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  1. Principled Mechanistic Explanations in Biology: A Case Study of Alzheimer's Disease.Sepehr Ehsani - manuscript
    Following an analysis of the state of investigations and clinical outcomes in the Alzheimer's research field, I argue that the widely-accepted 'amyloid cascade' mechanistic explanation of Alzheimer's disease appears to be fundamentally incomplete. In this context, I propose that a framework termed 'principled mechanism' (PM) can help with remedying this problem. First, using a series of five 'tests', PM systematically compares different components of a given mechanistic explanation against a paradigmatic set of criteria, and hints at various ways of making (...)
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  2. The Ethics of Hippocampal Prosthesis as a Potential Future Treatment for Alzheimer’s Disease.Matt Schuler - manuscript
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  3. The Accelerated Approval of Aducanumab Invites a Rethink of the Current Model of Drug Development for Alzheimer's Disease.Timothy Daly & Stéphane Epelbaum - forthcoming - American Journal of Bioethics Neuroscience:1-4.
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  4. Quality of Life: The Family and Alzheimer's Disease.Mary Guerriero Austrom & Hugh C. Hendrie - forthcoming - Journal of Palliative Care.
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  5. Hospice and Alzheimer Disease: A Study in Access and Simple Justice.Bruce Jennings - forthcoming - Hastings Center Report.
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  6. Ethics of Early Intervention in Alzheimer’s Disease.Alex McKeown, Gin S. Malhi & Ilina Singh - forthcoming - American Journal of Bioethics Neuroscience:1-18.
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  7. Should Doctors Offer Biomarker Testing to Those Afraid to Develop Alzheimer’s Dementia?Marthe Smedinga, Eline M. Bunnik, Edo Richard & Maartje H. N. Schermer - forthcoming - Journal of Bioethical Inquiry:1-11.
    An increasing number of people seek medical attention for mild cognitive symptoms at older age, worried that they might develop Alzheimer’s disease. Some clinical practice guidelines suggest offering biomarker testing in such cases, using a brain scan or a lumbar puncture, to improve diagnostic certainty about Alzheimer’s disease and enable an earlier diagnosis. Critics, on the other hand, point out that there is no effective Alzheimer treatment available and argue that biomarker tests lack clinical validity. The debate on the ethical (...)
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  8. Unfathomed Dangers From Aluminum — Alzheimer's? Autism? Multiple Sclerosis?Henry Bauer - 2022 - Journal of Scientific Exploration 35 (4).
    That aluminum is fatally toxic is beyond doubt, demonstrated by mass human poisoning at Camelford in Cornwall in Britain in 1988 and by occasional fish kills. Aluminum may also be a contributing factor in a number of human diseases, in particular those involving brain and nerves — autism, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis. Aluminum salts used in kidney dialysis may be responsible for dialysis-related encephalopathy. Aluminum adjuvants in vaccine can cause macrophagic myofasciitis as well as such whole-body ailments as (...)
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  9. Practitioner Bias as an Explanation for Low Rates of Palliative Care Among Patients with Advanced Dementia.Meira Erel, Esther-Lee Marcus & Freda Dekeyser-Ganz - 2022 - Health Care Analysis 30 (1):57-72.
    Patients with advanced dementia are less likely than those with other terminal illnesses to receive palliative care. Due to the nature and course of dementia, there may be a failure to recognize the terminal stage of the disease. A possible and under-investigated explanation for this healthcare disparity is the healthcare practitioner who plays a primary role in end-of-life decision-making. Two potential areas that might impact provider decision-making are cognitive biases and moral considerations. In this analysis, we demonstrate how the cognitive (...)
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  10. Invasive Experimental Brain Surgery for Dementia: Ethical Shifts in Clinical Research Practices?Frederic Gilbert, John Noel M. Viaña, Merlin Bittlinger, Ian Stevens, Maree Farrow, James Vickers, Susan Dodds & Judy Illes - 2022 - Bioethics 36 (1):25-41.
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  11. The Ethics of Disease-Modifying Drugs Targeting Alzheimer Disease: Response to Our Commentators.Erik Gustavsson, Pauline Raaschou, Gerd Lärfars, Lars Sandman & Niklas Juth - 2022 - Journal of Medical Ethics 48 (3):193-193.
    In Gustavsson et al,1 we discussed the ethical issues that arise when identifying the relevant population for disease-modifying drugs targeting Alzheimer disease. More specifically, we focused on novel immunotherapies aimed at amyloid β and tau, two relevant biomarkers. The commentaries to our paper2 3 acknowledge our conclusion: screening for AD involve ethical costs that cannot be justified unless a drug with clinically relevant effect becomes available. Since Aduhelm is the only immunotherapy targeting AD currently approved by the Food and Drug (...)
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  12. Preserving Narrative Identity for Dementia Patients: Embodiment, Active Environments, and Distributed Memory.Richard Heersmink - 2022 - Neuroethics 15 (8):1-16.
    One goal of this paper is to argue that autobiographical memories are extended and distributed across embodied brains and environmental resources. This is important because such distributed memories play a constitutive role in our narrative identity. So, some of the building blocks of our narrative identity are not brain-bound but extended and distributed. Recognising the distributed nature of memory and narrative identity, invites us to find treatments and strategies focusing on the environment in which dementia patients are situated. A second (...)
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  13. Development and Psychometric Evaluation of Family Caregivers’ Hardiness Scale: A Sequential-Exploratory Mixed-Method Study.Lida Hosseini, Hamid Sharif Nia & Mansoureh Ashghali Farahani - 2022 - Frontiers in Psychology 13.
    ObjectiveCaring for patients with Alzheimer’s disease is a stressful situation and an overwhelming task for family caregivers. Therefore, these caregivers need to have their hardiness empowered to provide proper and appropriate care to these older adults. From the introduction of the concept of hardiness, few studies have been conducted to assess the hardiness of caregivers of patients with AD. Presumably, one reason for this knowledge gap is the lack of a proper scale to evaluate hardiness in this group. This study (...)
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  14. A Comparison of Caregiver Burden for Different Types of Dementia: An 18-Month Retrospective Cohort Study.Wen-Chien Huang, Ming-Che Chang, Wen-Fu Wang & Kai-Ming Jhang - 2022 - Frontiers in Psychology 12.
    BackgroundThis study aimed to elucidate the influence of dementia etiologies on the degree of caregiver burden and determine which factors predict a high caregiving burden.MethodsThis 18-month retrospective cohort study enrolled 630 patients and their caregivers from the Dementia Center of Changhua Christian Hospital. The care team performed face-to-face interviews every 6 months, for 18 months from when a diagnosis of dementia was made. The primary outcome was the change in Zarit Burden Interview scores. Generalized estimating equations were used for the (...)
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  15. Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis.Susanna S. Kwok, Xuan-Mai T. Nguyen, Diana D. Wu, Raksha A. Mudar & Daniel A. Llano - 2022 - Frontiers in Psychology 12.
    An association between age-related hearing loss and Alzheimer's Disease has been widely reported. However, the nature of this relationship remains poorly understood. Quantification of hearing loss as it relates to AD is imperative for the creation of reliable, hearing-related biomarkers for earlier diagnosis and development of ARHL treatments that may slow the progression of AD. Previous studies that have measured the association between peripheral hearing function and AD have yielded mixed results. Most of these studies have been small and underpowered (...)
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  16. Making Art at the End of the World: Reimagining Feminist Bioethics Through Research-Creation.Caitlin Leach - 2022 - International Journal of Feminist Approaches to Bioethics 15 (1):123-128.
    My mother died within the first few months of the pandemic. Her sudden and rapid decline from Alzheimer's disease is difficult to separate from the COVID-19 restrictions put in place by her nursing home just two months prior. We went from visiting her daily to not at all, then to a strictly enforced twenty-minute hospice visit to say goodbye. After her passing, and still amidst the pandemic, I could not write. The conventional methods and outputs of bioethics inquiry felt impossible.Making (...)
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  17. Alzheimer’s Disease: History, Ethics and Medical Humanities in the Context of Assisted Suicide. [REVIEW]Thomas Horst Loew, Joachim Demling & Birgit Braun - 2022 - Philosophy, Ethics, and Humanities in Medicine 17 (1):1-7.
    IntroductionDementia diseases, especially Alzheimer’s disease, are of considerable importance in terms of social policy and health economics. Moreover, against the background of the current Karlsruhe judgement on the legalisation of assisted suicide, there are also questions to be asked about medical humanities in AD.MethodologyRelevant literature on complementary forms of therapy and prognosis was included and discussed.ResultsCreative sociotherapeutic approaches and validating psychotherapeutic approaches show promise for suitability and efficiency in the treatment of dementia, but in some cases still need to be (...)
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  18. “Ready for What?”: Timing and Speculation in Alzheimer’s Disease Drug Development.Richard Milne & Natassia F. Brenman - 2022 - Science, Technology, and Human Values 47 (3):597-622.
    “Readiness cohorts” are an innovation in clinical trial design to tackle the scarcity of time and people in drug studies. This has emerged in response to the challenges of recruiting the “right” research participants at the “right time” in the context of precision medicine. In this paper, we consider how the achievement of “readiness” aligns temporalities, biologies, and market processes of pharmaceutical innovation: how the promise of “willing bodies” in research emerges in relation to intertwined economic and biological time imperatives. (...)
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  19. The Capacity to Designate a Surrogate is Distinct From Decisional Capacity: Normative and Empirical Considerations.Mark Navin, Jason Adam Wasserman, Devan Stahl & Tom Tomlinson - 2022 - Journal of Medical Ethics 48 (3):189-192.
    The capacity to designate a surrogate is not simply another kind of medical decision-making capacity. A patient with DMC can express a preference, understand information relevant to that choice, appreciate the significance of that information for their clinical condition, and reason about their choice in light of their goals and values. In contrast, a patient can possess the CDS even if they cannot appreciate their condition or reason about the relative risks and benefits of their options. Patients who lack DMC (...)
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  20. Brain Atrophy and Clinical Characterization of Adults With Mild Cognitive Impairment and Different Cerebrospinal Fluid Biomarker Profiles According to the AT(N) Research Framework of Alzheimer’s Disease.Miguel Ángel Rivas-Fernández, Mónica Lindín, Montserrat Zurrón, Fernando Díaz, José Manuel Aldrey-Vázquez, Juan Manuel Pías-Peleteiro, Laura Vázquez-Vázquez, Arturo Xosé Pereiro, Cristina Lojo-Seoane, Ana Nieto-Vieites & Santiago Galdo-Álvarez - 2022 - Frontiers in Human Neuroscience 16.
    IntroductionThis study aimed to evaluate, in adults with mild cognitive impairment, the brain atrophy that may distinguish between three AT biomarker-based profiles, and to determine its clinical value.MethodsStructural MRI was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT profiles, namely, A−T−−: normal AD biomarkers; A+T−−: AD pathologic change; and A+T++: prodromal AD. Sensitivity and specificity of these changes were also estimated.ResultsAn initial atrophy in medial temporal lobe areas was found in the A+T−− and (...)
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  21. Classification of Alzheimer's Disease Using Convolutional Neural Networks.Lamis F. Samhan, Amjad H. Alfarra & Samy S. Abu-Naser - 2022 - International Journal of Academic Information Systems Research (IJAISR) 6 (3):18-23.
    Brain-related diseases are among the most difficult diseases due to their sensitivity, the difficulty of performing operations, and their high costs. In contrast, the operation is not necessary to succeed, as the results of the operation may be unsuccessful. One of the most common diseases that affect the brain is Alzheimer’s disease, which affects adults, a disease that leads to memory loss and forgetting information in varying degrees. According to the condition of each patient. For these reasons, it is important (...)
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  22. Moving in Semantic Space in Prodromal and Very Early Alzheimer's Disease: An Item-Level Characterization of the Semantic Fluency Task.Aino M. Saranpää, Sasa L. Kivisaari, Riitta Salmelin & Sabine Krumm - 2022 - Frontiers in Psychology 13.
    The semantic fluency task is a widely used clinical tool in the diagnostic process of Alzheimer's disease. The task requires efficient mapping of the semantic space to produce as many items as possible within a semantic category. We examined whether healthy volunteers and patients with early Alzheimer's disease take advantage of and travel in the semantic space differently. With focus on the animal fluency task, we sought to emulate the detailed structure of the multidimensional semantic space by utilizing word2vec-method from (...)
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  23. Path Integration in Normal Aging and Alzheimer’s Disease.Vladislava Segen, Johnson Ying, Erik Morgan, Mark Brandon & Thomas Wolbers - 2022 - Trends in Cognitive Sciences 26 (2):142-158.
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  24. Behavioral and Psychological Symptoms of Dementia as a Means of Communication: Considerations for Reducing Stigma and Promoting Person-Centered Care.Alison Warren - 2022 - Frontiers in Psychology 13.
    Dementia has rapidly become a major global health crisis. As the aging population continues to increase, the burden increases commensurately on both individual and societal levels. The behavioral and psychological symptoms of dementia are a prominent clinical feature of Alzheimer’s disease and related dementias. BPSD represent a myriad of manifestations that can create significant challenges for persons living with dementia and their care providers. As such, BPSD can result in detriments to social interaction with others, resulting in harm to the (...)
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  25. Classification of Alzheimer’s Disease Using Traditional Classifiers with Pre-Trained CNN.Husam R. Almadhoun & Samy S. Abu-Naser - 2021 - International Journal of Academic Health and Medical Research (IJAHMR) 5 (4):17-21.
    Abstract: Alzheimer's disease (AD) is one of the most common types of dementia. Symptoms appear gradually and end with severe brain damage. People with Alzheimer's disease lose the abilities of knowledge, memory, language and learning. Recently, the classification and diagnosis of diseases using deep learning has emerged as an active topic covering a wide range of applications. This paper proposes examining abnormalities in brain structures and detecting cases of Alzheimer's disease especially in the early stages, using features derived from medical (...)
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  26. Towards Computer-Based Automated Screening of Dementia Through Spontaneous Speech.Karol Chlasta & Krzysztof Wołk - 2021 - Frontiers in Psychology 11.
    Dementia, a prevalent disorder of the brain, has negative effects on individuals and society. This paper concerns using Spontaneous Speech Challenge of Interspeech 2020 to classify Alzheimer's dementia. We used VGGish, a deep, pretrained, Tensorflow model as an audio feature extractor, and Scikit-learn classifiers to detect signs of dementia in speech. Three classifiers were 59.1% accurate, which was 3% above the best-performing baseline models trained on the acoustic features used in the challenge. We also proposed DemCNN, a new PyTorch raw (...)
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  27. Personhood, Critical Interests, and the Moral Imperative of Advance Directives in Alzheimer’s Cases.Samuel Dale - 2021 - Voices in Bioethics 7.
    Photo by Jr Korpa on Unsplash INTRODUCTION The moral authority of advance directives is contingent on one of two metaphysical concepts of personhood common in the West. The first tradition originated in the ideas of David Hume and Jeremy Bentham. Hume asserts that the idea of personhood is socially fabricated and that we are nothing more than “bundles” of sensations.”[1] Bentham is famous for developing a utilitarian ethical approach predicated on Hume’s reductionist theory, a person who asserts the morally right (...)
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  28. The Poetics and Politics of Alzheimer’s Disease Life-Writing by Martina Zimmermann, London, UK: Palgrave McMillan, 2017.Kathryn Lafferty Danner - 2021 - Journal of Medical Humanities 42 (1):201-203.
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  29. Commentary to ‘Novel Drug Candidates Targeting Alzheimer’s Disease: Ethical Challenges with Identifying the Relevant Patient Population’.Maria Eriksdotter - 2021 - Journal of Medical Ethics 47 (9):617-617.
    The article by Gustavsson et al 1 addresses the important question how to handle new medications with focus on drug candidates that reduce Aβ or tau in the brain, for individuals with Alzheimer’s disease, where the need for a disease-modifying drug is enormous. There are several ethical issues to deal with. The challenges and ethical implications associated with whom should be eligible for treatment are thoroughly discussed in the article. Should treatment only be available to those with mild symptoms and/or (...)
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  30. A Narrative Review Examining the Utility of Interpersonal Synchrony for the Caregiver-Care Recipient Relationship in Alzheimer’s Disease and Related Dementias.Angela Gifford, Vivien Marmelat & Janelle N. Beadle - 2021 - Frontiers in Psychology 12.
    The stressful nature of caring for an older adult with a chronic disease, such as Alzheimer’s disease, can create barriers between the caregiver-care recipient, as they try to navigate their continuously changing social relationship. Interpersonal synchrony, is an innovative approach that could help to sustain caregiving relationship dynamics by promoting feelings of connection and empathy through shared behavior and experiences. This review investigates the current literature on interpersonal synchrony from an interdisciplinary perspective by examining interpersonal synchrony through psychological, neural, and (...)
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  31. Invasive Experimental Brain Surgery for Dementia: Ethical Shifts in Clinical Research Practices?Frederic Gilbert, John Noel M. Viaña, Merlin Bittlinger, Ian Stevens, Maree Farrow, James Vickers, Susan Dodds & Judy Illes - 2021 - Wiley: Bioethics 36 (1):25-41.
    Bioethics, Volume 36, Issue 1, Page 25-41, January 2022.
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  32. Do You Remember Who You Are? The Pillars of Identity in Dementia.Nada Gligorov & Christopher Langston - 2021 - In Veljko Dubljevic & Frances Bottenberg (eds.), Living With Dementia. pp. 39-54.
    Loss of personal identity in dementia can raise a number of ethical considerations, including the applicability of advance directives and the validity of patient preferences that seem incongruous with a previous history of values. In this chapter, we first endorse the self-concept view as the most appropriate approach to personal continuity in healthcare. We briefly describe two different types of dementia, Alzheimer’s dementia (AD) and behavioral-variant frontotemporal dementia (bv-FTD). We identify elements considered important for the continuation of a self-concept, including (...)
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  33. Alzheimer's Disease and Relationships of Value.Marion Godman - 2021 - Think 20 (57):39-51.
    In this article, I consider my relationship with my father who developed Alzheimer's disease and criticize dominant models of social interactions and relationships. I argue that the point of a relationship is not what we exchange or achieve within it. The point is not even that we depend on others for our vital needs. The point is simply that a relationship is valuable in and of itself.
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  34. Novel Drug Candidates Targeting Alzheimer’s Disease: Ethical Challenges with Identifying the Relevant Patient Population.Erik Gustavsson, Pauline Raaschou, Gerd Lärfars, Lars Sandman & Niklas Juth - 2021 - Journal of Medical Ethics 47 (9):608-614.
    Intensive research is carried out to develop a disease-modifying drug for Alzheimer’s disease. The development of drug candidates that reduce Aß or tau in the brain seems particularly promising. However, these drugs target people at risk for AD, who must be identified before they have any, or only moderate, symptoms associated with the disease. There are different strategies that may be used to identify these individuals. Each of these strategies raises different ethical challenges. In this paper, we analyse these challenges (...)
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  35. Classifying Alzheimer's Disease Using Audio and Text-Based Representations of Speech.R'mani Haulcy & James Glass - 2021 - Frontiers in Psychology 11.
    Alzheimer's Disease is a form of dementia that affects the memory, cognition, and motor skills of patients. Extensive research has been done to develop accessible, cost-effective, and non-invasive techniques for the automatic detection of AD. Previous research has shown that speech can be used to distinguish between healthy patients and afflicted patients. In this paper, the ADReSS dataset, a dataset balanced by gender and age, was used to automatically classify AD from spontaneous speech. The performance of five classifiers, as well (...)
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  36. Ten Years of Research on Automatic Voice and Speech Analysis of People With Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review Article.Israel Martínez-Nicolás, Thide E. Llorente, Francisco Martínez-Sánchez & Juan José G. Meilán - 2021 - Frontiers in Psychology 12.
    Background: The field of voice and speech analysis has become increasingly popular over the last 10 years, and articles on its use in detecting neurodegenerative diseases have proliferated. Many studies have identified characteristic speech features that can be used to draw an accurate distinction between healthy aging among older people and those with mild cognitive impairment and Alzheimer's disease. Speech analysis has been singled out as a cost-effective and reliable method for detecting the presence of both conditions. In this research, (...)
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  37. Avoiding Exceptionalism and Silver Bullets: Lessons From Public Health Ethics and Alzheimer’s Disease.Ignacio Mastroleo & Timothy Daly - 2021 - American Journal of Bioethics 21 (12):25-28.
    Lynch et al.’ s work “Helpful Lessons and Cautionary Tales: How Should COVID-19 Drug Development and Access Inform Approaches to Non-Pandemic Diseases?” is an essential c...
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  38. “Brain Fog” by COVID-19 or Alzheimer’s Disease? A Case Report.Jordi A. Matias-Guiu, Cristina Delgado-Alonso, Miguel Yus, Carmen Polidura, Natividad Gómez-Ruiz, María Valles-Salgado, Isabel Ortega-Madueño, María Nieves Cabrera-Martín & Jorge Matias-Guiu - 2021 - Frontiers in Psychology 12.
    Cognitive symptoms after COVID-19 have been increasingly recognized several months after the acute infection and have been designated as “brain fog.” We report a patient with cognitive symptoms that started immediately after COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer’s disease. Our case highlights the need to examine patients with cognitive symptoms following COVID-19 comprehensively. A detailed assessment combining clinical, cognitive, and biomarker studies may help disentangle the underlying mechanisms associated with cognitive dysfunction in each case. The (...)
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  39. Annette Leibing and Silke Schicktanz (Eds): Preventing Dementia?: Critical Perspectives on a New Paradigm of Preparing for Old Age: Berghahn Books, New York / Oxford, 2020. [REVIEW]Julia Perry & Niklas Petersen - 2021 - Monash Bioethics Review 39 (2):180-183.
    Given the lack of effective curative treatment options and in light of a significant reconceptualization of Alzheimer’s disease, the focus of dementia research has shifted towards prevention, risk prediction, and detection in very early disease stages. In the context of these shifts, the edited volume Preventing Dementia?: Critical Perspectives on a New Paradigm of Preparing for Old Age collects critical and insightful positions on the new paradigm of dementia prevention from an interdisciplinary and international perspective. The editors introduce the overarching (...)
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  40. Boosting Autobiographical Memory and the Sense of Identity of Alzheimer Patients Through Repeated Reminiscence Workshops?Hervé Platel, Marie-Loup Eustache, Renaud Coppalle, Armelle Viard, Francis Eustache, Mathilde Groussard & Béatrice Desgranges - 2021 - Frontiers in Psychology 12.
    Despite severe amnesia, some studies showed that Alzheimer Disease patients with moderate to severe dementia keep a consistent, but impoverished representation of themselves, showing preservation of the sense of identity even at severe stages of the illness. Some studies suggest that listening to music can facilitate the reminiscence of autobiographical memories and that stimulating autobiographical memory would be relevant to support the self of these patients. Consequently, we hypothesized that repeated participation to reminiscence workshops, using excerpts of familiar songs as (...)
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  41. Selecting the Target Population for New Alzheimer Drugs: Challenges and Expectations.Edo Richard - 2021 - Journal of Medical Ethics 47 (9):615-616.
    The Alzheimer field is in desperate need for an effective treatment. After decades of research, the available drugs treat only symptoms, and even their effectiveness is disputed. Because brain changes precede the clinical symptoms by years to decades, disease-modifying treatments should probably be started early, when the first symptoms occur—or even before. But how to determine who to treat? In this issue, Erik Gustavsson c.s. approach this question by addressing the benefits, harms and ethical issues encountered when using different modes (...)
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  42. Extending Medical Aid in Dying to Incompetent Patients: A Qualitative Descriptive Study of the Attitudes of People Living with Alzheimer’s Disease in Quebec.Vincent Thériault, Diane Guay & Gina Bravo - 2021 - Canadian Journal of Bioethics / Revue canadienne de bioéthique 4 (2).
    Background: In Quebec, medical aid in dying is legal under certain conditions. Access is currently restricted to patients who are able to consent at the time of the act, which excludes most people with dementia at an advanced stage. However, recent legislative and political developments have opened the door to an extension of the legislation that could give them access to MAiD. Our study aimed to explore the attitudes of people with early-stage dementia toward MAiD should it become accessible to (...)
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  43. Ethical Implications of Alzheimer’s Disease Prediction in Asymptomatic Individuals Through Artificial Intelligence.Frank Ursin, Cristian Timmermann & Florian Steger - 2021 - Diagnostics 11 (3):440.
    Biomarker-based predictive tests for subjectively asymptomatic Alzheimer’s disease (AD) are utilized in research today. Novel applications of artificial intelligence (AI) promise to predict the onset of AD several years in advance without determining biomarker thresholds. Until now, little attention has been paid to the new ethical challenges that AI brings to the early diagnosis in asymptomatic individuals, beyond contributing to research purposes, when we still lack adequate treatment. The aim of this paper is to explore the ethical arguments put forward (...)
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  44. Communicating About Alzheimer’s Disease: Designing and Testing a Campaign Using a Framing Approach.Julia Vacas, Juan A. Moriana, Adoración Antolí & Fátima Cuadrado - 2021 - Communications 46 (4):588-607.
    The prevalence of negative representations of Alzheimer’s disease reinforces the stigma and negative attitudes toward this dementia. To mitigate these negative views, campaigns have been launched by several organizations. This study aims to explore the effect of framing in AD campaigns on attitude change. For this purpose, several posters were designed with framed messages defining dementia and 189 participants were shown the posters. In order to analyze the effect of the different frames, a repeated-measures design was used, in which attitudes (...)
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  45. Altered Frequency-Dependent Brain Activation and White Matter Integrity Associated With Cognition in Characterizing Preclinical Alzheimer’s Disease Stages.Siyu Wang, Jiang Rao, Yingying Yue, Chen Xue, Guanjie Hu, Wenzhang Qi, Wenying Ma, Honglin Ge, Fuquan Zhang, Xiangrong Zhang & Jiu Chen - 2021 - Frontiers in Human Neuroscience 15.
    BackgroundSubjective cognitive decline, non-amnestic mild cognitive impairment, and amnestic mild cognitive impairment are regarded to be at high risk of converting to Alzheimer’s disease. Amplitude of low-frequency fluctuations can reflect functional deterioration while diffusion tensor imaging is capable of detecting white matter integrity. Our study aimed to investigate the structural and functional alterations to further reveal convergence and divergence among SCD, naMCI, and aMCI and how these contribute to cognitive deterioration.MethodsWe analyzed ALFF under slow-4 and slow-5 bands and white matter (...)
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  46. Assisted Diagnosis of Alzheimer’s Disease Based on Deep Learning and Multimodal Feature Fusion.Yu Wang, Xi Liu & Chongchong Yu - 2021 - Complexity 2021:1-10.
    With the development of artificial intelligence technologies, it is possible to use computer to read digital medical images. Because Alzheimer’s disease has the characteristics of high incidence and high disability, it has attracted the attention of many scholars, and its diagnosis and treatment have gradually become a hot topic. In this paper, a multimodal diagnosis method for AD based on three-dimensional shufflenet and principal component analysis network is proposed. First, the data on structural magnetic resonance imaging and functional magnetic resonance (...)
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  47. Preserved Consciousness in Alzheimer’s Disease and Other Dementias: Caregiver Awareness and Communication Strategies.Alison Warren - 2021 - Frontiers in Psychology 12.
    Alzheimer’s disease is an insidious onset neurodegenerative syndrome without effective treatment or cure. It is rapidly becoming a global health crisis that is overwhelming healthcare, society, and individuals. The clinical nature of neurocognitive decline creates significant challenges in bidirectional communication between caregivers and persons with Alzheimer’s disease that can negatively impact quality-of-life. This paper sought to understand how and to what extent would awareness training about the levels of consciousness in AD influence the quality-of-life interactions in the caregiver-patient dyad. A (...)
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  48. Case Report: Deep Brain Stimulation of the Nucleus Basalis of Meynert for Advanced Alzheimer's Disease.Wei Zhang, Wei Liu, Bhavana Patel, Yingchuan Chen, Kailiang Wang, Anchao Yang, Fangang Meng, Aparna Wagle Shukla, Shanshan Cen, John Yu, Adolfo Ramirez-Zamora & Jianguo Zhang - 2021 - Frontiers in Human Neuroscience 15.
    Patients with advanced Alzheimer's disease experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert has been reported to improve cognitive function in individuals with AD. Here, we report the effects of NBM-DBS on cognitive function in a subject with severe AD. An 80-year-old male with severe AD underwent surgery (...)
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  49. Addressing Ethical Challenges of Disclosure in Dementia Prediction: Limitations of Current Guidelines and Suggestions to Proceed.Zümrüt Alpinar-Sencan & Silke Schicktanz - 2020 - BMC Medical Ethics 21 (1):1-11.
    Background Biomarker research is gaining increasing attention focusing on the preclinical stages of the disease. Such interest requires special attention for communication and disclosure in clinical contexts. Many countries give dementia a high health policy priority by developing national strategies and by improving guidelines addressing disclosure of a diagnosis; however, risk communication is often neglected. Main text This paper aims to identify the challenges of disclosure in the context of dementia prediction and to find out whether existing clinical guidelines sufficiently (...)
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  50. Caring for Family Members With Alzheimer’s and Burnout Syndrome: Impairment of the Health of Housewives.María Luisa Avargues-Navarro, Mercedes Borda-Mas, Alina de las Mercedes Campos-Puente, María Ángeles Pérez-San-Gregorio, Agustín Martín-Rodríguez & Milagrosa Sánchez-Martín - 2020 - Frontiers in Psychology 11.
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