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  1. The Ethics of Hippocampal Prosthesis as a Potential Future Treatment for Alzheimer’s Disease.Matt Schuler - manuscript
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  2. Practitioner Bias as an Explanation for Low Rates of Palliative Care Among Patients with Advanced Dementia.Meira Erel, Esther-Lee Marcus & Freda Dekeyser-Ganz - forthcoming - Health Care Analysis:1-16.
    Patients with advanced dementia are less likely than those with other terminal illnesses to receive palliative care. Due to the nature and course of dementia, there may be a failure to recognize the terminal stage of the disease. A possible and under-investigated explanation for this healthcare disparity is the healthcare practitioner who plays a primary role in end-of-life decision-making. Two potential areas that might impact provider decision-making are cognitive biases and moral considerations. In this analysis, we demonstrate how the cognitive (...)
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  3. Quality of Life: The Family and Alzheimer's Disease.Mary Guerriero Austrom & Hugh C. Hendrie - forthcoming - Journal of Palliative Care.
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  4. Hospice and Alzheimer Disease: A Study in Access and Simple Justice.Bruce Jennings - forthcoming - Hastings Center Report.
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  5. Ethics of Early Intervention in Alzheimer’s Disease.Alex McKeown, Gin S. Malhi & Ilina Singh - forthcoming - American Journal of Bioethics Neuroscience:1-18.
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  6. The Capacity to Designate a Surrogate is Distinct From Decisional Capacity: Normative and Empirical Considerations.Mark Navin, Jason Adam Wasserman, Devan Stahl & Tom Tomlinson - forthcoming - Journal of Medical Ethics:medethics-2020-107078.
    The capacity to designate a surrogate is not simply another kind of medical decision-making capacity. A patient with DMC can express a preference, understand information relevant to that choice, appreciate the significance of that information for their clinical condition, and reason about their choice in light of their goals and values. In contrast, a patient can possess the CDS even if they cannot appreciate their condition or reason about the relative risks and benefits of their options. Patients who lack DMC (...)
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  7. Classification of Alzheimer’s Disease Using Traditional Classifiers with Pre-Trained CNN.Husam R. Almadhoun & Samy S. Abu-Naser - 2021 - International Journal of Academic Health and Medical Research (IJAHMR) 5 (4):17-21.
    Abstract: Alzheimer's disease (AD) is one of the most common types of dementia. Symptoms appear gradually and end with severe brain damage. People with Alzheimer's disease lose the abilities of knowledge, memory, language and learning. Recently, the classification and diagnosis of diseases using deep learning has emerged as an active topic covering a wide range of applications. This paper proposes examining abnormalities in brain structures and detecting cases of Alzheimer's disease especially in the early stages, using features derived from medical (...)
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  8. Towards Computer-Based Automated Screening of Dementia Through Spontaneous Speech.Karol Chlasta & Krzysztof Wołk - 2021 - Frontiers in Psychology 11.
    Dementia, a prevalent disorder of the brain, has negative effects on individuals and society. This paper concerns using Spontaneous Speech Challenge of Interspeech 2020 to classify Alzheimer's dementia. We used VGGish, a deep, pretrained, Tensorflow model as an audio feature extractor, and Scikit-learn classifiers to detect signs of dementia in speech. Three classifiers were 59.1% accurate, which was 3% above the best-performing baseline models trained on the acoustic features used in the challenge. We also proposed DemCNN, a new PyTorch raw (...)
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  9. Personhood, Critical Interests, and the Moral Imperative of Advance Directives in Alzheimer’s Cases.Samuel Dale - 2021 - Voices in Bioethics 7.
    Photo by Jr Korpa on Unsplash INTRODUCTION The moral authority of advance directives is contingent on one of two metaphysical concepts of personhood common in the West. The first tradition originated in the ideas of David Hume and Jeremy Bentham. Hume asserts that the idea of personhood is socially fabricated and that we are nothing more than “bundles” of sensations.”[1] Bentham is famous for developing a utilitarian ethical approach predicated on Hume’s reductionist theory, a person who asserts the morally right (...)
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  10. The Poetics and Politics of Alzheimer’s Disease Life-Writing by Martina Zimmermann, London, UK: Palgrave McMillan, 2017.Kathryn Lafferty Danner - 2021 - Journal of Medical Humanities 42 (1):201-203.
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  11. A Narrative Review Examining the Utility of Interpersonal Synchrony for the Caregiver-Care Recipient Relationship in Alzheimer’s Disease and Related Dementias.Angela Gifford, Vivien Marmelat & Janelle N. Beadle - 2021 - Frontiers in Psychology 12.
    The stressful nature of caring for an older adult with a chronic disease, such as Alzheimer’s disease, can create barriers between the caregiver-care recipient, as they try to navigate their continuously changing social relationship. Interpersonal synchrony, is an innovative approach that could help to sustain caregiving relationship dynamics by promoting feelings of connection and empathy through shared behavior and experiences. This review investigates the current literature on interpersonal synchrony from an interdisciplinary perspective by examining interpersonal synchrony through psychological, neural, and (...)
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  12. Do You Remember Who You Are? The Pillars of Identity in Dementia.Nada Gligorov & Christopher Langston - 2021 - In Veljko Dubljevic & Frances Bottenberg (eds.), Living With Dementia. pp. 39-54.
    Loss of personal identity in dementia can raise a number of ethical considerations, including the applicability of advance directives and the validity of patient preferences that seem incongruous with a previous history of values. In this chapter, we first endorse the self-concept view as the most appropriate approach to personal continuity in healthcare. We briefly describe two different types of dementia, Alzheimer’s dementia (AD) and behavioral-variant frontotemporal dementia (bv-FTD). We identify elements considered important for the continuation of a self-concept, including (...)
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  13. Alzheimer's Disease and Relationships of Value.Marion Godman - 2021 - Think 20 (57):39-51.
    In this article, I consider my relationship with my father who developed Alzheimer's disease and criticize dominant models of social interactions and relationships. I argue that the point of a relationship is not what we exchange or achieve within it. The point is not even that we depend on others for our vital needs. The point is simply that a relationship is valuable in and of itself.
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  14. Classifying Alzheimer's Disease Using Audio and Text-Based Representations of Speech.R'mani Haulcy & James Glass - 2021 - Frontiers in Psychology 11.
    Alzheimer's Disease is a form of dementia that affects the memory, cognition, and motor skills of patients. Extensive research has been done to develop accessible, cost-effective, and non-invasive techniques for the automatic detection of AD. Previous research has shown that speech can be used to distinguish between healthy patients and afflicted patients. In this paper, the ADReSS dataset, a dataset balanced by gender and age, was used to automatically classify AD from spontaneous speech. The performance of five classifiers, as well (...)
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  15. Ten Years of Research on Automatic Voice and Speech Analysis of People With Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review Article.Israel Martínez-Nicolás, Thide E. Llorente, Francisco Martínez-Sánchez & Juan José G. Meilán - 2021 - Frontiers in Psychology 12.
    Background: The field of voice and speech analysis has become increasingly popular over the last 10 years, and articles on its use in detecting neurodegenerative diseases have proliferated. Many studies have identified characteristic speech features that can be used to draw an accurate distinction between healthy aging among older people and those with mild cognitive impairment and Alzheimer's disease. Speech analysis has been singled out as a cost-effective and reliable method for detecting the presence of both conditions. In this research, (...)
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  16. Boosting Autobiographical Memory and the Sense of Identity of Alzheimer Patients Through Repeated Reminiscence Workshops?Hervé Platel, Marie-Loup Eustache, Renaud Coppalle, Armelle Viard, Francis Eustache, Mathilde Groussard & Béatrice Desgranges - 2021 - Frontiers in Psychology 12.
    Despite severe amnesia, some studies showed that Alzheimer Disease patients with moderate to severe dementia keep a consistent, but impoverished representation of themselves, showing preservation of the sense of identity even at severe stages of the illness. Some studies suggest that listening to music can facilitate the reminiscence of autobiographical memories and that stimulating autobiographical memory would be relevant to support the self of these patients. Consequently, we hypothesized that repeated participation to reminiscence workshops, using excerpts of familiar songs as (...)
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  17. Ethical Implications of Alzheimer’s Disease Prediction in Asymptomatic Individuals Through Artificial Intelligence.Frank Ursin, Cristian Timmermann & Florian Steger - 2021 - Diagnostics 11 (3):440.
    Biomarker-based predictive tests for subjectively asymptomatic Alzheimer’s disease (AD) are utilized in research today. Novel applications of artificial intelligence (AI) promise to predict the onset of AD several years in advance without determining biomarker thresholds. Until now, little attention has been paid to the new ethical challenges that AI brings to the early diagnosis in asymptomatic individuals, beyond contributing to research purposes, when we still lack adequate treatment. The aim of this paper is to explore the ethical arguments put forward (...)
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  18. Altered Frequency-Dependent Brain Activation and White Matter Integrity Associated With Cognition in Characterizing Preclinical Alzheimer’s Disease Stages.Siyu Wang, Jiang Rao, Yingying Yue, Chen Xue, Guanjie Hu, Wenzhang Qi, Wenying Ma, Honglin Ge, Fuquan Zhang, Xiangrong Zhang & Jiu Chen - 2021 - Frontiers in Human Neuroscience 15.
    BackgroundSubjective cognitive decline, non-amnestic mild cognitive impairment, and amnestic mild cognitive impairment are regarded to be at high risk of converting to Alzheimer’s disease. Amplitude of low-frequency fluctuations can reflect functional deterioration while diffusion tensor imaging is capable of detecting white matter integrity. Our study aimed to investigate the structural and functional alterations to further reveal convergence and divergence among SCD, naMCI, and aMCI and how these contribute to cognitive deterioration.MethodsWe analyzed ALFF under slow-4 and slow-5 bands and white matter (...)
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  19. Assisted Diagnosis of Alzheimer’s Disease Based on Deep Learning and Multimodal Feature Fusion.Yu Wang, Xi Liu & Chongchong Yu - 2021 - Complexity 2021:1-10.
    With the development of artificial intelligence technologies, it is possible to use computer to read digital medical images. Because Alzheimer’s disease has the characteristics of high incidence and high disability, it has attracted the attention of many scholars, and its diagnosis and treatment have gradually become a hot topic. In this paper, a multimodal diagnosis method for AD based on three-dimensional shufflenet and principal component analysis network is proposed. First, the data on structural magnetic resonance imaging and functional magnetic resonance (...)
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  20. Addressing Ethical Challenges of Disclosure in Dementia Prediction: Limitations of Current Guidelines and Suggestions to Proceed.Zümrüt Alpinar-Sencan & Silke Schicktanz - 2020 - BMC Medical Ethics 21 (1):1-11.
    BackgroundBiomarker research is gaining increasing attention focusing on the preclinical stages of the disease. Such interest requires special attention for communication and disclosure in clinical contexts. Many countries give dementia a high health policy priority by developing national strategies and by improving guidelines addressing disclosure of a diagnosis; however, risk communication is often neglected.Main textThis paper aims to identify the challenges of disclosure in the context of dementia prediction and to find out whether existing clinical guidelines sufficiently address the issues (...)
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  21. Caring for Family Members With Alzheimer’s and Burnout Syndrome: Impairment of the Health of Housewives.María Luisa Avargues-Navarro, Mercedes Borda-Mas, Alina de las Mercedes Campos-Puente, María Ángeles Pérez-San-Gregorio, Agustín Martín-Rodríguez & Milagrosa Sánchez-Martín - 2020 - Frontiers in Psychology 11.
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  22. Confabulations in Cases of Dementia: Atypical Early Sign of Alzheimer’s Disease or Misleading Feature in Dementia Diagnosis?Elisabetta Belli, Valentina Nicoletti, Claudia Radicchi, Joyce Bonaccorsi, Simona Cintoli, Roberto Ceravolo & Gloria Tognoni - 2020 - Frontiers in Psychology 11.
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  23. Implications for Technological Reserve Development in Advancing Age, Cognitive Impairment, and Dementia.Jared F. Benge & Michael K. Scullin - 2020 - Behavioral and Brain Sciences 43.
    This commentary draws connections between technological culture emergence and recent trends in using assistive technology to reduce the burden of Alzheimer's disease. By the technical-reasoning hypothesis, cognitively-impaired individuals will lack the cognitive ability to employ technologies. By the technological reserve hypothesis, social-motivational and cultural transmissibility factors can provide foundations for using technology as cognitive prosthetics even during neurodegenerative illnesses.
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  24. Response: Commentary: Metacognition and Perspective-Taking in Alzheimer's Disease: A Mini-Review.Elodie Bertrand, Anna Fischer & Daniel C. Mograbi - 2020 - Frontiers in Psychology 11.
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  25. Good Problems to Have? Policy and Societal Implications of a Disease-Modifying Therapy for Presymptomatic Late-Onset Alzheimer’s Disease. [REVIEW]Ornit Chiba-Falek, Boris Kantor, Anna Yang & Misha Angrist - 2020 - Life Sciences, Society and Policy 16 (1):1-11.
    In the United States alone, the prevalence of AD is expected to more than double from six million people in 2019 to nearly 14 million people in 2050. Meanwhile, the track record for developing treatments for AD has been marked by decades of failure. But recent progress in genetics, neuroscience and gene editing suggest that effective treatments could be on the horizon. The arrival of such treatments would have profound implications for the way we diagnose, triage, study, and allocate resources (...)
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  26. The ethics of innovation for Alzheimer’s disease: the risk of overstating evidence for metabolic enhancement protocols.Timothy Daly, Ignacio Mastroleo, David Gorski & Stéphane Epelbaum - 2020 - Theoretical Medicine and Bioethics 41 (5):223-237.
    Medical practice is ideally based on robust, relevant research. However, the lack of disease-modifying treatments for Alzheimer’s disease has motivated “innovative practice” to improve patients’ well-being despite insufficient evidence for the regular use of such interventions in health systems treating millions of patients. Innovative or new non-validated practice poses at least three distinct ethical questions: first, about the responsible application of new non-validated practice to individual patients ; second, about the way in which data from new non-validated practice are communicated (...)
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  27. Evaluation of Naturalistic Driving Behavior Using In-Vehicle Monitoring Technology in Preclinical and Early Alzheimer’s Disease.Jennifer D. Davis, Ganesh M. Babulal, George D. Papandonatos, Erin M. Burke, Christopher B. Rosnick, Brian R. Ott & Catherine M. Roe - 2020 - Frontiers in Psychology 11.
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  28. Cognitive Disability and Embodied, Extended Minds.Zoe Drayson & Andy Clark - 2020 - In David Wasserman & Adam Cureton (eds.), Oxford Handbook of Philosophy and Disability. Oxford: OUP.
    Many models of cognitive ability and disability rely on the idea of cognition as abstract reasoning processes implemented in the brain. Research in cognitive science, however, emphasizes the way that our cognitive skills are embodied in our more basic capacities for sensing and moving, and the way that tools in the external environment can extend the cognitive abilities of our brains. This chapter addresses the implications of research in embodied cognition and extended cognition for how we think about cognitive impairment (...)
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  29. Non-Invasive Brain Stimulation in Alzheimer's Disease and Mild Cognitive Impairment—A State-of-the-Art Review on Methodological Characteristics and Stimulation Parameters.Adrienn Holczer, Viola Luca Németh, Teodóra Vékony, László Vécsei, Péter Klivényi & Anita Must - 2020 - Frontiers in Human Neuroscience 14.
  30. Trehalose Against Alzheimer's Disease: Insights Into a Potential Therapy.Masoomeh Khalifeh, Morgayn I. Read, George E. Barreto & Amirhossein Sahebkar - 2020 - Bioessays 42 (8):1900195.
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  31. Corrigendum: Commentary: Metacognition and Perspective-Taking in Alzheimer's Disease: A Mini-Review.Rosalba Morese, Mario Stanziano & Sara Palermo - 2020 - Frontiers in Psychology 11.
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  32. Living with Alzheimer Disease and Other Types of Dementia: Stories From Caregivers.Jessica Mozersky & Dena S. Davis - 2020 - Narrative Inquiry in Bioethics 10 (2):89-93.
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  33. Advance Directives and Transformative Experience: Resilience in the Face of Change.Govind C. Persad - 2020 - American Journal of Bioethics 20 (8):69-71.
    In this commentary, I critique three aspects of Emily Walsh's proposal to reduce the moral and legal weight of advance directives: (1) the ambiguity of its initial thesis, (2) its views about the ethics and legality of clinical practice, and (3) its interpretation and application of Ronald Dworkin’s account of advance directives and L.A. Paul's view on transformative experience. I also consider what Walsh’s proposal would mean for people facing the prospect of dementia. I conclude that our reasons to honor (...)
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  34. More Than a Medical Condition: Qualitative Analysis of Media Representations of Dementia and Alzheimer’s Disease.Jana Plichtová & Anna Šestáková - 2020 - Human Affairs 30 (3):382-398.
    The aim of our research is to explore how Alzheimer’s disease and dementia are represented in the Slovak media. Data consisted of text documents from the Newton media database. Search criteria included TV, radio, print and web sources that mentioned the words “Alzheimer” and “dementia” between 2015 and 2018. A thematic discourse analysis was applied in order to identify the themes and their mutual semantic relations. The analysis was focused primarily on the headlines. The results show that the biomedical perspective (...)
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  35. Living With Alzheimer's Disease: A Shared Caregiver's Story.Catherine M. Politi - 2020 - Narrative Inquiry in Bioethics 10 (2):E8-E9.
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  36. What Drives Task Performance During Animal Fluency in People With Alzheimer’s Disease?Adrià Rofes, Vânia de Aguiar, Roel Jonkers, Se Jin Oh, Gayle DeDe & Jee Eun Sung - 2020 - Frontiers in Psychology 11.
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  37. Informed Consent in Two Alzheimer’s Disease Research Centers: Insights From Research Coordinators.Christine M. Suver, Jennifer K. Hamann, Erin M. Chin, Felicia C. Goldstein, Hanna M. Blazel, Cecelia M. Manzanares, Megan J. Doerr, Sanjay J. Asthana, Lara M. Mangravite, Allan I. Levey, James J. Lah & Dorothy F. Edwards - 2020 - Ajob Empirical Bioethics 11 (2):114-124.
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  38. Exploiting Common Aspects of Obesity and Alzheimer’s Disease.Sidra Tabassum, Afzal Misrani & Li Yang - 2020 - Frontiers in Human Neuroscience 14.
    Alzheimer’s disease is an example of age-related dementia, and there are still no known preventive or curative measures for this disease. Obesity and associated metabolic changes are widely accepted as risk factors of age-related cognitive decline. Insulin is the prime mediator of metabolic homeostasis, which is impaired in obesity, and this impairment potentiates amyloid-β accumulation and the formation of neurofibrillary tangles. Obesity is also linked with functional and morphological alterations in brain mitochondria leading to brain insulin resistance and memory deficits (...)
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  39. The Irrelevance of Origins: Dementia, Advance Directives, and the Capacity for Preferences.Jason Adam Wasserman & Mark Christopher Navin - 2020 - American Journal of Bioethics 20 (8):98-100.
    We agree with Emily Walsh (2020) that the current preferences of patients with dementia should sometimes supersede those patients’ advance directives. We also agree that consensus clinical ethics guidance does a poor job of explaining the moral value of such patients’ preferences. Furthermore, Walsh correctly notes that clinicians are often averse to treating patients with dementia over their objections, and that this aversion reflects clinical wisdom that can inform revisions to clinical ethics guidance. But Walsh’s account of the moral value (...)
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  40. Our Journey with Alzheimer's Disease: A Love Story.Scott Weikart - 2020 - Narrative Inquiry in Bioethics 10 (2):E11-E14.
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  41. An Analytic Framework for Conceptualisations of Disease: Nine Structuring Questions and How Some Conceptualisations of Alzheimer’s Disease Can Lead to ‘Diseasisation’.Kristin Zeiler - 2020 - Medicine, Health Care and Philosophy 23 (4):677-693.
    According to the US National Institute on Aging and the Alzheimer’s Association, Alzheimer’s disease should be understood as a biological construct. It can be diagnosed based on AD-characteristic biomarkers only, even if AD biomarkers can be present many years before a person experiences any symptoms of AD. The NIA-AA’s conceptualisation of AD radically challenges past AD conceptualisations. This article offers ananalytic framework for the clarification and analysis of meanings and effects of conceptualisations of diseases such as that of AD. This (...)
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  42. Physical Activity for Executive Function and Activities of Daily Living in AD Patients: A Systematic Review and Meta-Analysis.Lin Zhu, Long Li, Lin Wang, Xiaohu Jin & Huajiang Zhang - 2020 - Frontiers in Psychology 11.
    Objectives: The present study aimed to systematically analyze the effects of physical activity on executive function, working memory, cognitive flexibility, and activities of daily living in Alzheimer's disease patients and to provide a scientific evidence-based exercise prescription.Methods: Both Chinese and English databases were used as sources of data to search for randomized controlled trials published between January 1980 and December 2019 relating to the effects of physical activity on executive function, working memory, cognitive flexibility, and ADL issues in AD patients. (...)
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  43. An Integrative Memory Model of Recollection and Familiarity to Understand Memory Deficits.Christine Bastin, Gabriel Besson, Jessica Simon, Emma Delhaye, Marie Geurten, Sylvie Willems & Eric Salmon - 2019 - Behavioral and Brain Sciences 42.
    Humans can recollect past events in details and/or know that an object, person, or place has been encountered before. During the last two decades, there has been intense debate about how recollection and familiarity are organized in the brain. Here, we propose an integrative memory model which describes the distributed and interactive neurocognitive architecture of representations and operations underlying recollection and familiarity. In this architecture, the subjective experience of recollection and familiarity arises from the interaction between core systems and an (...)
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  44. The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review.Chelsie N. Berg, Neha Sinha & Mark A. Gluck - 2019 - Frontiers in Human Neuroscience 13.
  45. Differential Outcomes Training Ameliorates Visual Memory Impairments in Patients With Alzheimer’s Disease: A Pilot Study.Isabel Carmona, Ana B. Vivas & Angeles F. Estévez - 2019 - Frontiers in Psychology 9.
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  46. Consent’s Dominion: Dementia and Prior Consent to Sexual Relations.Samuel Director - 2019 - Bioethics 33 (9):1065-1071.
    In this paper, I answer the following question: suppose that two individuals, C and D, have been in a long-term committed relationship, and D now has dementia, while C is competent; if D agrees to have sex with C, is it permissible for C to have sex with D? Ultimately, I defend the view that, under certain conditions, D can give valid consent to sex with C, rendering sex between them permissible. Specifically, I argue there is compelling reason to endorse (...)
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  47. Divinity in Dementia.Any Docu Axelerad, Alina Zorina Stroe, Silviu Docu Axelerad & Daniel Docu Axelerad - 2019 - Dialogo 6 (1):187-194.
    Various studies have shown that religiosity has a favorable impact on health and the quality of life, but still not much is known about religiosity in Alzheimer’s disease and about the progression of its cognitive, behavioral, and functional symptoms1. Our purpose was to identify any affiliation between religiosity and the progress of cognitive decline and behavioral disorders in mild Alzheimer’s disease.
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  48. Publication Trends for Alzheimer's Disease Worldwide and in China: A 30-Year Bibliometric Analysis.Rui Dong, Hong Wang, Jishi Ye, Mingshan Wang & Yanlin Bi - 2019 - Frontiers in Human Neuroscience 13.
  49. Visual Imagery: The Past and Future as Seen by Patients with Alzheimer’s Disease.Mohamad El Haj, Ahmed A. Moustafa, Karim Gallouj & Frédérique Robin - 2019 - Consciousness and Cognition 68:12-22.
  50. Extracellular Vesicles From Mesenchymal Stem Cells Exert Pleiotropic Effects on Amyloid‐Β, Inflammation, and Regeneration: A Spark of Hope for Alzheimer's Disease From Tiny Structures?Chiara A. Elia, Morris Losurdo, Maria L. Malosio & Silvia Coco - 2019 - Bioessays 41 (4):1800199.
    No cure yet exists for devastating Alzheimer's disease (AD), despite many years and humongous efforts to find efficacious pharmacological treatments. So far, neither designing drugs to disaggregate amyloid plaques nor tackling solely inflammation turned out to be decisive. Mesenchymal stem cells (MSCs) and, in particular, extracellular vesicles (EVs) originating from them could be proposed as an alternative, strategic approach to attack the pathology. Indeed, MSC‐EVs—owing to their ability to deliver lipids/proteins/enzymes/microRNAs endowed with anti‐inflammatory, amyloid‐β degrading, and neurotrophic activities—may be exploited (...)
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