Switch to: References

Add citations

You must login to add citations.
  1. What Makes Placebo-Controlled Trials Unethical?Franklin G. Miller & Howard Brody - 2002 - American Journal of Bioethics 2 (2):3 – 9.
    The leading ethical position on placebo-controlled clinical trials is that whenever proven effective treatment exists for a given condition, it is unethical to test a new treatment for that condition against placebo. Invoking the principle of clinical equipoise, opponents of placebo-controlled trials in the face of proven effective treatment argue that they (1) violate the therapeutic obligation of physicians to offer optimal medical care and (2) lack both scientific and clinical merit. We contend that both of these arguments are mistaken. (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   56 citations  
  • When Argument Fails.Charles Weijer - 2002 - American Journal of Bioethics 2 (2):10 – 11.
  • The Rationale for Placebo-Controlled Trials: Methodology and Policy Considerations.Franklin G. Miller - 2009 - American Journal of Bioethics 9 (9):49-50.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  • Placebo Groups in Research on the Effectiveness of ABA Therapeutic Techniques.Przemysław Bąbel, Elżbieta Anita Bajcar, Katarzyna Marchewka & Katarzyna Sikora - 2018 - Frontiers in Psychology 9.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  • Benefits, Risks and Ethical Considerations in Translation of Stem Cell Research to Clinical Applications in Parkinson's Disease.Z. Master, M. McLeod & I. Mendez - 2007 - Journal of Medical Ethics 33 (3):169-173.
    Stem cells are likely to be used as an alternate source of biological material for neural transplantation to treat Parkinson’s disease in the not too distant future. Among the several ethical criteria that must be fulfilled before proceeding with clinical research, a favourable benefit to risk ratio must be obtained. The potential benefits to the participant and to society are evaluated relative to the risks in an attempt to offer the participants a reasonable choice. Through examination of preclinical studies transplanting (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark   11 citations  
  • A Renewed, Ethical Defense of Placebo-Controlled Trials of New Treatments for Major Depression and Anxiety Disorders.B. W. Dunlop & J. Banja - 2009 - Journal of Medical Ethics 35 (6):384-389.
    The use of placebo as a control condition in clinical trials of major depressive disorder and anxiety disorders continues to be an area of ethical concern. Typically, opponents of placebo controls argue that they violate the beneficent-based, “best proven diagnostic and therapeutic method” that the original Helsinki Declaration of 1964 famously asserted participants are owed. A more consequentialist, oppositional argument is that participants receiving placebo might suffer enormously by being deprived of their usual medication(s). Nevertheless, recent findings of potential for (...)
    Direct download (11 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  • A Randomised Controlled Trial of Ribavirin in Crimean Congo Haemorrhagic Fever: Ethical Considerations.B. Arda, A. Aciduman & J. C. Johnston - 2012 - Journal of Medical Ethics 38 (2):117-120.
    The randomised controlled trial (RCT) constitutes a quantitative, comparative, controlled study of a particular treatment, and provides invaluable evidence regarding its pharmacotherapeutic efficacy. These studies are generally predicated upon the ethical principle of clinical equipoise. However, this may be insufficient to justify withholding treatment from a control group while assessing drug therapy in a potentially fatal disease. Thus, the criteria for randomisation, informed consent methodology and timing, and consideration of treatment options in such a scenario remain the province of medical (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark  
  • Using Empirical Data to Inform the Ethical Evaluation of Placebo Controlled Trials.Jeremy Sugarman - 2004 - Science and Engineering Ethics 10 (1):29-35.
    There has been considerable debate about the ethical acceptability of using placebo-controls in clinical research. Although this debate has been rich in rhetoric, considering that much of this research is predicated upon the assumption that data from this research is vital to clinical decision-making, it is ironic that researchers have introduced little data into these discussions. Using some published research concerning the use of placebo-controls in clinical research in hypertension and psychiatric drug trials, I suggest some ways that such data (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  • Placebo in the Investigation of Psychotropic Drugs, Especially Antidepressants.Stanisław Pużyński - 2004 - Science and Engineering Ethics 10 (1):135-142.
    The paper presents major ethical, legal and methodological problems related to the use of placebo in mental disorders, especially in depression. It is pointed out that although authoritative groups of experts and numerous publications in the field of psychopharmacology indicate advisability of the double blind design with placebo in clinical trials of antidepressants, in recent years there have been more and more voices questioning legitimacy of this method. Objections of an ethical nature are raised, and reliability of this approach is (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark  
  • Placebo Orthodoxy and the Double Standard of Care in Multinational Clinical Research.Maya J. Goldenberg - 2015 - Theoretical Medicine and Bioethics 36 (1):7-23.
    It has been almost 20 years since the field of bioethics was galvanized by a controversial series of multinational AZT trials employing placebo controls on pregnant HIV-positive women in the developing world even though a standard of care existed in the sponsor countries. The trove of ethical investigations that followed was thoughtful and challenging, yet an important and problematic methodological assumption was left unexplored. In this article, I revisit the famous “double standard of care” case study in order to offer (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  • Informed Consent and the Use of Placebo in Poland: Ethical and Legal Aspects.Piotr Zaborowski & Adam Górski - 2004 - Science and Engineering Ethics 10 (1):167-178.
    The concept of informed consent was one of the most fruitful ideas that deeply changed the relationships between physicians and their patients from paternalism to respect for the personal autonomy of subjects needing professional medical care. The great progress in medicine, also involving the pharmaceutical industry, has created an increasing need to perform different clinical and experimental trials. The evolution of clinical research in the last decades has influenced strongly the design of these studies. One of the most important changes (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  • Placebos in Klinischen VersuchsreihenPlacebos in Clinical Trials. A Comparative Analysis of International Guidelines.Hans-Jörg Ehni & Urban Wiesing - 2006 - Ethik in der Medizin 18 (3):223-237.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  • I Need a Placebo Like I Need a Hole in the Head.Charles Weijer - 2002 - Journal of Law, Medicine and Ethics 30 (1):69-72.
  • The Ethical Analysis of Risk.Charles Weijer - 2000 - Journal of Law, Medicine and Ethics 28 (4):344-361.
  • Placebo Surgery for Parkinson's Disease: Do the Benefits Outweigh the Risks?Peter A. Clark - 2002 - Journal of Law, Medicine and Ethics 30 (1):58-68.
  • The Ethical Analysis of Risk.Charles Weijer - 2000 - Journal of Law, Medicine and Ethics 28 (4):344-361.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   19 citations  
  • I Need a Placebo Like I Need a Hole in the Head.Charles Weijer - 2002 - Journal of Law, Medicine and Ethics 30 (1):69-72.
    No categories
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  • Informed Consent and the Use of Placebo in Poland: Ethical and Legal Aspects. [REVIEW]Prof Piotr Zaborowski & Adam Górski - 2004 - Science and Engineering Ethics 10 (1):167-178.
    The concept of informed consent was one of the most fruitful ideas that deeply changed the relationships between physicians and their patients from paternalism to respect for the personal autonomy of subjects needing professional medical care. The great progress in medicine, also involving the pharmaceutical industry, has created an increasing need to perform different clinical and experimental trials. The evolution of clinical research in the last decades has influenced strongly the design of these studies. One of the most important changes (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  • Placebos in klinischen Versuchsreihen.Hans-Jörg Ehni & Urban Wiesing - 2006 - Ethik in der Medizin 18 (3):223-237.
    Die ethischen Aspekte der Verwendung von Placebos in klinischen Versuchsreihen wurden im letzten Jahrzehnt ausführlich und kontrovers diskutiert. Es fehlt dennoch eine gründliche vergleichende Analyse der verschiedenen internationalen Richtlinien, ihrer Terminologien und ihrer auf Placebo bezogenen Prinzipien. Das zentrale Problem ist die Rechtfertigung von Placebo bei einer nachgewiesen wirksamen Therapie. Alle aktuellen Versionen der untersuchten Richtlinien schlagen solche Rechtfertigungen vor, unterscheiden sich hierbei jedoch beträchtlich. Zunächst werden wir ein formales allgemeines Prinzip herausarbeiten. Dann werden wir drei verschiedene Kategorien von Kriterien (...)
    Direct download (4 more)  
    Translate
     
     
    Export citation  
     
    Bookmark