-setting bodies to address quality uncertainties and coordination issues across the global economy raises questions about how these bodies establish and maintain their legitimacy and accountability outside the sovereignty of democratic states. Based on a discussion of the legitimacy challenge posed by global governance, we provide an overview of mechanisms by which such bodies can defend their legitimacy claims and examine the actual mechanisms used by the International Accounting Standards Board (IASB). While the IASB staked (...) its initial credibility on technical competence and independence, it has increasingly emphasized due process norms in its claim for support. Our analysis evaluates the IASB due process against the cultural benchmarks established by domestic standard-setters in the USA and UK and against a normative model of procedural legitimacy. These comparisons help us to understand the modifications that were made in the hope of due process adding legitimacy to accounting standard-setting beyond the state. They also reveal the broader political context of competing legitimacy criteria that confronts transnational standard-setters. (shrink)

ABSTRACT Because of the existence of severely defective humans it is commonly held that whatever consideration is due to all humans is also due to many other animals, and that therefore speciesism, or the readiness to prefer the interest of humans to those of other animals, is unjustified. After criticism of this reasoning a ‘naturalised’ speciesism, acknowledging, for example, the affinities between species, is articulated and defended. A key to this defence is the separation of the task of specifying morally (...) significant differences between humans and other animals from the task of justifying the extension of consideration to defective humans. The conclusion is that more traditional vices than speciesism are chiefly to blame for the shabby treatment of animals by humans. (shrink)

Diagnostic self-testing devices are being developed for many illnesses, chronic diseases and infections. These will be used in hospitals, at point-of-care facilities and at home. Designed to allow earlier detection of diseases, self-testing diagnostic devices may improve disease prevention, slow the progression of disease and facilitate better treatment outcomes. These devices have the potential to benefit both the individual and society by enabling individuals to take a more proactive role in the maintenance of their health and by helping society improve (...) health and reduce health costs. However, the full implications of future home-based diagnostic technology for individuals and society remain unclear due to their novelty. We argue that the development of diagnostic tools, especially for home use, will heighten a number of ethical challenges. This paper will explore some of the ethical implications of home-based self-testing diagnostic devices for the autonomous and relational dimensions of the person. This will be facilitated by examining the impact of diagnostic devices for individual autonomy, for the delivery of accurate diagnosis and for the personal significance of the information for the user. The latter will be examined using Charles Taylor's view of personhood and his emphasis on human agency and interpretation. While the ethical issues are not necessarily new, the development of home-based self-testing diagnostic devices will make issues regarding autonomy, accuracy of information and personal significance more and more demanding. This will be the case particularly when an individual's autonomous choices come into conflict with the person's relational responsibilities. (shrink)

In the year of our Lord 1862, Polish painter Jan Matejko finished his first famous work, Stańczyk, fully translated into English as “Stańczyk during a ball at the court of Queen Bona in the face of the loss of Smolensk.”1 The piece was painted in oils and depicts a famous political figure of Renaissance Poland, Stańczyk the court jester. Stańczyk, an influential figure of Polish history who was as much a political philosopher as a funny man, is depicted in this (...) scene sitting alone and apoplectic as a royal party rages on just outside his door. As the illustration implies, he and the partygoers have just received some correspondence that declares the Polish territory of Smolensk has been besieged, and, appallingly.. (shrink)

This paper seeks to contribute to the discussion on national corporate social responsibility plans from the perspectives of the three logics as articulated in Caritas in Veritate, by using the Irish national CSR plan as an example. Good for Business, Good for the Community: Ireland’s National Plan on Corporate Social Responsibility 2014–2016 maintains that CSR activities can enable organisations to build relationships and trust with communities. One of the consequences of the 2008 financial crisis was the decrease in trust in (...) banking systems and in business more broadly. It is well recognised that relationships of trust are essential to the life of the market, the state and civil society. Pope Emeritus Benedict XVI’s Caritas in Veritate contends that corresponding to the life of the market, the state and civil society are three logics: the logic of exchange, the logic of public obligation and the logic of gift. This paper proposes that the normative framework of the three logics of Caritas in Veritate can be read into the Irish national CSR plan. This paper argues that the examples of CSR initiatives proffered by the plan could point organisations in the direction of the logic of gift and therefore enable the rebuilding of relationships of trust with citizens and communities. (shrink)

Due process is the means by which ethical constraints are placed on administrative decision-making. I have developed a model of variation in due process and use this model to explore the implementation of “due process” norms by three standard-setting bodies that are created, funded, and overseen by the Canadian Institute of Chartered Accountants – the Accounting Standards Board, the Auditing and Assurance Standards Board, and the Public Sector Accounting Standards Board. I conducted two analyses: a comparative analysis of the implementation (...) of due process norms based on differences among the three cases; and, a critique of the due process norms followed by these boards based on their internal logic and a set of best practices identified in other contexts for due process by standard setters. I have presented evidence that due process norms are more fully developed, where standards are enforced by the state and the heterogeneity of users is greatest. (shrink)

Alan J. Holland. Library of Congress Cataloging in Publication Data Main entry under title: Philosophy, its history and historiography. (Royal Institute of Philosophy Conference; v. 1983) ...

Social cognition refers to a discipline in which researchers seek to understand social phenomena in terms of models which emphasize the role of cognitive processes (e.g., attention, encoding, cognitive organization, storage, memory) in mediating social thought and action. Although social cognition is a relatively new field, it is important to note that social psychologists have long been concerned with many of the same issues that are central to cognitive science, such as how people store and retrieve information about their environment (...) in memory. Thus, it would be inaccurate to portray the emergence of social cognition as the first time that social psychologists have focused on the role of cognition in mediating social behavior. Nevertheless, it is true that in the mid‐to‐late 1970s, a branch of social psychology emerged which was unique in the extent to which it overlapped with the theoretical orientation of, and the methodological tools employed by, cognitive psychologists. It is this time period that most scholars peg as the era in which social cognition grew and matured as a discipline in its own right. (shrink)

In light of an historical obsession with human error, Krueger & Funder (K&F) suggest that social psychologists should emphasize the strengths of social perception. In our view, however, absolute levels of accuracy (or error) in any given experiment are less important than underlying processes. We discuss the use of the process-dissociation procedure for gaining insight into the mechanisms underlying accuracy and error.

In the twelfth century, when military orders were first being established, the custom of child oblation was in decline in western monasteries, and the novitiate was acquiring a new importance. New foundations of monks and regular canons sought to ensure that recruits were subjected to a period of testing and training before they made their profession, while at Cluny Peter the Venerable insisted on a probationary period of at least a month. Since the rules governing their conventual life were based (...) upon those of existing religious institutions, the military orders were inevitably influenced by these trends. They rejected the practice of child oblation and in most cases instituted a period of probation for recruits. (shrink)

The concept of missed care refers to an irrefragable truth that required nursing care, which is left undone, occurs in the delivery of health care. As a technical concept, missed care offers nurses the opportunity to articulate a problematic experience. But what are we to make of missed care from an ethical perspective? Can nurses be held morally responsible for missed care? Ethically speaking, it is generally accepted that if a person has a moral obligation to do something, s/he needs (...) to have the capacity to do it. If a person does not have the capacity to fulfil a moral obligation, then s/he cannot be held responsible for failing to do so. This is captured by the “ought implies can” (OIC) principle. This paper brings the OIC principle to the forefront of the discussion on missed care. It is contended that nurses – qua moral agents – may be discharged from a moral obligation to carry out a required caring act because of some inability that is not of their making and therefore may not be morally responsible for missed care. However, the OIC principle may not be applied to all situations of missed care depending on their causes. In addition, following in the thought of Sapontzis (The Southern Journal of Philosophy, 1991, XXIX, 383–393) it is contended that when an original obligation to deliver a required act of care cannot be fulfilled, other obligations may be generated as summed up in the “Principle of Making Amends” and the “Principle of Appropriate Feeling.” It is the view of this paper that these further principles could prevent the OIC principle from being used to simply excuse omissions of care from a normative standard and could support the view that nurses continue to have alternative obligations to make amends and to respond with appropriate feelings to missed care. (shrink)

This article attempts a contextual study of the origin and early development of August Kekulé's theory of aromatic compounds. The terminus a quo is essentially August Hofmann's coining of the modern chemical denotation of ‘aromatic’ in 1855; the terminus ad quem is the first full codification of Kekulé's theory in the sixth fascicle of his Lehrbuch der organischen Chemie, published in the summer of 1866. Kekulé's theory is viewed in context with the earlier and concurrent experimental work of such chemists (...) as Hermann Kolbe, Friedrich Beilstein, Rudolph Fittig, and Hugo Müller. The reception of the theory is briefly examined. Attention is paid to the role of Kekulé's molecular models and of his celebrated dream anecdote of the snake that seizes its own tail. The episode is used as a case study for the continuity of scientific progress, and to illustrate the close reciprocal interactions of hypothesis and experiment in the evolution of a scientific theory. (shrink)

Memory and Amnesia: An Introduction provides a clear and comprehensive account of amnesia set in the context of our understanding of how normal memory operates. Part 1 provides the reader with an up-to-date survey of contemporary memory theories. Part 2 deals with amnesia, incorporating all important new developments, and focuses on the nature and explanation of the amnesic syndrome.