Life

In this work I propose a theory of evolution as a process of unfolding. This theory is based on four logically concatenated principles. The principle of evolutionary order establishes that the more complex cannot be generated from the simpler. The principle of origin establishes that there must be a maximum complexity that originates the others by logical deduction. Finally, the principle of unfolding and the principle of actualization guarantee the development of the evolutionary process from the simplest to the most (...) complex. These logical principles determine the existence of a virtual ideological matrix that contains the sequence of the preformed and folded morphogenetic fields. In this manner, the evolutionary process consists of the sequential unfolding and actualization of these fields, which is motorized by a process of teleologization carried out by the opening consciousness of the forms included in the fields of the ideological matrix. This theory leads to a radical change of perspective regarding the materialist worldview, and places life at the center of the evolutionary process as an activity carried out by a consciousness that seeks to fulfill a purpose by actualizing its own potentialities. (shrink)

Life’s meaning is a deeply important yet perplexing topic. It is often unclear what people are talking about when they talk about life having “meaning”. This paper attempts to clarify things by articulating a schema for understanding claims about meaning. It defends a theory according to which X means Y iff Y is a correct interpretation of X—i.e., if Y is a correct answer to an interpretive question, Z. I argue that this (perhaps surprising) claim has impressive explanatory power. Applying (...) this schema to life explains the many ways in which people seem to think and talk about life’s meaning, and common claims in the philosophical literature. It also makes sense of empirical findings from psychological research on perceived meaning in life. (shrink)

The organism against its environment. The organism against other organisms, competing and struggling for life. Antagonism and confrontment as the only possible relation in nature. The tendency to anthropomorphize nature and explain it using concepts and facts from the human sphere. A stroll through the worlds of Uexküll and Merleau-Ponty in the search of alternative knowledge that allow us to understand relation from another point of view. A counterpoint and identification of common tonalities between the research programs from both thinkers (...) as a way to demonstrate the possibilities of a more fruitful approach. Umwelt as a generative system of meaningful relations in which its participants are not mutually exclusive, but express a melody that include them all. (shrink)

The influence of Kurt Goldstein on the thinking of Georges Canguilhem extended throughout his entire work. This paper seeks to examine this relationship in order to conduct a study of the norm as a nexus or connection between the concept and life. Consequently, this work will be a reflection on the approach to life as a normative activity and self-realization. For this, it will be necessary to redefine the concepts of health and disease, and make a crossover between the two. (...) At the end of this trajectory, it will be found that these concepts can explain the identity between the concept and life, which leads to the unexpected conclusion that the cure is ultimately self-healing. (shrink)

I årtusenden har människan försökt definiera livet – hur levande djur och växter skiljer sig från död materia. Problemet är dock att livet är mångfacetterat, och varje regel har sitt undantag. Vi försöker möta kommande utmaningar med nya livsformer, genom att lyfta fram en ny definition av liv.

Om människan någon gång kommer att få förmågan att skapa nya livsformer, hur kommer det att påverka livets värde? Detta är en fråga som kan vara en källa till oro när man diskuterar konstgjort liv, men är oron befogad? I ett försök att svara på den frågan kommer jag att gå igenom några möjliga skäl till varför förmågan att skapa konstgjort liv skulle hota livets värde, och se om de verkligen ger oss skäl att oroa oss.

This article interprets Jakob von Uexkull’s understanding of different beings’ Innenwelt, Gegenwelt, and umwelt through Deleuzian insights of multiplicity, context, and particularity. This Deleuzian interpolation into Uexkull’s insights acknowledges the absence of a unitary ‘human’ view of nature, recognizing instead that plural viewpoints of cultures, subgroups and individuals understand and interpret natural signs variously not just because of ideology but because of physiology and contrastive fundamental ways of accessing the world. Recent formative research in comparative neurobiology suggests that universal anthropological (...) claims of cross-cultural semiotic similarity are incorrect.Interpreting biosemiotics as the investigation of apprehending the Innenwelt of radically different others, such semiotic understandings themselves are not necessarily generalizable between different members of the same species in a group, same-species groups in different natural cultural contexts, or even the same animal at different points of time. Conjoining Deleuze’s insights of the complexity of multiplicity with Uexkull’s scientific-imaginative system of comprehending other creatures’ ways of understanding their world offers an increased self-reflexivity regarding the simultaneous levels of actual semiotic activity for biosemiotic inquiry. (shrink)

Is life a simple result of a conjunction of physico-chemical processes? Can be reduced to a mere juxtaposition of spatially determined events? What epistemology or world-view allows us to comprehend it? Aristotle built a novel philosophical system in which nature is a dynamical totality which is in constant movement. Life is a manifestation of it, and is formed and governed by the psyche. Psyche is the organizational principle of the different biological levels: nutritive, perceptive and intelective. Driesch's crucial experiment provided (...) empirical proof of the principle of life, which he called entelechy. Entelechy is an intensive manifoldness and cannot be comprehended by the usual extensive parameters. The entelechian's own ambiance is duration. This allows the reintroduction of the concept of teleology in the sphere of the living, understood not as a final cause, but as an order born from desire and leading to action. (shrink)

Life is the center of our existence. One would be tempted to say that first of all we live. However, our existence does not seem to pass in that modality. The exacerbated materialism in which our existence takes place, displaces life from the center of the scene. Our society is organized around production, consumerism, exploitation, efficiency, trade and propaganda. That is to say, our existence seems to have economy as the center of organization of our activities. The struggle of this (...) century that is beginning is to put life at the center of our existence, and to put economy in its proper place, that is, in the service of life. (shrink)

In this article, I expound and assess two theories of meaning in life informed by the indigenous sub-Saharan African philosophical tradition. According to one principle, a life is more meaningful, the more it promotes community with other human persons. According to the other principle, a life is more meaningful, the more it promotes vitality in oneself and others. I argue that, at least upon some refinement, both of these African conceptions of meaning merit global consideration from philosophers, but that the (...) vitality approach is more promising than the community one for capturing a wider array of intuitions about what confers meaning on a life. I further argue, however, that there are objections that apply with comparable force to both theories; neither one does a good job of entailing that and explaining why certain types of reason and progress can make a life more meaningful. Although these objections are characteristic of a ‘modern’ western outlook, I maintain that they are difficult for contemporary African philosophers to ignore and consider some ways they might respond to the objections. (shrink)

Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain bodily functions such as glucose metabolism. In particular, feedback loops focus on the maintenance of the plasma concentrations of glucose within a narrow range. Here, we put forward a different, organicist perspective on the endocrine regulation of glycaemia, by relying on the pivotal concept of closure of constraints. From this perspective, biological systems are understood as organized ones, which means that they are constituted of a set of (...) mutually dependent functional structures acting as constraints, whose maintenance depends on their reciprocal interactions. Closure refers specifically to the mutual dependence among functional constraints in an organism. We show that, when compared to feedback loops, organizational closure can generate much richer descriptions of the processes and constraints at play in the metabolism and regulation of glycaemia, by making explicit the different hierarchical orders involved. We expect that the proposed theoretical framework will open the way to the construction of original mathematical models, which would provide a better understanding of endocrine regulation from an organicist perspective. (shrink)

The topic of the relationship between the organism and its environment runs through the theories of Uexküll, Goldstein and Canguilhem with equal importance. In this work a counterpoint will be established between their theories, in the attempt to assess at which points the melodies are concordant and at which points they are discordant. As fundamental basis to his theory, Uexküll relies on the concept of conformity to a plan, which allows him to account for the congruity and perfect adjustment between (...) organisms and their Umwelten. For Goldstein and Canguilhem, the relationship between an organism and its environment resembles instead a debate or coming to terms, in which the organism, as to ensure the continuity of the state of health, must constantly create norms to maintain a productive relationship with its environment. The pinpointing of these conceptual frameworks allows to lay emphasis on that each theory relies on specific assumptions regarding teleology and sense in organisms, as well as on specific definitions of the concept of life in general. Ultimately, the view that organisms and their environments have an original and common source, a principle, or plan, which must possess all the creative characteristics of life, will be seen as prevailing. (shrink)

Ernst Mayr argued that the emergence of biology as a special science in the early nineteenth century was possible due to the demise of the mathematical model of science and its insistence on demonstrative knowledge. More recently, John Zammito has claimed that the rise of biology as a special science was due to a distinctive experimental, anti-metaphysical, anti-mathematical, and anti-rationalist strand of thought coming from outside of Germany. In this paper we argue that this narrative neglects the important role played (...) by the mathematical and axiomatic model of science in the emergence of biology as a special science. We show that several major actors involved in the emergence of biology as a science in Germany were working with an axiomatic conception of science that goes back at least to Aristotle and was popular in mid-eighteenth-century German academic circles due to its endorsement by Christian Wolff. More specifically, we show that at least two major contributors to the emergence of biology in Germany, Caspar Friedrich Wolff and Gottfried Reinhold Treviranus, sought to provide a conception of the new science of life that satisfies the criteria of a traditional axiomatic ideal of science. Both Caspar Friedrich Wolff and Treviranus took over strong commitments to the axiomatic model of science from major philosophers of their time, Christian Wolff and Friedrich Wilhelm Joseph Schelling respectively. The ideal of biology as an axiomatic science with specific biological fundamental concepts and principles thus played a role in the emergence of biology as a special science. (shrink)

Among those speaking in the name of materialism, whether speculative, dialectical, or "new," it is commonplace to dismiss with a single gesture a vast field of theoretical and philosophical endeavor, indicated as the last 50 or 250 years of theory and philosophy. Self-styled "speculative" writers who would surpass all philosophy since Kant, and various New Materialists who sequester decades of thought under the heading of "constructivism," manufacture the avant-garde status of their own work by claiming to delineate a simple break (...) with the past. We would be at a loss, and perhaps at risk of missing the point, if we sought to uncover the common essence underlying this "new" work, either by looking for an agreement... (shrink)

Since the early nineteenth century a membrane or wall has been cenptral to the cell’s identity as the elementary unit of life. Yet the literally and metaphorically marginal status of the cell membrane made it the site of clashes over the definition of life and the proper way to study it. In this article I show how the modern cell membrane was conceived of by analogy to the first “artificial cell,” invented in 1864 by the chemist Moritz Traube (1826–1894), and (...) reimagined by the plant physiologist Wilhelm Pfeffer (1845–1920) as a precision osmometer. Pfeffer’s artificial cell osmometer became the conceptual and empirical basis for the law of dilute solutions in physical chemistry, but his use of an artificial analogue to theorize the existence of the plasma membrane as distinct from the cell wall prompted debate over whether biology ought to be more closely unified with the physical sciences, or whether it must remain independent as the science of life. By examining how the histories of plant physiology and physical chemistry intertwined through the artificial cell, I argue that modern biology relocated vitality from protoplasmic living matter to nonliving chemical substances—or, in broader cultural terms, that the disenchantment of life was accompanied by the (re)enchantment of ordinary matter. (shrink)

The project “A Plurality of Lives” was funded and hosted by the Pufendorf Institute for Advanced Studies at Lund University, Sweden. The aim of the project was to better understand how a second origin of life, either in the form of a discovery of extraterrestrial life, life developed in a laboratory, or machines equipped with abilities previously only ascribed to living beings, will change how we understand and relate to life. Because of the inherently interdisciplinary nature of the project aim, (...) the project took an interdisciplinary approach with a research group made up of 12 senior researchers representing 12 different disciplines. The project resulted in a joint volume, an international symposium, several new projects, and a network of researchers in the field, all continuing to communicate about and advance the aim of the project. (shrink)

The impressive variation amongst biological individuals generates many complexities in addressing the simple-sounding question what is a biological individual? A distinction between evolutionary and physiological individuals is useful in thinking about biological individuals, as is attention to the kinds of groups, such as superorganisms and species, that have sometimes been thought of as biological individuals. More fully understanding the conceptual space that biological individuals occupy also involves considering a range of other concepts, such as life, reproduction, and agency. There has (...) been a focus in some recent discussions by both philosophers and biologists on how evolutionary individuals are created and regulated, as well as continuing work on the evolution of individuality. (shrink)

La vie est-elle un phénomène émergent ? Traduit-elle l'apparition de propriétés nouvelles au niveau d'un tout, qui seraient irréductibles aux propriétés et à l'organisation des composants de ce tout, ou encore imprédictibles à partir de ces mêmes éléments ? Développée à la charnière des XIXe et XXe siècles comme alternative aux deux approches antinomiques du vivant que sont le vitalisme et le mécanisme, la notion philosophique d'émergence connaît aujourd'hui de nouveaux développements : avec la prise de conscience de la complexité (...) du vivant, un nouveau discours émergentiste refait surface en biologie et dans le champ scientifique des origines de la vie. Que signifie la notion d'émergence lorsqu'elle s'applique à l'apparition de la vie sur Terre ? Quelles sont sa pertinence et sa portée ? Dans ce livre, Christophe Malaterre propose une clarification conceptuelle de la notion philosophique d'émergence ; il en défend une conception épistémique et contextuelle, adossée à la notion d'explication. En s'inspirant des travaux les plus contemporains sur les origines de la vie, il montre que, selon le contexte épistémique dans lequel le phénomène est évalué, la qualification de l'apparition de la vie comme émergente est, ou non, justifiée. Il défend alors la thèse selon laquelle la caractérisation émergentiste de l'apparition de la vie n'est qu'une conséquence temporaire des limites de nos connaissances scientifiques. (shrink)

The concept of “life” certainly is of some use to distinguish birds and beavers from water and stones. This pragmatic usefulness has led to its construal as a categorical predicate that can sift out living entities from non-living ones depending on their possessing specific properties—reproduction, metabolism, evolvability etc. In this paper, we argue against this binary construal of life. Using text-mining methods across over 30,000 scientific articles, we defend instead a degrees-of-life view and show how these methods can contribute to (...) experimental philosophy of science and concept explication. We apply topic-modeling algorithms to identify which specific properties are attributed to a target set of entities (bacteria, archaea, viruses, prions, plasmids, phages and the molecule of adenine). Eight major clusters of properties were identified together with their relative relevance for each target entity (two that relate to metabolism and catalysis, one to genetics, one to evolvability, one to structure, and—rather unexpectedly—three that concern interactions with the environment broadly construed). While aligning with intuitions—for instance about viruses being less alive than bacteria—these quantitative results also reveal differential degrees of performance that have so far remained elusive or overlooked. Taken together, these analyses provide a conceptual “lifeness space” that makes it possible to move away from a categorical construal of life by empirically assessing the relative lifeness of more-or-less alive entities. (shrink)

-/- Table des matières Remerciements 1 -/- INTRODUCTION 2 -/- PREMIERE PARTIE LE VIVANT ET LA REVOLUTION SCIENTIFIQUE 7 -/- ONTOLOGIE DU VIVANT OU BIOLOGIE ? LE CAS DE LA RÉVOLUTION SCIENTIFIQUE 8 -/- Introduction 8 La vie et le vivant sont-ils des thèmes de controverse explicites dans la philosophie naturelle de l’âge classique ? 18 Machines de la nature, ferments et métaphysique chimique 28 Crisis, what crisis ? 42 Conclusion 45 -/- LE MÉCANIQUE FACE AU VIVANT 49 -/- Introduction (...) 49 Que signifie : réduire l’homme (ou le vivant) à l’automate ? 51 Qu’est-ce qu’un vivant ? Un mécanisme élargi 56 Le vivant structuro-fonctionnel 64 Conclusion : l’automate affectif 70 -/- UN MATÉRIALISME VITAL ? 73 -/- Introduction : matérialisme et corps 73 Ontologie matérialiste de la Vie ou constitution progressive de la biologie ? 74 Un matérialisme vital 78 Conclusion 84 -/- DEUXIEME PARTIE MATÉRIALISMES ET VIE 87 -/- DÉTERMINISME MENTAL ET NATURALISATION DE L’ESPRIT, DE LOCKE A DIDEROT 88 -/- Introduction 89 Le déterminisme à l’âge classique et son interprétation 89 L’Âme Matérielle et le Traité de la liberté de l’âme : un déterminisme cérébral 94 Locke : la détermination est une perfection 101 Collins : suspendre son vouloir, c’est encore vouloir 105 Diderot : les « causes propres à l’homme » 111 Conclusion 115 -/- LA METTRIE : LA MÉDICALISATION DE LA MORALE ET L’APPROCHE MATÉRIALISTE DU CORPS 117 -/- Introduction 117 Une morale médicale ? 117 La réduction médicale de la morale 120 L’épicurisme médical 125 Une éthique machinale 130 Conclusion 132 -/- DES MOLÉCULES « INTELLIGENTES » A L’ORGANISATION ÉMERGENTE : LE DÉBAT MAUPERTUIS-DIDEROT 134 -/- Introduction 134 Le contexte newtonien et leibnizien 137 L’argument de Maupertuis 139 La critique de Diderot 143 La réponse de Maupertuis 145 Conclusion : enjeux de la discussion 147 -/- UNE BIOLOGIE CLANDESTINE ? LE PROJET D’UN SPINOZISME BIOLOGIQUE CHEZ DIDEROT 150 -/- Introduction 150 Diderot et la biologie 152 Excursus : la naissance de la biologie 155 Spinozistes anciens et modernes 161 Spinozisme et spinosisme 166 Conclusion 168 -/- TROISIEME PARTIE VITALISME 170 -/- ORGANISATION OU ORGANISME ? L’INDIVIDUATION ORGANIQUE SELON LE VITALISME MONTPELLIÉRAIN 171 -/- Introduction : pour introduire au vitalisme de Montpellier 171 Machine et organisation 174 Le concept vitaliste d’organisation, entre Vie et vies 179 Quelle individualité organique ? 186 Organisation ou organisme 190 Conclusion 197 -/- LES ANALOGIES NEWTONIENNES DANS LES SCIENCES DE LA VIE AU XVIIIE SIÈCLE : VITALISME ET PROCÉDÉS EXPLICATIFS PROVISOIREMENT INEXPLICABLES 200 -/- Introduction 200 Le newtonianisme médical littéral 206 Les transpositions non-littérales de la méthode newtonienne : Buffon, Maupertuis et Hartley 212 Haller : une physiologie de « noms d’attente » 216 Le vitalisme du XVIIIe siècle, un « positivisme prudent » plutôt qu’une « métaphysique impénitente » 220 L’antimathématisme de Mandeville et de Diderot 233 Conclusion 240 -/- VITALISME ET VIVISECTION : APPROCHES VITALISTES DE L’EXPÉRIMENTATION ANIMALE 245 -/- Introduction 245 Considérations préliminaires sur le XVIIe siècle 248 L’École de Montpellier 251 Ménuret de Chambaud 255 Un intermezzo sur Diderot 260 Fouquet et Bordeu contre Haller 263 Conclusion 267 -/- LE CHARME DISCRET DU VITALISME SANS MÉTAPHYSIQUE, XVIIIe - XXe SIÈCLES 272 -/- Introduction 272 Vitalisme substantiel et vitalisme fonctionnel 274 Vitalisme et biologie 279 Conclusion 283 -/- QUATRIEME PARTIE ORGANISME ET BIOPHILOSOPHIE 285 -/- L’ORGANISME : CONCEPT HYBRIDE ET POLÉMIQUE 285 -/- Introduction 286 L’organisme, un hybride 287 L’organisme comme individualité 290 Organisme et organicisme 296 L’organisme vitaliste 301 Ontologie de l’organisme 303 Conclusion 305 -/- LE RETOUR DU VITALISME : CANGUILHEM ET LE PROJET D’UNE BIOPHILOSOPHIE 307 -/- Introduction 307 Un vitalisme passe-partout 308 L’organisme entre épistémologie et ontologie 312 Une métaphysique de l’oursin ? Bioexceptionalisme et biochauvinisme 313 Vitalisme versus mysticisme de la chair 317 Conclusion 323 -/- HOLISME, ORGANICISME ET BIOCHAUVINISME 327 -/- Introduction : organicismes forts et faibles 327 Le holisme et l’organicisme plurivoques 329 Deux remarques critiques au sujet de deux périls étrangement connexes de la théorie holiste-organiciste 333 Holisme, biochauvinisme et subjectivité 337 Conclusion 341 -/- CONCLUSION : LA PHILOSOPHIE DE LA BIOLOGIE AVANT LA BIOLOGIE 345 -/- Bibliographie 350 Index 404. (shrink)

The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration, biological systems are often characterized as organized in such a way that they realize metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realize and on the continuous management of the exchange of matter and energy with their environment. One (...) of the virtues of the organismic approach focused on organization is that it can provide an understanding of how biological systems are functionally integrated into coherent wholes. Organismic frameworks have been primarily developed by focusing on unicellular life. Multicellularity, however, presents additional challenges to our understanding of biological systems, related to how cells are capable to live together in higher-order entities, in such a way that some of their features and behaviors are constrained and controlled by the system they realize. Whereas most accounts of multicellularity focus on cell differentiation and increase in size as the main elements to understand biological systems at this level of organization, we argue that these factors are insufficient to provide an understanding of how cells are physically and functionally integrated in a coherent system. In this paper, we provide a new theoretical framework to understand multicellularity, capable to overcome these issues. Our thesis is that one of the fundamental theoretical principles to understand multicellularity, which is missing or underdeveloped in current accounts, is the functional organization of the intercellular space. In our view, the capability to be organized in space plays a central role in this context, as it enables (and allows to exploit all the implications of) cell differentiation and increase in size, and even specialized functions such as immunity. We argue that the extracellular matrix plays a crucial active role in this respect, as an evolutionary ancient and specific (non-cellular) control subsystem that contributes as a key actor to the functional specification of the multicellular space and to modulate cell fate and behavior. We also analyze how multicellular systems exert control upon internal movement and communication. Finally, we show how the organization of space is involved in some of the failures of multicellular organization, such as aging and cancer. (shrink)

Jonas' philosophical biology is an attempt to overcome the dualism, i.e., the alienation between man and world, which characterizes both Gnostic thinking and the Heiddegerian exis­tentialist approach that Jonas had applied in its interpretation. This dualism leads both approaches to despise or, at least, to neglect nature.Jonas' philosophical biology is intended to provide an insight into the phe­nomenon of life that is more than a mere reflection of scientific episte­mology. Rather, it regards itself as a cognitively significant approach towards the (...) living in its own right. At the same time, philosophical biology is not intended as an alternative to the scientific enterprise, but instead as a desirable and even necessary complement of it. In develop­ing philosophical biology, Jonas additionally aims at securing a place for man in the order of the living that is more than just locating him somewhere in the order of primates. (shrink)

This paper focuses on the relation of genealogy and critique in Nietzsche’s late philosophy. It is argued that the late Nietzsche distinguishes between genealogy and critique. The genealogy of morality is a descriptive endeavor that shows the origin of values in processes of life. The critique of morality assesses the value of values from the perspective of life. It is argued that the concept of life is at the core of Nietzsche’s critical project and thus his fundamental standard. The paper (...) also examines the role of the genealogical method in Nietzsche’s critical project. It is shown that the genealogy of values prepares their critique. Moreover, Nietzsche regards the alleged epistemic success of his genealogies as an indirect confirmation of the superiority of his evaluative position, i.e. of his affirmation of life. (shrink)

A long-standing debate on the causality of levels in biological explanations has divided philosophers into two camps. The reductionist camp insists on the causal primacy of lower, molecular levels, while the critics point out the inescapable shifting, reciprocity, and circularity of levels across biological explanations. We argue, however, that many explanations in biology do not exclusively draw their explanatory power from detailed insights into inter-level interactions; they predominantly require identifying the adequate levels of biological complexity to be explained. Moreover, the (...) main explanatory strategies grounding both theoretical and experimental approaches to one of the central debates in contemporary biology, i.e., on the origin of life, are primarily and sometimes exclusively driven by issues concerning the levels of biochemical complexity, and these only subsequently frame more substantial and detailed accounts of inter-level biochemical interactions. (shrink)

In his book, The Human Predicament, David Benatar claims that our individual lives and human life, in general, do not make a difference beyond Earth and, therefore, are meaningless from the vast, cosmic perspective. In this paper, I will explain how what we do matters from the cosmic perspective. I will provide examples of how human beings have transcended our limits, thereby giving human life some meaning from the cosmic perspective. Also, I will argue that human life could become even (...) more meaningful by making some fundamental achievements, such as determining how life originated. (shrink)

Znanstveno proučavanje postanka prvog života unutar zasebnog područja teorijske biologije počinje pedesetih godina 20. stoljeća. To područje do danas nema stabilan oblik niti vladajuću teoriju, nego je predstavljeno brojnim teorijama koje proučavaju zasebne dijelove velike slagalice koja objašnjava podrijetlo prvog života. Ovaj rad: 1) daje kratak pregled i problematiku područja; 2) predstavlja najvažnije teorije postanka prvog života; 3) izdvaja odgovore na pitanje kada je nastao prvi život; 4) pita se kakvog je bio oblika; te 5) tumači empirijske podatke iz filozofske (...) perspektive. Razmatranje postojećih teorija i tumačenje empirijskih podataka ukazuje na jalovost dosadašnjih pokušaja kojima nedostaje teorijska konzistentnost ili empirijska potpora, iz čega se mogu interpretirati divergentne tvrdnje o naravi živog svijeta.The foundation of the scientific study of the first life within a separate field of theoretical biology begins in the nineteen fifties. This area has not yet reached a stable shape neither a dominant theory, but a number of theories that examine the separate parts of a large puzzle which explains the origin of the first life. This paper: 1) offers brief overview of the problem areas; 2) presents the most important theories on foundation of the first life; 3) emphasizes certain answers to the question of the first emergence; 4) asks what the first life was like; and 5) interpret the empirical data from philosophical perspective. Consideration of existing theories and interpretations of empirical data points to the futility of past attempts which lack theoretical consistency or empirical support, from which divergent arguments about the nature or the origin of the first life can be interpreted. (shrink)

Der Beschreibung der zeitlichen Entwicklung lebender Systeme kann eine reine Differentialanalyse nicht genügen. In solchen Fällen muss man sich an Stelle der gewöhnlichen Differentialgleichungen der integraldifferentiellen, bezw. der Integralgleichungen bedienen. Zur leichteren Veranschaulichung der mathematischen Darstellung betrachtet Verfasser zuerst diejenigen Systeme, deren innerer Zustand sich durch ein einziges Parameterc bestimmen lässt. Die zeitliche Entwicklung eines leblosen Systems dieser Klasse werde durch die Differentialgleichung dcdt=kf... dargestellt, wot=Zeit, undk eine Funktion der äusseren Parameterα, Β, γ. ist. Im Falle eines jeden Systems sind (...) die äusseren Parameterα, Β, γ. charakteristische individuelle Funktionen der Zeit. Misst manc am. Zeitpunktt, so lässt sich die Zukunft des Systems vermittelst der Gleichung berechnen, wenn die zukünftigen Werte der äusseren Parameter gegeben sind. Solche Systeme nennt Verfasser nicht-historische Systeme. Im Falle der lebenden Systeme werde die zeitliche Entwicklung durch die Integral-differentialgleichung dcdt=k1f1+∫t−λtk2f2dt........dargestellt, wof 1 undf 2 Funktionen des Zustandsparametersc, undk 1 undk 2 Funktionen der äusseren Parameter sind. Das Zeitintegral erstreckt sich auf das vergangene Zeitintervalt-λ →t, woλ einen positiven endlichen konstanten Wert besitzt. Diese Systeme nennt Verfasser historische Systeme. Setzt manH für das darin enthaltene Integralglied, so verwandelt sich die Gleichung in: dcdt=k1f1+H..........Misst man nunc am Zeitpunktt, so kann man in diesem Fall die Zukunft des Systems ohne Kenntnis des historischen GliedsH nicht berechnen. Das Vorkommen des historischen IntegralgliedsH nennt Verfasser Chronoholismus. Man kann deshalb die historischen Systeme auch chronoholistische Systeme nennen.Die biologische Interpretation dieser Betrachtungsweise wird vom Verfasser diskutiert, und die Gleichung auf Systeme mit erblichen Eigenschaften ausgedehnt. Es werden zuletzt Systeme mit vielen Zustandsparametern in gewissen einfachen Fällen kurz behandelt.L'analyse différentielle ne suffit pas, selon l'avis de de l'auteur, pour la description de l'évolution des systèmes vivants au cours des temps. Il faut utiliser dans ces cas les équations intégro-différentielles ou intégrales. Pour faciliter le traÎtement mathématique, on peut considérer d'abord les systèmes dont l'état intérieur est défini par un seul paramètrec. L'évolution d'un système inanimé de cette classe se laisse décrire par l'équation différentielle dcdt=kf,...........oùt=temps, etk est une fonction déterminée des paramètres extérieurs α,Β, γ.Si l'on connaÎtc à un temps donnét, l'état du système à un temps futurt′ se laisse prévoir au moyen de l'équation , quand les valeurs des paramètres extérieurs dans l'intervallet → t∼' sont fixées. L'auteur appelle les systèmes de cette classe des systèmes non-historiques.Pour les systèmes vivants, il faut se servir, selon l'avis de l'auteur, des équations intégro-différentielles. Pour les systèmes définis par un seul paramètrec, on peut se servir, par exemple, de l'équation dcdt=k1f1+∫t−λtk2f2dt........où k1 et k2 sont des fonctions déterminées des paramètres extérieurs. L'intégrale s'étend sur l'intervallet-λ→ t où λ est positif et constant. En indiquant le terme intégral par le symboleH, on peut écrire dcdt=k1f1+H..........La connaissance de c à un temps donnét ne laisse pas prévoir l'état du système à un temps futurt′ sans connaissance du terme historiqueH, quand mÊme les paramètres α, Β, γ,..., seraient des fonctions déterminées du temps dans l'intervallet→t′.L'auteur appelle l'existence du terme intégral historiqueH le chronoholisme. On peut appeler les systèmes de cette classe des systèmes historiques ou chronoholistiques.L'interprétation biologique de cette faÇon de traÎter les systèmes vivants est discutée par l'auteur, qui étend l'équation pour le faire représenter aussi les propriétés héréditaires des Êtres vivants.Quelques cas de systèmes dont l'état intérieur est défini par plusieurs paramètres et plusieurs phases sont traités brièvement. (shrink)

Scientific theories about the origin-of-life theories have historically been characterized by the chicken-and-egg problem of which essential aspect of life was the first to appear, replication or self-sustenance. By the 1950s the question was cast in molecular terms and DNA and proteins had come to represent the carriers of the two functions. Meanwhile, RNA, the other nucleic acid, had played a capricious role in origin theories. Because it contained building blocks very similar to DNA, biologists recognized early that RNA could (...) store information in its linear sequences. With the discovery in the 1980s that RNA molecules were capable of biological catalysis, a function hitherto ascribed to proteins alone, RNA took on the role of the single entity that could act as both chicken and egg. Within a few years of the discovery of these catalytic RNAs scientists had formulated an RNA World hypothesis that posited an early phase in the evolution of life where all key functions were performed by RNA molecules. This paper traces the history the role of RNA in origin-of-life theories with a focus on how the discovery of ribozymes influenced the discourse. (shrink)

A densely-packed critique of some current trends in semiotics.

Jakob von Uexküll’s problematic is manifested in his paradoxical portraiture of form within the plan of nature: the one a sensual schema and the other a transsensual ideal form. At first sight, Uexküll’s belief in the Platonic and the Reformational notions of the immobile becoming of form seems to be a resignation from the heated debates among his contemporary materialists, vitalists, dynamists, and evolutionists. However, in terms of the Kantian subjective teleology, Uexküll’s appropriation of the ancient philosophy reinstates the invisible, (...) static, but repetitive cycle as his regulating principle in the observation of the activity of animals. This regulating principle distinguishes itself from the rule of resemblance established by the appearances and fossil remains of animals, which is linear, incomplete, and digressive. In the light of Michel Foucault, the transition from the visible to the invisible recoups the study of nature from the living beings to the life itself, from natural philosophy to biology. My study suggests that we recast Uexküll’s sign theory from his observations on the crux that models and triggers an animal to action in its Umwelt. Bracketing Uexküll’s transcendental configuration of form and image, we still find that schema, in itssensual and functional context, evolves from a reflection of the objects to a summary of their features plus an ignorance of their proper names. Uexküll's erasure of proper names that directs our attention to the presentation in its pure form not only constitutes an important step in epistemology, but also in a life science that meticulously delves into the genotypes. (shrink)

The study of the origin and nature of life can be a problem, especially for a scientist whose method precludes any conclusion that would transcend the realm of empirical evidence. A scientist, and more specifically a biologist, can ascertain the characteristics that distinguish a living from a non-living being, but he is unable to attain to the source of those characteristics or life itself, which defies all empirical analysis. Here science must surrender to philosophy and let reason draw conclusions that (...) go beyond the data of experience and reach out into an area that many philosophers consider as their exclusive domain. (shrink)

Dr. Jennings states that his purpose in _The Universe and Life_ is to “try to show what positive outlook on life and the world is given by the study of biological science; and how this differs, if at all, from the outlook based on physics, or from the outlook presented in some of the religions of the world.” He believes that the study of biology aids in getting a unified view of the universe and of man in his relations with (...) it, and that it helps particularly in the problems of managing life, the problems of conduct, and in the determination of our attitude toward the world. Did life always exist? Does development produce what is really new? Do feelings, ideas, and knowledge have a function in the world? Was what occurs today predictable before life came into the world? Is man indispensable to the advancement of life? Does the study of biology lead to the belief that life tends toward a goal that is already existent? Does it lead to the divine right of the aristocrat? Do individuals continue to live after the event we call death? Professor Jennings sets forth his answers to these and other provocative questions in simple and clear-cut style, and concludes that life “is progressing in the present as it has in the past. In the future it may be expected to advance as it has done in the past—to heights that no one can predict, to which no one can set limits.”. (shrink)

p class="MsoNormal"span style="font-size: 11pt"The idea that life is based on signs and codes, i.e., that ldquo;Life is semiosisrdquo;, has been strongly suggested by the discovery of the genetic code, but so far it has made little impact, and is largely regarded as philosophy rather than science. The main reason for this is that there are at least three basic concepts in modern biology that keep semiosis squarely out of organic life./span/p p style="text-indent: 14.2pt; line-height: normal" class="Corpotesto"span style="font-family: quot;Times New Romanquot;" (...) The first is the classical model that describes the cell as a biological computer made of genotype and phenotype. A computer contains codes but is not a semiotic system, and this makes it possible to say that the cell too can have a genetic code without being a semiotic system. /span/p p style="text-indent: 14.2pt; line-height: normal" class="Corpotesto"span style="font-family: quot;Times New Romanquot;" The second idea/spanspan style="font-family: quot;Times New Romanquot;" is/spanspan style="font-family: quot;Times New Romanquot;" emphysicalism/em, the doctrine that everything in life must ultimately be accounted for by physical quantities. This/spanspan style="font-family: quot;Times New Romanquot;" amounts to saying that signs and codes do/spanspan style="font-family: quot;Times New Romanquot;" not exist at the molecular level and are but linguistic metaphors that biologists use simply because they are convenient./span/p p style="text-indent: 14.2pt; line-height: normal" class="Corpotesto"span style="font-family: quot;Times New Romanquot;" The third concept is the idea that all biological novelties have been brought into existence by natural selection, an idea which implies that semiotic processes did not have any creative role in evolution. /spanspan style="font-family: quot;Times New Romanquot;"/span/p p style="text-indent: 14.2pt; line-height: normal" class="Corpotesto"span style="font-family: quot;Times New Romanquot;"These arguments have effectively ruled out the existence of semiosis in the organic world, thus depriving the discovery of the genetic code of all its revolutionary potential, but here it will be shown that there are experimental facts against emall/em of them. More precisely, it will be shown that the cell is a true semiotic system, and that the genetic code has been the first of a long series of organic codes that have shaped the whole history of life on our planet. Biological semiosis, in other words, is a scientific reality because the organic codes are experimental realities. This paper intends to underline precisely the scientific nature of spannbsp;/spanbiosemiotics and argues that the time has come to acknowledge that semiosis not only is a fact of life but is spannbsp;/spanlsquo;thersquo; fact that allowed life to emerge from inanimate matter. /span/p. (shrink)

There have been many different ways of characterizing and describing the phenomenon of life over the years. One aspect that has not often been stressed is lifersquo;s emergent propertiesmdash;the synergies that are produced when many elements or parts combine to produce distinctive new ldquo;wholesrdquo;. Indeed, complex living systems represent a multi-leveled, multi-faceted hierarchy of synergistic effects that has evolved over several billion years. Some of the many examples of synergy at various levels of life are briefly described, and it is (...) emphasized that life is still creating itself and still exploring its potentialities. (shrink)

Philosophy of biology before biology -/- Edited by Cécilia Bognon-Küss & Charles T. Wolfe -/- Table of contents -/- Cécilia Bognon-Küss & Charles T. Wolfe. Introduction -/- 1. Cécilia Bognon-Küss & Charles T. Wolfe. The idea of “philosophy of biology before biology”: a methodological provocation -/- Part I. FORM AND DEVELOPMENT -/- 2. Stéphane Schmitt. Buffon’s theories of generation and the changing dialectics of molds and molecules 3. Phillip Sloan. Metaphysics and “Vital” Materialism: The Gabrielle Du Châtelet Circle and French (...) Vitalism 4. John Zammito. The Philosophical Reception of C. F. Wolff’s Epigenesis in Germany, 1770-1790: Herder, Tetens and Kant -/- Part II. ORGANISM & ORGANIZATION 5. François Duchesneau. Senebier and the Advent of General Physiology 6. Tobias Cheung. Organization and Process. Living Systems Between Inner and Outer Worlds: Cuvier, Hufeland, Cabanis. -/- Part III. SYSTEMS 7. Georg Toepfer. Philosophy of Ecology Long Before Ecology: Kant’s Idea of an Organized System of Organized Beings 8. Ina Goy. "All is leaf". Goethe's plant philosophy and poetry 9. Snait Gissis. ‘Biology’, Lamarck, Lamarckisms -/- POSTSCRIPTS 1. Lynn Nyhart. A Historical Proposal Around Prepositions -/- 2. Philippe Huneman. Philosophy after Philosophy of Biology before Biology -/- Cécilia Bognon-Küss and Charles T. Wolfe. Conclusion . (shrink)

In this paper we examine aspects of Canguilhem’s philosophy of biology, concerning the knowledge of life and its consequences on science and vitalism. His concept of life stems from the idea of a living individual, endowed with creative subjectivity and norms, a Kantian view which “disconcerts logic”. In contrast, two different approaches ground naturalistic perspectives to explore the logic of life and the logic of the living individual in the 1970s. Although Canguilhem is closer to the second, there are divergences; (...) for example, unlike them, he does not dismiss vitalism, often referring to it in his work and even at times describing himself as a vitalist. The reason may lie in their different views of science. (shrink)

Vitalism was long viewed as the most grotesque view in biological theory: appeals to a mysterious life-force, Romantic insistence on the autonomy of life, or worse, a metaphysics of an entirely living universe. In the early twentieth century, attempts were made to present a revised, lighter version that was not weighted down by revisionary metaphysics: “organicism”. And mainstream philosophers of science criticized Driesch and Bergson’s “neovitalism” as a too-strong ontological commitment to the existence of certain entities or “forces”, over and (...) above the system of causal relations studied by mechanistic science, rejecting the weaker form, organicism, as well. But there has been some significant scholarly “push-back” against this orthodox attitude, notably pointing to the 18th-century Montpellier vitalists to show that there are different historical forms of vitalism, including how they relate to mainstream scientific practice. Additionally, some trends in recent biology that run counter to genetic reductionism and the informational model of the gene present themselves as organicist. Here, we examine some cases of vitalism in the twentieth century and today, not just as a historical form but as a significant metaphysical and scientific model. We argue for vitalism’s conceptual originality without either reducing it to mainstream models of science or presenting it as an alternate model of science, by focusing on historical forms of vitalism, logical empiricist critiques thereof and the impact of synthetic biology on current theorizing of vitalism. (shrink)

Intellectual history still quite commonly distinguishes between the episode we know as the Scientific Revolution, and its successor era, the Enlightenment, in terms of the calculatory and quantifying zeal of the former—the age of mechanics—and the rather scientifically lackadaisical mood of the latter, more concerned with freedom, public space and aesthetics. It is possible to challenge this distinction in a variety of ways, but the approach I examine here, in which the focus on an emerging scientific field or cluster of (...) disciplines—the ‘life sciences’, particularly natural history, medicine, and physiology —is, not Romantically anti-scientific, but resolutely anti-mathematical. Diderot bluntly states, in his Thoughts on the interpretation of nature, that “We are on the verge of a great revolution in the sciences. Given the taste people seem to have for morals, belles-lettres, the history of nature and experimental physics, I dare say that before a hundred years, there will not be more than three great geometricians remaining in Europe. The science will stop short where the Bernoullis, the Eulers, the Maupertuis, the Clairauts, the Fontaines and the D’Alemberts will have left it.... We will not go beyond.” Similarly, Buffon in the first discourse of his Histoire naturelle speaks of the “over-reliance on mathematical sciences,” given that mathematical truths are merely “definitional” and “demonstrative,” and thereby “abstract, intellectual and arbitrary.” Earlier in the Thoughts, Diderot judges “the thing of the mathematician” to have “as little existence in nature as that of the gambler.” Significantly, this attitude—taken by great scientists who also translated Newton or wrote careful papers on probability theory, as well as by others such as Mandeville—participates in the effort to conceptualize what we might call a new ontology for the emerging life sciences, very different from both the ‘iatromechanism’ and the ‘animism’ of earlier generations, which either failed to account for specifically living, goal-directed features of organisms, or accounted for them in supernaturalistic terms by appealing to an ‘anima’ as explanatory principle. Anti-mathematicism here is then a key component of a naturalistic, open-ended project to give a successful reductionist model of explanation in ‘natural history’, a model which is no more vitalist than it is materialist—but which is fairly far removed from early modern mechanism. (shrink)

The species of vitalism discussed here is a malleable construct, often with a poisonous reputation (but one which I want to rehabilitate), hovering in between the realms of the philosophy of biology, the history of medicine, and the scientific background of the Radical Enlightenment (case in point, the influence of vitalist medicine on Diderot). This is a more vital vitalism, or at least a more ‘biologistic,’ ‘embodied,’ medicalized vitalism. I distinguish between what I would call ‘substantival’ and ‘functional’ forms of (...) vitalism, as applied to the eighteenth century. Substantival vitalism presupposes the existence of something like a (substantive) vital force which either plays a causal role in the natural world as studied by scientific means, or remains a kind of hovering, extra-causal entity. Functional vitalism tends to operate “post facto,” from the existence of living bodies to the desire to find explanatory models that will do justice to their uniquely ‘vital’ properties in a way that fully mechanistic models (such as Cartesian mechanism) cannot. I discuss some representative figures of the Montpellier school as being functional rather than substantival vitalists, particularly as regards the models of organic organization which they develop, and make some suggestions as to how these relate to the then-nascent science of biology. (shrink)

ABSTRACT: GEORGES CANGUILHEM’S BIOPHILOSOPHY The eminent French biologist and historian of biology, François Jacob, once notoriously declared «On n’interroge plus la vie dans les laboratoires»: laboratory research no longer inquires into the notion of “Life”. Certain influential French philosophers of science of the mid‐century such as Georges Canguilhem would disagree, or at least seek to resist some of Jacob’s diagnosis. Not by imposing a different kind of research program in laboratories, but by an unusual combination of historical and philosophical inquiry (...) into the foundations of the life sciences. Canguilhem speaks of «defending vitalist biology» and declares that Life cannot be grasped by logic. Is this history and philosophy of biology? Is it vitalism? It definitely is a different project from current philosophy of biology. One short‐lived term for it was “biophilosophy”. In this paper I explore the content of this term as it relates to the above questions. (shrink)

Philosophical biologists have attempted to define the distinction between life and non-life to more adequately define what it is to be human. They are reacting against idealism, but idealism is their point of departure, and they have embraced the reaction by idealists against the mechanistic notion of humans developed by the scientific materialists. Theoretical biologists also have attempted to develop a more adequate conception of life, but their point of departure has been within science itself. In their case, it has (...) involved efforts to overcome the reductionism of scientific materialism to develop a form of science able to identify and explain the distinctive characteristics of living beings. So, while both philosophical biologists and theoretical biologists are struggling to overcome scientific materialism, they are approaching the question: What is Life? from different directions. Focussing on the work of Robert Rosen, I will try to show what revisions in our understanding of science theoretical biologists need to accept in order to do justice to the insights of the philosophical biologists. I will suggest that not only will this involve major revisions in what we understand science to be, but that scientists must accept that science is indissociable from natural philosophy, and that to properly comprehend life mathematics must ultimately be subordinated to stories. (shrink)

Liv är ett centralt begrepp inom många forskningsområden, exempelvis inom biologi, astrobiologi, kemi och medicin, såväl som inom juridik, teologi och filosofi. Liv är också ett centralt tema i konsten. Det behandlas och begrundas i åtskilliga konstverk, i dikt, roman och film. Hur vi skall förstå, värdera och skydda livet, är oerhört fundamentala frågor. I framtiden kommer dessa frågor att bli än svårare och om möjligt ännu viktigare. Forskargrupper från hela världen arbetar idag med att skapa liv i laboratoriet, leta (...) efter liv i rymden och förse maskiner med egenskaper som tidigare bara har varit förunnade levande varelser, och utvecklingen går fort. Det är viktigt att vi samtidigt funderar över de utmaningar som detta innebär. Det kommer att ta tid att hitta sätt att leva i en värld där liv finns i former vi idag knappt kan föreställa oss och där gränsen mellan levande varelser och maskiner blir alltmer suddig. De beslut vi fattar idag kommer också att påverka utvecklingen inom samhälle, forskning och utveckling under lång tid framöver. -/- Den här boken är ett resultat av ett tvärvetenskapligt projekt vid Pufendorfinstitutet, Lunds universitet. Tolv forskare från lika många discipliner har ingått i projektet. Syftet har varit att belysa utmaningar som följer med utomjordiskt, artificiellt och syntetiskt liv. Det tvärvetenskapliga angreppssättet har gett oss möjlighet att belysa frågorna från alla upptänkliga vinklar, men också att hitta helt nya kombinationer av metoder och synsätt. Med tanke på livets mångsidighet och stora betydelse ur så många olika perspektiv, har detta grepp varit helt nödvändigt. -/- Vår förhoppning är att boken skall inspirera till nya tankar och diskussioner om liv. Boken vänder sig både till de som redan är intresserade och de som ännu inte har börjat fundera kring de utmaningar som utomjordiskt, artificiellt och syntetiskt liv innebär. (shrink)