The present thesis explores some metaphysical issues concerning biochemical kinds and the relations between chemical and biological properties and phenomena. The main result of this thesis is that there is something sui generis about biochemical kinds. This result is motivated by two theoretical steps. The first is characterising biochemical functions as weakly emergent from the chemical structure [Chapter 3, Chapter 6]. The second is via an account for which biochemical kinds are natural categories [Chapter 4, Chapter 7]. The thesis comprises (...) four parts. Part I [Chapter 1, Chapter 2] aims to offer the methodological and conceptual tools that underpin this research. Chapter 1 presents the debate on the unity of science and the motivation of the research. Chapter 2 presents the account of natural kinds that will be used throughout the thesis. Part II [Chapter 3, Chapter 4] offers a detailed metaphysical analysis of the molecular gene. Chapter 3 argues that molecular genes are weakly emergent from nucleic acids. Chapter 4 argues that the category "molecular gene" can be deemed a natural kind, following the account presented in Chapter 2. Part III [Chapter 5, Chapter 6, Chapter 7] explores some of the themes related to biochemical kinds and generalises some of the results from Part II. Chapter 5 considers biochemical functions and how functional attribution should be interpreted for biochemical molecules. Chapter 6 considers the relation between biochemical functions and structure, spelt in terms of weak emergence and explores unity in biochemistry. Chapter 7 considers the topic of biochemical kinds per se and argues that biochemical kinds are natural categories. Part IV [Chapter 8] elucidates the main outcome and the implications that this research can have for future discussion in the philosophy and metaphysics of biochemistry and the unity of science. (shrink)

Scientists cannot devise theories, construct models, propose explanations, make predictions, or even carry out observations, without first classifying their subject matter. The goal of scientific taxonomy is to come up with classification schemes that conform to nature's own. Another way of putting this is that science aims to devise categories that correspond to 'natural kinds.' The interest in ascertaining the real kinds of things in nature is as old as philosophy itself, but it takes on a different guise when one (...) adopts a naturalist stance in philosophy, that is when one looks closely at scientific practice and takes it as a guide for identifying natural kinds and investigating their general features. This Element surveys existing philosophical accounts of natural kinds, defends a naturalist alternative, and applies it to case studies in a diverse set of sciences. This title is also available as Open Access on Cambridge Core. (shrink)

There seems to be an emerging consensus among many philosophers of science that non-epistemic values ought to play a role in the process of scientific reasoning itself. Recently, a number of philosophers have focused on the role of values in scientific classification or taxonomy. Their claim is that a choice of ontology or taxonomic scheme can only be made, or should only be made, by appealing to non-epistemic or social values. In this paper, I take on this “argument from ontological (...) choice,” claiming that it equivocates on the notion of choice. An ontological choice can be understood either in terms of determining which taxonomic scheme is valid, or in terms of deciding which taxonomic scheme to deploy in a given context. I try to show that while the latter can be determined in part by social values, the former ought not to be so determined. (shrink)

Jonathan Y. Tsou examines and defends positions on central issues in philosophy of psychiatry. The positions defended assume a naturalistic and realist perspective and are framed against skeptical perspectives on biological psychiatry. Issues addressed include the reality of mental disorders; mechanistic and disease explanations of abnormal behavior; definitions of mental disorder; natural and artificial kinds in psychiatry; biological essentialism and the projectability of psychiatric categories; looping effects and the stability of mental disorders; psychiatric classification; and the validity of the DSM's (...) diagnostic categories. The main argument defended by Tsou is that genuine mental disorders are biological kinds with harmful effects. This argument opposes the dogma that mental disorders are necessarily diseases that result from biological dysfunction. Tsou contends that the broader ideal of biological kinds offers a more promising and empirically ascertainable naturalistic standard for assessing the reality of mental disorders and the validity of psychiatric categories. (shrink)

Unity of science was once a very popular idea among both philosophers and scientists. But it has fallen out of fashion, largely because of its association with reductionism and the challenge from multiple realisation. Pluralism and the disunity of science are the new norm, and higher-level natural kinds and special science laws are considered to have an important role in scientific practice. What kind of reductionism does multiple realisability challenge? What does it take to reduce one phenomenon to another? How (...) do we determine which kinds are natural? What is the ontological basis of unity? In this Element, Tuomas Tahko examines these questions from a contemporary perspective, after a historical overview. The upshot is that there is still value in the idea of a unity of science. We can combine a modest sense of unity with pluralism and give an ontological analysis of unity in terms of natural kind monism. This title is available as Open Access on Cambridge Core. (shrink)

A scientific explanatory project, part-whole explanation, and a kind of science, part-whole science are premised on identifying, investigating, and using parts and wholes. In the biological sciences, mechanistic, structuralist, and historical explanations are part-whole explanations. Each expresses different norms, explananda, and aims. Each is associated with a distinct partitioning frame for abstracting kinds of parts. These three explanatory projects can be complemented in order to provide an integrative vision of the whole system, as is shown for a detailed case study: (...) the tetrapod limb. My diagnosis of part-whole explanation in the biological sciences as well as in other domains exploring evolved, complex, and integrated systems (e.g., psychology and cognitive science) cross-cuts standard philosophical categories of explanation: causal explanation and explanation as unification. Part-whole explanation is itself one essential aspect of part-whole science. (shrink)

The dangers of character reification for cladistic inference are explored. The identification and analysis of characters always involves theory-laden abstraction—there is no theory-free “view from nowhere.” Given theory-ladenness, and given a real world with actual objects and processes, how can we separate robustly real biological characters from uncritically reified characters? One way to avoid reification is through the employment of objectivity criteria that give us good methods for identifying robust primary homology statements. I identify six such criteria and explore each (...) with examples. Ultimately, it is important to minimize character reification, because poor character analysis leads to dismal cladograms, even when proper phylogenetic analysis is employed. Given the deep and systemic problems associated with character reification, it is ironic that philosophers have focused almost entirely on phylogenetic analysis and neglected character analysis. (shrink)

Are acids natural kinds? Or are they merely relevant kinds? Although acidity has been one of the oldest and most important concepts in chemistry, surprisingly little ink has been spilled on the natural kind question. I approach the question from the perspective of microstructural essentialism. After explaining why both Brønsted acids and Lewis acids are considered functional kinds, I address the challenges of multiple realization and multiple determination. Contra Manafu and Hendry, I argue that the stereotypical properties of acids are (...) not multiply realized. Instead, given the equivalence between the proton-donating and electron-accepting mechanisms of Brønsted and Lewis, respectively, I show that acidity as a property type can be identified with a unique microstructural property, namely the presence of a LUMO or other low energy empty orbital. In doing so, I defend the view that the Lewis theory encompasses Brønsted–Lowry, and that all Brønsted acids are also Lewis acids. Contra Hacking and Chang, I thus maintain that the different concepts of acidity do not crosscut, and that the hierarchy requirement is met. Finally, by characterizing natural kinds as powerful objects and by adopting a dispositional view of functions, I illustrate how the microessentialist can make sense of the latent and relational character of most acids. In sum, I contend that acids are genuine natural kinds, even for the microstructural essentialist. (shrink)

Discussions of psychiatric nosology focus on a few popular examples of disorders, and on the validity of diagnostic criteria. Looking at Anorexia Nervosa, an example rarely mentioned in this literature, reveals a new problem: the DSM has a strict taxonomic structure, which assumes that disorders can only be located on one branch. This taxonomic assumption fails to fit the domain of psychopathology, resulting in obfuscation of cross-category connections. Poor outcomes for treatment of Anorexia may be due to it being pigeonholed (...) as an Eating Disorder, when a disturbance of body perception may be a more central symptom than food restriction. This paper explores the possibility of restructuring the DSM taxonomy to allow for a pluralist classification of disorders. This change could improve treatment and research without requiring any changes to diagnostic criteria. (shrink)

There is a vast literature within philosophy of mind that focuses on artificial intelligence, but hardly mentions methodological questions. There is also a growing body of work in philosophy of science about modeling methodology that hardly mentions examples from cognitive science. Here these discussions are connected. Insights developed in the philosophy of science literature about the importance of idealization provide a way of understanding the neural implausibility of connectionist networks. Insights from neurocognitive science illuminate how relevant similarities between models and (...) targets are picked out, how modeling inferences are justified, and the metaphysical status of models. (shrink)

This paper takes a hierarchical approach to the question whether species are individuals or natural kinds. The thesis defended here is that species are spatiotemporally located complex wholes (individuals), that are composed of (i.e., include) causally interdependent parts, which collectively also instantiate a homeostatic property cluster (HPC) natural kind. Species may form open or closed genetic systems that are dynamic in nature, that have fuzzy boundaries due to the processual nature of speciation, that may have leaky boundaries as is manifest (...) in lateral gene transfer and introgression, that may be of multiple origins through hybridization, and that may split and merge and split again over time. The identity conditions of species qua individuals will have to be anchored in their history, rather than in their unique evolutionary origin. Species qua historically conditioned HPC natural kinds requires the kind to be mereologically structured, subject to the part-whole relation rather than the membership relation. This implies that there can be more than one kind of natural kinds. (shrink)

Thomas Kuhn is mostly known for his contributions to the philosophy of science. However, it was chiefly to investigations in philosophy of language that he dedicated the last part of his career. The aim of this paper is to present a systematic view of Kuhn’s main ideas on this subject. I start by describing his theory of concept, in particular what he says about kind terms. Such terms, acquired in blocks that form contrast sets or “taxonomies,” are learned through ostensible (...) definitions. Next, I analyze Kuhn’s concepts of “meaning” and “truth.” Finally, I discuss a second type of kinds terms, not fully investigated by him, which is learned together with scientific laws. Resumo Thomas Kuhn é conhecido principalmente por suas contribuições para a filosofia da ciência. No entanto, foi em grande medida à filosofia da linguagem que ele dedicou a última parte de sua carreira. O objetivo deste artigo é apresentar uma visão sistemática das principais ideias de Kuhn sobre esse assunto. Começo descrevendo sua teoria do conceito, em particular o que ele diz sobre termos para espécie. Tais termos, aprendidos em blocos que formam conjuntos de contraste ou “taxonomias”, são aprendidos através de definições ostensivas. Em seguida, analiso as concepções de Kuhn de “significado” e “verdade”. Finalmente, discuto um segundo tipo de termo para espécies, não totalmente investigado por ele, que é aprendido junto com as leis científicas. (shrink)

Sometimes seeing sandal from non-smellable distance we obtain cognition in the form ‘surabhi candanam’ (that sandal out there is fragrant). According to the Naiyāyikas, this cognition is a single qualified visual perception, where fragrance is grasped by visual sense-faculty. Normally visual sense cannot grasp fragrance. But here fragrance is grasped by visual sense through an extraordinary sense-connection. The Nyāya holds that the memory of fragrance, working as cognition-induced extraordinary sensory connection (jñānalakṣaṇa alaukika sannikarṣa), connects its object, fragrance, with visual sense. (...) The Naiyāyikas use this thesis of jñānalakṣaṇa to explain illusion. For a direct realist like the Naiyāyikas, it is always difficult to explain illusion. But jñānalakṣaṇa explains how an object, which is absent in front, can be accessed directly by the operating sense-organ through an extraordinary sensory connection. However, there is a possible threat to the thesis of jñānalakṣaṇa. In the mechanism of jñānalakṣaṇa, memory plays a vital role. If one is already acquainted with the fragrance of sandal in some previous occasion, then the memory of fragrance can work as an extraordinary sensory connection for her. But the question arises as to what happens when she acquires the knowledge of fragrant sandal for the first time? Is it also an instance of extraordinary jñānalakṣaṇa perception? It is obvious that in such case no memory is there to help her connect her visual sense to fragrance. However, this first acquaintance is a precondition for the possibility of the later acquaintances of fragrant sandal. Hence, it is necessary for the Naiyāyikas to explain the mechanism of the first acquaintance of fragrant sandal. The Naiyāyikas will be able to save their thesis of jñānalakṣaṇa (and also their direct realism) if they can depict a moment-wise account of the whole process of the first acquaintance of fragrant sandal remaining consistent with their own basic tenets. It would require moment-analysis (kṣaṇavicāra) of that cognitive situation. In Nyāya-Vaiśeṣika tradition, several attempts have been made to solve the problem. Jayanta Bhaṭṭa in Nyāyamañjarī mentions that ‘madhura śarkarā’ or ‘sugandhi ketakī’ are cases of mental perception or mānasa pratyakṣa. He says that here manas functions as the means of perception being aided by external senses to produce such cognition. Jayanta Bhaṭṭa explains the other cases like illusion and recognition by the same model. On the other hand, Śrīdhara Bhaṭṭa in Nyāyakandalī says that in the case of the first acquaintance, at first the fragrance is grasped by the olfactory sense. Then, the visual sense-faculty, taking the perception of the fragrance as an associate cause, produces a cognition of the qualificand. The paper constructs several versions of moment examinations (kṣaṇavicāra) for both of these suggestions and evaluates them. It is observed that although Jayanta’s thesis may be accepted as an alternative Nyāya account of the first acquaintance of fragrant sandalwood, Śrīdhara’s account fails partially. On the other hand, Jayanta fails to explicate the inner psychological steps involved in the said cognition. This paper suggests that we can successfully construct moment examination of the first acquaintance of fragrant sandal; hence, the Nyāya thesis of jñānalakṣaṇa suffers no threat of internal inconsistency. However, the relevant sensory connection working there is not an olfactory perception. Rather, it also is a memory cognition, which is generated out of the memory-trace of fragrance produced on the spot from the aforesaid olfactory perception. Thus, the Naiyāyikas may save their thesis of jñānalakṣaṇa pratyakṣa as well as their direct realism. (shrink)

The following paper attempts to explore, criticizeand develop Thomas Kuhn's mostmature – and surprisingly neglected – view ofincommensurability. More specifically, itfocuses on (1) undermining an influential picture ofscientific kinds that lies at the heartof Kuhn's understanding of taxonomic incommensurability;(2) sketching an alternativepicture of scientific kinds that takes advantage ofKuhn's partially developed theory ofdisciplinary matrices; and (3) using these two resultsto motivate revisions to Kuhn'stheory of taxonomic incompatibility, as well as, tothe purported bridge betweentaxonomic incompatibility and some of the traditionalproblems associated (...) withincommensurability. (shrink)

The concept of “life” certainly is of some use to distinguish birds and beavers from water and stones. This pragmatic usefulness has led to its construal as a categorical predicate that can sift out living entities from non-living ones depending on their possessing specific properties—reproduction, metabolism, evolvability etc. In this paper, we argue against this binary construal of life. Using text-mining methods across over 30,000 scientific articles, we defend instead a degrees-of-life view and show how these methods can contribute to (...) experimental philosophy of science and concept explication. We apply topic-modeling algorithms to identify which specific properties are attributed to a target set of entities (bacteria, archaea, viruses, prions, plasmids, phages and the molecule of adenine). Eight major clusters of properties were identified together with their relative relevance for each target entity (two that relate to metabolism and catalysis, one to genetics, one to evolvability, one to structure, and—rather unexpectedly—three that concern interactions with the environment broadly construed). While aligning with intuitions—for instance about viruses being less alive than bacteria—these quantitative results also reveal differential degrees of performance that have so far remained elusive or overlooked. Taken together, these analyses provide a conceptual “lifeness space” that makes it possible to move away from a categorical construal of life by empirically assessing the relative lifeness of more-or-less alive entities. (shrink)

In E.J. Lowe's ontology, (individual) objects are property-bearers which 1) have identity and 2) are countable. This makes it possible to become or cease to be an object, by beginning or ceasing to fulfil one of these conditions. But the possibility of switching fundamental ontological categories should be excluded. Furthermore, Lowe does not show that “quasi-individuals” (which are not countable) can exist. I argue against Lowe that kinds cannot be property-bearers in a more genuine sense than properties, that they are (...) not absolutely countable, whether conceived according to science or common sense, and that they are dependent on individual objects. (shrink)

Scientific essentialism holds that: (1) each scientific kind is associated with the same set of properties in every possible world; and (2) every individual member of a scientific kind belongs to that kind in every possible world in which it exists. Recently, Ellis (Scientific essentialism, 2001 ; The philosophy of nature 2002 ) has provided the most sustained defense of scientific essentialism, though he does not clearly distinguish these two claims. In this paper, I argue that both claims face a (...) number of formidable difficulties. The necessities of scientific essentialism are not adequately distinguished from semantic necessities, they have not been shown to be necessities in the strictest sense, they must be relativized to context, and they must either be confined to a subset of scientific properties without warrant or their connection to causal powers must be revoked. Moreover, upon closer examination (1) turns out to be a trivial thesis that can be satisfied by non-kinds, and (2) is inapplicable to some of the most fundamental kinds in the basic sciences. (shrink)

There is a widespread assumption in cognitive science that there is anintrinsic link between the phenomena of innateness and domain specificity. Many authors seem to hold that given the properties of these two phenomena, it follows that innate mental states are domain-specific, or that domain-specific states are innate. My aim in this paper is to argue that there are no convincing grounds for asserting either claim. After introducing the notions of innateness and domain specificity, I consider some possible arguments for (...) the conclusion that innate cognitive states are domain-specific, or vice versa. Having shown that these arguments do not succeed, I attempt to explicate what I take to be the connection between innateness and domain specificity. I argue that it is simply easier to determine whether and to what extent domain-specific cognitive capacities are innate. That is,the relation between innateness and domain specificity is evidential or epistemic, rather than intrinsic. (shrink)

Functional reductionism concerning mental properties has recently been advocated by Jaegwon Kim in order to solve the problem of the 'causal exclusion' of the mental. Adopting a reductionist strategy first proposed by David Lewis, he regards psychological properties as being 'higher-order' properties functionally defined over 'lower-order' properties, which are causally efficacious. Though functional reductionism is compatible with the multiple realizability of psychological properties, it is blocked if psychological properties are subdivided or crosscut by neurophysiological properties. I argue that there is (...) recent evidence from cognitive neuroscience that shows that this is the case for the psychological property of fear. Though this may suggest that some psychological properties should be revised in order to conform to those of neurophysiology, the history of science demonstrates that this is not always the outcome, particularly with properties that play an important role in our folk theories and are central to human concerns. (shrink)

In this article I argue that structure in chemistry is a creature of abstraction: attending selectively to structural similarities, we neglect differences. There are different ways to abstract, so abstraction is interest dependent. So is structure. First, there are two different and mutually irreducible notions of structure in chemistry: bond structure and geometrical structure. Second, structure is relative to scale : the same substance has different structures at different scales, and relationships of structural sameness and difference vary across the scales. (...) However, these facts have no tendency to undermine structure’s claim to reality, or its metaphysical seriousness. (shrink)

There is a perennial philosophical dream of a certain natural order for the natural kinds. The name of this dream is ‘the hierarchy requirement’. According to this postulate, proper natural kinds form a taxonomy which is both unique and traditional. Here I demonstrate that complex scientific objects exist: objects which generate different systems of scientific classification, produce myriad legitimate alternatives amongst the nonetheless still natural kinds, and make the hierarchical dream impossible to realize, except at absurdly great cost. Philosophical hopes (...) for a certain order in nature cannot be fulfilled. Natural kinds crosscut one another, ubiquitously so, and this crosscutting spells the end of the hierarchical dream. (shrink)

Discussions in sociological theory often focus on ontological questions on the nature of social reality. Against the underlying epistemological realism, I argue for a constructivist notion of theory: Theories are webs of concepts that we use to guide empirical observations and to make sense of them. We cannot know the real features of the social world, only what our theoretical perspectives make us see. Theories therefore represent social phenomena by highlighting certain features and relating them in a logical system. In (...) this system, theoretical sentences can be considered true if they meet two conditions: They are consistent with the theory at hand and adequately map empirically observable relations between objects denoted by theoretical constructs. Truth is therefore relative to a perspective; it is not objectively determinable. Theories should be assessed not for their ontologies but for what they allow us to see and how they connect to empirical observations. (shrink)

Both realist and anti-realist accounts of natural kinds possess prima facie virtues: realists can straightforwardly make sense of the apparent objectivity of the natural kinds, and anti-realists, their knowability. This paper formulates a properly anti-realist account designed to capture both merits. In particular, it recommends understanding natural kinds as ‘categorical bottlenecks,’ those categories that not only best serve us, with our idiosyncratic aims and cognitive capacities, but also those of a wide range of alternative agents. By endorsing an ultimately subjective (...) categorical principle, this view sidesteps epistemological difficulties facing realist views. Yet, it nevertheless identifies natural kinds that are fairly, though not completely, stance-independent or objective. (shrink)

Pain continues to be one of the most controversial subjects in neurophilosophy. One focus of current debates is the apparent absence of an ideal brain‐based biomarker that could function as a coherent and distinct indicator for pain. One prominent reaction to this in the philosophical literature is scientific pain eliminativism. In this article, I argue for a non‐eliminative alternative that builds on family resemblances and provides a useful heuristic in the tradeoff between the idiosyncrasy of the neural processes corresponding to (...) different pain cases and the demand for generalizability in pain research. (shrink)

Hanoch Ben-Yami has argued that the theory of the semantics of natural kind terms proposed by Kripke and Putnam is false and has proposed an allegedly novel account of the semantics of kind terms. In this article, I critically examine Ben-Yami’s arguments. I will argue that Ben-Yami’s objections do not show that Kripke and Putnam’s theory is false, but at most that the specific versions of it held by Kripke and Putnam have some weaknesses. Moreover, I will argue that Ben-Yami’s (...) account is not a novel account but it is only an unsatisfactory version of Kripke and Putnam’s theory. (shrink)

Traditionally, accounts of natural kinds have run the gamut from strongly conventionalist to strongly realist views. Recently, however, there has been a significant shift toward more conventionalist-sounding positions, even (perhaps especially) among philosophers interested in scientific classification. The impetus for this is a trend toward making anthropocentric features of categories, namely, capacities to facilitate human epistemic (and other) interests via inductive inference, central to an account of kinds. I argue that taking these features seriously is both defensible and compatible with (...) conventionalism, but not compatible with a traditional realism about kinds specifically. Moreover, hopes of achieving compatibility by revising and extending kind realism—into what I call “hyperrealism”—face an insuperable dilemma. The news for realists is not all bad, however: though kind realism proves untenable, closely associated realisms underlying the objectivity of kind discourse may be viable nonetheless. (shrink)

The kinds of real or natural kinds that support explanation and prediction in the social sciences are difficult to identify and track because they change through time, intersect with one another, and they do not always exhibit their properties when one encounters them. As a result, conceptual practices directed at these kinds will often refer in ways that are partial, equivocal, or redundant. To improve this epistemic situation, it is important to employ open-ended classificatory concepts, to understand when different research (...) programs are tracking the same real kind, and to maintain an ongoing commitment to interact causally with real kinds to focus reference on those kinds. A tempting view of these non-idealized epistemic conditions should be avoided: that they signal an ontological structure of the social world so plentiful that it would permit ameliorated classificatory schemes to achieve their normative aims regardless of whether they defer to real-kind classificatory schemes. To ground these discussions, the essay appeals to an overlooked convergence in the systematic naturalistic frameworks of Richard Boyd and Ruth Millikan. (shrink)

Extended Cognition (EC) hypothesizes that there are parts of the world outside the head serving as cognitive vehicles. One criticism of this controversial view is the problem of “cognitive bloat” which says that EC is too permissive and fails to provide an adequate necessary criterion for cognition. It cannot, for instance, distinguish genuine cognitive vehicles from mere supports (e.g. the Yellow Pages). In response, Andy Clark and Mark Rowlands have independently suggested that genuine cognitive vehicles are distinguished from supports in (...) that the former have been “recruited,” i.e. they are either artifacts, or, products of evolution. I argue against this proposal. There are counter examples to the claim that “Teleological” EC is either necessary or sufficient for cognition. Teleological EC conflates different types of scientific projects, and inherits content externalism’s alienation from historically impartial cognitive science. (shrink)

Original in content and approach, Philosophy in Classical India focuses on the rational principles of Indian philosophical theory, rather than the mysticism usually associated with it. Ganeri explores the philosophical projects of a number of major Indian philosophers and looks into the methods of rational inquiry deployed within these projects. In so doing, he illuminates a network of mutual reference and criticism, influence and response, in which reason is simultaneously used constructively and to call itself into question.

Humeans and non-Humeans reasonably agree that there may be necessary connections between entities that are identical or merely partly distinct—between, e.g., sets and their individual members, fusions and their individual parts, instances of determinates and determinables, members of certain natural kinds and certain of their intrinsic properties, and (especially among physicalists) certain physical and mental states. Humeans maintain, however, that as per “Hume’s Dictum”, there are no necessary connections between entities that are wholly distinct;1 and in particular, no necessary causal (...) connections between such entities (even when the background conditions requisite for causation are in place). The Humean’s differential treatment appears principled, in reflecting that commonly accepted necessary connections involve constitutional relations, whereas wholly distinct entities (notably, causes and effects) do not constitute each other. I’ll argue, however, that the appearance of principle is not genuine, as per the following conditional: Constitutional→Causal: If one accepts certain constitutional necessities, one should accept certain causal necessities. This result provides needed leverage in assessing the two main frameworks in the metaphysics of science, treating natural kinds, causes, laws of nature, and the like. These frameworks differ primarily on whether Hume’s Dictum is taken as a working constraint on theorizing; and it has proved difficult for either side to criticize the other without presupposing their preferred stance on the dictum, hence talking past one another. The arguments for Constitutional→Causal are based, however, in general and independent considerations about what facts in the world might plausibly warrant our beliefs in certain constitutional necessities involving broadly scientific entities. The Humean can respond to these arguments, which reveal a deep tension in their view, at attendant costs of implausibilty and adhocery. The non-Humean framework doesn’t face any such tension between constitutional and causal necessities, however, and so in this respect comes out ahead. (shrink)

Are acids natural kinds? Or are they merely relevant kinds? Although acidity has been one of the oldest and most important concepts in chemistry, surprisingly little ink has been spilled on the natural kind question. I approach the question from the perspective of microstructural essentialism. After explaining why both Brønsted acids and Lewis acids are considered functional kinds, I address the challenges of multiple realization and multiple determination. Contra Manafu and Hendry, I argue that the stereotypical properties of acids are (...) not multiply realized. Instead, given the equivalence between the proton-donating and electron-accepting mechanisms of Brønsted and Lewis, respectively, I show that acidity as a property type can be identified with a unique microstructural property, namely the presence of a LUMO or other low energy empty orbital. In doing so, I defend the view that the Lewis theory encompasses Brønsted--Lowry, and that all Brønsted acids are also Lewis acids. Contra Hacking and Chang, I thus maintain that the different concepts of acidity do not crosscut, and that the hierarchy requirement is met. Finally, by characterizing natural kinds as powerful objects and by adopting a dispositional view of functions, I illustrate how the microessentialist can make sense of the latent and relational character of most acids. In sum, I contend that acids are genuine natural kinds, even for the microstructural essentialist. (shrink)

Cancer—and scientific research on cancer—raises a variety of compelling philosophical questions. This entry will focus on four topics, which philosophers of science have begun to explore and debate. First, scientific classifications of cancer have as yet failed to yield a unified taxonomy. There is a diversity of classificatory schemes for cancer, and while some are hierarchical, others appear to be “cross-cutting,” or non-nested. This literature thus raises a variety of questions about the nature of the disease and disease classification. Second, (...) philosophers of science have historically taken the aim of science to be arriving at true theories. However, scientists studying cancer come from a variety of disciplines, with different scientific as well as practical aims. Perhaps it is not surprising, then, that historians and philosophers of science do not seem to agree on how best to characterize the aim and structure of cancer research; it is far from clear whether the appropriate characterization of the aim is arriving at true theories, or even whether the proper units of analysis are “theories”, or instead, “models”, “explanatory frameworks”, “research programs”, “paradigms”, or perhaps, “experimental traditions”. With the rise of “big data” science—such as the Cancer Genome Atlas Project (or TCGA)—and “systems” approaches to the study of disease, both philosophers and historians of science are rethinking how best to describe and explain these distinctive kinds of scientific inquiry. -/- Third, cancer is in part a byproduct of our developmental and life history, as well as our evolutionary history. Cancer progression can be compared to a reversion of development, or, to the evolution of multicellularity. Thus, cancer raises intriguing questions about how we conceive of “functions”, “development”, and the role of our evolutionary history and particularly, selective trade-offs, in vulnerability to disease. -/- Last but not least, cancer research provides a case study for consideration of the roles of values at the science-policy interface. Epidemiological and toxicological research on cancer’s causes informs toxics law and regulatory policy, which raises a variety of questions about the nature of evidence and inductive risk in such contexts. (shrink)

Scientists represent their world, grouping and organizing phenomena into classes by means of concepts. Philosophers of science have historically been interested in the nature of these concepts, the criteria that inform their application and the nature of the kinds that the concepts individuate. They also have sought to understand whether and how different systems of classification are related and more recently, how investigative practices shape conceptual development and change. Our aim in this paper is to provide a critical overview of (...) some of the key developments in this philosophical literature and identify some interesting issues it raises about the prospects of the so-called “special sciences”, including psychiatry, psychology, and the mind-brain sciences more generally, to discover natural kinds. (shrink)

Selection explanations explain some non-accidental generalizations in virtue of a selection process. Such explanations are not particulaizable - they do not transfer as explanations of the instances of such generalizations. This is unlike many explanations in the physical sciences, where the explanation of the general fact also provides an explanation of its instances (i.e. standard D-N explanations). Are selection explanations (e.g. in biology) therefore a different kind of explanation? I argue that to understand this issue, we need to see that (...) a standard D-N explanation of some non-accidental generalization (al Fs are Gs) may also ipso facto explain its contrapositive (all non-Gs are non-Fs), but the explanation is particularizable with respect to the former but not to the latter. This can be seen by noting that the Raven Paradox counterexample to the H-D model of confirmation also generates a counterexample to the D-N model of explanation (all ravens are black does not explain why the non-black shoe is a non-raven). In such cases it is natural to take the generalization with the positive predicates to have a particularizable explanation. However, this need not be the case, and in selection explanations it is the generalization with the positive predicates whose explanation is no particularizable. Thus there is no need to suppose that selection explanations are fundamentally different. (shrink)

Naturalism about natural kinds is the view that they are none other than the kinds discoverable by science. This thesis is in tension with what is perhaps the dominant contemporary view of natural kinds: essentialism. According to essentialism, natural kinds constitute a small subset of our scientific categories, namely those definable in terms of intrinsic, microphysical properties, which are possessed necessarily rather than contingently by their bearers. Though essentialism may appear compatible with naturalism, and is indeed sometimes qualified with the (...) epithet “scientific,” it has become increasingly clear in recent years that only a minority of categories posited by science satisfy those conditions. I will not try to argue against essentialism directly in this chapter. Instead, I will attempt to articulate an alternative, naturalist conception of natural kinds, according to which the mark of natural kinds is their discoverability by science, not just basic science but the special sciences and even the social sciences. (shrink)

The theory of concepts advanced in the dissertation aims at accounting for a) how a concept makes successful practice possible, and b) how a scientific concept can be subject to rational change in the course of history. Traditional accounts in the philosophy of science have usually studied concepts in terms only of their reference; their concern is to establish a stability of reference in order to address the incommensurability problem. My discussion, in contrast, suggests that each scientific concept consists of (...) three components of content: 1) reference, 2) inferential role, and 3) the epistemic goal pursued with the concept's use. I argue that in the course of history a concept can change in any of these three components, and that change in one component—including change of reference—can be accounted for as being rational relative to other components, in particular a concept's epistemic goal.This semantic framework is applied to two cases from the history of biology: the homology concept as used in 19th and 20th century biology, and the gene concept as used in different parts of the 20th century. The homology case study argues that the advent of Darwinian evolutionary theory, despite introducing a new definition of homology, did not bring about a new homology concept (distinct from the pre-Darwinian concept) in the 19th century. Nowadays, however, distinct homology concepts are used in systematics/evolutionary biology, in evolutionary developmental biology, and in molecular biology. The emergence of these different homology concepts is explained as occurring in a rational fashion. The gene case study argues that conceptual progress occurred with the transition from the classical to the molecular gene concept, despite a change in reference. In the last two decades, change occurred internal to the molecular gene concept, so that nowadays this concept's usage and reference varies from context to context. I argue that this situation emerged rationally and that the current variation in usage and reference is conducive to biological practice.The dissertation uses ideas and methodological tools from the philosophy of mind and language, the philosophy of science, the history of science, and the psychology of concepts. (shrink)

In robustness analysis, hypotheses are supported to the extent that a result proves robust, and a result is robust to the extent that we detect it in diverse ways. But what precise sense of diversity is at work here? In this paper, I show that the formal explications of evidential diversity most often appealed to in work on robustness – which all draw in one way or another on probabilistic independence – fail to shed light on the notion of diversity (...) relevant to robustness analysis. I close by briefly outlining a promising alternative approach inspired by Horwich’s (1982) eliminative account of evidential diversity. (shrink)