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  1. Treatment Effectiveness and the Russo–Williamson Thesis, EBM+, and Bradford Hill's Viewpoints.Steven Tresker - 2022 - International Studies in the Philosophy of Science 34 (3):131-158.
    Establishing the effectiveness of medical treatments is one of the most important aspects of medical practice. Bradford Hill's viewpoints play an important role in inferring causality in medicine,...
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  • Six Theses on Mechanisms and Mechanistic Science.Stuart Glennan, Phyllis Illari & Erik Weber - 2022 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 53 (2):143-161.
    In this paper we identify six theses that constitute core results of philosophical investigation into the nature of mechanisms, and of the role that the search for and identification of mechanisms play in the sciences. These theses represent the fruits of the body of research that is now often called New Mechanism. We concisely present the main arguments for these theses. In the literature, these arguments are scattered and often implicit. Our analysis can guide future research in many ways: it (...)
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  • Treatment effectiveness, generalizability, and the explanatory/pragmatic-trial distinction.Steven Tresker - 2022 - Synthese 200 (4):1-29.
    The explanatory/pragmatic-trial distinction enjoys a burgeoning philosophical and medical literature and a significant contingent of support among philosophers and healthcare stakeholders as an important way to assess the design and results of randomized controlled trials. A major motivation has been the need to provide relevant, generalizable data to drive healthcare decisions. While talk of pragmatic and explanatory trials could be seen as convenient shorthand, the distinction can also be seen as harboring deeper issues related to inferential strategies used to evaluate (...)
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  • AI Models and the Future of Genomic Research and Medicine: True Sons of Knowledge?Harald König, Daniel Frank, Martina Baumann & Reinhard Heil - 2021 - Bioessays 43 (10):2100025.
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  • The Use of Mechanistic Reasoning in Assessing Coronavirus Interventions.Jeffrey K. Aronson, Daniel Auker-Howlett, Virginia Ghiara, Michael P. Kelly & Jon Williamson - 2021 - Journal of Evaluation in Clinical Practice 27 (3):684-693.
    Evidence-based medicine, the dominant approach to assessing the effectiveness of clinical and public health interventions, focuses on the results of association studies. EBM+ is a development of EBM that systematically considers mechanistic studies alongside association studies. In this paper we provide several examples of the importance of mechanistic evidence to coronavirus research. Assessment of combination therapy for MERS highlights the need for systematic assessment of mechanistic evidence. That hypertension is a risk factor for severe disease in the case of SARS-CoV-2 (...)
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  • Treating Real People: Science and Humanity.Michael Loughlin, Mathew Mercuri, Alexandra Parvan, Samantha Copeland, Mark Tonelli & Stephen Buetow - 2018 - Journal of Evaluation in Clinical Practice 24 (5):919-929.
    Something important is happening in applied, interdisciplinary research, particularly in the field of applied health research. The vast array of papers in this edition are evidence of a broad change in thinking across an impressive range of practice and academic areas. The problems of complexity, the rise of chronic conditions, over-diagnosis, co- and multimorbidity are serious and challenging, but we are rising to that challenge. Key conceptions regarding science, evidence, disease, clinical judgement, health and social care, are being revised and (...)
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  • The Guidelines Challenge-Philosophy, Practice, Policy.Rani Lill Anjum, Samantha Copeland, Roger Kerry & Elena Rocca - 2018 - Journal of Evaluation in Clinical Practice 24 (5):1120-1126.
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