Scientific Instruments

It seems that the reception of Conrad Hal Waddington’s work never really gathered speed in mainstream biology. This paper, offering a transdisciplinary survey of approaches using his epigenetic landscape images, argues that (i) Waddington’s legacy is much broader than is usually recognized—it is widespread across the life sciences (e.g. stem cell biology, developmental psychology and cultural anthropology). In addition, I will show that (ii) there exist as yet unrecognized heuristic roles, especially in model building and theory formation, which Waddington’s images (...) play within his work. These different methodological facets envisioned by Waddington are used as a natural framework to analyze and classify the manners of usage of epigenetic landscape images in post-Waddingtonian ‘landscape approaches’. This evaluation of Waddington’s pictorial legacy reveals that there are highly diverse lines of traditions in the life sciences, which are deeply rooted in Waddington’s methodological work. (shrink)

Western philosophers have traditionally concentrated on theory as the means for expressing knowledge about a variety of phenomena. This absorbing book challenges this fundamental notion by showing how objects themselves, specifically scientific instruments, can express knowledge. As he considers numerous intriguing examples, Davis Baird gives us the tools to "read" the material products of science and technology and to understand their place in culture. Making a provocative and original challenge to our conception of knowledge itself, _Thing Knowledge _demands that we (...) take a new look at theories of science and technology, knowledge, progress, and change. Baird considers a wide range of instruments, including Faraday's first electric motor, eighteenth-century mechanical models of the solar system, the cyclotron, various instruments developed by analytical chemists between 1930 and 1960, spectrometers, and more. (shrink)

Astronomer Charles Piazzi Smyth’s 1864–65 expedition to measure the Great Pyramid of Giza was planned around a system of linear measures designed to guarantee the validity of his measurements and settle ongoing uncertainties as to the Pyramid’s true size. When the intended system failed to come together, Piazzi Smyth was forced to improvise a replacement that presented a fundamental challenge to the metrological enterprise upon which his system had been based. The astronomer’s new system centered around a small lump of (...) basalt, now held at Cambridge’s Whipple Museum of the History of Science, which nucleated a wide array of material and scientific considerations. Through a bipartite analysis of the physical and narrative dimensions of Piazzi Smyth’s basalt Standard, I develop the implications of its use and construction for understanding the material constitution of scientific instruments. In particular, I illustrate how instruments are locally constituted through co-accountable systems and how their material features become integrally implicated in both their uses and meanings. (shrink)

The production of evidence for scientific hypotheses and theories often depends upon complex instruments and techniques for employing them. An important epistemological question arises as to how the reliability of these instruments and techniques is assessed. To address that question, this paper examines the introduction of electron microscopy and cell fractionation in cell biology. One important claim is that scientists often arrive at their techniques for employing instruments like the electron microscope and the ultracentrifuge by tinkering and that they evaluate (...) the resulting techniques in part by whether they produce plausible data given developing theories. (shrink)

I want to make plausible the following claim:Analyzing scientific inquiry as a species of socially distributed cognition has a variety of advantages for science studies, among them the prospects of bringing together philosophy and sociology of science. This is not a particularly novel claim, but one that faces major obstacles. I will retrace some of the major steps that have been made in the pursuit of a distributed cognition approach to science studies, paying special attention to the promise that such (...) an approach holds out for bridging the rift between philosophy and the social studies of science. (shrink)

This paper aims at extending the notion of thing knowledge put forth by Davis Baird. His Thing Knowledge (Baird 2004) proposes that scientific instruments constitute scientific knowledge and that to conceive scientific instruments as such brings about a new and better understanding of scientific development. By insisting on what “truth does for us,” Baird shows that the functional properties of truth are shared by the common scientific instrument. The traditional definition of knowledge as justified true belief would only apply to (...) scientific instrumentation if we were to reject the subjective (and intentional) aspect of it, viz. belief. In consequence, Baird insists that scientific instruments can be seen only as a kind of objective knowledge, that is knowledge maintained by the scientific community but not individually by a given scientist. In this paper, I will argue for a conception of subjective thing knowledge according to which some scientific instruments (especially material models) can be understood as justified true beliefs. By combining Davis Baird’s thing knowledge and Clark and Chalmers’ hypothesis of extended cognition, I will show that it is possible to derive an analysis of material models as cognitive augmentation of the scientist's mind, and that such scientific instruments are to be understood as a material form of subjective knowledge, i.e. as external-to-the-brain justified true beliefs. (shrink)

People are common instruments in the social sciences. They may act as experimenter, receiving and instructing the participants; they may be a stooge, a confederate of the experimenter who is part of the experimental manipulation; they may function as raters of their own personality or that of others; or they may conduct interviews and do observations. In most social scientific research, people are necessary to elicit, record, or measure the phenomena under study. They are an essential instrument in most social (...) science. (shrink)

Abstract During the last decades it has become widely accepted that scientific observations are ?theory?laden?. Scientists ?see? the world with their theories or theoretical presuppositions. In the present paper it is argued that they ?see? with their scientific instruments as well, as the uses of scientific instruments is an important characteristic of modern natural science. It is further argued that Euclidean geometry is intimately linked to technology, and hence that it plays a fundamental part in the construction and operation of (...) scientific instruments. Finally, Euclidean geometry is compared to fractal geometry, and the question of its a priori status is raised. Although the position that Euclidean geometry is a priori in the original Kantian sense is untenable, the paper concludes that in some restricted sense Euclidean geometry may be said to be a priori. (shrink)

Philosophers of experiment have acknowledged that experiments are often more than mere hypothesis-tests, once thought to be an experiment's exclusive calling. Drawing on examples from contemporary biology, I make an additional amendment to our understanding of experiment by examining the way that `wide' instrumentation can, for reasons of efficiency, lead scientists away from traditional hypothesis-directed methods of experimentation and towards exploratory methods.

Since the late 1950s one of the most important and influential views of post-positivist philosophy of science has been the theory-ladenness of observation. It comes in at least two forms: either as a psychological law pertaining to human perception (whether scientific or not) or as conceptual insight concerning the nature and functioning of scientific language and its meaning. According to its psychological form, perceptions of scientists, as perceptions of humans generally, are guided by prior beliefs and expectations, and perception has (...) a peculiar holist character. In its conceptual form it maintains that scientists’ observations rest on the theories they accept and that the meaning of the observational terms involved depends upon the theoretical context in which they occur. Frequently, these two versions are combined with each other and give rise to a constructivist view of scientific knowledge (I shall use the term “constructivism” roughly in the same way as Golinski [1998, chap. 1]). According to this outlook, our experience is categorized and preconditioned by prior belief since the process of gaining knowledge through science always involves the use of concepts from some theory or other. This view can easily be strengthened to serve as the cornerstone of a constructivist and anti-empiricist account of science: The categories in terms of which we carve up our experience are not read off from the external world but follow from prior theoretical commitments. (shrink)

Abstract: Hasok Chang (Sci Educ 20:317–341, 2011) shows how the recovery of past experimental knowledge, the physical replication of historical experiments, and the extension of recovered knowledge can increase scientific understanding. These activities can also play an important role in both science and history and philosophy of science education. In this paper I describe the implementation of an integrated learning project that I initiated, organized, and structured to complement a course in history and philosophy of the life sciences (HPLS). The (...) project focuses on the study and use of descriptions, observations, experiments, and recording techniques used by early microscopists to clas- sify various species of water flea. The first published illustrations and descriptions of the water flea were included in the Dutch naturalist Jan Swammerdam’s, Historia Insectorum Generalis (1669) (Algemeene verhandeling van de bloedeloose dierkens. t’Utrrecht, Me- inardus van Dreunen, ordinaris Drucker van d’Academie). After studying these, we first used the descriptions, techniques, and nomenclature recovered to observe, record, and classify the specimens collected from our university ponds. We then used updated recording techniques and image-based keys to observe and identify the specimens. The implementation of these newer techniques was guided in part by the observations and records that resulted from our use of the recovered historical methods of investigation. The series of HPLS labs constructed as part of this interdisciplinary project provided a space for students to consider and wrestle with the many philosophical issues that arise in the process of identifying an unknown organism and offered unique learning opportunities that engaged students’ curiosity and critical thinking skills. (shrink)

Arabidopsis is currently the most popular and well-researched model organism in plant biology. This paper documents this plant's rise to scientific fame by focusing on two interrelated aspects of Arabidopsis research. One is the extent to which the material features of the plant have constrained research directions and enabled scientific achievements. The other is the crucial role played by the international community of Arabidopsis researchers in making it possible to grow, distribute and use plant specimen that embody these material features. (...) I argue that at least part of the explosive development of this research community is due to its successful standardisation and to the subsequent use of Arabidopsis specimen as material models of plants. I conclude that model organisms have a double identity as both samples of nature and artifacts representing nature. It is the resulting ambivalence in their representational value that makes them attractive research tools for biologists. (shrink)

In der Wissenschaft spielen Visualisierungen eine immer wichtigere Rolle. Sie sind zum einen Gegenstand der Forschung und zum anderen unverzichtbares Hilfsmittel bei der Präsentation und Distribution von Forschungsergebnissen. Beides stellt neue Anforderungen an den Wissenschaftler und seine praktische wie auch theoretische Arbeit und lässt nach einer kritischen Reflexion dieses Bildhandelns fragen. Was zeigen uns MRT-Bilder in der Medizin wirklich? Wie hat die Weiterentwicklung der Mikroskopie-Technologie unsere Vorstellung von der menschlichen Zelle verändert? Welche Rolle können Bilder bei der Vermittlung von Wissen (...) im didaktischen Kontext spielen? Zeigen uns Visualisierungen die Wirklichkeit? Oder sind sie bloß ein weiterer Anhaltspunkt für die soziale Konstruktion wissenschaftlicher Erkenntnis? Kann es eine Logik der Bilder geben? In welchen Begriffen reden wir über Bilder? Ziel des Sammelbandes Visualisierung und Erkenntnis. Bildverstehen und Bildverwenden in Natur- und Geisteswissenschaften ist es, die Forschung mit und an Visualisierungen in den Einzelwissenschaften auf eine reflektierte Basis zu stellen. Zu diesem Zweck werden nicht nur die wissenschafts- und erkenntnistheoretischen Grundlagen und Herausforderungen beleuchtet, die die Verwendung von Visualisierungen mit sich bringt, sondern auch die Rolle der Visualisierungen im konkreten Anwendungsfall betrachtet. Der Band lässt dabei Geistes- und Naturwissenschaftler, Theoretiker und Praktiker in einen Dialog über den gemeinsamen Forschungsgegenstand treten. (shrink)

The present paper claims that M. S. Tswett’s chromatographic adsorption analysis, which today is a ubiquitous and instrumentally sophisticated chemical technique, was either ignored or outright rejected by chemists and botanists in the first three decades of the twentieth century because it did not make sense in terms of accepted chemical theory or practice. Evidence for this claim is culled from consideration of the botanical and chemical context of Tswett’s technique as well as an analysis of the protracted debate over (...) Tswett’s chromatographic analysis of chlorophyll between him and Leon Marchlewski, a noted chlorophyll chemist of the period. In this way, the paper expands and amends what it calls the ‘textbook story’ of the early history of chromatography, examples of which may be found in historical notes in many textbooks of chemical instrumental analysis and numerous short articles in chemistry journals. The paper also provides an accessible introduction to the early history of chromatography for historians of science likely to know little or nothing about it. (shrink)

The purpose of this article is twofold: on the one hand, we present the outlines of a history of university collections in Germany. On the other hand, we discuss this history as a case study of the changing attitudes of the sciences towards their material heritage. Based on data from 1094 German university collections, we distinguish three periods that are by no means homogeneous but offer a helpful starting point for a discussion of the entangled institutional and epistemic factors in (...) the history of university collections. In the 19th century, university collections were institutionalized and widely recognized as indispensable in research and teaching. During the 20th century, university collection became increasingly marginalized both on an institutional and theoretical level. Towards the end of the 20th century, the situation of university collections improved partly because of their reconsideration as material heritage. (shrink)

Elimination controversies are ubiquitous in philosophy and the human sciences. For example, it has been suggested that humanraces, hysteria, intelligence, mental disorder, propositional attitudes such as beliefs and desires, the self, and the super-ego should beeliminated from the list of respectable entities in the human sciences. I argue that eliminativist proposals are often presented in theframework of an oversimplified ‘‘phlogiston model’’ and suggest an alternative account that describes ontological elimination on a gradualscale between criticism of empirical assumptions and conceptual choices.

Galileo’s telescopic lunar observations, announced in Siderius Nuncius (1610), were a triumph of observational skill and ingenuity. Yet, unlike the Medicean stars, Galileo’s lunar “discoveries” were not especially novel. Indeed, Plutarch had noted the moon’s uneven surface in classical times, and many other renaissance observers had also turned their gaze moonward, even (in Harriot’s case) aided by telescopes of their own. Moreover, what Galileo and his contemporaries saw was colored by the assumptions they already had. Copernicans assumed the moon was (...) a terrestrial satellite, thus Galileo saw its mountains and Kepler “saw” the dwellings of its inhabitants. Aristotelians assumed the moon was a perfect sphere, so they saw differences in density and rarity in the lunar body. Theory corrected the results of observation, so Galileo’s lunar observations, like those that had come before, proved nothing. Yet this failure contained the germ of Galileo’s success, since the Siderius Nuncius gave observation a rhetorical force it did not have before. Observers on all sides set out to see for themselves what Galileo reported. Hence, all parties now had to answer to what they saw, whatever they believed. Thus, the Siderius Nuncius ultimately changed the grounds upon which natural philosophical argument and debate was carried out. In this new empirical arena, the Galilean science would eventually prevail. (shrink)

Alexander Bird argues for an epistemic account of scientific progress, whereas Darrell Rowbottom argues for a semantic account. Both appeal to intuitions about hypothetical cases in support of their accounts. Since the methodological significance of such appeals to intuition is unclear, I think that a new approach might be fruitful at this stage in the debate. So I propose to abandon appeals to intuition and look at scientific practice instead. I discuss two cases that illustrate the way in which scientists (...) make judgments about progress. As far as scientists are concerned, progress is made when scientific discoveries contribute to the increase of scientific knowledge of the following sorts: empirical, theoretical, practical, and methodological. I then propose to articulate an account of progress that does justice to this broad conception of progress employed by scientists. I discuss one way of doing so, namely, by expanding our notion of scientific knowledge to include both know-that and know-how. (shrink)

In today’s science, the output of measurement processes are often visual representations of the data detected. Moreover, we find such visual data as parts of scientific reasoning in different contexts. In this article, we will take a look at two of them. On the one hand, visual representations are used as a kind of surrogate for the real object to ask questions about it – we will call this the exploratory use of visual data. On the other hand, visualisations are (...) often used to communicate research results to scientific peers or to laymen. Instances of the latter case we will subsequently call the explanatory use of visual data. However, in both contexts the question arises what might justify these epistemic practices. Believing without reasons is epistemically irresponsible, it leads to gullibility. Thus, we will try to answer the question whether there are any reasons to support our epistemic practices concerning scientific visualisations in the above-mentioned senses and whether these are good reasons to rely on. (shrink)

Today we are all familiar with the iconic pictures of the nebulae produced by the Hubble Space Telescope’s digital cameras. But there was a time, before the successful application of photography to the heavens, in which scientists had to rely on handmade drawings of these mysterious phenomena. Observing by Hand sheds entirely new light on the ways in which the production and reception of handdrawn images of the nebulae in the nineteenth century contributed to astronomical observation. Omar W. Nasim investigates (...) hundreds of unpublished observing books and paper records from six nineteenth-century observers of the nebulae: Sir John Herschel; William Parsons, the third Earl of Rosse; William Lassell; Ebenezer Porter Mason; Ernst Wilhelm Leberecht Tempel; and George Phillips Bond. Nasim focuses on the ways in which these observers created and employed their drawings in data-driven procedures, from their choices of artistic materials and techniques to their practices and scientific observation. He examines the ways in which the act of drawing complemented the acts of seeing and knowing, as well as the ways that making pictures was connected to the production of scientific knowledge. An impeccably researched, carefully crafted, and beautifully illustrated piece of historical work, Observing by Hand will delight historians of science, art, and the book, as well as astronomers and philosophers. (shrink)

This article explores some of the roles of computer simulation in measurement. A model-based view of measurement is adopted and three types of measurement—direct, derived, and complex—are distinguished. It is argued that while computer simulations on their own are not measurement processes, in principle they can be embedded in direct, derived, and complex measurement practices in such a way that simulation results constitute measurement outcomes. Atmospheric data assimilation is then considered as a case study. This practice, which involves combining information (...) from conventional observations and simulation-based forecasts, is characterized as a complex measuring practice that is still under development. The case study reveals challenges that are likely to resurface in other measuring practices that embed computer simulation. It is also noted that some practices that embed simulation are difficult to classify; they suggest a fuzzy boundary between measurement and non-measurement. 1 Introduction2 A Contemporary View of Measurement3 Three Types of Measurement4 Can Computer Simulations Measure Real-World Target Systems?5 Case Study: Atmospheric Data Assimilation5.1 Why data assimilation?5.2 A complex measuring practice under development5.3 Epistemic iteration6 The Boundaries of Measurement7 Epistemology, Not Terminology. (shrink)

We claim that in contemporary studies in molecular biology and biomedicine, the nature of ‘manipulation’ and ‘intervention’ has changed. Traditionally, molecular biology and molecular studies in medicine are considered experimental sciences, whereas experiments take the form of material manipulation and intervention. On the contrary “big science” projects in biology focus on the practice of data mining of biological databases. We argue that the practice of data mining is a form of intervention although it does not require material manipulation. We also (...) suggest that material manipulation, although still present in in the practice of data mining, fulfill a different epistemic role. (shrink)