Results for 'Julio R. Tuma'

1000+ found
Order:
  1.  24
    Biological Boundaries and the Vertebrate Immune System.Julio R. Tuma - 2009 - Biological Theory 4 (3):287-293.
    Biological boundaries are important because of what they reveal about the evolution of a lineage, the relationship between organisms of different lineages, the structure and function of particular subsystems of the organism, the interconnection between an organism and its environment, and a myriad of other important issues related to individuality, development, and evolution. Since there is no single unifying theory for all biological sciences, there are various possible theoretical characterizations of what counts as a biological boundary. Theoretical specificity is crucial (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  2.  33
    Nanoethics and the Breaching of Boundaries: A Heuristic for Going from Encouragement to a Fuller Integration of Ethical, Legal and Social Issues and Science: Commentary on: “Adding to the Mix: Integrating ELSI into a National Nanoscale Science and Technology Center”. [REVIEW]Julio R. Tuma - 2011 - Science and Engineering Ethics 17 (4):761-767.
    The intersection of ELSI and science forms a complicated nexus yet their integration is an important goal both for society and for the successful advancement of science. In what follows, I present a heuristic that makes boundary identification and crossing an important tool in the discovery of potential areas of ethical, legal, and social concern in science. A dynamic and iterative application of the heuristic can lead towards a fuller integration and appreciation of the concerns of ELSI and of science (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  3.  31
    Nanoethics in a Nanolab: Ethics via Participation. [REVIEW]Julio R. Tuma - 2013 - Science and Engineering Ethics 19 (3):983-1005.
    A participant–observer who is both informed and interested in ethical issues, and is embedded within a nanotechnology research and development facility may be able to influence the ethical awareness of researchers in nanotechnology, and tease out the societal implications of the work being conducted. Two inter-disciplinary methods were employed: (1) regular involvement in the technical and scientific research at the facility by the participant–observer, and (2) repeated interactions and discussions between the participant–observer and the scientists. As a result of this (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  4.  44
    Integrando la Ciencia y la Sociedad a través de la Investigación Socio-Ecológica de Largo Plazo.Christopher B. Anderson, Gene E. Likens, Ricardo Rozzi, Julio R. Gutiérrez, Juan J. Armesto & Alexandria Poole - 2008 - Environmental Ethics 30 (9999):81-99.
    La investigación ecológica a largo plazo (Long Term Ecological Research, LTER) maneja problemas que abarcan décadas o plazos más largos. El programa y su nombre formal comenzaron en Estados Unidos en 1980. Si bien los estudios y observaciones a largo plazo comenzaron tempranamente en 1400 y 1800 en Asia y Europa, respectivamente, el enfoque a largo plazo no se formalizó sino hasta el establecimiento de los programas de investigación ecológica de largo plazo en Estados Unidos. Estos programas han permitido experimentos (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark  
  5.  45
    Integrando la Ciencia y la Sociedad a través de la Investigación Socio-Ecológica de Largo Plazo.Christopher B. Anderson, Gene E. Likens, Ricardo Rozzi, Julio R. Gutiérrez & Juan J. Armesto - 2008 - Environmental Ethics 30 (3):81-99.
    La investigación ecológica a largo plazo (Long Term Ecological Research, LTER) maneja problemas que abarcan décadas o plazos más largos. El programa y su nombre formal comenzaron en Estados Unidos en 1980. Si bien los estudios y observaciones a largo plazo comenzaron tempranamente en 1400 y 1800 en Asia y Europa, respectivamente, el enfoque a largo plazo no se formalizó sino hasta el establecimiento de los programas de investigación ecológica de largo plazo en Estados Unidos. Estos programas han permitido experimentos (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark  
  6.  11
    Integrando la Ciencia y la Sociedad a través de la Investigación Socio-Ecológica de Largo Plazo.Christopher B. Anderson, Gene E. Likens, Ricardo Rozzi, Julio R. Gutiérrez, Juan J. Armesto & Alexandria Poole - 2008 - Environmental Ethics 30 (9999):81-99.
    La investigación ecológica a largo plazo (Long Term Ecological Research, LTER) maneja problemas que abarcan décadas o plazos más largos. El programa y su nombre formal comenzaron en Estados Unidos en 1980. Si bien los estudios y observaciones a largo plazo comenzaron tempranamente en 1400 y 1800 en Asia y Europa, respectivamente, el enfoque a largo plazo no se formalizó sino hasta el establecimiento de los programas de investigación ecológica de largo plazo en Estados Unidos. Estos programas han permitido experimentos (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  7. Indice Del volumen XXXVII.Octavio N. Derisi, Carlos I. Massini, William R. Daros, Alberto Caturelli, Juan Cruz Cruz, Alfonso Garcia Marques, Mauricio Beuchot-Jose, Jaime Guerrero, Juan A. Casaubon & Julio R. Mendez - 1982 - Sapientia 143:319.
    No categories
     
    Export citation  
     
    Bookmark  
  8. Count on dopamine: influences of COMT polymorphisms on numerical cognition.Annelise Júlio-Costa, Andressa M. Antunes, Júlia B. Lopes-Silva, Bárbara C. Moreira, Gabrielle S. Vianna, Guilherme Wood, Maria R. S. Carvalho & Vitor G. Haase - 2013 - Frontiers in Psychology 4.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  9.  38
    A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington’s Disease.Filipa Júlio, Maria J. Ribeiro, Miguel Patrício, Alexandre Malhão, Fábio Pedrosa, Hélio Gonçalves, Marco Simões, Marieke van Asselen, Mário R. Simões, Miguel Castelo-Branco & Cristina Januário - 2019 - Frontiers in Psychology 10.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  10.  13
    Research with victims of disaster: institutional review board considerations.Lauren K. Collogan, Farris K. Tuma & Alan R. Fleischman - 2003 - IRB: Ethics & Human Research 26 (4):9-11.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  11.  15
    Did Kant have to combine thesis and antithesis of the third antinomy in 'Kritik der reinen Vernunft'.Julio C. R. Esteves - 2004 - Kant Studien 95 (2):146-170.
  12.  36
    Mußte Kant Thesis und Antithesis der dritten Antinomie der Kritik der reinen Vernunft vereinbaren?Julio C. R. Esteves - 2004 - Kant Studien 95 (2):146-170.
    No categories
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  13. Analisys of induction generators application in a distribution system.Júlio C. C. Ferreira, João A. Moor Neto, Diogo R. Costa Jr, Edson H. Watanabe & Luís G. B. Rolim - 2004 - Complexity 1:2.
    No categories
     
    Export citation  
     
    Bookmark  
  14.  27
    The Promise and Reality of Public Engagement in the Governance of Human Genome Editing Research.John M. Conley, R. Jean Cadigan, Arlene M. Davis, Eric T. Juengst, Kriste Kuczynski, Rami Major, Hayley Stancil, Julio Villa-Palomino, Margaret Waltz & Gail E. Henderson - 2023 - American Journal of Bioethics 23 (7):9-16.
    This paper analyses the activities of five organizations shaping the debate over the global governance of genome editing in order to assess current approaches to public engagement (PE). We compare the recommendations of each group with its own practices. All recommend broad engagement with the general public, but their practices vary from expert-driven models dominated by scientists, experts, and civil society groups to citizen deliberation-driven models that feature bidirectional consultation with local citizens, as well as hybrid models that combine elements (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   16 citations  
  15.  30
    Avian Emotions: Comparative Perspectives on Fear and Frustration.Mauricio R. Papini, Julio C. Penagos-Corzo & Andrés M. Pérez-Acosta - 2019 - Frontiers in Psychology 9:433390.
    Emotions are complex reactions that allow individuals to cope with significant positive and negative events. Research on emotion was pioneered by Darwin’s (1871) work on emotional expressions in humans and animals. But Darwin was concerned mainly with facial and bodily expressions of significance for humans, citing mainly examples from mammals (e.g., apes, dogs, and cats). In birds, emotional expressions are less evident for a human observer, so a different approach is needed. Understanding avian emotions will provide key evolutionary information on (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  16.  7
    Introducción al derecho: conocimiento y conocimiento científico historia de las ideas jurídicas teoría general del derecho teoría general aplicada.Enrique R. Aftaliâon, Josâe Vilanova & Julio C. Raffo - 1994 - Buenos Aires: Abeledo-Perrot. Edited by José Vilanova & Julio C. Raffo.
    Direct download  
     
    Export citation  
     
    Bookmark  
  17.  17
    The complexity of CTBT verification. Taking noble gas monitoring as an example.Martin B. Kalinowski, Andreas Becker, Paul R. J. Saey, Matthias P. Tuma & Gerhard Wotawa - 2008 - Complexity 14 (1):89-99.
    No categories
    Direct download  
     
    Export citation  
     
    Bookmark  
  18. Gargalhada da dôr.Julio] Cesar - 1933 - Rio: [de Janeiro] Papelaria Sul America.
    No categories
     
    Export citation  
     
    Bookmark  
  19.  20
    Decrease in Attentional Performance After Repeated Bouts of High Intensity Exercise in Association-Football Referees and Assistant Referees.Sergio L. Schmidt, Guilherme J. Schmidt, Catarina S. Padilla, Eunice N. Simões, Julio C. Tolentino, Paulo R. Barroso, Jorge H. Narciso, Erik S. Godoy & Rubens L. Costa Filho - 2019 - Frontiers in Psychology 10.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  20. Hacia una noción de interpretación en la ciencia: anotaciones críticas al planteamiento de N. R. Hanson.Julio Horta - 2016 - Interpretatio. Revista de Hermenéutica 1 (2): 89-118.
    Abstract: In the present work we have made a critical review of the philosophical propo­ sal of Norwood R. Hanson with the aim of exposing the limits of its theoretical approach on the problem of interpretation in science. The first part of this work exposes the hansonian project, looking for evidence of his contributions to the philosophy of science and scientific thinking. In the following two sections we present a critique to his philosophical proposal. We present two exercises of philosophical (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
  21. Color-Coded Epistemic Modes in a Jungian Hexagon of Opposition.Julio Michael Stern - 2022 - In Jean-Yves Beziau & Ioannis Vandoulakis (eds.), The Exoteric Square of Opposition. Birkhauser.
    This article considers distinct ways of understanding the world, referred to in psychology as Functions of Consciousness or as Cognitive Modes, having as the scope of interest epistemology and natural sciences. Inspired by C.G. Jung's Simile of the Spectrum, we consider three basic cognitive modes associated to: (R) embodied instinct, experience, and action; (G) reality perception and learning; and (B) concept abstraction, rational thinking, and language. RGB stand for the primary colors: red, green, and blue. Accordingly, a conceptual map between (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  22.  8
    Hitchcock entre Zizek y Aristóteles.Julio Cabrera - 2002 - Signos Filosóficos 8:135-146.
    In this paper I manage a set of categories and intended to integratethem as a method to analyze film images in a conceptual level. I try anapplication of this methodological tool in the particular case of AlfredHitchcock’s Vertigo, which I consider as an image-concept of the untruthfulcharacter of r..
    Direct download  
     
    Export citation  
     
    Bookmark  
  23. Color-Coded Epistemic Modes in a Jungian Hexagon of Opposition.Julio Michael Stern - 2022 - In Jean-Yves Beziau & Ioannis Vandoulakis (eds.), The Exoteric Square of Opposition. Birkhauser. pp. 303-332.
    This article considers distinct ways of understanding the world, referred to in psychology as functions of consciousness or as cognitive modes, having as the scope of interest epistemology and natural sciences. Inspired by C.G. Jung’s simile of the spectrum, we consider three basic cognitive modes associated to: (R) embodied instinct, experience, and action; (G) reality perception and learning; and (B) concept abstraction, rational thinking, and language. RGB stand for the primary colors: red, green, and blue. Accordingly, a conceptual map between (...)
    No categories
    Direct download  
     
    Export citation  
     
    Bookmark   1 citation  
  24. Cybersemiotics and Epistemology: a critical review of the conditions of “observation” from Transcendental Semiotics.Julio Horta - manuscript
    This chapter aims to establish a philosophical discussion about the epistemological conditions of “observation”, from the cybersemiotic transdisciplinary view of knowing. For this purpose, the discussion will be divided into three parts, each one of them with the intention of outlining a conceptual critique that later allows a pertinent justification of the observation from a transcendental semiotics. This work is based on a problem: it seeks to show that a the cybersemiotic point of view, to consider on a foundationalist stance, (...)
     
    Export citation  
     
    Bookmark  
  25.  8
    Cybersemiotics and Epistemology: A Critical Review of the Conditions of “Observation” from Transcendental Semiotics.Julio Horta - 2021 - In Carlos Vidales & Søren Brier (eds.), Introduction to Cybersemiotics: A Transdisciplinary Perspective. Springer Verlag. pp. 399-420.
    This chapter aims to establish a philosophical discussion about the epistemological conditions of “observation”, from the cybersemiotic transdisciplinary view of knowing. For this purpose, the discussion will be divided into three parts, each one of them with the intention of outlining a conceptual critique that later allows a pertinent justification of the observation from a transcendental semiotics. This work is based on a problem: it seeks to show that a the cybersemiotic point of view, to consider on a foundationalist stance, (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
  26.  14
    Husserl, E. (2020). Introducción a la ética. (M. Chu, M. Crespo & L. R. Rabanaque, Eds.). Trotta.Julio César Vargas Bejarano - 2022 - Estudios de Filosofía (Universidad de Antioquia) 67:173-179.
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  27.  7
    “Red-Green” or “Brown-Green” Dichromats? The Accuracy of Dichromat Basic Color Terms Metacognition Supports Denomination Change.Humberto Moreira, Julio Lillo & Leticia Álvaro - 2021 - Frontiers in Psychology 12.
    Two experiments compared “Red-Green” dichromats’ empirical and metacognized capacities to discriminate basic color categories and to use the corresponding basic color terms. A first experiment used a 102-related-colors set for a pointing task to identify all the stimuli that could be named with each BCT by each R-G dichromat type. In a second experiment, a group of R-G dichromats estimated their difficulty discriminating BCCs-BCTs in a verbal task. The strong coincidences between the results derived from the pointing and the verbal (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  28.  8
    El contenido no conceptual y la necesidad del esquematismo.Álvaro Julio Peláez Cedrés - 2020 - Tópicos: Revista de Filosofía 60:351-374.
    The contemporary debate that discusses whether the content of perceptual experience is or not conceptual claims I. Kant as its precursor. Surprisingly, both contenders in this debate do so. The Kantian non conceptualists, R. Hanna and L. Allais, among others, have support their arguments on Kant´s insistence on clearly separating intuitions and concepts and the faculties that make them possible, sensibility and understanding in order to emphasize that, once divided according to their functions, it makes sense to think that experience (...)
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  29.  7
    RESEÑA de : Lloyd, G.E.R. Cognitive variations : reflections on the unity and diversity of the human mind. Clarendon, 2006. [REVIEW]Julio César Armero Sanjosé - 2009 - Endoxa 23:377.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  30. MÉNDEZ, RAÚL JULIO: El amor fundamento de la participación metafísica: Hermenéutica de la "Summa contra gentiles".A. P. G. R. - 1992 - Pensamiento 48 (189/192):497-499.
    No categories
     
    Export citation  
     
    Bookmark  
  31.  25
    Construction of monadic three-valued łukasiewicz algebras.Luiz Monteiro, Sonia Savini & Julio Sewald - 1991 - Studia Logica 50 (3-4):473 - 483.
    The notion of monadic three-valued ukasiewicz algebras was introduced by L. Monteiro ([12], [14]) as a generalization of monadic Boolean algebras. A. Monteiro ([9], [10]) and later L. Monteiro and L. Gonzalez Coppola [17] obtained a method for the construction of a three-valued ukasiewicz algebra from a monadic Boolea algebra. In this note we give the construction of a monadic three-valued ukasiewicz algebra from a Boolean algebra B where we have defined two quantification operations and * such that *x=*x (where (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark  
  32.  9
    Significado lingüístico. Verdad y validez normativa: La fuerza social vinculante del habla a la luz de una pragmática trascendental del lenguaje.Karl Otto Apel & Julio De Zan - 1994 - Tópicos 2:7-57.
    I. Introducción: el horizonte verificacionista de la explicación del significado de las oraciones constatativas en la filosofía analítica del lenguaje.II. La aporética de la explicación verificacionista del significado en la filosofía analítica del lenguaje.II. 1. Explicación del significado ilocucionario de las oraciones o actos de habla no constatativos en los términos de "condiciones de realización". -Sobre la aporética del paradigma verificacionista en P. Strawson.II. 2. Explicación del significado ilocucionario de las oraciones o de los actos de habla no constatativos en (...)
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  33.  27
    A Prosopography of Julio–Claudian Equites.A. R. Birley - 1994 - The Classical Review 44 (01):126-.
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  34. Reivindicación Del gusto: Sujeto, experiencia estética Y recepción literaria signos filosóficos, Julio-diciembre, año/vol. VII, número 014 universidad autónoma metropolitana-iztapalapa distrito federal, méxico.R. Eivindicación Del Gusto - 2005 - Signos Filosóficos 7 (14):45-71.
    No categories
     
    Export citation  
     
    Bookmark  
  35. Replies to De Rizzo & Schnieder, Tegtmeier and Vallicella.Bo R. Meinertsen - 2022 - Philosophia 51 (1):437-447.
    In this piece I respond to commentaries by Julio De Rizzo & Benjamin Schnieder, Erwin Tegtmeier and William Vallicella on my book Metaphysics of States of Affairs (Springer, 2018).
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  36.  43
    Symbolae ad Jus et Historiam Antiquitatis pertinentes Julio Christiana van Oven Dedicatae . Ediderunt M. David, B. A. Van Groningen, E. M. Meijers. Pp. viii+ 410; portrait, 4 plates. Leiden: Brill, 1946. Cloth, 26 g. [REVIEW]R. W. Lee - 1947 - The Classical Review 61 (3-4):130-131.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  37.  18
    Comtismo, Castilhismo, and Varguismo: Anatomy of a Brazilian Creed.Jens R. Hentschke - 2021 - Locus: Revista de Hist 27 (2):245-287.
    The author argues that polity and policies of Getúlio Vargas’s Estado Novo cannot be fully understood without exploring the legacy of Rio Grande do Sul. The southern state’s first republican governor, Júlio de Castilhos, had taken inspiration in Auguste Comte’s multifaceted political philosophy and inculcated its authoritarian traits into political institutions. Yet, he and his followers substantially adapted Comte’s positivism to the specific economic and political circumstances in their republiqueta sui generis. In contrast to Comte, the State merged temporal and (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
  38.  50
    A Prosopography of Julio–Claudian Equites Ségolène Demougin: Prosopographie des Chevaliers Romains Julio–Claudiens (43 av. J.–C.—70 ap. J.–C). (Collection de ľÉcole Française de Rome, 153.) Pp. 715. Rome: École Française de Rome, 1992. Paper. [REVIEW]A. R. Birley - 1994 - The Classical Review 44 (01):126-127.
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  39.  23
    Inversión E invención de imágenes Y espejos: El “poeticismo” romántico de Julio cortázar en su narrativa breve a la Luz de imagen de John keats. [REVIEW]Emilio R. Báez Rivera - 2004 - Alpha (Osorno) 20.
    No categories
    Direct download  
     
    Export citation  
     
    Bookmark  
  40. JULIO R. MÉNDEZ: El amor, fundamento de la participación metafísica. Hermenéutica de la Summa contra Gentiles. [REVIEW]Octavio N. Derisi - 1990 - Sapientia 45 (77):239.
    No categories
     
    Export citation  
     
    Bookmark  
  41.  14
    Lo fantástico en Los cuentos de Julio R. ribeyro.Ewald Weitzdörfer - 2008 - Alpha (Osorno) 26.
    No categories
    Direct download  
     
    Export citation  
     
    Bookmark  
  42.  48
    M. K. and R. L. Thornton: Julio-Claudian Building Programs: a Quantitative Study in Political Management. Pp. xvii + 156; 25 illustrations. Wauconda, ILL: Bolchazy–Carducci, 1989. £24.00. [REVIEW]T. P. Wiseman - 1991 - The Classical Review 41 (1):255-256.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  43.  57
    Discurso de Julio Michael Stern por Ocasiao da Posse da cadeira 18 da Academia Brasileira de Filosofia.Julio Michael Stern - 2023 - In Edgard Leite (ed.), 200 Anos de Independencia e 33 mos de Academia Brasileira de Filosofia. FAPERJ. pp. 211-224.
    Inauguration speech at chair number 18 of the Brasilian Academy of Philosophy.
    Direct download  
     
    Export citation  
     
    Bookmark  
  44. Dynamic Oppositional Symmetries for Color, Jungian and Kantian Categories.Julio Michael Stern - manuscript
    This paper investigates some classical oppositional categories, like synthetic vs. analytic, posterior vs. prior, imagination vs. grammar, metaphor vs. hermeneutics, metaphysics vs. observation, innovation vs. routine, and image vs. sound, and the role they play in epistemology and philosophy of science. The epistemological framework of objective cognitive constructivism is of special interest in these investigations. Oppositional relations are formally represented using algebraic lattice structures like the cube and the hexagon of opposition, with applications in the contexts of modern color theory, (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  45.  6
    Elementos del pensamiento crítico.Julio César Herrero - 2018 - Madrid: Marcial Pons.
    No categories
    Direct download  
     
    Export citation  
     
    Bookmark  
  46. One monk, one donkey, one dead man : contexts for a homicide in a tenth-century Sahagún Charter.Julio Escalona - 2023 - In Isabel Alfonso Antón, José M. Andrade & André Evangelista Marques (eds.), Records and processes of dispute settlement in early medieval societies: Iberia and beyond. Boston: Brill.
     
    Export citation  
     
    Bookmark  
  47.  2
    Yoga e Montessori: perspectivas humanas.Júlio Maran - 1975 - São Paulo: Edições Loyola.
    Direct download  
     
    Export citation  
     
    Bookmark  
  48. De Lamennais a Maritain.Julio Meinvielle - 1967 - Buenos Aires,: Ediciones Theoría.
    No categories
     
    Export citation  
     
    Bookmark  
  49.  9
    Un progresismo vergonzante.Julio Meinvielle - 1967 - [Buenos Aires?]: Cruz y Fierro.
    Direct download  
     
    Export citation  
     
    Bookmark  
  50.  2
    El lenguaje de la física y su peculiar filosofía.Julio Palacios - 1953 - Madrid,: Real Academia Española. Edited by Rafael Estrada Y. Arnáiz.
    Direct download  
     
    Export citation  
     
    Bookmark  
1 — 50 / 1000