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  1. added 2019-01-02
    Authority Without Identity: Defending Advance Directives Via Posthumous Rights Over One’s Body.Govind Persad - forthcoming - Journal of Medical Ethics:medethics-2018-104971.
    This paper takes a novel approach to the active bioethical debate over whether advance medical directives have moral authority in dementia cases. Many have assumed that advance directives would lack moral authority if dementia truly produced a complete discontinuity in personal identity, such that the predementia individual is a separate individual from the postdementia individual. I argue that even if dementia were to undermine personal identity, the continuity of the body and the predementia individual’s rights over that body can support (...)
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  2. added 2018-10-16
    Cognitive Disability and Embodied, Extended Minds.Zoe Drayson & Andy Clark - forthcoming - In David Wasserman & Adam Cureton (eds.), The Oxford Handbook of Philosophy and Disability. OUP.
    Many models of cognitive ability and disability rely on the idea of cognition as abstract reasoning processes implemented in the brain. Research in cognitive science, however, emphasizes the way that our cognitive skills are embodied in our more basic capacities for sensing and moving, and the way that tools in the external environment can extend the cognitive abilities of our brains. This chapter addresses the implications of research in embodied cognition and extended cognition for how we think about cognitive impairment (...)
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  3. added 2018-10-07
    Alzheimer's in 3D Culture: Challenges and Perspectives.Carla D'Avanzo, Jenna Aronson, Young Hye Kim, Se Hoon Choi, Rudolph E. Tanzi & Doo Yeon Kim - 2015 - Bioessays 37 (10):1139-1148.
  4. added 2018-09-29
    Neuronal Hyperactivity - A Key Defect in Alzheimer's Disease?Marc Aurel Busche & Arthur Konnerth - 2015 - Bioessays 37 (6):624-632.
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  5. added 2017-02-13
    The Pathogenesis of Alzheimer's Disease. What Causes Dementia?R. D. Terry - 1992 - In Y. Christen & P. S. Churchland (eds.), Neurophilosophy and Alzheimer's Disease. Springer Verlag. pp. 123--130.
  6. added 2017-02-12
    The Ethical Challenges of Alzheimer Disease and Our Ageing Population.Anna Stokes - 1998 - Chisholm Health Ethics Bulletin 4 (2):8.
  7. added 2017-02-11
    Alzheimer's Disease and Personhood.Erik Parens - 2013 - Hastings Center Report 43 (1):1 - p.
  8. added 2017-02-11
    Alzheimer Disease and the "Then" Self.Stephen G. Post - 1995 - Kennedy Institute of Ethics Journal 5 (4):307-321.
  9. added 2017-02-10
    Alzheimer's Disease Dietary Supplements in Websites.Nicole Palmour, Brandy L. Vanderbyl, Emma Zimmerman, Serge Gauthier & Eric Racine - 2013 - HEC Forum 25 (4):361-382.
  10. added 2017-02-08
    Review of Andrea Gillies, Keeper: Living With Nancy, A Journey Into Alzheimer's. [REVIEW]Emma Zimmerman - 2010 - American Journal of Bioethics 10 (11):29-31.
  11. added 2017-02-08
    The Moral Challenge of Alzheimer Disease.J. Savulescu - 1997 - Journal of Medical Ethics 23 (4):259-260.
  12. added 2017-02-07
    Autonomy, Benevolence, and Alzheimer's Disease.Pam R. Sailors - 2001 - Cambridge Quarterly of Healthcare Ethics 10 (2):184-193.
    Medical ethics has traditionally been governed by two guiding, but sometimes conflicting, principlesthe Substituted Judgment Standard shows our concern for autonomy, whereas the Best Interest Standard shows our commitment to benevolence. Both standards are vulnerable to criticisms. Further, the principles can seem to offer conflicting prescriptions for action. The criticisms and conflict figure prominently in discussion of advance directive decisionmaking and Alzheimer's disease. After laying out each of the current standards and its problems, with Alzheimer's issues as my central concern, (...)
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  13. added 2017-01-14
    The Experimental Alzheimer's Disease Drug Posiphen [-Phenserine] Lowers Amyloid-Beta Peptide Levels in Cell Culture and Mice.D. K. Lahiri, D. Chen, B. Maloney, H. W. Holloway, Q. S. Yu, T. Utsuki, T. Giordano, K. Sambamurti & N. H. Greig - 2007 - J Pharmacol Exp Ther 320:386-96.
    Major characteristics of Alzheimer's disease are synaptic loss, cholinergic dysfunction, and abnormal protein depositions in the brain. The amyloid beta-peptide , a proteolytic fragment of amyloid beta precursor protein , aggregates to form neuritic plaques and has a causative role in AD. A present focus of AD research is to develop safe Abeta-lowering drugs. A selective acetylcholinesterase inhibitor, phenserine, in current human trials lowers both APP and Abeta. Phenserine is dose-limited in animals by its cholinergic actions; its cholinergically inactive enantiomer, (...)
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  14. added 2015-07-20
    Qualitative Assessment of Self-Identity in Advanced Dementia.Sadhvi Batra, Jacqueline Anne Sullivan, Beverly Williams & David Geldmacher - 2015 - Dementia: The International Journal of Social Research and Practice:1-19.
    This study aimed to understand the preserved elements of self-identity in persons with moderate to severe dementia attributable to Alzheimer’s disease. A semi-structured interview was developed to explore the narrative self among residents with dementia in a residential care facility and residents without dementia in an independent living setting. The interviews were transcribed verbatim from audio recordings and analyzed for common themes, while being sensitive to possible differences between the groups. The participants with dementia showed evidence of self-reference even though (...)
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  15. added 2015-03-25
    Spect Imaging In Alzheimer's Disease. B. Leanard Holman, Brigham And Women's Hospital.Keith Johnson & Thomas Hill - 1988 - Journal of Mind and Behavior 9 (3).
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  16. added 2015-03-24
    Caregiving Men of Alzheimer’s Disease Sufferers in Nuevo Leo´N : Experiences and Meanings.J. Azoh Barry - 2014 - Vulnerable Groups and Inclusion 5.
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  17. added 2015-03-24
    Relationships Between Psychosocial Stress, Cortisol, Apolipoprotein Є4, Beta-Amyloid, Hippocampal Volume, and Alzheimer's Disease in a Sample of South African Older Adults.Katharine Ann James - unknown
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  18. added 2015-03-24
    Neural Network Plasticity, BDNF and Behavioral Interventions in Alzheimer s Disease.P. Hubka - 2006 - Cognition 50 (56):57.
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  19. added 2015-03-24
    The Moral Challenge of Alzheimer Disease.Stephen G. Post & Robert Young - 1997 - Bioethics 11 (2):177-178.
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  20. added 2015-03-24
    Spect Imaging In Alzheimer's Disease. B. Leanard Holman, Brigham And Women's Hospital.B. Leonard Holman, Keith A. Johnson & Thomas C. Hill - 1988 - Journal of Mind and Behavior 9 (3).
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  21. added 2015-03-23
    PharmAD-Ventures: A Feminist Analysis of the Pharmacological Imaginary of Alzheimer's Disease.Cecilia Åsberg & Jennifer Lum - 2009 - Body and Society 15 (4):95-117.
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  22. added 2015-03-23
    Alzheimer Disease.Elizabeth A. Kensinger & Suzanne Corkin - 2002 - In Lynn Nadel (ed.), The Encyclopedia of Cognitive Science. Macmillan.
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  23. added 2015-03-23
    Alzheimer's Disease.Daniel I. Kaufer - 2002 - In Elaine Perry, Heather Ashton & Andrew W. Young (eds.), Neurochemistry of Consciousness: Neurotransmitters in Mind. John Benjamins. pp. 36--229.
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  24. added 2015-03-23
    The Cognitive Neuropsychology of Alzheimer's Disease.Robert D. Nebes - 2000 - In Martha J. Farah & Todd E. Feinberg (eds.), Patient-Based Approaches to Cognitive Neuroscience. MIT Press. pp. 369--375.
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  25. added 2015-03-23
    Descartes RV 5-8. 14. 25 Diagnosis of Alzheimer's Disease 132 Down Syndrome 67. 132 Early Detection of Brain Pathology in Alzheimer's Disease 131-143. [REVIEW]C. Bernard - 1992 - In Y. Christen & P. S. Churchland (eds.), Neurophilosophy and Alzheimer's Disease. Springer Verlag. pp. 80--151.
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  26. added 2015-03-23
    Consciousness: Evidence of Four Components in Alzheimer's Disease.J. L. Signoret - 1992 - In Y. Christen & P. S. Churchland (eds.), Neurophilosophy and Alzheimer's Disease. Springer Verlag. pp. 144--150.
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  27. added 2015-03-23
    Introduction: Neurophilosophy and Alzheimer's Disease.P. S. Churchland - 1992 - In Y. Christen & P. S. Churchland (eds.), Neurophilosophy and Alzheimer's Disease. Springer Verlag. pp. 1--4.
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  28. added 2015-03-23
    Alzheimer's Disease: Disruption of Mind-Brain Relations.S. I. Rapoport - 1992 - In Y. Christen & P. S. Churchland (eds.), Neurophilosophy and Alzheimer's Disease. Springer Verlag. pp. 86--107.
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  29. added 2015-03-22
    Alzheimer's Disease, Tube Feeding, and Prudential Judgment.Vince A. Punzo - 2013 - The National Catholic Bioethics Quarterly 13 (3):469-482.
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  30. added 2015-03-22
    Ethics and Alzheimer's Disease: Widening the Lens.Martha B. Holstein - 1998 - Journal of Clinical Ethics 9 (1):13.
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  31. added 2014-11-11
    No ECSIT-Stential Evidence for a Link with Alzheimer's Disease Yet.Tomer Illouz & Eitan Okun - 2015 - Bioessays 37 (1):5-5.
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  32. added 2014-10-06
    Alzheimer Neurodegeneration, Autophagy, and Abeta Secretion: The Ins and Outs.Ralph A. Nixon - 2014 - Bioessays 36 (6):547-547.
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  33. added 2014-10-05
    Dual Roles for Autophagy: Degradation and Secretion of Alzheimer's Disease Aβ Peptide.Per Nilsson & Takaomi C. Saido - 2014 - Bioessays 36 (6):570-578.
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  34. added 2014-04-28
    Selective Attention in Early Dementia of Alzheimer Type.Diego Fernandez-Duque - manuscript
    This study explored possible deficits in selective attention brought about by Dementia of Alzheimer Type (DAT). In three experiments, we tested patients with early DAT, healthy elderly, and young adults under low memory demands to assess perceptual filtering, conflict resolution, and set switching abilities. We found no evidence of impaired perceptual filtering nor evidence of impaired conflict resolution in early DAT. In contrast, early DAT patients did exhibit a global cost in set switching consistent with an inability to maintain the (...)
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  35. added 2014-04-28
    Alzheimer’s Disease and Impairment of the Self.M. N. Fargeau, N. Jaafari, S. Ragot, J. L. Houeto, C. Pluchon & R. Gil - 2010 - Consciousness and Cognition 19 (4):969-976.
    Impairment of the Self has been described in frontal–temporal dementia but little research has been carried out in patients with Alzheimer’s disease .ObjectiveThe aim of this study was to explore changes in the self in patients with AD.MethodForty-seven patients with mild to moderate AD were examined using a semi-structured scale designed to assess the self-concept along three dimensions, namely, the Material Self, the Social Self and the Spiritual Self.ResultsThe majority of patients presented impairment of at least one dimension of the (...)
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  36. added 2014-04-21
    Attentional Networks in Normal Aging and Alzheimer's Disease.Sandra E. Black - unknown
    By combining a flanker task and a cuing task into a single paradigm, the authors assessed the effects of orienting and alerting on conflict resolution and explored how normal aging and Alzheimer’s disease (AD) modulate these attentional functions. Orienting failed to enhance conflict resolution; alerting was most beneficial for trials without conflict, as if acting on response criterion rather than on information processing. Alerting cues were most effective in the older groups— healthy aging and AD. Conflict resolution was impaired only (...)
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  37. added 2014-04-03
    Cellular and Molecular Biology of Alzheimer's Disease.Donald L. Price, Edward H. Koo & Axel Unterbeck - 1989 - Bioessays 10 (2-3):69-74.
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  38. added 2014-03-30
    Alzheimer's Disease Untangled.Fiona Crawford & Alison Goate - 1992 - Bioessays 14 (11):727-734.
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  39. added 2014-03-26
    Steps Towards a Mouse Model of Alzheimer's Disease.R. Anthony Crowther - 1995 - Bioessays 17 (7):593-595.
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  40. added 2014-03-22
    In Silico Approaches and the Role of Ontologies in Aging Research.Georg Fuellen, Melanie Börries, Hauke Busch, Aubrey de Grey, Udo Hahn, Thomas Hiller, Andreas Hoeflich, Ludger Jansen, Georges E. Janssens, Christoph Kaleta, Anne C. Meinema, Sascha Schäuble, Paul N. Schofield, Barry Smith & Others - 2013 - Rejuvenation Research 16 (6):540-546.
    The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, as these are a key technology to systematically integrate heterogeneous information about the aging process. Related topics were databases and data integration. Other talks tackled modeling issues and applications, the latter including talks focussed on marker development and cellular stress as well as on diseases, in particular on diseases of kidney (...)
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  41. added 2014-03-22
    Inflammation, Antichymotrypsin, and Lipid Metabolism: Autogenic Etiology of Alzheimer's Disease.S. Janciauskiene & H. T. Wright - 1998 - Bioessays 20 (12):1039-1046.
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  42. added 2014-03-19
    Alzheimer Vaccine: Amyloid‐Β on Trial.Stephen R. Robinson, Glenda M. Bishop & Gerald Münch - 2003 - Bioessays 25 (3):283-288.
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  43. added 2014-03-14
    Proline-Directed Phosphorylation and Isomerization in Mitotic Regulation and in Alzheimer's Disease.Kun Ping Lu, Yih-Cherng Liou & Inez Vincent - 2003 - Bioessays 25 (2):174-181.
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  44. added 2014-03-12
    When Parsimony Backfires: Neglecting DNA Repair May Doom Neurons in Alzheimer's Disease.Thierry Nouspikel & Philip C. Hanawalt - 2003 - Bioessays 25 (2):168-173.
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  45. added 2014-03-12
    Alzheimer's Amyloid Beta Oligomers and Lipoprotein apoA?: Mistaken Identity is Possible.Natalia V. Koudinova - 2003 - Bioessays 25 (10):1024-1024.
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  46. added 2014-02-19
    Alzheimer's Disease, Aging, Chance, and Race.Atwood D. Gaines - 2006 - Philosophy, Psychiatry, and Psychology 13 (1):83-85.
  47. added 2014-02-19
    Building a Mystery: Alzheimer's Disease, Mild Cognitive Impairment, and Beyond.Atwood D. Gaines & Peter J. Whitehouse - 2006 - Philosophy, Psychiatry, and Psychology 13 (1):61-74.
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  48. added 2014-02-01
    Alzheimer Vaccine: Amyloid-Β on Trial.Stephen R. Robinson, Glenda M. Bishop & Gerald Münch - 2003 - Bioessays 25 (3):283-288.
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  49. added 2014-02-01
    Alzheimer Vaccine: An Update.Stephen R. Robinson, Glenda M. Bishop & Gerald Münch - 2003 - Bioessays 25 (10):1025-1025.
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  50. added 2014-01-19
    The Neurological Disease Ontology.Mark Jensen, Alexander P. Cox, Naveed Chaudhry, Marcus Ng, Donat Sule, William Duncan, Patrick Ray, Bianca Weinstock-Guttman, Barry Smith, Alan Ruttenberg, Kinga Szigeti & Alexander D. Diehl - 2013 - Journal of Biomedical Semantics 4 (42).
    We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...)
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