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Summary Articles included in Developmental Biology, Misc. are those that do not focus on a topic from any other sub-category.   
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  1. Aristotle on Epigenesis.Devin Henry - 2018
    It has become somewhat of a platitude to call Aristotle the first epigenesist insofar as he thought form and structure emerged gradually from an unorganized, amorphous embryo. But modern biology now recognizes two senses of “epigenesis”. The first is this more familiar idea about the gradual emergence of form and structure, which is traditionally opposed to the idea of preformationism. But modern biologists also use “epigenesis” to emphasize the context-dependency of the process itself. Used in this sense development is not (...)
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  2. Multiple-Models Juxtaposition and Trade-Offs Among Modeling Desiderata.Yoshinari Yoshida - 2021 - Philosophy of Science 88 (1):103-123.
    This article offers a characterization of what I call multiple-models juxtaposition, a strategy for managing trade-offs among modeling desiderata. MMJ displays models of distinct phenomena to...
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  3. Character Identity Mechanisms: A Conceptual Model for Comparative-Mechanistic Biology.James DiFrisco, Alan C. Love & Günter P. Wagner - 2020 - Biology and Philosophy 35 (4):1-32.
    There have been repeated attempts in the history of comparative biology to provide a mechanistic account of morphological homology. However, it is well-established that homologues can develop from diverse sets of developmental causes, appearing not to share any core causal architecture that underwrites character identity. We address this challenge with a new conceptual model of Character Identity Mechanisms. ChIMs are cohesive mechanisms with a recognizable causal profile that allows them to be traced through evolution as homologues despite having a diverse (...)
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  4. A Theory of Evolution as a Process of Unfolding.Agustin Ostachuk - 2020 - Cosmos and History: The Journal of Natural and Social Philosophy 16 (1):347-379.
    In this work I propose a theory of evolution as a process of unfolding. This theory is based on four logically concatenated principles. The principle of evolutionary order establishes that the more complex cannot be generated from the simpler. The principle of origin establishes that there must be a maximum complexity that originates the others by logical deduction. Finally, the principle of unfolding and the principle of actualization guarantee the development of the evolutionary process from the simplest to the most (...)
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  5. The Unfolding of a New Vision of Life, Cosmos and Evolution.Agustin Ostachuk - 2020 - Ludus Vitalis 28 (53):81-83.
    Has science already answered the fundamental questions about the concepts of Life, Cosmos and Evolution? Has science not relegated these fundamental questions by following up on more immediate, “useful” and practical endeavors that ultimately ensure that the wheel of capitalism keeps spinning in its frantic search for material and economic progress? There is something terribly wrong with the current theory of evolution, understood as the Darwinian theory with its successive versions and extensions. The concept of natural selection, the cornerstone of (...)
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  6. The Quest for a Holistic and Historical-Developmental Theory of the Organism.Agustin Ostachuk - 2019 - Ludus Vitalis 27 (51):23-42.
    In this work the doctrine of organicism will be addressed, as explained and seen mainly by Bertalanffy. We will study how this doctrine represents and embodies the ambiguity of Kantian teleology as a regulative principle, and how this same problem leads to consider a real problem as a knowledge problem. It will be concluded that organicism, conceived in this way, does not represent a true holism, but what we will call a syn-holism, a synthesis or assembly, and that to obtain (...)
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  7. Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function.Zachary T. Calamari, Jimmy Kuang‐Hsien Hu & Ophir D. Klein - 2018 - Bioessays 40 (12):1800140.
    Efforts from diverse disciplines, including evolutionary studies and biomechanical experiments, have yielded new insights into the genetic, signaling, and mechanical control of tooth formation and functions. Evidence from fossils and non‐model organisms has revealed that a common set of genes underlie tooth‐forming potential of epithelia, and changes in signaling environments subsequently result in specialized dentitions, maintenance of dental stem cells, and other phenotypic adaptations. In addition to chemical signaling, tissue forces generated through epithelial contraction, differential growth, and skeletal constraints act (...)
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  8. Microbial Diversity in the Eukaryotic SAR Clade: Illuminating the Darkness Between Morphology and Molecular Data.Jean-David Grattepanche, Laura M. Walker, Brittany M. Ott, Daniela L. Paim Pinto, Charles F. Delwiche, Christopher E. Lane & Laura A. Katz - 2018 - Bioessays 40 (4):1700198.
    Despite their diversity and ecological importance, many areas of the SAR—Stramenopila, Alveolata, and Rhizaria—clade are poorly understood as the majority (90%) of SAR species lack molecular data and only 5% of species are from well‐sampled families. Here, we review and summarize the state of knowledge about the three major clades of SAR, describing the diversity within each clade and identifying synapomorphies when possible. We also assess the “dark area” of SAR: the morphologically described species that are missing molecular data. The (...)
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  9. Microbial Diversity in the Eukaryotic SAR Clade: Illuminating the Darkness Between Morphology and Molecular Data.Jean‐David Grattepanche, Laura M. Walker, Brittany M. Ott, Daniela L. Paim Pinto, Charles F. Delwiche, Christopher E. Lane & Laura A. Katz - 2018 - Bioessays 40 (4).
    Despite their diversity and ecological importance, many areas of the SAR—Stramenopila, Alveolata, and Rhizaria—clade are poorly understood as the majority of SAR species lack molecular data and only 5% of species are from well-sampled families. Here, we review and summarize the state of knowledge about the three major clades of SAR, describing the diversity within each clade and identifying synapomorphies when possible. We also assess the “dark area” of SAR: the morphologically described species that are missing molecular data. The majority (...)
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  10. Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont.Alexander V. Klimovich & Thomas C. G. Bosch - 2018 - Bioessays 40 (9):1800060.
    Here we evaluate our current understanding of the function of the nervous system in Hydra, a non‐bilaterian animal which is among the first metazoans that contain neurons. We highlight growing evidence that the nervous system, with its rich repertoire of neuropeptides, is involved in controlling resident beneficial microbes. We also review observations that indicate that microbes affect the animal's behavior by directly interfering with neuronal receptors. These findings provide new insight into the original role of the nervous system, and suggest (...)
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  11. Visions of Eye Commensals: The Known and the Unknown About How the Microbiome Affects Eye Disease.Anthony J. St Leger & Rachel R. Caspi - 2018 - Bioessays 40 (11):1800046.
    Until recently, the ocular surface is thought by many to be sterile and devoid of living microbes. It is now becoming clear that this may not be the case. Recent and sophisticated PCR analyses have shown that microbial DNA‐based “signatures” are present within various ethnic, geographic, and contact lens wearing communities. Furthermore, using a mouse model of ocular surface disease, we have shown that the microbe, Corynebacterium mastitidis (C. mast), can stably colonize the ocular mucosa and that a causal relationship (...)
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  12. The Evolution Concept: The Concept Evolution.Agustin Ostachuk - 2018 - Cosmos and History: The Journal of Natural and Social Philosophy 14 (3):354-378.
    This is an epistemologically-driven history of the concept of evolution. Starting from its inception, this work will follow the development of this pregnant concept. However, in contradistinction to previous attempts, the objective will not be the identification of the different meanings it adopted through history, but conversely, it will let the concept to be unfolded, to be explicated and to express its own inner potentialities. The underlying thesis of the present work is, therefore, that the path that leads to the (...)
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  13. How-Possibly Explanation in Biology: Lessons From Wilhelm His’s ‘Simple Experiments’ Models.Christopher Pearson - 2018 - Philosophy, Theory, and Practice in Biology 10 (4).
    A common view of how-possibly explanations in biology treats them as explanatorily incomplete. In addition to this interpretation of how-possibly explanation, I argue that there is another interpretation, one which features what I term “explanatory strategies.” This strategy-centered interpretation of how-possibly explanation centers on there being a different explanatory context within which how-possibly explanations are offered. I contend that, in conditions where this strategy context is recognized, how-possibly explanations can be understood as complete explanations. I defend this alternative interpretation by (...)
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  14. Evo-Devo: A Science of Dispositions.Christopher Austin - 2017 - European Journal for Philosophy of Science 7 (2):373-389.
    Evolutionary developmental biology represents a paradigm shift in the understanding of the ontogenesis and evolutionary progression of the denizens of the natural world. Given the empirical successes of the evo-devo framework, and its now widespread acceptance, a timely and important task for the philosophy of biology is to critically discern the ontological commitments of that framework and assess whether and to what extent our current metaphysical models are able to accommodate them. In this paper, I argue that one particular model (...)
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  15. Recent Work in The Philosophy of Biology.Christopher J. Austin - 2017 - Analysis 77 (2):anx032.
    The biological sciences have always proven a fertile ground for philosophical analysis, one from which has grown a rich tradition stemming from Aristotle and flowering with Darwin. And although contemporary philosophy is increasingly becoming conceptually entwined with the study of the empirical sciences with the data of the latter now being regularly utilised in the establishment and defence of the frameworks of the former, a practice especially prominent in the philosophy of physics, the development of that tradition hasn’t received the (...)
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  16. Stem Cell Lineages: Between Cell and Organism.Melinda Bonnie Fagan - 2017 - Philosophy, Theory, and Practice in Biology 9 (6).
    Ontologies of living things are increasingly grounded on the concepts and practices of current life science. Biological development is a process, undergone by living things, which begins with a single cell and (in an important class of cases) ends with formation of a multicellular organism. The process of development is thus prima facie central for ideas about biological individuality and organismality. However, recent accounts of these concepts do not engage developmental biology. This paper aims to fill the gap, proposing the (...)
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  17. Tell Us Your Story About You and Your Proteins.Green Linna - 2017
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  18. Could We Also Be Regenerative Superheroes, Like Salamanders?Alessandra Dall'Agnese & Pier Lorenzo Puri - 2016 - Bioessays 38 (9):917-926.
  19. Cellular Lifespan and Senescence: A Complex Balance Between Multiple Cellular Pathways.David Dolivo, Sarah Hernandez & Tanja Dominko - 2016 - Bioessays 38 (S1):S33-S44.
  20. Eine neue Sicht der Evolution: Ist es nur der Zufall, der sie leitet?Paul Gottlob Layer - 2016 - BRIEFE Zur Orientierung Im Konflikt Mensch - Erde, Evangelische Akademie Sachsen-Anhalt E.V 121 (4):16-24.
    Nach neodarwinistischem Verständnis der Evolution entstehen neue Organismen letztlich durch rein zufällige Mutationsprozesse auf genetischer Ebene. Ihre Überlebenschancen werden dann durch die jeweilig herrschende Umwelt begünstigt oder unterdrückt. Die Evolution ist demnach nur vom reinen Zufall geleitet. Neuere Einsichten aus Entwicklungsbiologie (EvoDevo) und Epigenetik haben unsere Sicht der Evolutionsabläufe jedoch deutlich erweitert. Dabei kommt der Umwelt eine lenkende Rolle zu, der reine Zufall verliert an Bedeutung. Damit lässt sich naturwissenschaftliches Verständnis wieder besser mit herkömmlichen Schöpfungsbildern versöhnen.
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  21. The Principle of Life: from Aristotelian Psyche to Drieschian Entelechy.Agustin Ostachuk - 2016 - Ludus Vitalis 24 (45):37-59.
    Is life a simple result of a conjunction of physico-chemical processes? Can be reduced to a mere juxtaposition of spatially determined events? What epistemology or world-view allows us to comprehend it? Aristotle built a novel philosophical system in which nature is a dynamical totality which is in constant movement. Life is a manifestation of it, and is formed and governed by the psyche. Psyche is the organizational principle of the different biological levels: nutritive, perceptive and intelective. Driesch's crucial experiment provided (...)
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  22. Abstrakt - Affektiv - Multimodal. Zur Verarbeitung von Bewegtbildern Im Anschluss an Cassirer, Langer Und Krois.Martina Sauer - 2016 - In Lars Christian Grabbe, Patrick Rupert-Kruse & Norbert M. Schmitz (eds.), Bildkörper. Zum Verhältnis von Bildtechnologien und Embodiment. Kiel, Germany: Büchner-Verlag. pp. 46-71.
    Is it true that there is an analogy between modes of creation and such of perception? Respective to the cultural anthropological research of Ernst Cassirer, Susanne K. Langer and John M. Krois and by the analysis of a tape of the Swiss video-artist Pipilotti Rist this initial thesis of Formal Aesthetics shall be supported. - I - -/- Lässt sich die Behauptung stützen, dass zwischen Gestaltungsweisen und Wahrnehmungsweisen eine Analogie besteht? Aufbauend auf den kulturanthropologischen Forschungen von Ernst Cassirer, Susanne K. (...)
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  23. Mitochondria: The Red Queen Lies Within.Bram Kuijper - 2015 - Bioessays 37 (9):934-934.
  24. Pre‐Modern Islamic Medical Ethics and Graeco‐Islamic‐Jewish Embryology.Mohammed Ghaly - 2014 - Bioethics 28 (2):49-58.
    This article examines the, hitherto comparatively unexplored, reception of Greek embryology by medieval Muslim jurists. The article elaborates on the views attributed to Hippocrates (d. ca. 375 BC), which received attention from both Muslim physicians, such as Avicenna (d. 1037), and their Jewish peers living in the Muslim world including Ibn Jumayʽ (d. ca. 1198) and Moses Maimonides (d. 1204). The religio-ethical implications of these Graeco-Islamic-Jewish embryological views were fathomed out by the two medieval Muslim jurists Shihāb al-Dīn al-Qarāfī (d. (...)
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  25. Targeting Cancer's Weaknesses : Therapeutic Strategies Suggested by the Atavistic Model.Charles H. Lineweaver, Paul C. W. Davies & Mark D. Vincent - 2014 - Bioessays 36 (9):827-835.
    In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target‐the‐weakness strategy. Our most detailed example involves the immune system. The absence of adaptive immunity in immunosuppressed (...)
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  26. The Plant Ontology as a Tool for Comparative Plant Anatomy and Genomic Analyses.Laurel Cooper, Ramona Walls, Justin Elser, Maria A. Gandolfo, Dennis W. Stevenson, Barry Smith & Others - 2013 - Plant and Cell Physiology 54 (2):1-23..
    The Plant Ontology (PO; http://www.plantontology.org/) is a publicly-available, collaborative effort to develop and maintain a controlled, structured vocabulary (“ontology”) of terms to describe plant anatomy, morphology and the stages of plant development. The goals of the PO are to link (annotate) gene expression and phenotype data to plant structures and stages of plant development, using the data model adopted by the Gene Ontology. From its original design covering only rice, maize and Arabidopsis, the scope of the PO has been expanded (...)
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  27. Phosphatidylinositol‐4‐Phosphate: The Golgi and Beyond.Maria A. De Matteis, Cathal Wilson & Giovanni D'Angelo - 2013 - Bioessays 35 (7):612-622.
  28. Lehrman's Dictum: Information and Explanation in Developmental Biology.Paul E. Griffiths - 2013 - Developmental Psychobiology 55 (1):22--32.
  29. Théorie mathématique des catégories en biologie et notion d’équivalence naturelle chez Robert Rosen.Franck Varenne - 2013 - Revue d'Histoire des Sciences 66 (1):167-197.
    The aim of this paper is to describe and analyze the epistemological justification of a proposal initially made by the bio-mathematician Robert Rosen in 1958. In this theoretical proposal, Rosen suggests using the mathematical concept of « category » and the correlative concept of « natural equivalence » in mathematical modeling applied to living beings. Our questions are the following: according to Rosen, to what extent does the mathematical notion of category give access to more « natural » formalisms in (...)
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  30. Predictive Power of “A Minima” Models in Biology.L. Almeida & J. Demongeot - 2012 - Acta Biotheoretica 60 (1-2):3-19.
    Many apparently complex mechanisms in biology, especially in embryology and molecular biology, can be explained easily by reasoning at the level of the “efficient cause” of the observed phenomenology: the mechanism can then be explained by a simple geometrical argument or a variational principle, leading to the solution of an optimization problem, for example, via the co-existence of a minimization and a maximization problem . Passing from a microscopic level to the macroscopic level often involves an averaging effect that gives (...)
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  31. Detecting Themes and Variations: The Use of Cases in Developmental Biology.Rachel A. Ankeny - 2012 - Philosophy of Science 79 (5):644-654.
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  32. Analysis of Generative Mechanisms.Björn Blom & Stefan Morén - 2011 - Journal of Critical Realism 10 (1):60-79.
    The focus of this article is the analysis of generative mechanisms, a basic concept and phenomenon within the metatheoretical perspective of critical realism. It is emphasized that research questions and methods, as well as the knowledge it is possible to attain, depend on the basic view – ontologically and epistemologically – regarding the phenomenon under scrutiny. A generative mechanism is described as a trans empirical but real existing entity, explaining why observable events occur. Mechanisms are mostly possible to grasp only (...)
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  33. The Ethics of Synthetic Biology: Guiding Principles for Emerging Technologies.Amy Gutmann - 2011 - Hastings Center Report 41 (4):17-22.
    The Presidential Commission for the Study of Bioethical Issues released its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, on December 16, 2010.1 President Barack Obama had requested this report following the announcement last year that the J. Craig Venter Institute had created the world’s first self-replicating bacterial cell with a completely synthetic genome. The Venter group’s announcement marked a significant scientific milestone in synthetic biology, an emerging field of research that aims to combine the knowledge (...)
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  34. Information in Biology: A Fictionalist Account.Arnon Levy - 2011 - Noûs 45 (4):640-657.
  35. Becoming Organisms. The Development of Organisation and the Organisation of Development.Laura Nuño de la Rosa - 2010 - History and Philosophy of Life Sciences 32:289-316.
    Despite the radical importance of embryology in the development of organi- cism, developmental biology remains philosophically underexplored as a theoretical and empirical resource to clarify the nature of organisms. This paper discusses how embryology can help develop the organisational definition of the organism as a differentiated, function- ally integrated, and autonomous system. I distinguish two conceptions of development in the organisational tradition that yield two different conceptions of the organism: the life- history view claims that organisms can be considered as (...)
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  36. What is an Organism? An Immunological Answer.Thomas Pradeu - 2010 - History and Philosophy of the Life Sciences 32 (2-3):247-267.
    The question “What is an organism?”, formerly considered as essential in biology, has now been increasingly replaced by a larger question, “What is a biological individual?”. On the grounds that i) individuation is theory-dependent, and ii) physiology does not offer a theory, biologists and philosophers of biology have claimed that it is the theory of evolution by natural selection which tells us what counts as a biological individual. Here I show that one physiological field, immunology, offers a theory, which makes (...)
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  37. Google Embryo for Building Quantitative Understanding of an Embryo As It Builds Itself. II. Progress Toward an Embryo Surface Microscope.Richard Gordon - 2009 - Biological Theory 4 (4):396-412.
    Embryos start out as tiny globes, on which many important events occur, including cell divisions, shape changes and changes of neighbors, waves of contraction and expansion, motion of cell sheets, extension of filopodia, shearing of cell connections, and differentiation and morphogenesis of tissues such as skin and brain. I propose to build a robotic microscope that would enable a new way to look at embryos: Google Embryo. This is akin to sending a space probe to Jupiter and its moons, sending (...)
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  38. Google Embryo for Building Quantitative Understanding of an Embryo As It Builds Itself. I. Lessons From Ganymede and Google Earth.Richard Gordon - 2009 - Biological Theory 4 (4):390-395.
    Google Earth allows us to obtain a new vision of the planet we live on, with an ability to zoom in from space to ground level detail at any point on Earth. As it is only recently that we have been able to look toward the Earth from space, we review instead the history of imaging of the Jupiter moon Ganymede, another globe, first seen by Galileo. Observations of Ganymede are mined for lessons on the importance and impact of improving (...)
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  39. Aristotle’s Generation of Animals.Devin Henry - 2009 - In Georgios Anagnostopoulos (ed.), A Companion to Aristotle. Blackwell-Wiley.
    A general article discussing philosophical issues arising in connection with Aristotle's "Generation of Animals" (Chapter from Blackwell's Companion to Aristotle).
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  40. Imitation as an Inheritance System.Nicholas Shea - 2009 - Philosophical Transactions of the Royal Society B 364:2429-2443.
    What is the evolutionary significance of the various mechanisms of imitation, emulation and social learning found in humans and other animals? This paper presents an advance in the theoretical resources for addressing that question, in the light of which standard approaches from the cultural evolution literature should be refocused. The central question is whether humans have an imitationbased inheritance system—a mechanism that has the evolutionary function of transmitting behavioural phenotypes reliably down the generations. To have the evolutionary power of an (...)
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  41. A Companion to Aristotle.Georgios Anagnostopoulos (ed.) - 2008 - Wiley-Blackwell.
    _The Blackwell Companion to Aristotle_ provides in-depth studies of the main themes of Aristotle's thought, from art to zoology. The most comprehensive single volume survey of the life and work of Aristotle Comprised of 40 newly commissioned essays from leading experts Coves the full range of Aristotle's work, from his 'theoretical' inquiries into metaphysics, physics, psychology, and biology, to the practical and productive "sciences" such as ethics, politics, rhetoric, and art.
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  42. Recycling Nonlinear Evolutionary Living Into Linear Developmental Lives.Myrdene Anderson & Devika Chawla - 2008 - Semiotics:156-162.
  43. Which Way Does the Wnt Blow? Exploring the Duality of Canonical Wnt Signaling on Cellular Aging.Nathan A. DeCarolis, Keith A. Wharton & Amelia J. Eisch - 2008 - Bioessays 30 (2):102-106.
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  44. Decision-Making Processes Among Contemporary ʻulamā: Islamic Embryology and the Discussion of Frozen Embryos.Thomas Eich - 2008 - In Jonathan E. Brockopp & Thomas Eich (eds.), Muslim Medical Ethics: From Theory to Practice. University of South Carolina Press.
  45. Conrad H. Waddington: Towards a Theoretical Biology.Brian K. Hall & Manfred D. Laubichler - 2008 - Biological Theory 3 (3):233-237.
  46. Review of Jan-Christoph Heiliger (ed.), Naturgeschichte der Freiheit. [REVIEW]Marco Solinas - 2008 - Iride: Filosofia e Discussione Pubblica (54):496-498.
  47. Scientific Exchange: Jacques Loeb (1859–1924) and Emil Godlewski (1875–1944) as Representatives of a Transatlantic Developmental Biology. [REVIEW]Heiner Fangerau & Irmgard Müller - 2007 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 38 (3):608-617.
    The German–American physiologist Jacques Loeb (1859–1924) and the Polish embryologist Emil Godlewski, jr. (1875–1944) contributed many valuable works to the body of developmental biology. Jacques Loeb was world famous at the beginning of the twentieth century for his development and demonstration of artificial parthenogenesis in 1899 and his experiments on regeneration. He served as a role model for the younger Polish experimenter Emil Godlewski, who began his career as a researcher like Loeb at the Zoological Station in Naples. Following Godlewski’s (...)
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  48. A Note on Metaphysics and Embryology.Alfonso Gómez-Lobo - 2007 - Theoretical Medicine and Bioethics 28 (4):331-335.
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  49. How Sexist is Aristotle's Developmantal Biology?Devin Henry - 2007 - Phronesis 52 (3):251-69.
    The aim of this paper is to evaluate the level of gender bias in Aristotle’s Generation of Animals while exercising due care in the analysis of its arguments. I argue that while the GA theory is clearly sexist, the traditional interpretation fails to diagnose the problem correctly. The traditional interpretation focuses on three main sources of evidence: (1) Aristotle’s claim that the female is, as it were, a “disabled” (πεπηρωμένον) male; (2) the claim at GA IV.3, 767b6-8 that females are (...)
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  50. Finding the Way in Phenotypic Space: The Origin and Maintenance of Constraints on Organismal Form.Massimo Pigliucci - 2007 - Annals of Botany 100:433-438.
    Background: One of the all-time questions in evolutionary biology regards the evolution of organismal shapes, and in particular why certain forms appear repeatedly in the history of life, others only seldom and still others not at all. Recent research in this field has deployed the conceptual framework of constraints and natural selection as measured by quantitative genetic methods. Scope: In this paper I argue that quantitative genetics can by necessity only provide us with useful statistical sum- maries that may lead (...)
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