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Equipoise and randomization

In Ezekiel J. Emanuel (ed.), The Oxford Textbook of Clinical Research Ethics. Oxford University Press. pp. 245--60 (2008)

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  1. Outcome-Adaptive Randomization in Clinical Trials: Issues of Participant Welfare and Autonomy.Julius Sim - 2019 - Theoretical Medicine and Bioethics 40 (2):83-101.
    Outcome-adaptive randomization has been proposed as a corrective to certain ethical difficulties inherent in the traditional randomized clinical trial using fixed-ratio randomization. In particular, it has been suggested that OAR redresses the balance between individual and collective ethics in favour of the former. In this paper, I examine issues of welfare and autonomy arising in relation to OAR. A central issue in discussions of welfare in OAR is equipoise, and the moral status of OAR is crucially influenced by the way (...)
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