Nanotechnology

Claims have been made that the current COVID-19 pandemic is a message from nature to stop exploiting the earth to the extent that we have been. While there is no direct evidence that this pandemic is a result of human actions with respect to the earth, ample evidence exists that deforestation and other environmental changes, together with climate change, do make it more likely that viruses will cross from wildlife to humans. We humans are mammals and our welfare depends on (...) the health of the earth. We are not so different from other living creatures in this regard. It is in our interests to look after the earth, something that Indigenous Australians knew well. Mother Earth must be cared for if she is to care for us. Nature perhaps is sending us a message in the same sense that my car does if I do not maintain it. It stops functioning properly. We have to modify nature to satisfy our needs but we must be careful how we modify it. (shrink)

Finding avenues for collaboration and engagement between the arts and the sciences was a central theme of investigation for the Responsible Research and Innovation and Public Engagement programme at BrisSynBio, a BBSRC/EPSRC Synthetic Biology Research Centre that is now part of the Bristol BioDesign Institute at University of Bristol. The reflections and experiments that appear in this dossier are a sample of these investigations and are contributed by Maria Fannin, Katy Connor and David Roden. Darian Meacham coordinated and introduces the (...) dossier. (shrink)

Here I examine the potential for art-science collaborations to be the basis for deliberative discussions on research agendas and direction. Responsible Research and Innovation has become a science policy goal in synthetic biology and several other high-profile areas of scientific research. While art-science collaborations offer the potential to engage both publics and scientists and thus possess the potential to facilitate the desired “mutual responsiveness” between researchers, institutional actors, publics and various stakeholders, there are potential challenges in effectively implementing collaborations as (...) well as dangers in potentially instrumentalizing artistic work for science policy or innovation agendas when power differentials in collaborations remain unacknowledged. Art-science collaborations can be thought of as processes of exchange which require acknowledgement of and attention to artistic agendas as well as identification of and attention to aesthetic dimensions of scientific research. I suggest the advantage of specifically identifying public engagement/science communication as a distinct aspect of such projects so that aesthetic, scientific or social science/philosophical research agendas are not subsumed to the assumption that the primary or only value of art-science collaborations is as a form of public engagement or science communication to mediate biological research community public relations. Likewise, there may be potential benefits of acknowledging an art-science-RRI triangle as stepping stone to a more reflexive research agenda within the STS/science communication/science policy community. Using BrisSynBio, an EPSRC/BBSRC-funded research centre in synthetic biology, I will discuss the framing for art-science collaborations and practical implementation and make remarks on what happened there. The empirical evidence reviewed here supports the model I propose but additionally, points to the need to broaden the conception of and possible purposes, or motivations for art, for example, in the case of cross-sectoral collaboration with community engaged art. (shrink)

This paper explores the functional role of noise in synthetic biology and its relation to the concept of randomness. Ongoing developments in the field of synthetic biology are pursuing the re-organisation and control of biological components to make functional devices. This paper addresses the distinction between noise and randomness in reference to the functional relationships that each may play in the evolution of living and/or synthetic systems. The differentiation between noise and randomness in its constructive role, that is, between noise (...) as a perturbation in routine behaviours and noise as a source of variability that cells may exploit, indicates the need for a clarification and rectification of the conflicting uses of the notion of noise in the studies of the so-called noise biology. (shrink)

This paper presents scientists’ understanding of their roles in society and corresponding responsibilities. It discusses the researchers’ perspective against the background of the contemporary literature on scientific responsibility in the social sciences and philosophy and proposes a heuristic that improves the understanding of the complexity of scientific responsibility. The study is based on qualitative interviews with senior scientists. The presented results show what researchers themselves see as their responsibilities, how they assume them, and what challenges they perceive with respect to (...) their responsibilities. Regarding the latter, the interviewed researchers highlight those aspects of responsibility that go beyond the expertise of their professional role, and thus cannot be carried by scientists alone. For example, scientists alone cannot determine the general direction science takes, or the useful application of their research. The interviewed researchers describe those challenges as responsibilities that must be shared across different societal groups. In the theoretical literature, responsibility has been described as a relation between an actor, the action for which someone is responsible, and the normative framework against which someone is responsible. We will draw on this concept of “relational responsibility” to identify the various actors, normative frameworks, and actions relevant to scientific responsibility. This will serve as a heuristic tool to help identify the entanglement of responsibilities spread across several societal groups. (shrink)

Nanotechnology has revolutionized various industries and has become a notable catalyst for economic growth. The emerging issues of human health and safety associated with nanotechnology development have raised regulatory concerns worldwide. In occupational settings, the same novel characteristics of nanomaterials that are utilized for innovation may also be the source of toxins with adverse health effects for workers. The existing regulatory framework may function effectively to regulate chemical substances in their conventional forms but may not be adequate with regard to (...) the specific issues of nanoform substances. A foundation of knowledge concerning properties of nanomaterials, and risk management approaches for these materials have been established, but conclusive results remain elusive. It is difficult for lawmakers to regulate nanotechnology-related activities effectively if conventional regulatory mechanisms are applied. The present article analyses in a country study the adequacy of existing Malaysian occupational safety and health law with regard to the specific issues presented by nanotechnology. The applicable regulatory approaches are examined to justify the adoption of soft law instruments as regulatory mechanisms for nanotechnology. A number of soft law best practices are briefly discussed as a basis to recommend practical solutions to close the existing regulatory gap. (shrink)

This work presents a blueprint or set of guidelines for the planning and development of sustainable national centers dealing with the safety of nanomaterials and nanotechnologies toward public health and environment. The blueprint was developed following a methodological approach of EU-wide online survey and workshop with several stakeholders. The purpose was to identify the key elements and challenges in the development and sustainability of a national nanosafety center. The responses were received from representatives of 16 national nanosafety centers across Europe (...) and 44 people from 18 EU member states who represented the stakeholder groups of researchers, academics, industry, regulators, civil society, and consultants. By providing an overview of the organizational design of existing national nanosafety centers across EU and converging demands in the field of nanosafety, the blueprint principally benefits those EU member states who do not have a national nanosafety center, but intend to develop an entity to manage the human health, environmental, ethical, and social concerns/risks toward the growing nationwide activities on engineered nanomaterials, e.g., their production, use or disposal, at national level. (shrink)

Discourses on Responsible Innovation and Responsible Research and Innovation, in short RI, have revolved around but not elaborated on the notion of critique. In this article, generative critique is introduced to RI as a practice that sits in-between adversarial armchair critique and co-opted, uncritical service. How to position oneself and be positioned on this spectrum has puzzled humanities scholars and social scientists who engage in interdisciplinary collaborations with scientists, engineers, and other professionals. Recently, generative critique has been presented as a (...) solution to the puzzle in interdisciplinary collaborations on neuroscientific experiments. Generative critique seeks to create connections across disciplines that help remake seemingly stable objects in moments when taken-for-granted ways of seeing and approaching objects are unsettled. In order to translate generative critique from the neurosciences to RI, socio-technical integration research is proposed as a practice of generative critique in interdisciplinary RI collaborations. These collaborations aim to account for societal aspects in research and technology development. For this purpose, a variety of approaches have been developed, including STIR and video-reflexive ethnography. STIR and VRE resemble each other but diverge on affective, collaborative, and temporal dimensions. Their juxtaposition serves to develop suggestions for how STIR could be modified on these dimensions to better enact generative critique in interdisciplinary RI collaborations. In this way, the article contributes to ongoing discussions in RI and in the engaged programme in science and technology studies more broadly on the dynamics of positioning in collaborative work. (shrink)

This chapter outlines different ethical approaches of relevance for a normative assessment of nano-release. We elaborate on traditional risk assessment and the well-known notion of a Precautionary Principle in order to demonstrate that these accounts need to be complemented to provide ethical guidance with regard to environmental influence of emerging technologies. We conclude that it is obligatory to engage in what they call an “eco-centric evaluation” of nano-release.

A recurrent theme in the characterization of synthetic biology is the role of engineering. This theme is widespread in the accounts of scholars studying this field and the biologists working in it, in those of the biologists themselves, as well as in policy documents. The aim of this article is to open this black-box of engineering that is supposed to influence and change contemporary life sciences. Too often, both synthetic biologists and their critics assume a very narrow understanding of what (...) engineering is about, resulting in an unfruitful debate about whether synthetic biology possesses genuine engineering methodologies or not. By looking in more detail to the diversity of engineering conceptions in debates concerning synthetic biology, a richer perspective can be developed. In this article, I will examine five influential ways in which engineering is understood in these debates, namely engineering as applied science, as rational methodology, context-sensitive practice, cunning activity or design. The claim is first of all thus to argue that engineering must not be seen as something stable or characterized by a fixed essence. It rather has multiple meanings and interpretations. Secondly, the claim is that most of the debates on synthetic biology cannot be indifferent towards the question which conception of engineering is at play, since the specific questions and concerns that pop up depend to a great extent on the precise conception of engineering one has in account. Many of the existing debates around synthetic biology can thus be reinterpreted and readdressed once one is aware of which conception of engineering is at play. (shrink)

In this paper, we examine the use of the term ‘life’ in the debates within and about synthetic biology. We review different positions within these debates, focusing on the historical background, the constructive epistemology of laboratory research and the pros and cons of metaphorical speech. We argue that ‘life’ is used as buzzword, as folk concept, and as theoretical concept in inhomogeneous ways. Extending beyond the review of the significant literature, we also argue that ‘life’ can be understood as a (...) Burstword in two concrete senses. Firstly, terms such as life easily turn into fuzzy, foggy and buzzy clouds of nonsense, if their use is not appropriately reflected. In these cases, the semantic orientation is detonated. This is the Burstword I characteristic of the concept of ‘life’ that we reveal for its unclear terminological use. Secondly, and in contrast to Burstword I, we show that the concept of ‘life’ can be used in a methodologically controlled way. We call this kind of use Burstword II. Here the concept of ‘life’ fulfils the function of expanding an inadequately narrow disciplinary or conceptual focus in different discursive contexts. In this second sense, ‘life’ receives an important operational function, for instance as a transdisciplinary research principle. It turns out that the innovative function and paradigm-changing power of metaphorical speech belong here as well. Finally, we illustrate three ethically relevant examples that show how ‘life’ can be applied as Burstword II in the context of synthetic biology. (shrink)

This paper gives an introduction to the interdisciplinary special section. Against the historical and ethical background of reproductive technologies, it explores future scenarios of human reproduction and analyzes ways of mutual engagement between fictional and academic endeavors. The underlying idea is that we can make use of human reproduction scenarios in at least two ways: we can use them to critique technologies by imagining terrible consequences for humanity but also to defend positions that favor scientific and technological development.

Within biology and in society, living creatures have long been described using metaphors of machinery and computation: ‘bioengineering’, ‘genes as code’ or ‘biological chassis’. This paper builds on Lakoff and Johnson’s argument that such language mechanisms shape how we understand the world. I argue that the living machines metaphor builds upon a certain perception of life entailing an idea of radical human control of the living world, looking back at the historical preconditions for this metaphor. I discuss how design is (...) perceived to enable us to shape natural beings to our will, and consider ethical, epistemological and ontological implications of the prevalence of this metaphor, focusing on its use within synthetic biology. I argue that we urgently need counter-images to the dominant metaphor of living machines and its implied control and propose that artworks can provide such counter-images through upsetting the perception of life as controllable. This is argued through discussion of artworks by Oron Catts and Ionat Zurr, by Tarsh Bates and by Ai Hasegawa, which in different ways challenge mechanistic assumptions through open-ended engagement with the strangeness and messiness of life. (shrink)

This art-science-interaction article focuses on moral implications of a recent science announcement. Against the background of literary and cultural theories, it compares a YouTube story with narratives employed in fictional stories.

The aim of the presentation is to focus on the differences between two scientific contexts: the genetic engineering context of the 1970s, with specific attention paid to the use of the recombinant DNA technique to generate genetically modified molecules, and the current genome editing context, with specific attention paid to the use of CRISPR-Cas9 technology to modify human germ line cells genetically. In both events, scientists have been involved in discussions that have gone beyond mere professional deontology touching on specific (...) policy issues such as freedom of research, responsibility for the consequences of research, the right of the public to participate in the evaluation of the goals of research methods, the relationship between cost and benefit and possible social consequences. The comparison between these two scientific contexts suggests the need of handling such issues by defining procedures that meet the criteria of democracy and responsibility towards society. The underlying objective should be to effectively launch actions and interventions based not on a hierarchical approach but rather a reticular conception of knowledge. (shrink)

Public and experts’ perceptions of benefits and risks of nanotechnology constitute an important element of nanoethics studies. On the one hand, compared with traditional ethics, nanoethics is a future-oriented ethics. The construction of ethical norms requires public participation. On the other hand, nanotechnology is characterized by uncertainty. Our previous research showed the Chinese public’s support for nanotechnology was associated more with beliefs, including views of technology and the weighing of benefits and risks of nanotechnology, and less with knowledge about nanotechnology; (...) the support was high but might change over time. Meanwhile, Chinese researchers have been actively conducting studies on nanotechnology while being highly aware of nanosafety issues. In this context, we further examined in the present study Chinese nanoresearchers’ perceptions of specific benefits and risks of nanotechnology, compared them with those of the Chinese public, and examined the Chinese nanoresearchers’ perceptions of risks of specific nanoapplications. Initial cross-regional comparisons were made with results from equivalent US and European surveys. Results showed Chinese nanoresearchers perceived a higher level of overall nanobenefits than the public and an almost equal level of overall nanorisks with the public. Four nanorisks were perceived by a higher proportion of experts than public; the experts likely relied on technical expertise while the public, possessing little knowledge about nanotechnology, might have exercised caution based on experiences and observations of other technologies. Of 23 nanoapplications, Chinese nanoresearchers regarded food using nanomaterials as the most risky and displays using nanomaterials as the least risky. Similarities and differences were observed in comparisons of Chinese with US and European survey results. In our age of technology and economic globalization, this research is of significance both for China’s formulation of nanotechnology development strategies and for the further study on nanoethics and good governance of emerging technologies such as nanotechnology worldwide. (shrink)

This essay examines the fantasy of life extension enabled through the transfer of one’s consciousness to new, cloned bodies in the event of disease, accident, or old age. This vision has recently been dramatized in both fiction and film, bearing witness to the power of this imaginary scenario. This eventuality would raise wide-ranging ethical issues, which speculative bioethics should begin to contemplate. Interestingly, it is young adult fiction that has recently provided an extensive and consistent cluster of novels dealing not (...) only with this topic but also with the interrelated notion of clones purposely grown to replace a loved one, with a concomitant array of further ethical concerns. These and related topics will be examined here through the lens of fiction and recent theoretical work on future biotechnological scenarios. (shrink)

Comparisons between germline gene editing using CRISPR technology and a renewal of eugenics are evident in the current bioethical discussions. This article examines the different roles of such references to the past. In the first part, the alleged parallels between gene editing of the germline and eugenics are addressed from three perspectives: First, the historical adequacy of such comparisons is questioned. Second, it is asked whether the evils of the past can in fact be attributed to practices of germline gene (...) editing. Third, it is discussed whether the alleged hazards of eugenics should in fact universally be condemned from a moral perspective. The article attempts to show that references to the eugenic past to rebut gene editing are highly selective and should be abandoned to allow for a more transparent ethical discourse. While the comparison with a eugenic past is frequently drawn by opponents of germline gene editing, the remaining part of this article investigates historic references from the proponents of germline gene editing. It is argued that they also employ different narratives of the past to justify their own liberal position. While such references are equally problematic, some lessons from the history of eugenics will be spelled out that can inform future debates on germline gene editing. (shrink)

The revolutionary potential of the CRISPR-Cas9 gene editing technique has created a resurgence in enthusiasm and concern in genetic research perhaps not seen since the mapping of the human genome at the turn of the century. Some such concerns and anxieties revolve around crossing lines between somatic and germline interventions as well as treatment and enhancement applications. Underpinning these concerns, there are familiar concepts of safety, unintended consequences and damage to genetic identity and the creation of designer children through pursuing (...) human enhancement and eugenics. In the policy realm, these morally laden distinctions and anxieties are emerging as the basis for making important and applied measures to respond to the fast-evolving scientific developments. This paper argues that the dominant normative framing for such responses is insufficient for this task. This paper illustrates this insufficiency as arising from a continued reliance on misleading genetic essentialist assumptions that generate groundless speculation and over-reactionary normative responses. This phenomenon is explicit with regard to prospective human genetic enhancements. While many normative theorists and state-of-the-art reports continue to gesture toward the influence of environmental and social influences on a person and their traits and capacities, this recognition does not extend to the substance of the arguments themselves which tend to revert to the debunked genetic determinist framework. Given the above, this paper argues that there is a pressing need for a more central role for sociological input into particular aspects of this “enhancement myth” in order to give added weight, detail and substance to these environmental influences and influence from social structures. (shrink)

Two Worlds represents an attempt to overcome the boundaries between science fiction and fantasy. The story is set in a remote future, on an Earth very different from today: the Chimeric development has taken human evolution on strange paths, paths that have led to the advent of other races; hybrid species that possess in their modified DNA genes coming from birds and fishes. The presence of a mysterious Tower of Seeds—a long forgotten place—will rekindle in some people new hopes and (...) the desire, perhaps utopian, to restore the ancient environmental balance with planet Earth. (shrink)

This discussion note offers a preliminary analysis of what recent developments in human germline gene editing tell us about the effectiveness of speculative and anticipatory modes of techno-ethics. It argues that the benefits of speculative discussions are difficult to detect thus far, and that pushing the focal point of ethical discourse well ahead of the current state of technology may prematurely undermine existing norms long before a broad consensus would justify moving beyond them.

Media carry the message of the scientific community into the wider world, though sometimes it would be more appropriate to say: of a certain scientific group. For the field of bioethics, this is particularly true. From films such as Gattaca to TV series like Black Mirror, the relationship between science and science fiction appears evidently bidirectional. This relationship is not new of course, but this paper discusses quasi-science-fictional experiments such as that of Sergio Canavero and the recent TV series Altered (...) Carbon through the lenses of the philosophical background they both rely on: immortality is achievable—and it should be sought with vehemence. At least by the rich. (shrink)

This article is concerned with two interrelated questions: what, if anything, distinguishes synthetic from natural organisms, and to what extent, if any, creating the former is of moral significance. These are ontological and ethical questions, respectively. As the title indicates, I address both from a broadly neo-Aristotelian perspective, i.e. a teleological philosophy of life and virtue ethics. For brevity’s sake, I shall not argue for either philosophical position at length, but instead hope to demonstrate their legitimacy through their explanatory power. (...) I firstly argue that synthetic organisms differ in kind from natural organisms and machines, and differ only by degree from genetically modified organisms. I then suggest that this is nevertheless sufficient to give us specific ethical reservations about synthetic biology: namely, that more than any other widely used biotechnology, it is characterised by a drive to mastery that stands opposed to due appreciation of the giftedness of life. (shrink)

Advanced nanotechnology promises to be one of the fundamental transformational emerging technologies alongside others such as artificial intelligence, biotechnology, and other informational and cognitive technologies. Although scholarship on nanotechnology, particularly advanced nanotechnology such as molecular manufacturing has nearly ceased in the last decade, normal nanotechnology that is building the foundations for more advanced versions has permeated many industries and commercial products and has become a billion dollar industry. This paper acknowledges the socialtechnicity of advanced nanotechnology and proposes how its convergence (...) with other enabling technologies like AI can be anticipated and designed with human values in mind. Preliminary guidelines inspired by the Value Sensitive Design approach to technology design are proposed for molecular manufacturing in the age of artificial intelligence. (shrink)