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  1. An RNA Phage Lab: MS2 in Walter Fiers’ Laboratory of Molecular Biology in Ghent, From Genetic Code to Gene and Genome, 1963–1976. [REVIEW]Jérôme Pierrel - 2012 - Journal of the History of Biology 45 (1):109 - 138.
    The importance of viruses as model organisms is well-established in molecular biology and Max Delbrück's phage group set standards in the DNA phage field. In this paper, I argue that RNA phages, discovered in the 1960s, were also instrumental in the making of molecular biology. As part of experimental systems, RNA phages stood for messenger RNA (mRNA), genes and genome. RNA was thought to mediate information transfers between DNA and proteins. Furthermore, RNA was more manageable at the bench than DNA (...)
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  • Ray Wu as Fifth Business: Deconstructing Collective Memory in the History of DNA Sequencing.Lisa A. Onaga - 2014 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 46 (1):1-14.
    The concept of ‘Fifth Business’ is used to analyze a minority standpoint and bring serious attention to the role of scientists who play a galvanizing role in a science but for multiple reasons appear less prominently in more common recounts of any particular development. Biochemist Ray Wu published a DNA sequencing experiment in March 1970 using DNA polymerase catalysis and specific nucleotide labeling, both of which are foundational to general sequencing methods today. The scant mention of Wu’s work from textbooks, (...)
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  • Big Data-Revolution Oder Datenhybris?Big Data Revolution or Data Hubris?Gabriele Gramelsberger - 2017 - NTM Zeitschrift für Geschichte der Wissenschaften, Technik und Medizin 25 (4):459-483.
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  • Contrasting Approaches to a Biological Problem: Paul Boyer, Peter Mitchell and the Mechanism of the ATP Synthase, 1961–1985. [REVIEW]John N. Prebble - 2013 - Journal of the History of Biology 46 (4):699-737.
    Attempts to solve the puzzling problem of oxidative phosphorylation led to four very different hypotheses each of which suggested a different view of the ATP synthase, the phosphorylating enzyme. During the 1960s and 1970s evidence began to accumulate which rendered Peter Mitchell’s chemiosmotic hypothesis, the novel part of which was the proton translocating ATP synthase (ATPase), a plausible explanation. The conformational hypothesis of Paul Boyer implied an enzyme where ATP synthesis was driven by the energy of conformational changes in the (...)
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  • Making a Virus Visible: Francis O. Holmes and a Biological Assay for Tobacco Mosaic Virus. [REVIEW]Karen-Beth G. Scholthof - 2014 - Journal of the History of Biology 47 (1):107-145.
    In the early twentieth century, viruses had yet to be defined in a material way. Instead, they were known better by what they were not – not bacteria, not culturable, and not visible with a light microscope. As with the ill-defined “gene” of genetics, viruses were microbes whose nature had not been revealed. Some clarity arrived in 1929 when Francis O. Holmes, a scientist at the Boyce Thompson Institute for Plant Research reported that Tobacco mosaic virus could produce local necrotic (...)
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  • The Long and Winding Road of Molecular Data in Phylogenetic Analysis.Edna Suárez-Díaz - 2014 - Journal of the History of Biology 47 (3):443-478.
    The use of molecules and reactions as evidence, markers and/or traits for evolutionary processes has a history more than a century long. Molecules have been used in studies of intra-specific variation and studies of similarity among species that do not necessarily result in the analysis of phylogenetic relations. Promoters of the use of molecular data have sustained the need for quantification as the main argument to make use of them. Moreover, quantification has allowed intensive statistical analysis, as a condition and (...)
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  • From the Genetic to the Computer Program: The Historicity of 'Data' and 'Computation' in the Investigations on the Nematode Worm C. Elegans (1963–1998). [REVIEW]Miguel García-Sancho - 2012 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 43 (1):16-28.