Attempts to close the mind-body gap traditionally resort to a priori speculations. Motivated by dissatisfaction with such accounts, neurophenomenology constitutes one of the first attempts to close the mind-body gap non-metaphysically. Nonetheless, it faces significant challenges. Many of these challenges arise from its abandoning of transcendentality and its dim view of bioinformation. In this paper, I propose a superior non-metaphysical alternative: a combination of a reformed biosemiotics and transcendental phenomenology. My approach addresses the difficulties of neurophenomenology, while retaining the merit (...) of mutual constraints. Biosemiotics pays respect to bioinformation while imposing the sign-meaning duality on primitive forms of life, which is a relic of anthropomorphism. To avoid this unjustified commitment, I argue for a sign-free biosemantics which replaces Peirce’s semiotics with Husserl’s theory of meaning and exchanges naturalism for transcendentalism. Meaning, according to the resulting account, is the “intended as such”. The irreality of meaning results from what I term the ‘higher visibility’ of intentionality. I argue that the mind-body gap can be locally closed in a non-metaphysical manner as the result of reflection upon empirical biological investigations. Sign-free biosemantics uncovers the meanings for the organism that are implicit in biological research, while transcendental phenomenology analyses the experiences that biologists undergo when associating the physical with the biological level, while at the same time also analysing the very framework within which they work. Meanwhile, biosemiotics frees phenomenology from its methodological limitations, and the two domains establish mutual constraints in a more radical form than neurophenomenology. (shrink)