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  1. Gene-concept pluralism, causal specificity, and information. [REVIEW]Ronald J. Planer - forthcoming - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences.
  2. The meaning of "cause" in genetics.Kate E. Lynch - 2021 - Combining Human Genetics and Causal Inference to Understand Human Disease and Development. Cold Spring Harbor Perspectives in Medicine.
    Causation has multiple distinct meanings in genetics. One reason for this is meaning slippage between two concepts of the gene: Mendelian and molecular. Another reason is that a variety of genetic methods address different kinds of causal relationships. Some genetic studies address causes of traits in individuals, which can only be assessed when single genes follow predictable inheritance patterns that reliably cause a trait. A second sense concerns the causes of trait differences within a population. Whereas some single genes can (...)
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  3. Why genes are like lemons.F. Boem, E. Ratti, M. Andreoletti & G. Boniolo - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 57 (June):88-95.
    In the last few years, the lack of a unitary notion of gene across biological sciences has troubled the philosophy of biology community. However, the debate on this concept has remained largely historical or focused on particular cases presented by the scientific empirical advancements. Moreover, in the literature there are no explicit and reasonable arguments about why a philosophical clarification of the concept of gene is needed. In our paper, we claim that a philosophical clarification of the concept of gene (...)
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  4. Origins of the Classical Gene Concept, 1900–1950: Genetics, Mechanistic, Philosophy, and the Capitalization of Agriculture. [REVIEW]Garland E. Allen - 2014 - Perspectives in Biology and Medicine 57 (1):8-39.
    As many of the papers in this Special Symposium Issue discuss, by the 21st century we have moved well beyond the notion of a gene as a single particulate unit coding for a given protein, or especially a single phenotypic trait. Yet notions of genes as some kind of single, particulate entity still persist, especially in textbooks and writings about genetics for the general public. To understand this disjunct between the professional geneticist’s view of genes and their complex interactions, and (...)
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  5. Genetics and Philosophy: An Introduction.Monika Piotrowska - 2014 - International Studies in the Philosophy of Science 28 (2):223-226.
    Much of the book is aimed at persuading the reader that genes are not ‘the prime movers in all biological processes’ and that ‘postgenomic genes’ are better understood in a functional sense, as ‘things an organism can do with its genome.' With the main argument in place, the authors examine its impact on a number of philosophical debates. I will discuss three of them: causation, information, and reduction.
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  6. Are all genes regulatory genes?Rosario Michael Piro - 2011 - Biology and Philosophy 26 (4):595-602.
    Although much has been learned about hereditary mechanisms since Gregor Mendel’s famous experiments, gene concepts have always remained vague, notwithstanding their central role in biology. During over hundred years of genetic research, gene concepts have often and dynamically changed to accommodate novel experimental findings, without ever providing a generally accepted definition of the ‘gene.’ Yet, the distinction between ‘regulatory genes’ and ‘structural genes’ has remained a common theme in modern gene concepts since the definition of the operon-model. This distinction is (...)
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  7. Genes versus Genomes: The Role of Genome Organization in Evolution.Ehud Lamm - 2010 - Dissertation, Tel Aviv University
    Recent and not so recent advances in our molecular understanding of the genome make the once prevalent view of the genome as a passive container of genetic information (i.e., genes) untenable, and emphasize the importance of the internal organization and re-organization dynamics of the genome for both development and evolution. While this conclusion is by now well accepted, the construction of a comprehensive conceptual framework for studying the genome as a dynamic system, capable of self-organization and adaptive behavior is still (...)
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  8. What are genes “for” or where are traits “from”? What is the question?Anne V. Buchanan, Samuel Sholtis, Joan Richtsmeier & Kenneth M. Weiss - 2009 - Bioessays 31 (2):198-208.
    For at least a century it has been known that multiple factors play a role in the development of complex traits, and yet the notion that there are genes “for” such traits, which traces back to Mendel, is still widespread. In this paper, we illustrate how the Mendelian model has tacitly encouraged the idea that we can explain complexity by reducing it to enumerable genes. By this approach many genes associated with simple as well as complex traits have been identified. (...)
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