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  1. added 2020-06-30
    The Limits of Narrative and Culture: Reflections on Lorrie Moore's “People Like That Are the Only People Here: Canonical Babbling in Peed Onk”.Pamela Schaff & Johanna Shapiro - 2006 - Journal of Medical Humanities 27 (1):1-17.
    This article provides a discussion of the limits of both narrative and culture based on a close textual analysis of the short story, “People Like That Are the Only People Here: Canonical Babbling in Peed Onk,” by Lorrie Moore. In this story, a mother describes her experiences on a pediatric oncology ward when her infant son develops Wilms' tumor. The authors examine how the story satirically portrays the spurious claims of language, story, and culture to protect us from an unjust (...)
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  2. added 2020-06-24
    Cervical Cancer Screening in India.Sandhya Srinivasan, Veena Johari & Amar Jesani - 2018 - In Doris Schroeder, Julie Cook, François Hirsch, Solveig Fenet & Vasantha Muthuswamy (eds.), Ethics Dumping: Case Studies From North-South Research Collaborations. Springer. pp. 33-48.
    Three clinical trials took place in India between 1998 and 2015 in Urban and Rural areas of Mumbai, Osmanabad and Dindigul. The trials aimed to determine whether trained health care workers could conduct cervical cancer screening in a Community using cheap methods of testing – primarily visual inspection with acetic acid – to reduce the incidence and mortality rate of cervical cancer. The clinical trials were conducted on approximately 374,000 Women, of whom about 141,000 were placed in the Control arm. (...)
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  3. added 2020-06-24
    Risk-Reducing Salpingectomy and Ovarian Cancer.Rachelle Barina - 2014 - The National Catholic Bioethics Quarterly 14 (1):67-79.
    Following new scientific evidence, removal of the fallopian tubes or the ovaries, or both, are options for reducing the risk of ovarian cancer. This paper examines the new scientific evidence on the origin of ovarian cancer and argues that the removal of fallopian tubes or ovaries in high-risk patients for the purpose of reducing risk of cancer is not intrinsically disordered. Although a present and serious pathology may not exist, this removal constitutes an indirect sterilization, because the immediate and primary (...)
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  4. added 2020-06-24
    The Ethical Issues of Terminal Cancer Patients.Wenhao Su - 2006 - Philosophy and Culture 33 (4):5-15.
    Cancer has become the main cause of death people, due to advances in medical technology, human life is gradually extended. As life expectancy increases, changes in the environment,罹probability of cancer is also relatively increased. We also have access to more cancer patients, medical staff are facing terminal cancer patients more than before, so for cancer patients in medical knowledge more important than before. For the past can no longer accept the curative treatment of terminal cancer patients, often only painful death. (...)
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  5. added 2020-06-24
    Cancer From the Medical and Existential Points of View.Mario V. Fiorentino - 2001 - In Anna-Teresa Tymieniecka & Evandro Agazzi (eds.), Life Interpretation and the Sense of Illness Within the Human Condition. Kluwer Academic Publishers. pp. 71--79.
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  6. added 2020-06-24
    Face, Honor and Dignity in the Context of Colon Cancer.Miles Little, Christopher F. C. Jordens, Kim Paul, Emma Sayers & Dhananjayan Sriskandarajah - 2000 - Journal of Medical Humanities 21 (4):229-243.
    Illness narratives from patients with colorectal cancer commonly record patterns of change in social relationships that follow the diagnosis and treatment of the condition. We believe that these changes are best explained as a process of facework, which reflects losses of face on the part of the patient, and which assists in the creation of new faces that convey new senses of identity. Facework is familiar in the work by E. Goffman (1955) and has been extensively reworked since his time. (...)
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  7. added 2020-06-24
    Illness, the Mind, and the Body: Cancer and Immunology: An Introduction.Jurrit Bergsma - 1994 - Theoretical Medicine and Bioethics 15 (4).
    From the sixties on it has become clear how the human physical condition could be influenced by human behavior. Although hypothesis were lacking to understand these connections, nursing research especially proved how systematically introduced patient behavior during illness and hospitalization could induce better recovery results and better prognosis for the patient.Information andattitude proved to be crucial elements in these processes of improved patient expectations. It took less than two decades to get to the insights we have in 1994. Recent research (...)
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  8. added 2020-06-03
    The Vitality of Mortality: Being-Toward-Death and Long-Term Cancer Survivorship.Jeanette Bresson Ladegaard Knox - forthcoming - Journal of Medicine and Philosophy:jhaa010.
    Long-term cancer survivorship is an emerging field that focuses on physical late-effects and psychosocial implications for the inflicted. This study wishes to cast light on the underlying ontological aspect of long-term survivorship by philosophically exploring how being in life post cancer is perceived by survivors. Sixteen in-depth interviews with 14 Danish cancer survivors were conducted by the author. Having faced a life-threatening disease but no longer being in imminent danger of dying, survivors still considered death a defining yet dynamic component (...)
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  9. added 2020-05-15
    Factors Influencing the Decision-Making of Elderly Acute Leukemia Patients in Japan Regarding Their Treatment.Miki Fukuyama, Atsushi Asai, Taeko Hanada, Kenji Sakai & Yasuhiro Kadooka - 2017 - Eubios Journal of Asian and International Bioethics 27 (4):106-112.
    Objective: This study examined the process through which elderly patients with new-onset acute leukemia make treatment decisions from the time of diagnosis, in order to identify factors influencing this decision-making process in Japan. Methods: Semi-structured interviews were conducted with twenty-two elderly patients with leukemia. The data were analyzed using the modified grounded theory approach. Results: The process of decision-making in elderly patients with leukemia includes three stages: Initial reactions at diagnosis, change in attitudes, and entrusting the physician with the treatment (...)
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  10. added 2020-05-11
    On Her Death. The Case of Introspection in the Face of Imminent Death.Velga Vevere - 2018 - Proceedings of the XXIII World Congress of Philosophy 28:157-161.
    The present paper is devoted to the exploration of the life and work of Alice James – the younger sister of the psychologist and philosopher William James and the famous novelist Henry James. The paper describes her inability to thrive intellectually and emotionally and express herself fully within the family and society environment of the times. Her only “career”, her only “profession” was to be a patient, an object of thorough scrutiny. The main part of the paper is devoted to (...)
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  11. added 2020-05-11
    Prostatic Cancer, Coital Rates, Vasectomy and Testosterone.William H. James - 1994 - Journal of Biosocial Science 26 (2):269-272.
    SummaryIt is usually supposed that androgens play a major role in the aetiology of prostatic cancer. This note suggests that the association of the disease with low coital rates and its apparent association with vasectomy can both be reconciled with the hypothesised androgenic involvement.
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  12. added 2020-05-08
    The Paradoxical Body: A Glimpse of a Deeper Truth Through Relatives’ Stories.Vibeke Bruun Lorentsen, Dagfinn Nåden & Berit Sæteren - 2019 - Nursing Ethics 26 (6):1611-1622.
    Background: People with progressive cancer experience that their bodies change due to disease and/or treatment. The body is integral to the unity of the human being, a unity that must be perceived as whole if dignity shall be experienced. Relatives are in touch with the suffering bodies of their dear ones, physically, socially, mentally, and existentially, and thus the relatives’ experiences of the bodies of their dear ones might yield insight into the concept of dignity. Aim: The aim of this (...)
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  13. added 2020-05-08
    Transoral Laser Surgery for Laryngeal Carcinoma: Has Steiner Achieved a Genuine Paradigm Shift in Oncological Surgery?A. T. Harris, Attila Tanyi, R. D. Hart, J. Trites, M. H. Rigby, J. Lancaster, A. Nicolaides & S. M. Taylor - 2018 - Annals of the Royal College of Surgeons of England 100 (1):2-5.
    Transoral laser microsurgery applies to the piecemeal removal of malignant tumours of the upper aerodigestive tract using the CO2 laser under the operating microscope. This method of surgery is being increasingly popularised as a single modality treatment of choice in early laryngeal cancers (T1 and T2) and occasionally in the more advanced forms of the disease (T3 and T4), predomi- nantly within the supraglottis. Thomas Kuhn, the American physicist turned philosopher and historian of science, coined the phrase ‘paradigm shift’ in (...)
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  14. added 2020-05-08
    Calibrating Independence Goals and Partner Support: Couples Adjust to Functional Limitations After Tumor Surgery.N. Knoll, A. U. Wiedemann, M. Schrader, J. Felber, S. Burkert, I. Daig & J. Heckhausen - unknown
    © 2015 The International Association of Applied Psychology. When patients recover from disease-related functional limitations, support received from partners may not always match patients' changing independence goals. The lines of defense model proposes a hierarchy of independence goals, ranging from minimising discomfort by disengagement to protection of self-reliance. Prostate cancer patients' LoDs were examined as moderators of the association between partner support and patients' and partners' affect during patients' recovery from postsurgical functional limitations. Methods: Data from 169 couples were assessed (...)
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  15. added 2020-05-08
    The Sexual Ethics of HPV Vaccination for Boys.Jeroen Luyten, Bart Engelen & Philippe Beutels - 2014 - HEC Forum 26 (1):27-42.
    Human papillomavirus (HPV) is one of the most common sexually transmitted infections. It is a leading cause of cervical cancer in women but the virus is increasingly being linked to several other cancers in men and women alike. Since the introduction of safe and effective but also expensive vaccines, many developed countries have implemented selective vaccination programs for girls. Some however argue that these programs should be expanded to include boys, since (1) HPV constitutes non-negligible health risks for boys as (...)
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  16. added 2020-05-08
    Comunicación, información y relación entre paciente oncológico, personal sanitario y familiares.Paola Delbon, Giordano Beretta, Cristina Wührer & Adelaida Conti - 2010 - Medicina y Ética 21:327-346.
    Los autores pretenden profundizar en la problemática ética conexa a la información, a la comunicación y al involucramiento de los familiares en la relación entre personal sanitario y paciente oncológico; también a través de la suministración de un cuestionario a los pacientes hospitalizados en una Unidad Operativa de Oncología o externos frecuentes al Day Hospital en la misma Sección, ya los familiares de los pacientes. Los datos recopilados a través de la investigación han evidenciado cómo el diálogo y la comunicación (...)
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  17. added 2020-05-08
    Challenges of Informed Choice in Organised Screening.W. Østerlie, M. Solbjør, J. -A. Skolbekken, S. Hofvind & A. R. Sætnan - 2008 - Journal of Medical Ethics 34 (9):e5-e5.
    Context: Despite much research on informed choice and the individuals’ autonomy in organised medical screening, little is known about the individuals’ decision-making process as expressed in their own words.Objectives: To explore the decision-making process among women invited to a mammography screening programme.Setting: Women living in the counties of Sør- and Nord-Trøndelag, Norway, invited to the first round of the Norwegian Breast Cancer Screening Program in 2003.Methods: Qualitative methods based on eight semistructured focus-group interviews with a total of 69 women aged (...)
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  18. added 2020-05-08
    Beyond the Oncogene Paradigm: Understanding Complexity in Cancerogenesis.M. Bizzarri, A. Cucina, F. Conti & F. D’Anselmi - 2008 - Acta Biotheoretica 56 (3):173-196.
    In the past decades, an enormous amount of precious information has been collected about molecular and genetic characteristics of cancer. This knowledge is mainly based on a reductionistic approach, meanwhile cancer is widely recognized to be a ‘system biology disease’. The behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. There is not solely a matter how to integrate all available knowledge in such a way that we can still deal with complexity, (...)
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  19. added 2020-05-08
    Challenges of Informed Choice in Organised Screening.W. Osterlie, M. Solbjor, J.-A. Skolbekken, S. Hofvind, A. R. Saetnan & S. Forsmo - 2008 - Journal of Medical Ethics 34 (9):e5-e5.
    Context: Despite much research on informed choice and the individuals’ autonomy in organised medical screening, little is known about the individuals’ decision-making process as expressed in their own words.Objectives: To explore the decision-making process among women invited to a mammography screening programme.Setting: Women living in the counties of Sør- and Nord-Trøndelag, Norway, invited to the first round of the Norwegian Breast Cancer Screening Program in 2003.Methods: Qualitative methods based on eight semistructured focus-group interviews with a total of 69 women aged (...)
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  20. added 2020-05-08
    Assessing the Interpretation of Criteria for Clinical Trial Eligibility: A Survey of Oncology Investigators.Charles Weijer, Benjamin Freedman, Stanley Shapiro, Abraham Fuks, Myriam Skrutkowska & Maria Sigurjonsdottir - unknown
    OBJECTIVE: To investigate whether eligibility criteria that exclude the elderly, persons with psychiatric disease, and persons with substance abuse problems from participation in randomized controlled trials (RCTs) are subjective and hence a source of variability in enrolment decisions and investigator uncertainty. DESIGN: Survey questionnaire. PARTICIPANTS: Cancer investigators from the United States and Canada. INTERVENTIONS: Investigators were presented with clinical vignettes from 3 patient categories--eligible, ineligible and uncertain--for each of 5 eligibility criteria--3 subjective and 2 objective--and were asked whether they would (...)
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  21. added 2020-05-08
    The Questionable Practice of Clinical Staging.Chandler Smith - 1976 - Perspectives in Biology and Medicine 19 (2):273-277.
    Cancer therapy is evaluated by comparing the rates of survival after different methods of treatment. Valid comparison, however, requires that the two groups of patients be uniform with respect to tumor spread so that a difference in results may be attributed to the quality of the respective methods. Clinical staging is the practice used to equate the patient groups for this purpose. Several different staging systems are extant, revisions of them are periodically made, and the practice is in worldwide use. (...)
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  22. added 2020-05-01
    Genital Melanoma: Are We Adequately Screening Our Patients?Zikry Joseph, W. Chapman Lance, Z. Korta Dorota & Smith Janellen - unknown
    Full-body skin exams play an integral role inearly detection and treatment of skin cancer. Promptdetection of melanoma is especially importantas survival outcomes decrease significantly withpresentation of advanced disease. Given thatmelanoma may grow in areas of skin with little to nosun exposure, genital melanomas are a recognizedentity in cutaneous oncology.
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  23. added 2020-05-01
    Applications of the ACGT Master Ontology on Cancer.Mathias Brochhausen, Gabriele Weiler, Luis Martín, Cristian Cocos, Holger Stenzhorn, Norbert Graf, Martin Dörr, Manolis Tsiknakis & Barry Smith - 2008 - In R. Meersman & P. Herrero (eds.), Proceedings of 4th International IFIP Workshop On Semantic Web and Web Semantics (OTM 2008: Workshops), LNCS 5333. pp. 1046–1055.
    In this paper we present applications of the ACGT Master Ontology (MO) which is a new terminology resource for a transnational network providing data exchange in oncology, emphasizing the integration of both clinical and molecular data. The development of a new ontology was necessary due to problems with existing biomedical ontologies in oncology. The ACGT MO is a test case for the application of best practices in ontology development. This paper provides an overview of the application of the ontology within (...)
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  24. added 2020-04-30
    On Somatic Mutations and Tissue Fields in Cancer.Satgé Daniel - 2011 - Bioessays 33 (12):922-923.
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  25. added 2020-04-30
    Scientific Discovery and Scientific Reputation: The Reception of Peyton Rous' Discovery of the Chicken Sarcoma Virus. [REVIEW]Eva Becsei-Kilborn - 2010 - Journal of the History of Biology 43 (1):111 - 157.
    This article concerns itself with the reception of Rous' 1911 discovery of what later came to be known as the Rous Sarcoma Virus (RSV). Rous made his discovery at the Rockefeller Institute for Medical Research which had been primarily established to conduct research into infectious diseases. Rous' chance discovery of a chicken tumor led him to a series of conjectures about cancer causation and about whether cancer could have an extrinsic cause. Rous' finding was received with some scepticism by the (...)
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  26. added 2020-04-30
    A Century of Research Into the Cause of Cancer: Is the New Oncogene Paradigm Revolutionary?Ton van Helvoort - 1999 - History and Philosophy of the Life Sciences 21 (3):293 - 330.
    Contemporary oncological research is predominantly characterised by genetic explanations, a situation which may be briefly denoted as the oncogene paradigm. This essay discusses why the new paradigm was perceived so attractive that it could take over the whole field of oncology within a time-span of less than two decades. It is argued that the revolutionary character of the oncogene paradigm stems from the fact that it transcends a dichotomy which has kept experimental cancer research divided for more than three quarters (...)
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  27. added 2020-04-30
    From the Regulatory Vision of Cancer to the Oncogene Paradigm, 1975–1985.Michel Morange - 1997 - Journal of the History of Biology 30 (1):1 - 29.
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  28. added 2020-04-30
    Definition and Classification of Cancer: Monothetic or Polythetic?Paolo Vineis - 1993 - Theoretical Medicine and Bioethics 14 (3).
    Since the microbiological revolution, most infectious diseases have been defined and classified according to an etiologic criterion, i.e. the identification of single, external necessary causes (for example, Mycobacterium for tuberculosis). This is not the case with cancer. Not only external necessary causes of cancer have not been identified, but also the morphological classification cannot be based on univocal criteria. Although neoplasia and anaplasia appear to be universal attributes of cancer, these events are only quantitative. Neoplastic growth can be fast or (...)
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  29. added 2020-04-29
    Quantitative Modeling of Tumor Dynamics and Radiotherapy.Heiko Enderling, Mark A. J. Chaplain & Philip Hahnfeldt - 2010 - Acta Biotheoretica 58 (4):341-353.
    Cancer is a complex disease, necessitating research on many different levels; at the subcellular level to identify genes, proteins and signaling pathways associated with the disease; at the cellular level to identify, for example, cell-cell adhesion and communication mechanisms; at the tissue level to investigate disruption of homeostasis and interaction with the tissue of origin or settlement of metastasis; and finally at the systems level to explore its global impact, e.g. through the mechanism of cachexia. Mathematical models have been proposed (...)
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  30. added 2020-04-29
    An Essay on Basement Membranes and Their Involvement in Cancer.A. Van Den Hooff - 1989 - Perspectives in Biology and Medicine 32 (3):401.
  31. added 2020-04-28
    Cancer and the Emotions in 18th-Century Literature.Noelle Gallagher - forthcoming - Medical Humanities:medhum-2018-011639.
    This essay argues that the emotional rhetoric of today’s breast cancer discourse—with its emphasis on stoicism and ‘positive thinking’ in the cancer patient, and its use of sympathetic feeling to encourage charitable giving—has its roots in the long 18th century. While cancer had long been connected with the emotions, 18th-century literature saw it associated with both ‘positive’ and ‘negative’ feelings, and metaphors describing jealousy, love and other sentiments as ‘like a cancer’ were used to highlight the danger of allowing feelings—even (...)
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  32. added 2020-04-28
    Relation of Common ABL Kinase Domain Mutations with Resistance to Tyrosine Kinase Inhibiters in Patients with Chronic Myeloid Leukemia in Middle Euphrates of Iraq.Mohammed Sadeq Mahdi Al- Musawi - 2020 - International Journal of Scientific Research and Management (IJSRM) 8 (02).
    Background: Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease, associated with a reciprocal translocation between chromosomes 9 and chromosome 22, lead to the formation of the BCRABL fusion gene (Philadelphia chromosome). This fusion gene is believed to play golden role in the initial development of CML with constitutive tyrosine kinase activation. Successful use of tyrosine kinase inhibiters (TKIs) play a role in improve survival and increase prevalence of CML, but un fortunately mutations in the BCR-ABL kinase domain may (...)
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  33. added 2020-04-28
    Moral Ambivalence Towards the Cancer Drugs Fund.Ilias Ektor Epanomeritakis - 2019 - Journal of Medical Ethics 45 (9):623-626.
    The UK’s Cancer Drugs Fund was introduced in 2010 following the Conservative Party’s promise to address the fact that numerous efficacious cancer drugs were not available because of their cost ineffectiveness, as deduced by the National Institute of Health and Care Excellence. While, at face value, this policy appears only to promote the UK’s public welfare, a deeper analysis reveals the ethically unjustifiable inconsistencies that the CDF introduces; where is the analogous fund for other equally severe diseases? Have the patients (...)
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  34. added 2020-04-28
    The Bible as Coping Tool: Its Use and Psychological Functions in a Sample of Practicing Christians Living with Cancer.Mikael Lundmark - 2019 - Archive for the Psychology of Religion 41 (2):141-158.
    This study addresses the Bible as a coping tool in a sample of Swedish practising Christians living with cancer, gathered through a qualitative, in-depth interview study, on religious experiences and expressions that serve in the process of coping with a life situation changed by the disease. Through content analyses, and case studies combining tools from Pargament’s coping theory with, above all, role theory, it is shown that the Bible is a part of the coping process for approximately half of the (...)
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  35. added 2020-04-28
    A Proposed Expert System for Diagnosing Skin Cancer Using SL5 Object.Mohammed O. Al-Shawwa & Samy S. Abu-Naser - 2019 - International Journal of Academic Information Systems Research (IJAISR) 4 (3):1-9.
    Skin is considered the largest organ of the body, with a total area of about 20 square feet. The skin protects us from microbes and the elements, helps regulate body temperature, and permits the sensations of touch, heat, and cold. For a patient to recover from any illness or weakness that affects the skin, he/she requires an accurate diagnosis of his/her the situation. In this paper will present an expert system that quickly diagnosis patient’s condition and propose a suitable solution (...)
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  36. added 2020-04-28
    Cancer Modeling: The Advantages and Limitations of Multiple Perspectives.A. Plutynski - 2019 - In Michela Massimi & Casey McCoy (eds.), Understanding Perspectivism: Scientific Challenges and Methodological Prospects. New York: Routledge.
    Cancer is a paradigmatic case of a complex causal process; causes of cancer operate at a variety of temporal and spatial scales, and the respects in which these causes act and interact are diverse. There are, for instance, temporal order effects, organizational effects, structural effects, and dynamic relationships between causes operating at different temporal and spatial scales. Because of this complexity, models of cancer initiation and progression often involve deliberate choices to focus on one time scale, one causal pathway, or (...)
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  37. added 2020-04-28
    Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset.Jochen Kaiser, Jörg Dietrich, Miena Amiri, Isa Rüschel, Hazal Akbaba, Nonda Hantke, Klaus Fliessbach, Bianca Senf, Christine Solbach & Christoph Bledowski - 2019 - Frontiers in Psychology 10.
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  38. added 2020-04-28
    Metastatic Metaphors: Poetry, Cancer Imagery, and the Imagined Self.Lois Leveen - 2019 - Perspectives in Biology and Medicine 62 (4):737-757.
    In 1997, the poet Judy Rowe Michaels was diagnosed with ovarian cancer. Over the ensuing 20-plus years, she has published four books of poetry and experienced six recurrences of the disease. This double corpus—the body of literary work produced by a body affected by illness, diagnosis, treatment, remission, and recurrence—provides rich insight into experiences of health, disease, and medical care. But I find Michaels's poetry especially significant because it also offers a means to examine what poetry does, and doesn't do, (...)
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  39. added 2020-04-28
    More Than One Way to Measure? A Casuistic Approach to Cancer Clinical Trials.Mattia Andreoletti - 2018 - Perspectives in Biology and Medicine 61 (2):174-190.
    In recent years, science and technology have made great progress towards a better understanding of fundamental biological mechanisms of the diseases. Physicians, relying just on their own clinical experience, have long recognized that each patient is different from every other patient in many aspects. It is a matter of simple facts that many patients die without responding to any treatment, while others with the same disease survive. In oncology, the variability of treatment response has been a long-standing problem. Nowadays, thanks (...)
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  40. added 2020-04-28
    Application of the Rapid Ethical Assessment Approach to Enhance the Ethical Conduct of Longitudinal Population Based Female Cancer Research in an Urban Setting in Ethiopia.Alem Gebremariam, Alemayehu Worku Yalew, Selamawit Hirpa, Abigiya Wondimagegnehu, Mirgissa Kaba, Mathewos Assefa, Israel Mitiku, Eva Johanna Kantelhardt, Ahmedin Jemal & Adamu Addissie - 2018 - BMC Medical Ethics 19 (1):87.
    Rapid Ethical Assessment is an approach used to design context tailored consent process for voluntary participation of participants in research including human subjects. There is, however, limited evidence on the design of ethical assessment in studies targeting cancer patients in Ethiopia. REA was conducted to explore factors that influence the informed consent process among female cancer patients recruited for longitudinal research from Addis Ababa Population-based Cancer Registry. Qualitative study employing rapid ethnographic approach was conducted from May–July, 2017, at the Tikur (...)
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  41. added 2020-04-28
    Breast Cancer Knowledge Based System.Suheir H. Almurshidi & Samy S. Abu-Naser - 2018 - International Journal of Academic Health and Medical Research (IJAHMR) 2 (12):7-22.
    The Knowledge Based System for Diagnosing Breast Cancer is used to assist medical students to improve their education on diagnosis and counseling the process of analyzing the biopsy image of the microscope, determining the type of tumor and the treatment method for each case and identifying the disease related questions. According to the Ministry of Health in its annual report in Gaza, between 2009 and 2014 there are 7069 cases of breast cancer, and in 2014 there are 1502 cases of (...)
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  42. added 2020-04-28
    Oncogenesis as a Selective Force: Adaptive Evolution in the Face of a Transmissible Cancer.Tracey Russell, Thomas Madsen, Frédéric Thomas, Nynke Raven, Rodrigo Hamede & Beata Ujvari - 2018 - Bioessays 40 (3):1700146.
    Similar to parasites, malignant cells exploit the host for energy, resources and protection, thereby impairing host health and fitness. Although cancer is widespread in the animal kingdom, its impact on life history traits and strategies have rarely been documented. Devil facial tumour disease, a transmissible cancer, afflicting Tasmanian devils, provides an ideal model system to monitor the impact of cancer on host life-history, and to elucidate the evolutionary arms-race between malignant cells and their hosts. Here we provide an overview of (...)
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  43. added 2020-04-28
    Diagnosing Breast Cancer Using Expert System.Suheir H. Almurshidi - 2018 - Dissertation, Al-Azhar University, Gaza
    The “Expert System for Diagnosing Breast Cancer" is used to assist medical students to improve their education on diagnosis and counseling the process of analyzing the biopsy image of the microscope, determining the type of tumor and the treatment method for each case and identifying the disease related questions. According to the Ministry of Health in its annual report in Gaza, between 2009 and 2014 there are 7069 cases of breast cancer, and in 2014 there are 1502 cases of breast (...)
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  44. added 2020-04-28
    Who are benefitted with the new knowledge and therapies directed to combat cancer?Héctor Eduardo Sánchez Vargas & Mirtha Juliana Yordi García - 2017 - Humanidades Médicas 17 (3):538-564.
    Este trabajo presenta como objetivo revelar la influencia de los contextos socioeconómicos en las maneras de afrontamiento al cáncer como enfermedad. Se muestra un análisis sobre el cáncer como problema social y de salud; se analiza el papel de algunos entes sociales involucrados, el acceso de los enfermos a las terapias y de los productores de fármacos a las nuevas tecnologías. Se reflexiona acerca de la sobreevaluación de los fármacos que dificulta el acceso a novedosas y efectivas terapias; la supeditación (...)
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  45. added 2020-04-28
    How Cancer Spreads: Reconceptualizing a Disease.Alan Love - 2017 - In G. Boliolo & M. J. Nathan (eds.), Philosophy of Molecular Medicine: Foundational Issues in Research and Practice. New York and London: Routledge. pp. 100-121.
    Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope, and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored (...)
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  46. added 2020-04-28
    Causality in Cancer Research: A Journey Through Models in Molecular Epidemiology and Their Philosophical Interpretation.Paolo Vineis, Phyllis Illari & Federica Russo - 2017 - Emerging Themes in Epidemiology 14 (7):1-8.
    In the last decades, Systems Biology (including cancer research) has been driven by technology, statistical modelling and bioinformatics. In this paper we try to bring biological and philosophical thinking back. We thus aim at making diferent traditions of thought compatible: (a) causality in epidemiology and in philosophical theorizing—notably, the “sufcient-component-cause framework” and the “mark transmission” approach; (b) new acquisitions about disease pathogenesis, e.g. the “branched model” in cancer, and the role of biomarkers in this process; (c) the burgeoning of omics (...)
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  47. added 2020-04-28
    Ethical Issues Raised by Thyroid Cancer Overdiagnosis: A Matter for Public Health?Wendy A. Rogers, Wendy L. Craig & Vikki A. Entwistle - 2017 - Bioethics 31 (8):590-598.
    Current practices of identifying and treating small indolent thyroid cancers constitute an important but in some ways unusual form of overdiagnosis. Overdiagnosis refers to diagnoses that generally harm rather than benefit patients, primarily because the diagnosed condition is not a harmful form of disease. Patients who are overdiagnosed with thyroid cancer are harmed by the psycho-social impact of a cancer diagnosis, as well as treatment interventions such partial or total thyroidectomy, lifelong thyroid replacement hormone, monitoring, surgical complications and other side (...)
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  48. added 2020-04-28
    The Genes of Life and Death: A Potential Role for Placental-Specific Genes in Cancer.Erin C. Macaulay, Aniruddha Chatterjee, Xi Cheng, Bruce C. Baguley, Michael R. Eccles & Ian M. Morison - 2017 - Bioessays 39 (11):1700091.
    The placenta invades the adjacent uterus and controls the maternal immune system, like a cancer invades surrounding organs and suppresses the local immune response. Intriguingly, placental and cancer cells are globally hypomethylated and share an epigenetic phenomenon that is not well understood – they fail to silence repetitive DNA sequences that are silenced in healthy somatic cells. In the placenta, hypomethylation of retrotransposons has facilitated the evolution of new genes essential for placental function. In cancer, hypomethylation is thought to contribute (...)
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  49. added 2020-04-28
    Chance, Necessity, Love: An Evolutionary Theology of Cancer.Leonard M. Hummel & Gayle E. Woloschak - 2016 - Zygon 51 (2):293-317.
    In his 1970s work Chance and Necessity, Jacques Monod provided an explanatory framework not only for the biological evolution of species, but, as has become recently apparent, for the evolutionary development of cancers. That is, contemporary oncological research has demonstrated that cancer is an evolutionary disease that develops according to the same dynamics of chance and necessity at work in all evolutionary phenomena. And just as various challenges are raised for religious thought by the operations of chance and necessity within (...)
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