||The vegetative state (VS) and coma are categorized as disorders of consciousness. Both are states of unconsciousness, in which patients are defined as being unaware; the VS is a state of wakeful unconsciousness, in which patients experience sleep/wake cycles, which distinguishes it from coma. It has long been suspected that the rate of misdiagnosis in the VS is as high as 40%. That is, ~40% of patients diagnosed as unconsciousness may in fact be conscious. Recent neuroscientific developments, particularly in functional neuroimaging, have identified patients who are functionally locked in, unable to respond behaviorally, but able to wilfully modulate their brain activity to indicate that they are conscious. This has resulted in an effort to rename the VS as Unresponsive Wakefulness Syndrome (UWS), both to more accurately describe the condition, and to remove the stigma and negative associations of the term "vegetative" (and the pejorative "vegetable").The key ethical issues with VS and Coma are the right to die and the value of life in a state of unconsciousness, along with ancillary questoins about precedent autonomy. Other ethical issues include the high rate of misdiagnosis, controversy concerning the concept of brain-based "behavior," and questions about quality of life and the best interests of unconscious persons.