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  1. Teleology and Defining Sex.Nathan K. Gamble & Michal Pruski - 2018 - The New Bioethics 24 (2):176-189.
    Disorders of sexual differentiation lead to what is often referred to as an intersex state. This state has medical, as well as some legal, recognition. Nevertheless, the question remains whether intersex persons occupy a state in between maleness and femaleness or whether they are truly men or women. To answer this question, another important conundrum needs to be first solved: what defines sex? The answer seems rather simple to most people, yet when morphology does not coincide with haplotypes, and genetics (...)
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  • Birth of the Eukaryotes by a Set of Reactive Innovations: New Insights Force Us to Relinquish Gradual Models.Dave Speijer - 2015 - Bioessays 37 (12):1268-1276.
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  • Mitonuclear Mate Choice: A Missing Component of Sexual Selection Theory?Geoffrey E. Hill - 2018 - Bioessays 40 (3):1700191.
    The fitness of a eukaryote hinges on the coordinated function of the products of its nuclear and mitochondrial genomes in achieving oxidative phosphorylation. I propose that sexual selection plays a key role in the maintenance of mitonuclear coadaptation across generations because it enables pre-zygotic sorting for coadapted mitonuclear genotypes. At each new generation, sexual reproduction creates new combinations of nuclear and mitochondrial genes, and the potential arises for mitonuclear incompatibilities and reduced fitness. In reviewing the literature, I hypothesize that individuals (...)
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  • Intracellular Evolution of Mitochondrial DNA and the Tragedy of the Cytoplasmic Commons.David Haig - 2016 - Bioessays 38 (6):549-555.
    Mitochondria exist in large numbers per cell. Therefore, the strength of natural selection on individual mtDNAs for their contribution to cellular fitness is weak whereas the strength of selection in favor of mtDNAs that increase their own replication without regard for cellular functions is strong. This problem has been solved for most mitochondrial genes by their transfer to the nucleus but a few critical genes remain encoded by mtDNA. Organisms manage the evolution of mtDNA to prevent mutational decay of essential (...)
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  • Mitochondria: The Red Queen Lies Within.Bram Kuijper - 2015 - Bioessays 37 (9):934-934.
  • Mitochondrial Genome Erosion and the Evolution of Sex.Arunas L. Radzvilavicius - 2016 - Bioessays 38 (10):941-942.
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