Meiosis is the process by which diploid germ cells divide to produce haploid gametes for sexual reproduction. The process is highly conserved in eukaryotes, however the recent availability of mouse models for meiotic recombination has revealed surprising regulatory differences between simple unicellular organisms and those with increasingly complex genomes. Moreover, in these higher eukaryotes, the intervention of physiological and sex-specific factors may also influence how meiotic recombination and progression are monitored and regulated. This review will focus on the recent studies (...) involving mouse mutants for meiosis, and will highlight important differences between traditional model systems for meiosis (such as yeast) and those involving more complex cellular, physiological and genetic criteria. BioEssays 23:996–1009, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Given the Sellarsian distinction between the space of causes and the space of reasons, the naturalist seeks to articulate how these two spaces are unproblematically related. In Mind and World (1996) John McDowell suggests that such a naturalism can be achieved by pointing out that we work our way into the space of reasons by the process of upbringing he calls Bildung. 'The resulting habits of thought and action', writes McDowell, 'are second nature' (p. 84). In this paper I (...) expose one implication of this remark, namely, that Bildung naturalism requires a conception of a type of action which is at once rational and habitual. Current orthodoxies in the philosophy of action prevent these two features from easily co-existing. Whilst various reconciliations are possible, I argue that only one keeps Bildung naturalism intact. This, however, commits the naturalist to a conception of reasons more radically external than any to be found in current literature, according to which the agent need have no conception of what her reasons are at the time of acting. This is what I call acting in the dark of reasons. One upshot for McDowell is that this conception of reasons may be in tension with some of his other claims. (shrink)

We mathematical animals should be grateful that mathematics is instrumentally useful. We should not, however, forget its other contributions to human happiness. Bertrand Russell and John Dewey offer timely reminders that provide insight into the role of non-mathematicians in the evaluation of mathematics.

ABSTRACT A review of Songs of Nature, a study by John Sallis of the landscapes of the modern Chinese artist Cao Jun, with philosophical emphases on the notion of landscape, this analysis widens out to a relevance to all creative work. It homes in on the comparative or intercultural overlap between Western and Eastern traditions. as well as that between painting and music and the other senses. The focus is on the elemental. Art is at base a return to (...) nature with earth and sky as the horizons of what it means to be human. (shrink)

The SRL of King is a sound, complete and decidable logic designed specifically to support formalisms for the HPSG of Pollard and Sag. The SRL notion of modellability in a signature is particularly important for HPSG, and the present paper modifies an elegant method due to Blackburn and Spaan in order to prove that – modellability in each computable signature is 1 0 – modellability in some finite signature is 1 0 -hard, and – modellability in some finite signature (...) is decidable. (shrink)

_ Source: _Volume 46, Issue 1, pp 117 - 134 This essay attends to both the critical and poetic work of David Pollard. In so doing, it not only engages the works themselves, but also allows the contours of such an engagement to manifest themselves, both with regards to the works at hand and more broadly. What does reading and thinking with Pollard give us to experience about reading and thinking as such?

CarloCellucci. Rethinking Knowledge: The Heuristic View. Cham, Switzerland: Springer International Publishing, 2017. ISBN 978-3-319-53236-3, 978-3-319-53237-0. Pp. xx + 428††.

Though the revised edition of A Theory of Justice, published in 1999, is the definitive statement of Rawls's view, so much of the extensive literature on Rawls's theory refers to the first edition. This reissue makes the first edition once again available for scholars and serious students of Rawls's work.

John MacFarlane explores how we might make sense of the idea that truth is relative. He provides new, satisfying accounts of parts of our thought and talk that have resisted traditional methods of analysis, including what we mean when we talk about what is tasty, what we know, what will happen, what might be the case, and what we ought to do.

For this second edition, the editors have returned to Austin's original lecture notes, amending the printed text where it seemed necessary.

Much as we would like to conceive empirical thought as rationally grounded in experience, pitfalls await anyone who tries to articulate this position, and ...

In a finitary closure space, irreducible sets behave like two-valued models, with membership playing the role of satisfaction. If f is a function on such a space and the membership of in an irreducible set is determined by the presence or absence of the inputs in that set, then f is a kind of truth function. The existence of some of these truth functions is enough to guarantee that every irreducible set is maximally consistent. The closure space is then said (...) to be expressive. This paper identifies the two-valued truth functional conditions that guarantee expressiveness. (shrink)

What psychological and philosophical significance should we attach to recent efforts at computer simulations of human cognitive capacities? In answering this question, I find it useful to distinguish what I will call "strong" AI from "weak" or "cautious" AI. According to weak AI, the principal value of the computer in the study of the mind is that it gives us a very powerful tool. For example, it enables us to formulate and test hypotheses in a more rigorous and precise fashion. (...) But according to strong AI, the computer is not merely a tool in the study of the mind; rather, the appropriately programmed computer really is a mind, in the sense that computers given the right programs can be literally said to. (shrink)

Normative requirements are often overlooked, but they are central features of the normative world. Rationality is often thought to consist in acting for reasons, but following normative requirements is also a major part of rationality. In particular, correct reasoning – both theoretical and practical – is governed by normative requirements rather than by reasons. This article explains the nature of normative requirements, and gives examples of their importance. It also describes mistakes that philosophers have made as a result of confusing (...) normative requirements with reasons. (shrink)

This essay shows that some recent work by George Weaver can be reformulated in an especially perspicuous way within the theory of closure systems. Closure theoretic generalizations of some theorems of Robert Goldblatt are presented. And, more generally, the relation between closure systems and the deducibility relations of Goldblatt is explored.

This book is the one to put into the hands of those who have been over-impressed by Austin 's critics....[Warnock's] brilliant editing puts everybody who is concerned with philosophical problems in his debt.

This new edition of the classic Contemporary Theories of Knowledge has been significantly updated to include analyses of the recent literature in epistemology.

Say that a property is topological if and only if it is invariant under homeomorphism. Homeomorphism would be a successful criterion for the equivalence of logical systems only if every logically significant property of every logical system were topological. Alas, homeomorphisms are sometimes insensitive to distinctions that logicians value: properties such as functional completeness are not topological. So logics are not just devices for exploring closure topologies. One still wonders, though, how much of logic is topological. This essay examines some (...) logically significant properties that are topological (or are topological in some important class). In the process, we learn something about the conditions under which the meaning of a connective can be "given by the connective's role in inference.". (shrink)

The expressive truth functions of two-valued logic have all been identified. This paper begins the task of identifying the expressive truth functions of n-valued logic by characterizing the unary ones. These functions have distinctive algebraic, semantic, and closure-theoretic properties.

This study provides a comprehensive reinterpretation of the meaning of Locke's political thought. John Dunn restores Locke's ideas to their exact context, and so stresses the historical question of what Locke in the Two Treatises of Government was intending to claim. By adopting this approach, he reveals the predominantly theological character of all Locke's thinking about politics and provides a convincing analysis of the development of Locke's thought. In a polemical concluding section, John Dunn argues that liberal and (...) Marxist interpretations of Locke's politics have failed to grasp his meaning. Locke emerges as not merely a contributor to the development of English constitutional thought, or as a reflector of socio-economic change in seventeenth-century England, but as essentially a Calvinist natural theologian. (shrink)

This is a selection of essays on moral responsibility that represent the major components of John Martin Fischer's overall approach to freedom of the will and moral responsibility. The collection exhibits the overall structure of Fischer's view and shows how the various elements fit together to form a comprehensive framework for analyzing free will and moral responsibility. The topics include deliberation and practical reasoning, freedom of the will, freedom of action, various notions of control, and moral accountability. The essays (...) seek to provide a foundation for our practices of holding each other (and ourselves) morally and legally accountable for our behavior. A crucial move is the distinction between two kinds of control. According to Fischer, "regulative control" involves freedom to choose and do otherwise ("alternative possibilities"), whereas "guidance control" does not. Fischer contends that guidance control is all the freedom we need to be morally responsible agents. Further, he contends that such control is fully compatible with causal determinism. Additionally, Fischer argues that we do not need genuine access to alternative possibilities in order for there to be a legitimate point to practical reasoning. Fischer's overall framework contains an argument for the contention that guidance control, and not regulative control, is associated with moral responsibility, a sketch of a comprehensive theory of moral responsibility (that ties together responsibility for actions, omissions, consequences, and character), and an account of the value of moral responsibility. On this account, the value of exhibiting freedom (of the relevant sort) and thus being morally responsible for one's behavior is a species of the value of artistic self-expression. (shrink)

John Hyman explores central problems in philosophy of action and the theory of knowledge, and connects these areas of enquiry in a new way. His approach to the dimensions of human action culminates in an original analysis of the relation between knowledge and rational behaviour, which provides the foundation for a new theory of knowledge itself.

This anthology is a thorough introduction to classic literature for those who have not yet experienced these literary masterworks. For those who have known and loved these works in the past, this is an invitation to reunite with old friends in a fresh new format. From Shakespeare's finesse to Oscar Wilde's wit, this unique collection brings together works as diverse and influential as The Pilgrim's Progress and Othello. As an anthology that invites readers to immerse themselves in the masterpieces of (...) the literary giants, it is must-have addition to any library. (shrink)

John Stuart Mill's Utilitarianism is one of the most important, controversial, and suggestive works of moral philosophy ever written. Mill defends the view that all human action should produce the greatest happiness overall, and that happiness itself is to be understood as consisting in "higher" and "lower" pleasures. This volume uses the 1871 edition of the text, the last to be published in Mill's lifetime. The text is preceded by a comprehensive introduction assessing Mill's philosophy and the alternatives to (...) utilitarianism, and discussing some of the specific issues Mill raises in Utilitarianism. (shrink)

BackgroundCurrent guidelines do not clearly outline when assent should be attained from paediatric research participants, nor do they detail the necessary elements of the assent process. This stems from the fact that the fundamental justification behind the concept of assent is misunderstood. In this paper, we critically assess three widespread ethical arguments used for assent: children’s rights, the best interests of the child, and respect for a child’s developing autonomy. We then outline a newly-developed two-fold justification for the assent process: (...) respect for the parent’s pedagogical role in teaching their child to become an autonomous being and respect for the child’s moral worth.DiscussionWe argue that the ethical grounding for the involvement of young children in medical decision-making does not stem from children’s rights, the principle of best interests, or respect for developing autonomy. An alternative strategy is to examine the original motivation to engage with the child. In paediatric settings there are two obligations on the researcher: an obligation to the parents who are responsible for determining when and under what circumstances the child develops his capacity for autonomy and reasoning, and an obligation to the child himself. There is an important distinction between respecting a decision and encouraging a decision. This paper illustrates that the process of assent is an important way in which respect for the child as an individual can be demonstrated, however, the value lies not in the child’s response but the fact that his views were solicited in the first place.SummaryThis paper demonstrates that the common justifications for the process of assent are incomplete. Assent should be understood as playing a pedagogical role for the child, helping to teach him how specific decisions are made and therefore helping him to become a better decision-maker. How the researcher engages with the child supports his obligation to the child’s parents, yet why the researcher engages with the child stems from the child’s moral worth. Treating a child as having moral worth need not mean doing what they say but it may mean listening, considering, engaging or involving them in the decision. (shrink)

"A modern classic. Dewey's lectures have lost none of their vigor...The historical approach, which underlay the central argument, is beautifully exemplified in his treatments of the origin of philosophy."-- Philosophy and Phenomenological Research "It was with this book that Dewey fully launched his campaign for experimental philosophy."-- The New Republic Written by an eminent philosopher shortly after the shattering effects of World War I, this volume offers an insightful introduction to the concept of pragmatic humanism. Dewey presents persuasive arguments against (...) traditional philosophical constructs, suggesting their basis in self-justification. He proposes, instead, an examination of core values in terms of their ultimate effects on the self and others. This experimental philosophy was received with both outrage and acclaim for daring to mingle ethics and science. Delivered in 1919 as a series of lectures, Dewey's landmark work appears here in an enlarged edition that features an informative introduction by the author, written more than 25 years after the book's initial publication. (shrink)

This is a new revised version of Dr. Laslett's standard edition of Two Treatises. First published in 1960, and based on an analysis of the whole body of Locke's publications, writings, and papers. The Introduction and text have been revised to incorporate references to recent scholarship since the second edition and the bibliography has been updated.

Reissued here in its corrected second edition of 1864, this essay by John Stuart Mill argues for a utilitarian theory of morality. Originally printed as a series of three articles in Fraser's Magazine in 1861, the work sought to refine the 'greatest happiness' principle that had been championed by Jeremy Bentham, defending it from common criticisms, and offering a justification of its validity. Following Bentham, Mill holds that actions can be judged as right or wrong depending on whether they (...) promote happiness or 'the reverse of happiness'. Although attracted by Bentham's consequentialist framework based on empirical evidence rather than intuition, Mill separates happiness into 'higher' and 'lower' pleasures, arguing for a weighted system of measurement when making and judging decisions. Dissected and debated since its first appearance, the essay is Mill's key discussion on the topic and remains a fundamental text in the study of ethics. (shrink)