Other Disorders and Syndromes

In this report, we describe the case of a patient who has remained in a comatose state for more than one year after a traumatic and hypoxic brain injury. This state, which we refer to as long-lasting coma (LLC), may be a disorder of consciousness with significantly different features from those of conventional coma, the vegetative state, or brain death. On the basis of clinical, neurophysiological and neuroimaging data, we hypothesize that a multilevel involvement of the ascending reticular activating system (...) is required in LLC. This description may be useful for the identification of other patients suffering from this severe disorder of consciousness, which raises important ethical issues. (shrink)

Disturbances of consciousness, including fluctuations in attention and awareness, are a common and clinically important symptom in dementia with Lewy bodies . In the present study we investigate potential mechanisms of such disturbances of consciousness in a clinicopathological study evaluating specific components of the cholinergic system. [3H]Epibatidine binding to the high-affinity nicotinic receptor in the temporal cortex differentiated DLB cases with and without DOC, being 62–66% higher in those with DOC . The were no differences between DLB patients with or (...) without DOC in 125I-labeled α-bungaratoxin binding to the low-affinity nicotinic receptor, [3H]pirenzepine binding to the muscarinic M1 receptor, or in choline acetyltransferase activity. These findings provide support for the hypothesis that cholinergic activity is an important neural correlate if consciousness and suggest a mechanism of DOC in DLB involving alterations in the nicotinic receptor, composed of predominantly α4 and β2 subunits. (shrink)

Descartes was certain that he was thinking and he was accordingly certain that he existed. Like Descartes, we seem to be more certain of our thoughts and our existence than of anything else. What is less clear is the reason why we are thus certain. Philosophers throughout history have provided different interpretations of the cogito, disagreeing both on the kind of thoughts it characterizes and on the reasons for its cogency. According to what we may call the empiricist interpretation of (...) the cogito, I can only claim to be certain of having experiences, and this certainty, as well as that of my own existence, stems from their phenomenal and subjective character. According to rationalist interpretations, on the other hand, I am certain of having some self-reflexive propositional attitudes, and this certainty derives from their rational features. Psychiatric patients suffering from acute forms of depersonalization or of the Cotard syndrome often doubt that they think and exist, and might even believe that they don't. I argue that their study allows us to favor the empiricist interpretation of the cogito. (shrink)

This volume takes the first step toward building the necessary local bridges.

Studies of perception have focussed on sensation, though more recently the perception of action has, once more, become the subject of investigation. These studies have looked at acute experimental situations. The present paper discusses the subjective experience of those with either clinical syndromes of loss of movement or sensation (spinal cord injury, sensory neuronopathy syndrome or motor stroke), or with experimental paralysis or sensory loss. The differing phenomenology of these is explored and their effects on intention and agency discussed. It (...) is shown that sensory loss can have effects on the focussing of motor command and that for some a sense of agency can return despite paralysis. (shrink)

Traditionally, what we are conscious of in self-consciousness is something non-corporeal. But anti-Cartesian philosophers argue that the self is as much corporeal as it is mental. Because we have the sense of proprioception, a kind of body awareness, we are immediately aware of ourselves as bodies in physical space. In this debate the case histories of patients who have lost their sense of proprioception are clearly relevant. These patients do retain an awareness of themselves as corporeal beings, although they hardly (...) feel their bodies . They can initiate movements, and with the help of visual feedback learn to control them. It is shown that the traditional view of the self as immaterial is not supported by these cases. But the argument against this view has to be amended. It relies too much on bodily sensations, and misses the importance of active self-movement. (shrink)

Can we learn without consciousness? When the eminent neuropsychologist, Lawrence Weiskrantz first coined the term 'blindsight' to describe a condition whereby a patient could demonstrate that they were aware of some object, yet insist that they were completely unaware of its existence, the response from some in the scientific community was one of extreme skepticism. Even now, there are those who question the existence of unconscious learning, and the topic remains one of the most actively researched and debated in psychology. (...) In recent years evidence for unconscious processing across a range of sensory modalities have come from studies of vision, audition, memory, emotion, and action. Never before have these studies of unconscious processing in the different senses been brought together into a single volume. In a book dedicated to Lawrence Weiskrantz, some of the leading psychologists and cognitive neuroscientists of the day explain what we know about unconscious processing in the different senses. Including contributions from, amongst others, David Milner, Jon Driver, Alan Cowey, and Ray Dolan, the book presents a state of the art account of what we now know about 'the unconscious'. The book will provide a fascinating account for students and researchers in psychology, cognitive neuroscience, and philosophy. (shrink)

Zadra, Desjardins, and Marcotte tested several predictions derived from the Threat Simulation Theory of dreaming in a large sample of recurrent dreams. In response to these findings, Valli and Revonsuo presented a commentary outlining alternate conceptualizations and explanations for the results obtained. We argue that many points raised by Valli and Revonsuo do not accurately reflect our main findings and at times present a biased assessment of the data. In this article, we provide necessary clarifications and responses to each one (...) of their main points of discussion. (shrink)

INTRODUCTION TO ASPECTS OF FACE PROCESSING: TEN QUESTIONS IN NEED OF ANSWERS. HD Ellis 1. INTRODUCTION These proceedings of the first international ...

This book provides a state-of-the-art review of high-level vision and the brain.

A key element of the distinction between explicit and implicit cognitive functioning is the presence or absence of conscious awareness. In this review, we consider the proposal that neuropsychological disorders can best be considered in terms of a decoupling between preserved implicit or unconscious processing and impaired explicit or conscious processing. Evidence for dissociations between implicit and explicit processes in blindsight, amnesia, object agnosia, prosopagnosia, hemi-neglect, and aphasia is examined. The implications of these findings for a) our understanding of a (...) variety of neuropsychological disorders, b) the conceptualization of normal cognitive functioning, c) the neural basis of consciousness, and d) the clinical rehabilitation of brain-injured individuals are also discussed. (shrink)

Localizing the self in the brain has been the goal of consciousness research for centuries. Recently, there has been an increase in attention to the localization of the self. Here we present data from patients suffering from a loss of self in an attempt to understand the neural correlates of consciousness. Focusing on delusional misidentification syndrome , we find that frontal regions, as well as the right hemisphere appear to play a significant role in DMS and DMS related disorders. These (...) data are placed in the context of neuroimaging findings. (shrink)

The third edition of a work that defines the field of cognitive neuroscience, with extensive new material including new chapters and new contributors.