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  1. Are Synthetic Genomes Parts of a Genetic Lineage?Gunnar Babcock - forthcoming - British Journal for the Philosophy of Science.
    Biologists are nearing the creation of the first fully synthetic eukaryotic genome. Does this mean that we still soon be able to create genomes that are parts of an existing genetic lineage? If so, it might be possible to bring back extinct species. But do genomes that are synthetically assembled, no matter how similar they are to native genomes, really belong to the genetic lineage on which they were modelled? This article will argue that they are situated within the same (...)
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  • Techniques et concepts du vivant en biologie synthétique.Alberto Molina Pérez - 2009 - Ludus Vitalis 17 (31):237-240.
  • Kuhn, Nominalism, and Empiricism.Alexander Bird - 2003 - Philosophy of Science 70 (4):690-719.
    In this paper I draw a connection between Kuhn and the empiricist legacy, specifically between his thesis of incommensurability, in particular in its later taxonomic form, and van Fraassen's constructive empiricism. I show that if it is the case the empirically equivalent but genuinely distinct theories do exist, then we can expect such theories to be taxonomically incommensurable. I link this to Hacking's claim that Kuhn was a nominalist. I also argue that Kuhn and van Fraassen do not differ as (...)
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  • Synthetic Biology and Synthetic Knowledge.Christophe Malaterre - 2013 - Biological Theory (8):346–356.
    Probably the most distinctive feature of synthetic biology is its being “synthetic” in some sense or another. For some, synthesis plays a unique role in the production of knowledge that is most distinct from that played by analysis: it is claimed to deliver knowledge that would otherwise not be attained. In this contribution, my aim is to explore how synthetic biology delivers knowledge via synthesis, and to assess the extent to which this knowledge is distinctly synthetic. On the basis of (...)
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  • Can Synthetic Biology Shed Light on the Origin of Life?Christophe Malaterre - 2009 - Biological Theory 4 (4):357-367.
    It is a most commonly accepted hypothesis that life originated from inanimate matter, somehow being a synthetic product of organic aggregates, and as such, a result of some sort of prebiotic synthetic biology. In the past decades, the newly formed scientific discipline of synthetic biology has set ambitious goals by pursuing the complete design and production of genetic circuits, entire genomes or even whole organisms. In this paper, I argue that synthetic biology might also shed some novel and interesting perspectives (...)
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  • Life’s Demons: Information and Order in Biology.Philippe M. Binder & Antoine Danchin - 2011 - EMBO Reports 12 (6):495-499.
    Two decades ago, Rolf Landauer (1991) argued that “information is physical” and ought to have a role in the scientific analysis of reality comparable to that of matter, energy, space and time. This would also help to bridge the gap between biology and mathematics and physics. Although it can be argued that we are living in the ‘golden age’ of biology, both because of the great challenges posed by medicine and the environment and the significant advances that have been made—especially (...)
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  • Anticipation and the Artificial: Aesthetics, Ethics, and Synthetic Life. [REVIEW]Mihai Nadin - 2010 - AI and Society 25 (1):103-118.
    If complexity is a necessary but not sufficient premise for the existence and expression of the living, anticipation is the distinguishing characteristic of what is alive. Anticipation is at work even at levels of existence where we cannot refer to intelligence. The prospect of artificially generating aesthetic artifacts and ethical constructs of relevance to a world in which the natural and the artificial are coexistent cannot be subsumed as yet another product of scientific and technological advancement. Beyond the artificial, the (...)
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  • Rational Engineering Principles in Synthetic Biology: A Framework for Quantitative Analysis and an Initial Assessment.Bernd Giese, Stefan Koenigstein, Henning Wigger, Jan C. Schmidt & Arnim von Gleich - 2013 - Biological Theory 8 (4):324-333.
    The term “synthetic biology” is a popular label of an emerging biotechnological field with strong claims to robustness, modularity, and controlled construction, finally enabling the creation of new organisms. Although the research community is heterogeneous, it advocates a common denominator that seems to define this field: the principles of rational engineering. However, it still remains unclear to what extent rational engineering—rather than “tinkering” or the usage of random based or non-rational processes—actually constitutes the basis for the techniques of synthetic biology. (...)
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  • Is Artefactualness a Value-Relevant Property of Living Things?Ronald Sandler - 2012 - Synthese 185 (1):89-102.
    Artefacts are often regarded as being mere things that possess only instrumental value. In contrast, living entities (or some subset of them) are often regarded as possessing some form of intrinsic (or non-instrumental) value. Moreover, in some cases they are thought to possess such value precisely because they are natural (i.e., non-artefactual). However, living artefacts are certainly possible, and they may soon be actual. It is therefore necessary to consider whether such entities should be regarded as mere things (like most (...)
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  • Experimental Research in Whole Brain Emulation: The Need for Innovativein Vivomeasurement Techniques.Randal A. Koene - 2012 - International Journal of Machine Consciousness 4 (01):35-65.
  • The Good of Non-Sentient Entities: Organisms, Artifacts, and Synthetic Biology.John Basl & Ronald Sandler - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):697-705.
    Synthetic organisms are at the same time organisms and artifacts. In this paper we aim to determine whether such entities have a good of their own, and so are candidates for being directly morally considerable. We argue that the good of non-sentient organisms is grounded in an etiological account of teleology, on which non-sentient organisms can come to be teleologically organized on the basis of their natural selection etiology. After defending this account of teleology, we argue that there are no (...)
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  • Echoing Demystified Aspirations: Human Flourishing and the Dialectic of Happiness.Patrick Joseph Ahern - unknown
    PHILOSOPHY Echoing Demystified Aspirations: Human Flourishing and the Dialectic of Happiness Patrick Joseph Ahern Dissertation under the direction of Idit Dobbs-Weinstein The question of the possibility or even the concern for human happiness has proven to be a point of contention for political thinkers confronting the ideological injunction to be happy in the face of material conditions that stifle the capacity for human flourishing. It can be argued that the appeal to human happiness as a political norm occludes as much (...)
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  • A Powerful Toolkit for Synthetic Biology: Over 3.8 Billion Years of Evolution.Lynn J. Rothschild - 2010 - Bioessays 32 (4):304-313.
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  • Synthetic Biology and the Technicity of Biofuels.Adrian Mackenzie - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):190-198.
    The principal existing real-world application of synthetic biology is biofuels. Several ‘next generation biofuel’ companies—Synthetic Genomics, Amyris and Joule Unlimited Technologies—claim to be using synthetic biology to make biofuels. The irony of this is that highly advanced science and engineering serves the very mundane and familiar realm of transport. Despite their rather prosaic nature, biofuels could offer an interesting way to highlight the novelty of synthetic biology from several angles at once. Drawing on the French philosopher of technology and biology (...)
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  • Synthetic Biology Needs A Synthetic Bioethics.Paul B. Thompson - 2012 - Ethics, Policy and Environment 15 (1):1 - 20.
    Recent developments in synthetic biology are described and characterized as moving the era of biotechnology into platform technologies. Platform technologies enable rapid and diffuse innovations and simultaneous product development in diffuse markets, often targeting sectors of the economy that have traditionally been thought to have little relationship to one another. In the case of synthetic biology, pharmaceutical and biofuel product development are occurring interactively. But the regulatory and ethical issues associated with these two applications share very little overlap. As such, (...)
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  • The Strength of Weak Artificial Consciousness.Anil Seth - 2009 - International Journal of Machine Consciousness 1 (1):71-82.
  • Synthetic Biology and the Ethics of Knowledge.T. Douglas & J. Savulescu - 2010 - Journal of Medical Ethics 36 (11):687-693.
    Synthetic biologists aim to generate biological organisms according to rational design principles. Their work may have many beneficial applications, but it also raises potentially serious ethical concerns. In this article, we consider what attention the discipline demands from bioethicists. We argue that the most important issue for ethicists to examine is the risk that knowledge from synthetic biology will be misused, for example, in biological terrorism or warfare. To adequately address this concern, bioethics will need to broaden its scope, contemplating (...)
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  • Synthetic Biology: Something Old, Something New ….Víctor de Lorenzo - 2010 - Bioessays 32 (4):267-270.
  • Environmental Biosafety in the Age of Synthetic Biology: Do We Really Need a Radical New Approach?Victor de Lorenzo - 2010 - Bioessays 32 (11):926-931.
  • Total Synthesis of a Eukaryotic Chromosome: Redesigning and SCRaMbLE-Ing Yeast.Dejana Jovicevic, Benjamin A. Blount & Tom Ellis - 2014 - Bioessays 36 (9):855-860.
    A team of US researchers recently reported the design, assembly and in vivo functionality of a synthetic chromosome III (SynIII) for the yeast Saccharomyces cerevisiae. The synthetic chromosome was assembled bottom‐up from DNA oligomers by teams of students working over several years with researchers as the first part of an international synthetic yeast genome project. Embedded into the sequence of the synthetic chromosome are multiple design changes that include a novel in‐built recombination scheme that can be induced to catalyse intra‐chromosomal (...)
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  • Building Artificial Cells and Protocell Models: Experimental Approaches with Lipid Vesicles.Peter Walde - 2010 - Bioessays 32 (4):296-303.
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  • The Cytoplasmic Structure Hypothesis for Ribosome Assembly, Vertical Inheritance, and Phylogeny.David S. Thaler - 2009 - Bioessays 31 (7):774-783.
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  • Research on Small Genomes: Implications for Synthetic Biology.Lisa Klasson & Siv G. E. Andersson - 2010 - Bioessays 32 (4):288-295.
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  • An Update of Public Perceptions of Synthetic Biology: Still Undecided?Mirko Ancillotti, Virgil Rerimassie, Stefanie B. Seitz & Walburg Steurer - 2016 - NanoEthics 10 (3):309-325.
    The discourse on the fundamental issues raised by synthetic biology, such as biosafety and biosecurity, intellectual property, environmental consequences and ethical and societal implications, is still open and controversial. This, coupled with the potential and risks the field holds, makes it one of the hottest topics in technology assessment today. How a new technology is perceived by the public influences the manner in which its products and applications will be received. Therefore, it is important to learn how people perceive synthetic (...)
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  • The Ethics of Synthetic Biology:Next Steps and Prior Questions.Gregory E. Kaebnick, Michael K. Gusmano & Thomas H. Murray - 2014 - Hastings Center Report 44 (S5):S4-S26.
  • Resurrecting Ancient Animal Genomes: The Extinct Moa and More.Leon Huynen, Craig D. Millar & David M. Lambert - 2012 - Bioessays 34 (8):661-669.
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  • Microbial Systems Engineering: First Successes and the Way Ahead.Sven Dietz & Sven Panke - 2010 - Bioessays 32 (4):356-362.
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  • Synthetic Cells and Organelles: Compartmentalization Strategies.Renée Roodbeen & Jan C. M. van Hest - 2009 - Bioessays 31 (12):1299-1308.
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