There is a widespread assumption that the universe in general, and life in particular, is 'getting more complex with time'. This book brings together a wide range of experts in science, philosophy and theology and unveils their joint effort in exploring this idea. They confront essential problems behind the theory of complexity and the role of life within it: what is complexity? When does it increase, and why? Is the universe evolving towards states of ever greater complexity and diversity? If (...) so, what is the source of this universal enrichment? This book addresses those difficult questions, and offers a unique cross-disciplinary perspective on some of the most profound issues at the heart of science and philosophy. Readers will gain insights in complexity that reach deep into key areas of physics, biology, complexity science, philosophy and religion. (shrink)

Astrobiologists are aware that extraterrestrial life might differ from known life, and considerable thought has been given to possible signatures associated with weird forms of life on other planets. So far, however, very little attention has been paid to the possibility that our own planet might also host communities of weird life. If life arises readily in Earth-like conditions, as many astrobiologists contend, then it may well have formed many times on Earth itself, which raises the question whether one or (...) more shadow biospheres have existed in the past or still exist today. In this paper, we discuss possible signatures of weird life and outline some simple strategies for seeking evidence of a shadow biosphere. Key Words: Weird life—Multiple origins of life—Biogenesis—Biomarkers—Extremophiles—Alternative biochemistry. Astrobiology 9, 241–249. (shrink)

In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target‐the‐weakness strategy. Our most detailed example involves the immune system. The absence of adaptive immunity in immunosuppressed (...) tumor environments is an irreversible weakness of cancer that can be exploited by creating a challenge that only the presence of adaptive immunity can meet. This leaves tumor cells more vulnerable than healthy tissue to pathogenic attack. Such a target‐the‐weakness therapeutic strategy has broad applications, and contrasts with current therapies that target the main strength of cancer: cell proliferation. (shrink)

This book tackles the most difficult and profound open questions about life and its origins from an information-based perspective.

The importance of applying game theory to the evolution of information in the presence of noise has recently become widely recognized. This Special Issue addresses the theme of spontaneously emergent order in both classical and quantum systems subject to external noise, and includes papers directly related to game theory or the development of supporting techniques. In the following editorial overview we examine the broader context of the subject, including the tension between the destructive and creative aspects of noise, and foreshadow (...) the significance of some of the subsequent papers in the volume. (shrink)

The problem of life’s origin remains one of the great outstanding challenges to science. Ever since Charles Darwin mused about a “warm little pond” incubating life beneath sunny primeval skies, scientists have speculated about the exact location of this transforming event. Nearly a century and a half later, we remain almost completely ignorant of the physical processes that led from a nonliving chemical mixture to the first autonomous organism. However, some progress at least has been made on tracking down where (...) and when life first established itself on Earth. Fossil evidence suggests that the biological record extends back at least 3.5 billion years, pointing to a still earlier origin1. But this presents a problem. The cratering record of the moon implies that Earth was subjected to intense bombardment by large comets and asteroids over an extended duration until about 3.8 billion years ago. The largest of these impacts would have released enough energy to swathe the planet in incandescent rock vapour, boiling the oceans and sending sterilizing heat pulses a kilometre into the exposed crust2. This unpromising setting – hardly a secure one for warm little ponds – has prompted some astrobiologists to conjecture that life began somewhere else and came to Earth readymade3. Favourite among extraterrestrial originating locations is the planet Mars4. (shrink)

: All known life requires phosphorus (P) in the form of inorganic phosphate (PO43x or Pi) and phosphate-containing organic molecules. Pi serves as the backbone of the nucleic acids that constitute genetic material and as the major repository of chemical energy for metabolism in polyphosphate bonds. Arsenic (As) lies directly below P on the periodic table and so the two elements share many chemical properties, although their chemistries are sufficiently dissimilar that As cannot directly replace P in modern biochemistry. Arsenic (...) is toxic because As and P are similar enough that organisms attempt this substitution. We hypothesize that ancient biochemical systems, analogous to but distinct from those known today, could have utilized arsenate in the equivalent biological role as phosphate. Organisms utilizing such ‘ weird life ’ biochemical pathways may have supported a ‘ shadow biosphere ’ at the time of the origin and early evolution of life on Earth or on other planets. Such organisms may even persist on Earth today, undetected, in unusual niches. (shrink)

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi‐unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular‐to‐unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one‐off multicellular‐to‐unicellular reversion, and are (...) better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular‐eukaryote‐to‐multicellular‐eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions. Also see the video abstract here: https://youtu.be/3unEu5JYJrQ. (shrink)

We present an exactly soluble electron trajectory that permits an analysis of the soft (deep infrared) radiation emitted, the existence of which has been experimentally observed during beta decay via lowest order inner bremsstrahlung. Our treatment also predicts the time evolution and temperature of the emission, and possibly the spectrum, by analogy with the closely related phenomenon of the dynamic Casimir effect.

This book is a survey of the range of apparently miraculous accidents of nature that have enabled the universe to evolve its familiar structures (atoms, stars, galaxies, and life itself) concludes with an investigation of the so-called anthropic principle.

In this sweeping survey, acclaimed science writers Paul Davies and John Gribbin provide a complete overview of advances in the study of physics that have revolutionized modern science. From the weird world of quarks and the theory of relativity to the latest ideas about the birth of the cosmos, the authors find evidence for a massive paradigm shift. Developments in the studies of black holes, cosmic strings, solitons, and chaos theory challenge commonsense concepts of space, time, and matter, (...) and demand a radically altered and more fully unified view of the universe. (shrink)

Paul Davies explains the significance of the amazing quantum universe, where fact is stranger than any science fiction. He takes us into a world where commonsense notions of space, time, and causality must be left behind as the realm of solid matter dissolves into vibrating patterns of ghostly energy, and where mind and matter are interwoven in a subtle and holistic manner. An Australian physicist and author of GOD AND THE NEW PHYSICS, Davies writes for the lay (...) reader in simple language. (shrink)

C. Stephen Layman contends that an argument supporting theism over naturalism can be constructed based on three defensible, non–question-begging premises about the moral order. Previous critics of Layman’s argument have challenged the truth of these premises. We stipulate them arguendo but go on to show that there is a deeper problem: a fourth premise introduced to complete the argument—the “completion premise,” as we call it—is true only if we assume that God exists or we concede that there is no afterlife. (...) We close with suggestions for how Layman’s argument must be strengthened to meet with dialectical success. (shrink)

A comparison of the literatures on how infants represent generic object classes, gender and race information in faces, and emotional expressions reveals both common and distinctive developments in the three domains. In addition, the review indicates that some very basic questions remain to be answered regarding how infants represent facial displays of emotion, including (a) whether infants form category representations for discrete classes of emotion, (b) when and how such representations come to incorporate affective meaning, (c) the developmental trajectory for (...) representation of emotional expression at different levels of inclusiveness (i.e., from broad to narrow or narrow to broad?), and (d) whether there is superior discrimination ability operating within more frequently experienced emotion categories. (shrink)

A comparison of the literatures on how infants represent generic object classes, gender and race information in faces, and emotional expressions reveals both common and distinctive developments in the three domains. In addition, the review indicates that some very basic questions remain to be answered regarding how infants represent facial displays of emotion, including (a) whether infants form category representations for discrete classes of emotion, (b) when and how such representations come to incorporate affective meaning, (c) the developmental trajectory for (...) representation of emotional expression at different levels of inclusiveness (i.e., from broad to narrow or narrow to broad?), and (d) whether there is superior discrimination ability operating within more frequently experienced emotion categories. (shrink)

Corporate social responsibility is a tortured concept. We review the current state of the art across a number of academic disciplines, from accounting to management to theology. In a world that is increasingly global and pluralistic, progress in our understanding of CSR must include theorizing around the micro-level processes practicing managers engage in when allocating resources toward social initiatives, as well as refined measurement of the outcomes of those initiatives on stakeholder and shareholder interests. Scholarship must also account for the (...) influence of diverse, and even maladaptive, stakeholders as well as more fully incorporate non-Western philosophical and economic perspectives. Based on this review, we pose five questions that scholars from each of these disciplines should address as the CSR field moves forward. We hope our questions provoke deeper thinking and greater rigor and attention to detail in this important area of business research. (shrink)

Over 90% of the organs transplanted in China before 2010 were procured from prisoners. Although Chinese officials announced in December 2014 that the country would completely cease using organs harvested from prisoners, no regulatory adjustments or changes in China’s organ donation laws followed. As a result, the use of prisoner organs remains legal in China if consent is obtained. We have collected and analysed available evidence on human rights violations in the organ procurement practice in China. We demonstrate that the (...) practice not only violates international ethics standards, it is also associated with a large scale neglect of fundamental human rights. This includes organ procurement without consent from prisoners or their families as well as procurement of organs from incompletely executed, still-living prisoners. The human rights critique of these practices will also address the specific situatedness of prisoners, often conditioned and traumatized by a cascade of human rights abuses in judicial structures. To end the unethical practice and the abuse associated with it, we suggest to inextricably bind the use of human organs procured in the Chinese transplant system to enacting Chinese legislation prohibiting the use of organs from executed prisoners and making explicit rules for law enforcement. Other than that, the international community must cease to abet the continuation of the present system by demanding an authoritative ban on the use of organs from executed Chinese prisoners. (shrink)

Corporate social responsibility is a tortured concept. We review the current state of the art across a number of academic disciplines, from accounting to management to theology. In a world that is increasingly global and pluralistic, progress in our understanding of CSR must include theorizing around the micro-level processes practicing managers engage in when allocating resources toward social initiatives, as well as refined measurement of the outcomes of those initiatives on stakeholder and shareholder interests. Scholarship must also account for the (...) influence of diverse, and even mal-adaptive, stakeholders as well as more fully incorporate non-Western philosophical and economic perspectives. Based on this review, we pose five questions that scholars from each of these disciplines should address as the CSR field moves forward. We hope our questions provoke deeper thinking and greater rigor and attention to detail in this important area of business research. (shrink)

Organ donation after brain death has been practiced in China since 2003 in the absence of brain death legislation. Similar to international standards, China’s brain death diagnostic criteria include coma, absence of brainstem reflexes, and the lack of spontaneous respiration. The Chinese criteria require that the lack of spontaneous respiration must be verified with an apnea test by disconnecting the ventilator for 8 min to provoke spontaneous respiration. However, we have found publications in Chinese medical journals, in which the donors (...) were declared to be brain dead, yet without an apnea test. The organ procurement procedures started with initiating “intratracheal intubation for mechanical ventilation after brain death,” indicating that a brain death diagnosis was not performed. The purpose of the intubation was not to resuscitate the patient but rather was directly related to facilitating the explantation of organs. Moreover, it was unmistakably stated in two of these publications that the cardiac arrest was induced in these patients without brain death determination by cold St. Thomas cardioplegic solution or other cold myocardial protection solutions. This means that the condition of these donors neither met the criteria of brain death nor that of cardiac death. In other words, the “donor organs” may well have been procured in these cases from living human beings. Thus, brain death definition is abused in China by some individuals for organ harvesting, and a systematic investigation is needed to clarify the situation of organ donation after brain death in China. (shrink)

There have been many claims that quantum mechanics plays a key role in the origin and/or operation of biological organisms, beyond merely providing the basis for the shapes and sizes of biological molecules and their chemical affinities. These range from Schr¨odinger’s suggestion that quantum fluctuations produce mutations, to Hameroff and Penrose’s conjecture that quantum coherence in microtubules is linked to consciousness. I review some of these claims in this paper, and discuss the serious problem of decoherence. I advance some further (...) conjectures about quantum information processing in bio-systems. Some possible experiments are suggested. © 2004 Elsevier Ireland Ltd. All rights reserved. (shrink)

Institute of Theoretical Astronomy, University of Cambridge, Cambridge, UK 3fS. received 28th August 1970, in final revised form 1st July 1971..

An inquiry into the nature of the universe draws out the implications of the quantum theory and argues that our universe is only one among many possible universes and that other universes may exist.

Recent advances in string theory and inflationary cosmology have led to a surge of interest in the possible existence of an ensemble of cosmic regions, or “universes”, among the members of which key physical parameters, such as the masses of elementary particles and the coupling constants, might assume different values. The observed values in our cosmic region are then attributed to an observer selection effect (the so-called anthropic principle). The assemblage of universes has been dubbed “the multiverse”. In this paper (...) we review the multiverse concept and the criticisms that have been advanced against it on both scientific and philosophical grounds. (shrink)

Paperback reissue of a book first published in 1991. The authors demonstrate how the materialistic and mechanistic world-view that has dominated western culture and science during the last few centuries is being challenged by the findings of modern physics, ranging from relativity to quantum physics. Includes a bibliography and an index. British-born, Davies is a well-known physicist and has written many other books including 'The Mind of God', winner of the 1992 Eureka Science Book Prize. He is currently professor (...) of mathematical physics at the University of Adelaide. Gribbin trained as an astrophysicist and is now a full-time science writer in Britain. (shrink)

The Unruh-Wald scenario for mining quantum black holes is applied to de Sitter space. The following questions are addressed: Will the generalized second law of thermodynamics be maintained for de Sitter horizons? Does the mining process allow the recovery of unlimited energy from the cosmological gravitational field? The evaporation of a black hole in de Sitter space is also investigated in the context of the second law.

It is widely accepted that EinstcinRi7;s general theory of relativity is an satisfactory description of gravity 0nly in the macroscopic limit, where quantum eiTcc1;s may be neglected. Presumably this theory is inapplicable at the Planck length, but recently much attention has been devoted to gravitational theory at intermediate length scales where quantum affects 0f matter are inescapable, but where there is an general assumption that the gravitational Held may bc treated as a classical background, augmented if necessary by quamtizcd linearized (...) pertur-. (shrink)

We study the response of a uniformly accelerated model particle detector in a spacetime with compact spatial sections. The basic thermal character of the response re-emerges, in spite of the fact that the spacetime does not possess event horizons. Our model also permits a study of detector response to twisted field states.

Paul C. Taylor provides an accessible guide to a well-travelled but still-mysterious area of the contemporary social landscape. The result is the first philosophical introduction to the field of race theory and to a non-biological and situational notion of race. Provides the first philosophical introduction to the field of race theory. Outlines the main features and implications of race-thinking; asks questions such as: What is race-thinking? Don’t we know better than to talk about race now? Are there any races? (...) What is it like to have a racial identity? Engages with the ideas of such important figures as Linda Alcoff, K. Anthony Appiah, W.E.B. Du Bois, Howard Winant, and Naomi Zack. Explores the enduring significance of race in relation to culture, personal relationships and social justice. (shrink)

The hypothesis that life’s rapid appearance on Earth justifies the belief that life is widespread in the universe has been investigated mathematically by Lineweaver and Davis (Astrobiol- ogy 2002;2:293–304). However, a rapid appearance could also be interpreted as evidence for a nonterrestrial origin. I attempt to quantify the relative probabilities for a non-indigenous ver- sus indigenous origin, on the assumption that biogenesis involves one or more highly im- probable steps, using a generalization of Carter’s well-known observer-selection argument. The analysis is (...) specifically applied to a Martian origin of life, with subsequent transfer to Earth within impact ejecta. My main result is that the relatively greater probability of a Mar- tian origin rises sharply as a function of the number of difficult steps involved in biogene- sis. The actual numerical factor depends on what is assumed about conditions on early Mars, but for a wide range of assumptions a Martian origin of life is decisively favored. By con- trast, an extrasolar origin seems unlikely using the same analysis. These results complement those of Lineweaver and Davis. Key Words: Origin of life—Mars—Probability theory— Carter—Transpermia. Astrobiology 3, 673–679. (shrink)

The fine structure constant α ≡ e2/ c ≈ 1/137 is one of the fundamental parameters of the standard model of particle physics. There is a long history of attempts to derive the measured value of α from an underlying theory, or exhibit it in the form of a compact mathematical expression [2–4, 6, 8, 14–16]. The most significant advance in this endeavour was made by Dirac, who showed that if magnetic monopoles exist, with magnetic charge μ, then..

Using a model quantum clock, I evaluate an expression for the time of a nonrelativistic quantum particle to transit a piecewise geodesic path in a background gravitational field with small spacetime curvature (gravity gradient), in the case that the apparatus is in free fall. This calculation complements and extends an earlier one (Davies 2004) in which the apparatus is fixed to the surface of the Earth. The result confirms that, for particle velocities not too low, the quantum and classical (...) transit times coincide, in conformity with the principle of equivalence. I also calculate the quantum corrections to the transit time when the de Broglie wavelengths are long enough to probe the spacetime curvature. The results are compared with the calculation of Chiao and Speliotopoulos (2003), who propose an experiment to measure the foregoing effects. (shrink)

The massless Thirring model of a self-interacting ferinion field in a curved two-dimensional background spacetime is considered. The exact operator solution for the fields and the equation for the two-point function are given and used to examine the radiation emitted by a two-dimensional black hole. The radiation is found to be thermal in nature, confirming general predictions to this effect. We compute the particle spectrum of the Thirring fermions at finite temperature in Minkowski space and point out errors in a (...) previous attempt at this calculation. Finally we calculate the vacuum expectation value of the stress tensor in an arbitrary two-dimensional spacetime by exploiting the connection between the thermal Hawking radiation from a black hole and the value of the so-called conformal trace anomaly. The latter is also computed quite independently, using dimensional regularization, from general considerations of the renormalization group. (shrink)

of a logarithmic time dependence of the fine structure constant is apparently within the limits discussed if there is a corresponding logarithmic time dependence of the strong coupling constant also. Moreover the recent discover> of naturally occurring ' Pu places the Gamow hypothesis of e' r much nearer the allov'able limits than had previously been supposed.

We discuss the Starobinskii-Unruh process for the Kerr black hole. We show how this effect is related to the theory of squeezed states. We then consider a simple model for a highly relativistic rotating star and show that the Starobinskii-Unruh effect is absent.

An analogue of Hawking's black hole area theorem is proved for Friedmann-type cosmological models with event horizons. The generalised second law of thermodynamics is investigated in cases where the horizon shrinks.